Gene-gene Interaction Analyses for Atrial Fibrillation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-08

AUTHORS

Honghuang Lin, Martina Mueller-Nurasyid, Albert V. Smith, Dan E. Arking, John Barnard, Traci M. Bartz, Kathryn L. Lunetta, Kurt Lohman, Marcus E. Kleber, Steven A. Lubitz, Bastiaan Geelhoed, Stella Trompet, Maartje N. Niemeijer, Tim Kacprowski, Daniel I. Chasman, Derek Klarin, Moritz F. Sinner, Melanie Waldenberger, Thomas Meitinger, Tamara B. Harris, Lenore J. Launer, Elsayed Z. Soliman, Lin Y. Chen, Jonathan D. Smith, David R. Van Wagoner, Jerome I. Rotter, Bruce M. Psaty, Zhijun Xie, Audrey E. Hendricks, Jingzhong Ding, Graciela E. Delgado, Niek Verweij, Pim van der Harst, Peter W. Macfarlane, Ian Ford, Albert Hofman, André Uitterlinden, Jan Heeringa, Oscar H. Franco, Jan A. Kors, Stefan Weiss, Henry Völzke, Lynda M. Rose, Pradeep Natarajan, Sekar Kathiresan, Stefan Kääb, Vilmundur Gudnason, Alvaro Alonso, Mina K. Chung, Susan R. Heckbert, Emelia J. Benjamin, Yongmei Liu, Winfried März, Michiel Rienstra, J. Wouter Jukema, Bruno H. Stricker, Marcus Dörr, Christine M. Albert, Patrick T. Ellinor

ABSTRACT

Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in an independent cohort for replication, which included more than 2,363 AF cases and 114,746 AF-free referents. One interaction, between rs7164883 at the HCN4 locus and rs4980345 at the SLC28A1 locus, was found to be significantly associated with AF in the discovery cohorts (interaction OR = 1.44, 95% CI: 1.27–1.65, P = 4.3 × 10–8). Eight additional gene-gene interactions were also marginally significant (P < 5 × 10–7). However, none of the top interactions were replicated. In summary, we did not find significant interactions that were associated with AF susceptibility. Future increases in sample size and denser genotyping might facilitate the identification of gene-gene interactions associated with AF. More... »

PAGES

35371

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

6

Author Affiliations

  • Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA
  • DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
  • Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  • McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Cleveland Clinic, Cleveland, OH, USA
  • Department of Biostatistics, University of Washington, Seattle, WA, USA
  • Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
  • Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany
  • Harvard Medical School, Boston, MA, USA
  • Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
  • Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
  • Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
  • DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
  • Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA
  • Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
  • Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany
  • Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
  • Institute of Human Genetics, Technische Universität München, Munich, Germany
  • National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
  • Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
  • Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
  • Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA
  • Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA
  • Mathematical and Statistical Sciences, University of Colorado, Denver, Denver, CO, USA
  • Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Institute of Health and Wellbeing, College of Veterinary, Medical and Life Sciences, University of Glasgow, United Kingdom
  • Robertson Center for Biostatistics, University of Glasgow, United Kingdom
  • Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
  • Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, the Netherlands
  • Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  • Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
  • Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
  • Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
  • Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
  • Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
  • Department of Cardiology, Leiden University Medical Center, the Netherlands
  • Inspectorate of Health Care, Utrecht, the Netherlands
  • Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep35371

