Therapeutic efficacy and safety of S-1-based combination therapy compare with S-1 monotherapy following gemcitabine failure in pancreatic cancer: a meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-11

AUTHORS

Sinan Lu, Yuan Zhang, Xiaohu Zhou, Dongkai Zhou, Qifan Yang, Bingjie Ju, Xinyi Zhao, Zhenhua Hu, Haiyang Xie, Lin Zhou, Shusen Zheng, Weilin Wang

ABSTRACT

S-1 monotherapy is widely used following gemcitabine failure in pancreatic cancer, especially in East Asia. We performed a meta-analysis to determine whether S-1-based combination therapy had better efficacy and safety compared with S-1 monotherapy. We searched Pubmed, Web of Science, ClinicalTrials.gov, and Cochrane CENTRAL and subsequently included five trials with a total of 690 patients. The combined hazard ratio (HR) or risk ratio; the corresponding 95% confidence intervals of progression-free survival, overall survival, and overall response rate; and grade 3–4 adverse events were examined. Five randomized controlled trials were included. Meta-analysis demonstrated S-1-based combination therapy significantly increased progression-free survival (HR = 0.78, 95% confidence interval [CI]: 0.67–0.90, p = 0.0009) and overall response rate (HR = 1.74, 95% CI: 1.20–2.52, p = 0.003). Evidence was insufficient to confirm that S-1-based combined regimens improved overall survival (HR = 0.87, 95% CI: 0.75–1.00, p = 0.05). There was no significant difference in adverse events between the two treatment arms. In conclusion, S-1-based combination therapy improved progression-free survival and overall response rate compared to S-1 monotherapy with acceptable toxicity. More... »

