Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-10

AUTHORS

Hoang Kim Tu Trinh, Su-Chin Kim, Kumsun Cho, Su-Jung Kim, Ga-Young Ban, Hyun-Ju Yoo, Joo-Youn Cho, Hae-Sim Park, Seung-Hyun Kim

ABSTRACT

Sphingolipid (SL) metabolites have been suggested to be important inflammatory mediators in airway inflammation and asthma. However, little is known about SL metabolites in aspirin-exacerbated respiratory disease (AERD). We aimed to explore the potential AERD biomarkers by conducting lipidomics targeting SL metabolites. The levels of SL metabolites in serum and urine samples from 45 AERD patients and 45 aspirin-tolerant asthma (ATA) patients were quantified through mass spectrometry. During the lysine-aspirin bronchoprovocation test (ASA-BPT), the levels of serum sphingomyelin (SM) were significantly decreased in AERD (P < 0.05) but not in ATA. The serum SM levels were positively correlated with airway responsiveness to methacholine. At the basal status before the ASA-BPT, the levels of serum sphingosine-1-phosphate (S1P) and urine sphingosine were significantly higher in the AERD patients compared with that of ATA patients (P < 0.001) and were positively correlated with a greater decrease in FEV1 (%) values following the ASA-BPT test (P < 0.001 for each), and with serum periostin level (P < 0.05 for each). This study is the first to evaluate serum S1P and urine sphingosine as potential biomarkers of AERD as well as to examine the metabolic disturbance of SL in AERD patients. More... »

PAGES

36599

References to SciGraph publications

  • 2015-02-15. Autophagy in the light of sphingolipid metabolism in APOPTOSIS
  • 2010. An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown in SPHINGOLIPIDS AS SIGNALING AND REGULATORY MOLECULES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep36599

    DOI

    http://dx.doi.org/10.1038/srep36599

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028339978

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27830727


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