    DOI

    http://dx.doi.org/10.1038/srep35371

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022760205

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27824142


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Atrial Fibrillation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epistasis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Association Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Transport Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multivariate Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Muscle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Potassium Channels", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "National Heart Lung and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, Framingham, MA, USA", 
                "Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Honghuang", 
            "id": "sg:person.01033261006.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033261006.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany", 
                "Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany", 
                "DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mueller-Nurasyid", 
            "givenName": "Martina", 
            "id": "sg:person.0711543202.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711543202.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Faculty of Medicine, University of Iceland, Reykjavik, Iceland", 
              "id": "http://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "Icelandic Heart Association, Kopavogur, Iceland", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Albert V.", 
            "id": "sg:person.01112257404.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112257404.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arking", 
            "givenName": "Dan E.", 
            "id": "sg:person.01304013052.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304013052.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barnard", 
            "givenName": "John", 
            "id": "sg:person.01303061642.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303061642.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, University of Washington, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Biostatistics, University of Washington, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bartz", 
            "givenName": "Traci M.", 
            "id": "sg:person.01204276533.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204276533.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "National Heart Lung and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, Framingham, MA, USA", 
                "Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lunetta", 
            "givenName": "Kathryn L.", 
            "id": "sg:person.012600555377.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012600555377.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
              "id": "http://www.grid.ac/institutes/grid.241167.7", 
              "name": [
                "Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lohman", 
            "givenName": "Kurt", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kleber", 
            "givenName": "Marcus E.", 
            "id": "sg:person.01341032053.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341032053.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA", 
                "Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lubitz", 
            "givenName": "Steven A.", 
            "id": "sg:person.01270001061.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270001061.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geelhoed", 
            "givenName": "Bastiaan", 
            "id": "sg:person.01274573677.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274573677.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Department of Cardiology, Leiden University Medical Center, the Netherlands", 
                "Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trompet", 
            "givenName": "Stella", 
            "id": "sg:person.0747162463.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747162463.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niemeijer", 
            "givenName": "Maartje N.", 
            "id": "sg:person.01274203424.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274203424.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany", 
                "DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kacprowski", 
            "givenName": "Tim", 
            "id": "sg:person.01224707123.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224707123.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Division of Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chasman", 
            "givenName": "Daniel I.", 
            "id": "sg:person.0760704165.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760704165.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA", 
                "Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA", 
                "Department of Surgery, Massachusetts General Hospital, Boston, MA, USA", 
                "Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klarin", 
            "givenName": "Derek", 
            "id": "sg:person.012353231675.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012353231675.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sinner", 
            "givenName": "Moritz F.", 
            "id": "sg:person.01034221256.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034221256.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany", 
                "Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany", 
                "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waldenberger", 
            "givenName": "Melanie", 
            "id": "sg:person.0611237150.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611237150.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Human Genetics, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.6936.a", 
              "name": [
                "DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany", 
                "Institute of Human Genetics, Helmholtz Zentrum M\u00fcnchen - German Research Center for Environmental Health, Neuherberg, Germany", 
                "Institute of Human Genetics, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meitinger", 
            "givenName": "Thomas", 
            "id": "sg:person.015725517277.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015725517277.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute on Aging, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.419475.a", 
              "name": [
                "National Institute on Aging, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harris", 
            "givenName": "Tamara B.", 
            "id": "sg:person.010065171457.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010065171457.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute on Aging, National Institutes of Health, Bethesda, MD, USA", 
              "id": "http://www.grid.ac/institutes/grid.419475.a", 
              "name": [
                "National Institute on Aging, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Launer", 
            "givenName": "Lenore J.", 
            "id": "sg:person.013236063322.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013236063322.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA", 
              "id": "http://www.grid.ac/institutes/grid.241167.7", 
              "name": [
                "Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soliman", 
            "givenName": "Elsayed Z.", 
            "id": "sg:person.0770165456.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770165456.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA", 
              "id": "http://www.grid.ac/institutes/grid.17635.36", 
              "name": [
                "Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Lin Y.", 
            "id": "sg:person.016503223004.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016503223004.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "Jonathan D.", 
            "id": "sg:person.01171736007.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171736007.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Van Wagoner", 
            "givenName": "David R.", 
            "id": "sg:person.01153552461.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153552461.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.239844.0", 
              "name": [
                "Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rotter", 
            "givenName": "Jerome I.", 
            "id": "sg:person.012264440652.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012264440652.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.280243.f", 
              "name": [
                "Departments of Medicine, Cardiovascular Health Research Unit, Epidemiology and Health Services, University of Washington, Seattle, WA, USA", 
                "Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Psaty", 
            "givenName": "Bruce M.", 
            "id": "sg:person.0763727005.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763727005.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xie", 
            "givenName": "Zhijun", 
            "id": "sg:person.0615417510.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615417510.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mathematical and Statistical Sciences, University of Colorado, Denver, Denver, CO, USA", 
              "id": "http://www.grid.ac/institutes/grid.241116.1", 
              "name": [
                "National Heart Lung and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, Framingham, MA, USA", 
                "Mathematical and Statistical Sciences, University of Colorado, Denver, Denver, CO, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hendricks", 
            "givenName": "Audrey E.", 
            "id": "sg:person.01353455717.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353455717.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
              "id": "http://www.grid.ac/institutes/grid.241167.7", 
              "name": [
                "Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ding", 
            "givenName": "Jingzhong", 
            "id": "sg:person.0774130006.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774130006.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delgado", 
            "givenName": "Graciela E.", 
            "id": "sg:person.01227616264.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227616264.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Verweij", 
            "givenName": "Niek", 
            "id": "sg:person.01302157177.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302157177.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Harst", 
            "givenName": "Pim", 
            "id": "sg:person.0742714555.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742714555.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Health and Wellbeing, College of Veterinary, Medical and Life Sciences, University of Glasgow, United Kingdom", 
              "id": "http://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Institute of Health and Wellbeing, College of Veterinary, Medical and Life Sciences, University of Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Macfarlane", 
            "givenName": "Peter W.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Robertson Center for Biostatistics, University of Glasgow, United Kingdom", 
              "id": "http://www.grid.ac/institutes/grid.8756.c", 
              "name": [
                "Robertson Center for Biostatistics, University of Glasgow, United Kingdom"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ford", 
            "givenName": "Ian", 
            "id": "sg:person.01205163364.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205163364.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hofman", 
            "givenName": "Albert", 
            "id": "sg:person.0670056120.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670056120.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Uitterlinden", 
            "givenName": "Andr\u00e9", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heeringa", 
            "givenName": "Jan", 
            "id": "sg:person.0776762265.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776762265.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Franco", 
            "givenName": "Oscar H.", 
            "id": "sg:person.01171532202.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171532202.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5645.2", 
              "name": [
                "Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kors", 
            "givenName": "Jan A.", 
            "id": "sg:person.0727627446.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727627446.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany", 
                "DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiss", 
            "givenName": "Stefan", 
            "id": "sg:person.013436612575.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013436612575.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5603.0", 
              "name": [
                "DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany", 
                "Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "V\u00f6lzke", 
            "givenName": "Henry", 
            "id": "sg:person.0712400456.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712400456.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Division of Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rose", 
            "givenName": "Lynda M.", 
            "id": "sg:person.01172204022.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172204022.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Harvard Medical School, Boston, MA, USA", 
                "Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA", 
                "Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA", 
                "Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Natarajan", 
            "givenName": "Pradeep", 
            "id": "sg:person.01120503505.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120503505.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "Harvard Medical School, Boston, MA, USA", 
                "Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA", 