PAGES

36944

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep36944

DOI

http://dx.doi.org/10.1038/srep36944

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040460167

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27833144


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxycytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxonic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tegafur", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Sinan", 
        "id": "sg:person.011253463361.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011253463361.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yuan", 
        "id": "sg:person.01147706741.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147706741.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Xiaohu", 
        "id": "sg:person.0704171750.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704171750.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Dongkai", 
        "id": "sg:person.01116414242.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116414242.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Qifan", 
        "id": "sg:person.01050207347.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050207347.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ju", 
        "givenName": "Bingjie", 
        "id": "sg:person.015036745761.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015036745761.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Xinyi", 
        "id": "sg:person.014254154311.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014254154311.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Zhenhua", 
        "id": "sg:person.0622167130.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622167130.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Haiyang", 
        "id": "sg:person.0657720126.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657720126.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Lin", 
        "id": "sg:person.0753155421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753155421.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China", 
            "Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Shusen", 
        "id": "sg:person.0640501242.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640501242.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 310003, Hangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.13402.34", 
          "name": [
            "Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China", 
            "Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 310003, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Weilin", 
        "id": "sg:person.01352111344.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352111344.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2015.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006465045", 
          "https://doi.org/10.1038/bjc.2015.103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-008-0741-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028625223", 
          "https://doi.org/10.1007/s00280-008-0741-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12029-014-9603-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045726909", 
          "https://doi.org/10.1007/s12029-014-9603-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-013-0747-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028362452", 
          "https://doi.org/10.1007/s12032-013-0747-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-011-1786-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012015751", 
          "https://doi.org/10.1007/s00280-011-1786-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-010-1311-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049771159", 
          "https://doi.org/10.1007/s00280-010-1311-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-011-9687-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004937992", 
          "https://doi.org/10.1007/s10637-011-9687-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00534-011-0400-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027231049", 
          "https://doi.org/10.1007/s00534-011-0400-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11-11", 
    "datePublishedReg": "2016-11-11", 
    "description": "S-1 monotherapy is widely used following gemcitabine failure in pancreatic cancer, especially in East Asia. We performed a meta-analysis to determine whether S-1-based combination therapy had better efficacy and safety compared with S-1 monotherapy. We searched Pubmed, Web of Science, ClinicalTrials.gov, and Cochrane CENTRAL and subsequently included five trials with a total of 690 patients. The combined hazard ratio (HR) or risk ratio; the corresponding 95% confidence intervals of progression-free survival, overall survival, and overall response rate; and grade 3\u20134 adverse events were examined. Five randomized controlled trials were included. Meta-analysis demonstrated S-1-based combination therapy significantly increased progression-free survival (HR\u2009=\u20090.78, 95% confidence interval [CI]: 0.67\u20130.90, p\u2009=\u20090.0009) and overall response rate (HR\u2009=\u20091.74, 95% CI: 1.20\u20132.52, p\u2009=\u20090.003). Evidence was insufficient to confirm that S-1-based combined regimens improved overall survival (HR\u2009=\u20090.87, 95% CI: 0.75\u20131.00, p\u2009=\u20090.05). There was no significant difference in adverse events between the two treatment arms. In conclusion, S-1-based combination therapy improved progression-free survival and overall response rate compared to S-1 monotherapy with acceptable toxicity.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep36944", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "progression-free survival", 
      "overall response rate", 
      "combination therapy", 
      "response rate", 
      "gemcitabine failure", 
      "hazard ratio", 
      "overall survival", 
      "adverse events", 
      "pancreatic cancer", 
      "combined hazard ratio", 
      "Web of Science", 
      "acceptable toxicity", 
      "Cochrane CENTRAL", 
      "treatment arms", 
      "risk ratio", 
      "grade 3", 
      "monotherapy", 
      "better efficacy", 
      "therapeutic efficacy", 
      "therapy", 
      "confidence intervals", 
      "survival", 
      "significant differences", 
      "cancer", 
      "trials", 
      "efficacy", 
      "safety", 
      "regimens", 
      "patients", 
      "failure", 
      "PubMed", 
      "rate", 
      "total", 
      "toxicity", 
      "events", 
      "conclusion", 
      "arm", 
      "interval", 
      "evidence", 
      "differences", 
      "Central", 
      "ratio", 
      "Web", 
      "compare", 
      "Asia", 
      "East Asia", 
      "science"
    ], 
    "name": "Therapeutic efficacy and safety of S-1-based combination therapy compare with S-1 monotherapy following gemcitabine failure in pancreatic cancer: a meta-analysis", 
    "pagination": "36944", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040460167"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep36944"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27833144"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep36944", 
      "https://app.dimensions.ai/details/publication/pub.1040460167"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_720.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep36944"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep36944'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep36944'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep36944'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep36944'


 

This table displays all metadata directly associated to this object as RDF triples.

