FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Ramón Martínez-Mármol, Bruna Barneda-Zahonero, David Soto, Rosa Maria Andrés, Elena Coccia, Xavier Gasull, Laura Planells-Ferrer, Rana S Moubarak, Eduardo Soriano, Joan X Comella

ABSTRACT

Caspases have recently emerged as key regulators of axonal pruning and degeneration and of long-term depression (LTD), a long-lasting form of synaptic plasticity. However, the mechanism underlying these functions remains unclear. In this context, XIAP has been shown to modulate these processes. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. Additionally, we demonstrate that the participation of FAIM-L in these two processes is dependent on its capacity to stabilize XIAP protein levels. Our data reveal FAIM-L as a regulator of axonal degeneration and synaptic plasticity. More... »

PAGES

35775

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep35775

DOI

http://dx.doi.org/10.1038/srep35775

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018639246

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27767058


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep35775'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep35775'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep35775'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep35775'


 

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