                "Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA", 
                "Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kathiresan", 
            "givenName": "Sekar", 
            "id": "sg:person.0767751267.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767751267.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany", 
              "id": "http://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany", 
                "DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "K\u00e4\u00e4b", 
            "givenName": "Stefan", 
            "id": "sg:person.01073126776.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073126776.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Faculty of Medicine, University of Iceland, Reykjavik, Iceland", 
              "id": "http://www.grid.ac/institutes/grid.14013.37", 
              "name": [
                "Icelandic Heart Association, Kopavogur, Iceland", 
                "Faculty of Medicine, University of Iceland, Reykjavik, Iceland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gudnason", 
            "givenName": "Vilmundur", 
            "id": "sg:person.012745117217.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012745117217.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alonso", 
            "givenName": "Alvaro", 
            "id": "sg:person.01353707271.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353707271.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chung", 
            "givenName": "Mina K.", 
            "id": "sg:person.013572701325.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013572701325.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA", 
              "id": "http://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA", 
                "Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heckbert", 
            "givenName": "Susan R.", 
            "id": "sg:person.01013304513.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013304513.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "National Heart Lung and Blood Institute\u2019s and Boston University\u2019s Framingham Heart Study, Framingham, MA, USA", 
                "Department of Medicine, Section of Cardiovascular Medicine and Preventive Medicine, Boston University School of Medicine, Boston, MA, USA", 
                "Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benjamin", 
            "givenName": "Emelia J.", 
            "id": "sg:person.01153350506.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153350506.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA", 
              "id": "http://www.grid.ac/institutes/grid.241167.7", 
              "name": [
                "Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Yongmei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Synlab Academy, Synlab Services, GmbH P5,7, 68161 Mannheim, Germany", 
                "Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria", 
                "Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00e4rz", 
            "givenName": "Winfried", 
            "id": "sg:person.01200771067.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200771067.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rienstra", 
            "givenName": "Michiel", 
            "id": "sg:person.01314201467.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314201467.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cardiology, Leiden University Medical Center, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Department of Cardiology, Leiden University Medical Center, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jukema", 
            "givenName": "J. Wouter", 
            "id": "sg:person.016674701102.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016674701102.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inspectorate of Health Care, Utrecht, the Netherlands", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands", 
                "Inspectorate of Health Care, Utrecht, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stricker", 
            "givenName": "Bruno H.", 
            "id": "sg:person.0724723304.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724723304.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5603.0", 
              "name": [
                "DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany", 
                "Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u00f6rr", 
            "givenName": "Marcus", 
            "id": "sg:person.0705572413.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705572413.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Division of Preventive Medicine, Brigham and Women\u2019s Hospital, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Albert", 
            "givenName": "Christine M.", 
            "id": "sg:person.0657662374.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657662374.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard Medical School, Boston, MA, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ellinor", 
            "givenName": "Patrick T.", 
            "id": "sg:person.01300106701.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300106701.65"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004086691", 
              "https://doi.org/10.1038/ng.416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-005-0034-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011929926", 
              "https://doi.org/10.1007/s00439-005-0034-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050786599", 
              "https://doi.org/10.1038/nature06007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415141a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001484556", 
              "https://doi.org/10.1038/415141a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35048107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010548523", 
              "https://doi.org/10.1038/35048107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812064", 
              "https://doi.org/10.1038/nature15393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02623", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017921358", 
              "https://doi.org/10.1038/nature02623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005147626", 
              "https://doi.org/10.1038/nature08494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-6-114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021250631", 
              "https://doi.org/10.1186/1471-2407-6-114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/456018a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050730348", 
              "https://doi.org/10.1038/456018a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050255522", 
              "https://doi.org/10.1038/ng.2261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010185673", 
              "https://doi.org/10.1038/ng.537"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-11-08", 
        "datePublishedReg": "2016-11-08", 
        "description": "Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in an independent cohort for replication, which included more than 2,363 AF cases and 114,746 AF-free referents. One interaction, between rs7164883 at the HCN4 locus and rs4980345 at the SLC28A1 locus, was found to be significantly associated with AF in the discovery cohorts (interaction OR\u2009=\u20091.44, 95% CI: 1.27\u20131.65, P\u2009=\u20094.3\u2009\u00d7\u200910\u20138). Eight additional gene-gene interactions were also marginally significant (P\u2009<\u20095\u2009\u00d7\u200910\u20137). However, none of the top interactions were replicated. In summary, we did not find significant interactions that were associated with AF susceptibility. Future increases in sample size and denser genotyping might facilitate the identification of gene-gene interactions associated with AF.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/srep35371", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.100055738", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691844", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.100064981", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345220", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696072", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345504", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2421237", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2543000", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2540422", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345695", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.10015685", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430033", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3792773", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2419858", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3778051", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691245", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684605", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7939927", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2722989", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8008871", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4138109", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345510", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345564", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2665655", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705215", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541050", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430175", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430170", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691632", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2542914", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705143", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430167", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3780474", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430169", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430171", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541272", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705139", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2429985", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2447663", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2545601", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541398", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8023964", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3536262", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345491", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2439028", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7970318", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4139030", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705236", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2536122", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4136838", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430174", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2543107", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430173", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541780", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2542084", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430176", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345526", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430025", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2665668", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7942144", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2430172", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345516", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2446659", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2722972", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684810", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345522", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7942283", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2447974", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.10015615", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2543537", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2447234", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2345497", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4242960", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7970327", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541401", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "keywords": [
          "gene-gene interactions", 
          "genome-wide SNPs", 
          "large-scale association analysis", 
          "gene-gene interaction analysis", 
          "association analysis", 
          "heritable disease", 
          "putative interactions", 
          "genetic determinants", 
          "AF susceptibility", 
          "loci", 
          "SNPs", 
          "top interactions", 
          "future increases", 
          "interaction analysis", 
          "discovery cohort", 
          "interaction", 
          "independent cohort", 
          "extensive efforts", 
          "replication", 
          "susceptibility", 
          "genotyping", 
          "discovery", 
          "identification", 
          "significant interaction", 
          "analysis", 
          "determinants", 
          "study", 
          "summary", 
          "individuals", 
          "disease", 
          "additional gene\u2013gene interaction", 
          "association", 
          "AF cases", 
          "size", 
          "increase", 
          "sample size", 
          "effect", 
          "efforts", 
          "cohort", 
          "objective", 
          "cases", 
          "atrial fibrillation", 
          "fibrillation", 
          "referents"
        ], 
        "name": "Gene-gene Interaction Analyses for Atrial Fibrillation", 
        "pagination": "35371", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1022760205"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/srep35371"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27824142"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/srep35371", 
          "https://app.dimensions.ai/details/publication/pub.1022760205"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_714.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/srep35371"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep35371'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep35371'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep35371'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep35371'