284 TRIPLES      21 PREDICATES      96 URIs      80 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep36944 schema:about N1194a1d0998e499eb2301338dfc7ba54
2 N3117ae5852094e258b185705ee0f00ba
3 N3b4ebbb0b2894400933e1c2f8ca5a3b7
4 N44774e02c2664a7291fc46bc6d5ea86c
5 N56110d5425064f2bad11c16c634ce8f5
6 N693343d597ba402e91d8b062dade4711
7 N7a0e71bf3a5747e7a2eda6bd97bc5e2b
8 Na2b4325ef55f484c924048f5e7794dff
9 Naa91b3cfb02446678ca2d3d1e9334aed
10 Nb1eb275cf47843e980eb8757de4f4d19
11 Nd20f315a743d4c05836ca83fafc0e440
12 Ndc436cb115614b78bcb1b5b6e3d08275
13 Ndcc82ea66b7541779bec5dfd078499b9
14 Nddacb589521f409680ad9582fb02d853
15 Nefe125011e094cb2939c603787cd2bb1
16 Nf6667ab075d841ef95179264215f8478
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Na9eb22aaf8c34708a5189b6aaf838dab
20 schema:citation sg:pub.10.1007/s00280-008-0741-7
21 sg:pub.10.1007/s00280-010-1311-3
22 sg:pub.10.1007/s00280-011-1786-6
23 sg:pub.10.1007/s00534-011-0400-y
24 sg:pub.10.1007/s10637-011-9687-4
25 sg:pub.10.1007/s12029-014-9603-1
26 sg:pub.10.1007/s12032-013-0747-9
27 sg:pub.10.1038/bjc.2015.103
28 schema:datePublished 2016-11-11
29 schema:datePublishedReg 2016-11-11
30 schema:description S-1 monotherapy is widely used following gemcitabine failure in pancreatic cancer, especially in East Asia. We performed a meta-analysis to determine whether S-1-based combination therapy had better efficacy and safety compared with S-1 monotherapy. We searched Pubmed, Web of Science, ClinicalTrials.gov, and Cochrane CENTRAL and subsequently included five trials with a total of 690 patients. The combined hazard ratio (HR) or risk ratio; the corresponding 95% confidence intervals of progression-free survival, overall survival, and overall response rate; and grade 3–4 adverse events were examined. Five randomized controlled trials were included. Meta-analysis demonstrated S-1-based combination therapy significantly increased progression-free survival (HR = 0.78, 95% confidence interval [CI]: 0.67–0.90, p = 0.0009) and overall response rate (HR = 1.74, 95% CI: 1.20–2.52, p = 0.003). Evidence was insufficient to confirm that S-1-based combined regimens improved overall survival (HR = 0.87, 95% CI: 0.75–1.00, p = 0.05). There was no significant difference in adverse events between the two treatment arms. In conclusion, S-1-based combination therapy improved progression-free survival and overall response rate compared to S-1 monotherapy with acceptable toxicity.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N444186f9eda44fee9c1fa8fb850a004f
34 Nef9916ade5f9448db3ed315e17e4fd8c
35 sg:journal.1045337
36 schema:keywords Asia
37 Central
38 Cochrane CENTRAL
39 East Asia
40 PubMed
41 Web
42 Web of Science
43 acceptable toxicity
44 adverse events
45 arm
46 better efficacy
47 cancer
48 combination therapy
49 combined hazard ratio
50 compare
51 conclusion
52 confidence intervals
53 differences
54 efficacy
55 events
56 evidence
57 failure
58 gemcitabine failure
59 grade 3
60 hazard ratio
61 interval
62 monotherapy
63 overall response rate
64 overall survival
65 pancreatic cancer
66 patients
67 progression-free survival
68 rate
69 ratio
70 regimens
71 response rate
72 risk ratio
73 safety
74 science
75 significant differences
76 survival
77 therapeutic efficacy
78 therapy
79 total
80 toxicity
81 treatment arms
82 trials
83 schema:name Therapeutic efficacy and safety of S-1-based combination therapy compare with S-1 monotherapy following gemcitabine failure in pancreatic cancer: a meta-analysis
84 schema:pagination 36944
85 schema:productId N08897e326499475eaacc7c081c89fa47
86 N9663f4031f6c4d3eaac4fdeb51a2a895
87 Nd18817a661b14e8b95127d34c848b0a5
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040460167
89 https://doi.org/10.1038/srep36944
90 schema:sdDatePublished 2022-10-01T06:42
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Nb2702cc6fdc7427bb1d8065a8c8d60f9
93 schema:url https://doi.org/10.1038/srep36944
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N06e84719ed4d47ddbf25ae2b0cd8d1c7 rdf:first sg:person.01352111344.36
98 rdf:rest rdf:nil
99 N08897e326499475eaacc7c081c89fa47 schema:name pubmed_id
100 schema:value 27833144
101 rdf:type schema:PropertyValue
102 N0c56b1e50aa54ce8b571d4b48e61d3ff rdf:first sg:person.014254154311.91
103 rdf:rest N10a3f336b2734b6fa6ecadb551e6d986
104 N10a3f336b2734b6fa6ecadb551e6d986 rdf:first sg:person.0622167130.49