     

    This table displays all metadata directly associated to this object as RDF triples.

    903 TRIPLES      21 PREDICATES      100 URIs      80 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/srep35371 schema:about N0cf79640046f4e29b339fa45c3ea8f37
    2 N0d0a9723dcac4159aa8ea4d6f6207a33
    3 N110c8436dcfb4242b9d37b1c2cef4918
    4 N227be7b0abd8417197c584d712009c25
    5 N25e2a37c57414bd1a2e471cdff7c46a4
    6 N262f9d2c4863459aa33740dfe1b96f46
    7 N26cc7bfc517b418c8379db34c1efa2ec
    8 N2871b94a14f54612a7c3333c833a278b
    9 N38ad04e6604d44a485b2b9090ae06a7a
    10 N5f600f9b77b74ad998baa6b22d71c0cf
    11 N6dc02dd59bdb4544814827e75c26a113
    12 N767644efb9844735a7e9ea532fc32ee8
    13 Na79c5eb0929e443c9ec86e05007f96fa
    14 Nc5dfeec48b6e460c979b09a9ac2c3c8e
    15 Nc695c2ada2534dfd8bdaab92380546ee
    16 Ncb08361b11b540ce84ffa35ad828233e
    17 Nf0e98b2ea8964757bde6306d1f98a439
    18 Nf704653ee40545229a5ec273ed4c6834
    19 Nfb19a9a60d0e4facbabc3c27e48a0f53
    20 anzsrc-for:06
    21 anzsrc-for:0604
    22 schema:author N17ee388ec75e40b3a493eb15d7b05ce4
    23 schema:citation sg:pub.10.1007/s00439-005-0034-8
    24 sg:pub.10.1038/35048107
    25 sg:pub.10.1038/415141a
    26 sg:pub.10.1038/456018a
    27 sg:pub.10.1038/nature02623
    28 sg:pub.10.1038/nature06007
    29 sg:pub.10.1038/nature08494
    30 sg:pub.10.1038/nature15393
    31 sg:pub.10.1038/ng.2261
    32 sg:pub.10.1038/ng.416
    33 sg:pub.10.1038/ng.537
    34 sg:pub.10.1186/1471-2407-6-114
    35 schema:datePublished 2016-11-08
    36 schema:datePublishedReg 2016-11-08
    37 schema:description Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in an independent cohort for replication, which included more than 2,363 AF cases and 114,746 AF-free referents. One interaction, between rs7164883 at the HCN4 locus and rs4980345 at the SLC28A1 locus, was found to be significantly associated with AF in the discovery cohorts (interaction OR = 1.44, 95% CI: 1.27–1.65, P = 4.3 × 10–8). Eight additional gene-gene interactions were also marginally significant (P < 5 × 10–7). However, none of the top interactions were replicated. In summary, we did not find significant interactions that were associated with AF susceptibility. Future increases in sample size and denser genotyping might facilitate the identification of gene-gene interactions associated with AF.
    38 schema:genre article
    39 schema:isAccessibleForFree true
    40 schema:isPartOf N10c51c447d914f37bbb64eec4240b277
    41 N5aca06e2594a4afa933f66345a836ebf
    42 sg:journal.1045337
    43 schema:keywords AF cases
    44 AF susceptibility
    45 SNPs
    46 additional gene–gene interaction
    47 analysis
    48 association
    49 association analysis
    50 atrial fibrillation
    51 cases
    52 cohort
    53 determinants
    54 discovery
    55 discovery cohort
    56 disease
    57 effect
    58 efforts
    59 extensive efforts
    60 fibrillation
    61 future increases
    62 gene-gene interaction analysis
    63 gene-gene interactions
    64 genetic determinants
    65 genome-wide SNPs
    66 genotyping
    67 heritable disease
    68 identification
    69 increase
    70 independent cohort
    71 individuals
    72 interaction
    73 interaction analysis
    74 large-scale association analysis
    75 loci
    76 objective
    77 putative interactions
    78 referents
    79 replication
    80 sample size
    81 significant interaction
    82 size
    83 study
    84 summary
    85 susceptibility
    86 top interactions
    87 schema:name Gene-gene Interaction Analyses for Atrial Fibrillation
    88 schema:pagination 35371
    89 schema:productId N02e96657a4114c11a00f1a5661b8f55b
    90 N1d2f20af51914811bb33171318bde58c
    91 Nc75ca77e088e48329b02d2da003b3765
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022760205
    93 https://doi.org/10.1038/srep35371
    94 schema:sdDatePublished 2022-12-01T06:35
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher N719358304f8341f0a18e00c8a8275296
    97 schema:url https://doi.org/10.1038/srep35371
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N00a4a95a9d2b41748f3237f12c25792b rdf:first sg:person.0657662374.06
    102 rdf:rest Na149c83b74c549118c6cfa39e012e46d
    103 N02e96657a4114c11a00f1a5661b8f55b schema:name pubmed_id
    104 schema:value 27824142
    105 rdf:type schema:PropertyValue
    106 N038f1e7d14e4410a857302a1d379a41a rdf:first sg:person.01227616264.01
    107 rdf:rest N990c81574df6447c839525e9ce30cc49
    108 N0a697e5367664a55aaa60884c5b2ea9d rdf:first Nc3f26451eba74ed4aef4cc6c6b679dbb
    109 rdf:rest N2c325634e5c147a2af6c70c7629b4743
    110 N0b0a9666335648b980bafabf4c39ce0a rdf:first sg:person.0711543202.46
    111 rdf:rest N5bf5e17cb34c418bae994cb061fdc37b
    112 N0cf79640046f4e29b339fa45c3ea8f37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Genome-Wide Association Study
    114 rdf:type schema:DefinedTerm
    115 N0d0a9723dcac4159aa8ea4d6f6207a33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Potassium Channels
    117 rdf:type schema:DefinedTerm
    118 N10c51c447d914f37bbb64eec4240b277 schema:volumeNumber 6
    119 rdf:type schema:PublicationVolume
    120 N110c8436dcfb4242b9d37b1c2cef4918 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Male
    122 rdf:type schema:DefinedTerm
    123 N17ee388ec75e40b3a493eb15d7b05ce4 rdf:first sg:person.01033261006.89
    124 rdf:rest N0b0a9666335648b980bafabf4c39ce0a
    125 N1d2f20af51914811bb33171318bde58c schema:name dimensions_id
    126 schema:value pub.1022760205
    127 rdf:type schema:PropertyValue
    128 N1d5c9d67a3f846919d804e8f8f63cc85 rdf:first sg:person.013436612575.23
    129 rdf:rest N7f16f9117d3745ad9544f716039a28c3
    130 N227be7b0abd8417197c584d712009c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Polymorphism, Single Nucleotide
    132 rdf:type schema:DefinedTerm
    133 N230379ef1007404485106f69da399012 rdf:first sg:person.01270001061.21
    134 rdf:rest Ne958ff7bbabc44ef86069c7eb30a58d8
    135 N2336025b5c23428886524554d21dc639 rdf:first sg:person.01304013052.15
    136 rdf:rest N5a6c034ddf4e4d42b1c0753163f7e427
    137 N25e2a37c57414bd1a2e471cdff7c46a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Genetic Predisposition to Disease
    139 rdf:type schema:DefinedTerm
    140 N262f9d2c4863459aa33740dfe1b96f46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
    142 rdf:type schema:DefinedTerm
    143 N26cc7bfc517b418c8379db34c1efa2ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Genetic Association Studies
    145 rdf:type schema:DefinedTerm
    146 N2871b94a14f54612a7c3333c833a278b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Epistasis, Genetic
    148 rdf:type schema:DefinedTerm
    149 N2c325634e5c147a2af6c70c7629b4743 rdf:first sg:person.01341032053.15
    150 rdf:rest N230379ef1007404485106f69da399012
    151 N2ec3c9c4a6a54dc29b5565dba3c5355d rdf:first sg:person.01120503505.13
    152 rdf:rest N60860692917b477da1128cc2b77cfc3a
    153 N35779e3b55bf410a8dfa3be2963b806f rdf:first sg:person.01353455717.52
    154 rdf:rest N7bdfdc2f0af54854a84de870ea61a5a5
    155 N38ad04e6604d44a485b2b9090ae06a7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Oligonucleotide Array Sequence Analysis
    157 rdf:type schema:DefinedTerm
    158 N3c24756698a54964a9e64af7b8aa5a54 schema:affiliation grid-institutes:grid.8756.c
    159 schema:familyName Macfarlane
    160 schema:givenName Peter W.
    161 rdf:type schema:Person
    162 N3ed566ec00834b1f8f2b0e351c7e4f93 schema:affiliation grid-institutes:grid.241167.7
    163 schema:familyName Liu
    164 schema:givenName Yongmei
    165 rdf:type schema:Person
    166 N45e7d1bbe92d4ab79459632f1ddbddc7 schema:affiliation grid-institutes:grid.5645.2
    167 schema:familyName Uitterlinden
    168 schema:givenName André
    169 rdf:type schema:Person
    170 N46ace311b8e34d7cacd007a850968d51 rdf:first sg:person.0742714555.32
    171 rdf:rest N5bb8d88efd094416b959aa0dffd19f97
    172 N4fad510231de454fa501baf2de2faa4b rdf:first sg:person.01073126776.18
    173 rdf:rest Nd89746a2689940ee90d7665715a4ac7d
    174 N52d2a72069214fbd96ed6a86929d4ea3 rdf:first sg:person.01314201467.23
    175 rdf:rest Ne3981d9ee54947c1904e2b93b2d855e0
    176 N530f99cd3c1149dba4070d20b20ac381 rdf:first N3ed566ec00834b1f8f2b0e351c7e4f93
    177 rdf:rest Ncfc98ba6a8664e8b85dc80ebcd515db0
    178 N5a6c034ddf4e4d42b1c0753163f7e427 rdf:first sg:person.01303061642.91
    179 rdf:rest Ncc4b9ec9687d4cfe98fa252d0a2a9ab6
    180 N5aca06e2594a4afa933f66345a836ebf schema:issueNumber 1
    181 rdf:type schema:PublicationIssue
    182 N5bb8d88efd094416b959aa0dffd19f97 rdf:first N3c24756698a54964a9e64af7b8aa5a54
    183 rdf:rest N86ad4645791b4033922ddbbfd5fa0f31
    184 N5bf5e17cb34c418bae994cb061fdc37b rdf:first sg:person.01112257404.07
    185 rdf:rest N2336025b5c23428886524554d21dc639
    186 N5f600f9b77b74ad998baa6b22d71c0cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Muscle Proteins
    188 rdf:type schema:DefinedTerm
    189 N60860692917b477da1128cc2b77cfc3a rdf:first sg:person.0767751267.74
    190 rdf:rest N4fad510231de454fa501baf2de2faa4b
    191 N616d2415e9f64a718518e4da8b846483 rdf:first sg:person.0670056120.12
    192 rdf:rest Nf9db1948d74e4bb6a5358fae10e6813d
    193 N6c71044691ec449a80892b5c00ea21c0 rdf:first sg:person.01274203424.28
    194 rdf:rest Nddd2a9aeb5fb4768a360f334c208d828
    195 N6dc02dd59bdb4544814827e75c26a113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Aged
    197 rdf:type schema:DefinedTerm
    198 N719358304f8341f0a18e00c8a8275296 schema:name Springer Nature - SN SciGraph project
    199 rdf:type schema:Organization
    200 N767644efb9844735a7e9ea532fc32ee8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Middle Aged
    202 rdf:type schema:DefinedTerm
    203 N7bdfdc2f0af54854a84de870ea61a5a5 rdf:first sg:person.0774130006.94
    204 rdf:rest N038f1e7d14e4410a857302a1d379a41a
    205 N7d1c52611bef4684b0423c13dd44aefe rdf:first sg:person.01013304513.36
    206 rdf:rest Nab19a62c9d2a4b46a95fcf0856c59607
    207 N7f16f9117d3745ad9544f716039a28c3 rdf:first sg:person.0712400456.14
    208 rdf:rest Ne81fba8e2ac449af85e33d566ce8876d
    209 N7f84a22f63f94963a0b2d2643000f712 rdf:first sg:person.0615417510.81
    210 rdf:rest N35779e3b55bf410a8dfa3be2963b806f
    211 N86ad4645791b4033922ddbbfd5fa0f31 rdf:first sg:person.01205163364.12
    212 rdf:rest N616d2415e9f64a718518e4da8b846483
    213 N86ee004133f4478599311770eafbab13 rdf:first sg:person.012600555377.86
    214 rdf:rest N0a697e5367664a55aaa60884c5b2ea9d
    215 N878d77050de34f70a0b1fb4e7fe15094 rdf:first sg:person.01153552461.69
    216 rdf:rest Na47ea54eb64b436d8ff542c1ed1c3e92
    217 N8bbf1b2933564f8890d32ff30a9b23e3 rdf:first sg:person.012353231675.17
    218 rdf:rest N9f649bf6cf5040b58b5b8672dc732b7d
    219 N98b69c237b784bc9b5e734730a39cd1a rdf:first sg:person.0724723304.99
    220 rdf:rest Nc23892d2364748b191f477ac6692bc0a
    221 N990c81574df6447c839525e9ce30cc49 rdf:first sg:person.01302157177.43
    222 rdf:rest N46ace311b8e34d7cacd007a850968d51
    223 N9c665c39407a462aa99176df92d4dc44 rdf:first sg:person.0770165456.06
    224 rdf:rest Nb0b28d0d598e4129b9547888b8677fa7
    225 N9f649bf6cf5040b58b5b8672dc732b7d rdf:first sg:person.01034221256.17
    226 rdf:rest Ndb87ca149a7c4ab6a0f3bff6d64346d8
    227 Na149c83b74c549118c6cfa39e012e46d rdf:first sg:person.01300106701.65
    228 rdf:rest rdf:nil
    229 Na47ea54eb64b436d8ff542c1ed1c3e92 rdf:first sg:person.012264440652.05
    230 rdf:rest Nb151ea02f49e4e8fb386c0774e3d86dc
    231 Na73f6aa855ec415d89a8964f27ea3ad9 rdf:first sg:person.0760704165.88
    232 rdf:rest N8bbf1b2933564f8890d32ff30a9b23e3
    233 Na79c5eb0929e443c9ec86e05007f96fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Atrial Fibrillation
    235 rdf:type schema:DefinedTerm
    236 Nab19a62c9d2a4b46a95fcf0856c59607 rdf:first sg:person.01153350506.35
    237 rdf:rest N530f99cd3c1149dba4070d20b20ac381
    238 Nb0b28d0d598e4129b9547888b8677fa7 rdf:first sg:person.016503223004.14
    239 rdf:rest Nbfacf9a4c5a943289628bee40670a2d3
    240 Nb1330ec19c6642bb9b53b96ca6227ee7 rdf:first sg:person.01171532202.66
    241 rdf:rest Nc637310cb12b49e5a1de6bd49b0b727d
    242 Nb151ea02f49e4e8fb386c0774e3d86dc rdf:first sg:person.0763727005.09
    243 rdf:rest N7f84a22f63f94963a0b2d2643000f712
    244 Nb53f4916fc114091b1d6e534a5cddc60 rdf:first sg:person.0747162463.84
    245 rdf:rest N6c71044691ec449a80892b5c00ea21c0
    246 Nbbfa63c2107e4138b7d74cb1555ba489 rdf:first sg:person.013236063322.64
    247 rdf:rest N9c665c39407a462aa99176df92d4dc44
    248 Nbfacf9a4c5a943289628bee40670a2d3 rdf:first sg:person.01171736007.19
    249 rdf:rest N878d77050de34f70a0b1fb4e7fe15094
    250 Nc23892d2364748b191f477ac6692bc0a rdf:first sg:person.0705572413.42
    251 rdf:rest N00a4a95a9d2b41748f3237f12c25792b
    252 Nc3f26451eba74ed4aef4cc6c6b679dbb schema:affiliation grid-institutes:grid.241167.7
    253 schema:familyName Lohman
    254 schema:givenName Kurt
    255 rdf:type schema:Person
    256 Nc5dfeec48b6e460c979b09a9ac2c3c8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Female
    258 rdf:type schema:DefinedTerm
    259 Nc637310cb12b49e5a1de6bd49b0b727d rdf:first sg:person.0727627446.38
    260 rdf:rest N1d5c9d67a3f846919d804e8f8f63cc85
    261 Nc695c2ada2534dfd8bdaab92380546ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Membrane Transport Proteins
    263 rdf:type schema:DefinedTerm
    264 Nc75ca77e088e48329b02d2da003b3765 schema:name doi
    265 schema:value 10.1038/srep35371