105 rdf:rest N6a64d876116642a7b87ce9afbce2a136
106 N1194a1d0998e499eb2301338dfc7ba54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Aged
108 rdf:type schema:DefinedTerm
109 N3117ae5852094e258b185705ee0f00ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Oxonic Acid
111 rdf:type schema:DefinedTerm
112 N370fcacf29064553b8d1e9050e3b051e rdf:first sg:person.015036745761.37
113 rdf:rest N0c56b1e50aa54ce8b571d4b48e61d3ff
114 N3b4ebbb0b2894400933e1c2f8ca5a3b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Drug Combinations
116 rdf:type schema:DefinedTerm
117 N3cf374d834a849dc8b0ca9232e263a8e rdf:first sg:person.01050207347.03
118 rdf:rest N370fcacf29064553b8d1e9050e3b051e
119 N444186f9eda44fee9c1fa8fb850a004f schema:issueNumber 1
120 rdf:type schema:PublicationIssue
121 N44774e02c2664a7291fc46bc6d5ea86c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Aged, 80 and over
123 rdf:type schema:DefinedTerm
124 N5280d3e7e5964b88baaa27b998357821 rdf:first sg:person.01116414242.02
125 rdf:rest N3cf374d834a849dc8b0ca9232e263a8e
126 N56110d5425064f2bad11c16c634ce8f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Tegafur
128 rdf:type schema:DefinedTerm
129 N693343d597ba402e91d8b062dade4711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Randomized Controlled Trials as Topic
131 rdf:type schema:DefinedTerm
132 N6a64d876116642a7b87ce9afbce2a136 rdf:first sg:person.0657720126.04
133 rdf:rest N8212aa2271284bb8a13839123d7fd2c6
134 N7a0e71bf3a5747e7a2eda6bd97bc5e2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Antineoplastic Combined Chemotherapy Protocols
136 rdf:type schema:DefinedTerm
137 N7f005cd7cd7a4c9d973215bb271859a3 rdf:first sg:person.0640501242.51
138 rdf:rest N06e84719ed4d47ddbf25ae2b0cd8d1c7
139 N8212aa2271284bb8a13839123d7fd2c6 rdf:first sg:person.0753155421.39
140 rdf:rest N7f005cd7cd7a4c9d973215bb271859a3
141 N85517c7b2ccb4d038bcd29eb18566cd1 rdf:first sg:person.0704171750.34
142 rdf:rest N5280d3e7e5964b88baaa27b998357821
143 N86c1e6eea2c04f46b553c9e7695d31c4 rdf:first sg:person.01147706741.42
144 rdf:rest N85517c7b2ccb4d038bcd29eb18566cd1
145 N9663f4031f6c4d3eaac4fdeb51a2a895 schema:name doi
146 schema:value 10.1038/srep36944
147 rdf:type schema:PropertyValue
148 Na2b4325ef55f484c924048f5e7794dff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Pancreatic Neoplasms
150 rdf:type schema:DefinedTerm
151 Na9eb22aaf8c34708a5189b6aaf838dab rdf:first sg:person.011253463361.23
152 rdf:rest N86c1e6eea2c04f46b553c9e7695d31c4
153 Naa91b3cfb02446678ca2d3d1e9334aed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Disease-Free Survival
155 rdf:type schema:DefinedTerm
156 Nb1eb275cf47843e980eb8757de4f4d19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Middle Aged
158 rdf:type schema:DefinedTerm
159 Nb2702cc6fdc7427bb1d8065a8c8d60f9 schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Nd18817a661b14e8b95127d34c848b0a5 schema:name dimensions_id
162 schema:value pub.1040460167
163 rdf:type schema:PropertyValue
164 Nd20f315a743d4c05836ca83fafc0e440 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Deoxycytidine
166 rdf:type schema:DefinedTerm
167 Ndc436cb115614b78bcb1b5b6e3d08275 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Humans
169 rdf:type schema:DefinedTerm
170 Ndcc82ea66b7541779bec5dfd078499b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Adult
172 rdf:type schema:DefinedTerm
173 Nddacb589521f409680ad9582fb02d853 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Treatment Outcome
175 rdf:type schema:DefinedTerm
176 Nef9916ade5f9448db3ed315e17e4fd8c schema:volumeNumber 6
177 rdf:type schema:PublicationVolume
178 Nefe125011e094cb2939c603787cd2bb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Male
180 rdf:type schema:DefinedTerm
181 Nf6667ab075d841ef95179264215f8478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Female
183 rdf:type schema:DefinedTerm
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
188 schema:name Oncology and Carcinogenesis
189 rdf:type schema:DefinedTerm
190 sg:journal.1045337 schema:issn 2045-2322
191 schema:name Scientific Reports
192 schema:publisher Springer Nature
193 rdf:type schema:Periodical
194 sg:person.01050207347.03 schema:affiliation grid-institutes:grid.13402.34
195 schema:familyName Yang
196 schema:givenName Qifan
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050207347.03
198 rdf:type schema:Person
199 sg:person.01116414242.02 schema:affiliation grid-institutes:grid.13402.34
200 schema:familyName Zhou
201 schema:givenName Dongkai
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116414242.02
203 rdf:type schema:Person
204 sg:person.011253463361.23 schema:affiliation grid-institutes:grid.13402.34
205 schema:familyName Lu
206 schema:givenName Sinan
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011253463361.23
208 rdf:type schema:Person
209 sg:person.01147706741.42 schema:affiliation grid-institutes:grid.13402.34
210 schema:familyName Zhang
211 schema:givenName Yuan
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147706741.42
213 rdf:type schema:Person
214 sg:person.01352111344.36 schema:affiliation grid-institutes:grid.13402.34
215 schema:familyName Wang
216 schema:givenName Weilin
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352111344.36
218 rdf:type schema:Person
219 sg:person.014254154311.91 schema:affiliation grid-institutes:grid.13402.34
220 schema:familyName Zhao
221 schema:givenName Xinyi
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014254154311.91
223 rdf:type schema:Person
224 sg:person.015036745761.37 schema:affiliation grid-institutes:grid.13402.34
225 schema:familyName Ju
226 schema:givenName Bingjie
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015036745761.37
228 rdf:type schema:Person
229 sg:person.0622167130.49 schema:affiliation grid-institutes:grid.13402.34
230 schema:familyName Hu
231 schema:givenName Zhenhua
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622167130.49
233 rdf:type schema:Person
234 sg:person.0640501242.51 schema:affiliation grid-institutes:grid.13402.34
235 schema:familyName Zheng
236 schema:givenName Shusen
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640501242.51
238 rdf:type schema:Person
239 sg:person.0657720126.04 schema:affiliation grid-institutes:grid.13402.34
240 schema:familyName Xie
241 schema:givenName Haiyang
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657720126.04
243 rdf:type schema:Person
244 sg:person.0704171750.34 schema:affiliation grid-institutes:grid.13402.34
245 schema:familyName Zhou
246 schema:givenName Xiaohu
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704171750.34
248 rdf:type schema:Person
249 sg:person.0753155421.39 schema:affiliation grid-institutes:grid.13402.34
250 schema:familyName Zhou
251 schema:givenName Lin
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753155421.39
253 rdf:type schema:Person
254 sg:pub.10.1007/s00280-008-0741-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028625223
255 https://doi.org/10.1007/s00280-008-0741-7
256 rdf:type schema:CreativeWork
257 sg:pub.10.1007/s00280-010-1311-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049771159
258 https://doi.org/10.1007/s00280-010-1311-3
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s00280-011-1786-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012015751
261 https://doi.org/10.1007/s00280-011-1786-6
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s00534-011-0400-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1027231049
264 https://doi.org/10.1007/s00534-011-0400-y
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s10637-011-9687-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004937992
267 https://doi.org/10.1007/s10637-011-9687-4
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s12029-014-9603-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045726909
270 https://doi.org/10.1007/s12029-014-9603-1
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s12032-013-0747-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028362452
273 https://doi.org/10.1007/s12032-013-0747-9
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/bjc.2015.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006465045
276 https://doi.org/10.1038/bjc.2015.103
277 rdf:type schema:CreativeWork
278 grid-institutes:grid.13402.34 schema:alternateName Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 310003, Hangzhou, China
279 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China
280 Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China
281 schema:name Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 310003, Hangzhou, China
282 Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 310003, Hangzhou, China
283 Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, China
284 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...