    266 rdf:type schema:PropertyValue
    267 Nca06ef630ef446ce82bfa143bfdb8732 rdf:first sg:person.015725517277.33
    268 rdf:rest Ne503b7a32efe40d2b2315bb6d966e2e1
    269 Ncb08361b11b540ce84ffa35ad828233e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Cohort Studies
    271 rdf:type schema:DefinedTerm
    272 Ncc4b9ec9687d4cfe98fa252d0a2a9ab6 rdf:first sg:person.01204276533.76
    273 rdf:rest N86ee004133f4478599311770eafbab13
    274 Ncfc98ba6a8664e8b85dc80ebcd515db0 rdf:first sg:person.01200771067.24
    275 rdf:rest N52d2a72069214fbd96ed6a86929d4ea3
    276 Nd89746a2689940ee90d7665715a4ac7d rdf:first sg:person.012745117217.03
    277 rdf:rest Nea39c5a7b6564cf8a017ce6b91bf5a43
    278 Ndb87ca149a7c4ab6a0f3bff6d64346d8 rdf:first sg:person.0611237150.50
    279 rdf:rest Nca06ef630ef446ce82bfa143bfdb8732
    280 Nddd2a9aeb5fb4768a360f334c208d828 rdf:first sg:person.01224707123.73
    281 rdf:rest Na73f6aa855ec415d89a8964f27ea3ad9
    282 Ne3981d9ee54947c1904e2b93b2d855e0 rdf:first sg:person.016674701102.75
    283 rdf:rest N98b69c237b784bc9b5e734730a39cd1a
    284 Ne503b7a32efe40d2b2315bb6d966e2e1 rdf:first sg:person.010065171457.69
    285 rdf:rest Nbbfa63c2107e4138b7d74cb1555ba489
    286 Ne81fba8e2ac449af85e33d566ce8876d rdf:first sg:person.01172204022.21
    287 rdf:rest N2ec3c9c4a6a54dc29b5565dba3c5355d
    288 Ne958ff7bbabc44ef86069c7eb30a58d8 rdf:first sg:person.01274573677.76
    289 rdf:rest Nb53f4916fc114091b1d6e534a5cddc60
    290 Nea39c5a7b6564cf8a017ce6b91bf5a43 rdf:first sg:person.01353707271.93
    291 rdf:rest Nfb16aec069494e5db3fc63aaddc5cc35
    292 Ned24b64ca8a84b78b5548af019a8f056 rdf:first sg:person.0776762265.15
    293 rdf:rest Nb1330ec19c6642bb9b53b96ca6227ee7
    294 Nf0e98b2ea8964757bde6306d1f98a439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Genotype
    296 rdf:type schema:DefinedTerm
    297 Nf704653ee40545229a5ec273ed4c6834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    298 schema:name Multivariate Analysis
    299 rdf:type schema:DefinedTerm
    300 Nf9db1948d74e4bb6a5358fae10e6813d rdf:first N45e7d1bbe92d4ab79459632f1ddbddc7
    301 rdf:rest Ned24b64ca8a84b78b5548af019a8f056
    302 Nfb16aec069494e5db3fc63aaddc5cc35 rdf:first sg:person.013572701325.94
    303 rdf:rest N7d1c52611bef4684b0423c13dd44aefe
    304 Nfb19a9a60d0e4facbabc3c27e48a0f53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    305 schema:name Humans
    306 rdf:type schema:DefinedTerm
    307 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    308 schema:name Biological Sciences
    309 rdf:type schema:DefinedTerm
    310 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    311 schema:name Genetics
    312 rdf:type schema:DefinedTerm
    313 sg:grant.100055738 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    314 rdf:type schema:MonetaryGrant
    315 sg:grant.100064981 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    316 rdf:type schema:MonetaryGrant
    317 sg:grant.10015615 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    318 rdf:type schema:MonetaryGrant
    319 sg:grant.10015685 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    320 rdf:type schema:MonetaryGrant
    321 sg:grant.2345220 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    322 rdf:type schema:MonetaryGrant
    323 sg:grant.2345491 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    324 rdf:type schema:MonetaryGrant
    325 sg:grant.2345497 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    326 rdf:type schema:MonetaryGrant
    327 sg:grant.2345504 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    328 rdf:type schema:MonetaryGrant
    329 sg:grant.2345510 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    330 rdf:type schema:MonetaryGrant
    331 sg:grant.2345516 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    332 rdf:type schema:MonetaryGrant
    333 sg:grant.2345522 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    334 rdf:type schema:MonetaryGrant
    335 sg:grant.2345526 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    336 rdf:type schema:MonetaryGrant
    337 sg:grant.2345564 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    338 rdf:type schema:MonetaryGrant
    339 sg:grant.2345695 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    340 rdf:type schema:MonetaryGrant
    341 sg:grant.2419858 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    342 rdf:type schema:MonetaryGrant
    343 sg:grant.2421237 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    344 rdf:type schema:MonetaryGrant
    345 sg:grant.2429985 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    346 rdf:type schema:MonetaryGrant
    347 sg:grant.2430025 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    348 rdf:type schema:MonetaryGrant
    349 sg:grant.2430033 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    350 rdf:type schema:MonetaryGrant
    351 sg:grant.2430167 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    352 rdf:type schema:MonetaryGrant
    353 sg:grant.2430169 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    354 rdf:type schema:MonetaryGrant
    355 sg:grant.2430170 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    356 rdf:type schema:MonetaryGrant
    357 sg:grant.2430171 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    358 rdf:type schema:MonetaryGrant
    359 sg:grant.2430172 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    360 rdf:type schema:MonetaryGrant
    361 sg:grant.2430173 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    362 rdf:type schema:MonetaryGrant
    363 sg:grant.2430174 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    364 rdf:type schema:MonetaryGrant
    365 sg:grant.2430175 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    366 rdf:type schema:MonetaryGrant
    367 sg:grant.2430176 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    368 rdf:type schema:MonetaryGrant
    369 sg:grant.2439028 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    370 rdf:type schema:MonetaryGrant
    371 sg:grant.2446659 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    372 rdf:type schema:MonetaryGrant
    373 sg:grant.2447234 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    374 rdf:type schema:MonetaryGrant
    375 sg:grant.2447663 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    376 rdf:type schema:MonetaryGrant
    377 sg:grant.2447974 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    378 rdf:type schema:MonetaryGrant
    379 sg:grant.2536122 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    380 rdf:type schema:MonetaryGrant
    381 sg:grant.2540422 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    382 rdf:type schema:MonetaryGrant
    383 sg:grant.2541050 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    384 rdf:type schema:MonetaryGrant
    385 sg:grant.2541272 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    386 rdf:type schema:MonetaryGrant
    387 sg:grant.2541398 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    388 rdf:type schema:MonetaryGrant
    389 sg:grant.2541401 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    390 rdf:type schema:MonetaryGrant
    391 sg:grant.2541780 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    392 rdf:type schema:MonetaryGrant
    393 sg:grant.2542084 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    394 rdf:type schema:MonetaryGrant
    395 sg:grant.2542914 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    396 rdf:type schema:MonetaryGrant
    397 sg:grant.2543000 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    398 rdf:type schema:MonetaryGrant
    399 sg:grant.2543107 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    400 rdf:type schema:MonetaryGrant
    401 sg:grant.2543537 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    402 rdf:type schema:MonetaryGrant
    403 sg:grant.2545601 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    404 rdf:type schema:MonetaryGrant
    405 sg:grant.2665655 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    406 rdf:type schema:MonetaryGrant
    407 sg:grant.2665668 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    408 rdf:type schema:MonetaryGrant
    409 sg:grant.2684605 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    410 rdf:type schema:MonetaryGrant
    411 sg:grant.2684810 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    412 rdf:type schema:MonetaryGrant
    413 sg:grant.2691245 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    414 rdf:type schema:MonetaryGrant
    415 sg:grant.2691632 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    416 rdf:type schema:MonetaryGrant
    417 sg:grant.2691844 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    418 rdf:type schema:MonetaryGrant
    419 sg:grant.2696072 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    420 rdf:type schema:MonetaryGrant
    421 sg:grant.2705139 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    422 rdf:type schema:MonetaryGrant
    423 sg:grant.2705143 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    424 rdf:type schema:MonetaryGrant
    425 sg:grant.2705215 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    426 rdf:type schema:MonetaryGrant
    427 sg:grant.2705236 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    428 rdf:type schema:MonetaryGrant
    429 sg:grant.2722972 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    430 rdf:type schema:MonetaryGrant
    431 sg:grant.2722989 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    432 rdf:type schema:MonetaryGrant
    433 sg:grant.3536262 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    434 rdf:type schema:MonetaryGrant
    435 sg:grant.3778051 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    436 rdf:type schema:MonetaryGrant
    437 sg:grant.3780474 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    438 rdf:type schema:MonetaryGrant
    439 sg:grant.3792773 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    440 rdf:type schema:MonetaryGrant
    441 sg:grant.4136838 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    442 rdf:type schema:MonetaryGrant
    443 sg:grant.4138109 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    444 rdf:type schema:MonetaryGrant
    445 sg:grant.4139030 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    446 rdf:type schema:MonetaryGrant
    447 sg:grant.4242960 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    448 rdf:type schema:MonetaryGrant
    449 sg:grant.7939927 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    450 rdf:type schema:MonetaryGrant
    451 sg:grant.7942144 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    452 rdf:type schema:MonetaryGrant
    453 sg:grant.7942283 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    454 rdf:type schema:MonetaryGrant
    455 sg:grant.7970318 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    456 rdf:type schema:MonetaryGrant
    457 sg:grant.7970327 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    458 rdf:type schema:MonetaryGrant
    459 sg:grant.8008871 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    460 rdf:type schema:MonetaryGrant
    461 sg:grant.8023964 http://pending.schema.org/fundedItem sg:pub.10.1038/srep35371
    462 rdf:type schema:MonetaryGrant
    463 sg:journal.1045337 schema:issn 2045-2322
    464 schema:name Scientific Reports
    465 schema:publisher Springer Nature
    466 rdf:type schema:Periodical
    467 sg:person.010065171457.69 schema:affiliation grid-institutes:grid.419475.a
    468 schema:familyName Harris
    469 schema:givenName Tamara B.
    470 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010065171457.69
    471 rdf:type schema:Person
    472 sg:person.01013304513.36 schema:affiliation grid-institutes:grid.34477.33
    473 schema:familyName Heckbert
    474 schema:givenName Susan R.
    475 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013304513.36
    476 rdf:type schema:Person
    477 sg:person.01033261006.89 schema:affiliation grid-institutes:grid.189504.1
    478 schema:familyName Lin
    479 schema:givenName Honghuang
    480 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033261006.89
    481 rdf:type schema:Person
    482 sg:person.01034221256.17 schema:affiliation grid-institutes:grid.5252.0
    483 schema:familyName Sinner
    484 schema:givenName Moritz F.
    485 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034221256.17
    486 rdf:type schema:Person
    487 sg:person.01073126776.18 schema:affiliation grid-institutes:grid.452396.f
    488 schema:familyName Kääb
    489 schema:givenName Stefan
    490 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073126776.18
    491 rdf:type schema:Person
    492 sg:person.01112257404.07 schema:affiliation grid-institutes:grid.14013.37
    493 schema:familyName Smith
    494 schema:givenName Albert V.
    495 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112257404.07
    496 rdf:type schema:Person
    497 sg:person.01120503505.13 schema:affiliation grid-institutes:grid.66859.34
    498 schema:familyName Natarajan
    499 schema:givenName Pradeep
    500 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120503505.13
    501 rdf:type schema:Person
    502 sg:person.01153350506.35 schema:affiliation grid-institutes:grid.189504.1
    503 schema:familyName Benjamin
    504 schema:givenName Emelia J.
    505 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153350506.35
    506 rdf:type schema:Person
    507 sg:person.01153552461.69 schema:affiliation grid-institutes:grid.239578.2
    508 schema:familyName Van Wagoner
    509 schema:givenName David R.
    510 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153552461.69
    511 rdf:type schema:Person
    512 sg:person.01171532202.66 schema:affiliation grid-institutes:grid.5645.2
    513 schema:familyName Franco
    514 schema:givenName Oscar H.
    515 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171532202.66
    516 rdf:type schema:Person
    517 sg:person.01171736007.19 schema:affiliation grid-institutes:grid.239578.2
    518 schema:familyName Smith
    519 schema:givenName Jonathan D.
    520 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171736007.19
    521 rdf:type schema:Person
    522 sg:person.01172204022.21 schema:affiliation grid-institutes:grid.62560.37
    523 schema:familyName Rose
    524 schema:givenName Lynda M.
    525 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172204022.21
    526 rdf:type schema:Person
    527 sg:person.01200771067.24 schema:affiliation grid-institutes:grid.7700.0
    528 schema:familyName März
    529 schema:givenName Winfried
    530 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200771067.24
    531 rdf:type schema:Person
    532 sg:person.01204276533.76 schema:affiliation grid-institutes:grid.34477.33
    533 schema:familyName Bartz
    534 schema:givenName Traci M.
    535 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204276533.76
    536 rdf:type schema:Person
    537 sg:person.01205163364.12 schema:affiliation grid-institutes:grid.8756.c
    538 schema:familyName Ford
    539 schema:givenName Ian
    540 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205163364.12
    541 rdf:type schema:Person
    542 sg:person.01224707123.73 schema:affiliation grid-institutes:grid.452396.f
    543 schema:familyName Kacprowski
    544 schema:givenName Tim
    545 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224707123.73
    546 rdf:type schema:Person
    547 sg:person.012264440652.05 schema:affiliation grid-institutes:grid.239844.0
    548 schema:familyName Rotter
    549 schema:givenName Jerome I.
    550 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012264440652.05
    551 rdf:type schema:Person
    552 sg:person.01227616264.01 schema:affiliation grid-institutes:grid.7700.0
    553 schema:familyName Delgado
    554 schema:givenName Graciela E.
    555 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227616264.01
    556 rdf:type schema:Person
    557 sg:person.012353231675.17 schema:affiliation grid-institutes:grid.66859.34
    558 schema:familyName Klarin
    559 schema:givenName Derek
    560 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012353231675.17
    561 rdf:type schema:Person
    562 sg:person.012600555377.86 schema:affiliation grid-institutes:grid.189504.1
    563 schema:familyName Lunetta
    564 schema:givenName Kathryn L.
    565 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012600555377.86
    566 rdf:type schema:Person
    567 sg:person.01270001061.21 schema:affiliation grid-institutes:grid.38142.3c
    568 schema:familyName Lubitz
    569 schema:givenName Steven A.
    570 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270001061.21
    571 rdf:type schema:Person
    572 sg:person.01274203424.28 schema:affiliation grid-institutes:grid.5645.2
    573 schema:familyName Niemeijer
    574 schema:givenName Maartje N.
    575 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274203424.28
    576 rdf:type schema:Person
    577 sg:person.012745117217.03 schema:affiliation grid-institutes:grid.14013.37
    578 schema:familyName Gudnason
    579 schema:givenName Vilmundur
    580 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012745117217.03
    581 rdf:type schema:Person
    582 sg:person.01274573677.76 schema:affiliation grid-institutes:grid.4494.d
    583 schema:familyName Geelhoed
    584 schema:givenName Bastiaan
    585 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274573677.76
    586 rdf:type schema:Person
    587 sg:person.01300106701.65 schema:affiliation grid-institutes:grid.38142.3c
    588 schema:familyName Ellinor
    589 schema:givenName Patrick T.
    590 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300106701.65
    591 rdf:type schema:Person
    592 sg:person.01302157177.43 schema:affiliation grid-institutes:grid.4494.d
    593 schema:familyName Verweij
    594 schema:givenName Niek
    595 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302157177.43
    596 rdf:type schema:Person
    597 sg:person.01303061642.91 schema:affiliation grid-institutes:grid.239578.2
    598 schema:familyName Barnard
    599 schema:givenName John
    600 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303061642.91
    601 rdf:type schema:Person
    602 sg:person.01304013052.15 schema:affiliation grid-institutes:grid.21107.35
    603 schema:familyName Arking
    604 schema:givenName Dan E.
    605 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304013052.15
    606 rdf:type schema:Person
    607 sg:person.01314201467.23 schema:affiliation grid-institutes:grid.4494.d
    608 schema:familyName Rienstra
    609 schema:givenName Michiel
    610 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314201467.23
    611 rdf:type schema:Person
    612 sg:person.013236063322.64 schema:affiliation grid-institutes:grid.419475.a
    613 schema:familyName Launer
    614 schema:givenName Lenore J.
    615 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013236063322.64
    616 rdf:type schema:Person
    617 sg:person.01341032053.15 schema:affiliation grid-institutes:grid.7700.0
    618 schema:familyName Kleber
    619 schema:givenName Marcus E.
    620 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341032053.15
    621 rdf:type schema:Person
    622 sg:person.013436612575.23 schema:affiliation grid-institutes:grid.452396.f
    623 schema:familyName Weiss
    624 schema:givenName Stefan
    625 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013436612575.23
    626 rdf:type schema:Person
    627 sg:person.01353455717.52 schema:affiliation grid-institutes:grid.241116.1
    628 schema:familyName Hendricks
    629 schema:givenName Audrey E.
    630 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353455717.52
    631 rdf:type schema:Person
    632 sg:person.01353707271.93 schema:affiliation grid-institutes:grid.189967.8
    633 schema:familyName Alonso
    634 schema:givenName Alvaro
    635 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353707271.93
    636 rdf:type schema:Person
    637 sg:person.013572701325.94 schema:affiliation grid-institutes:grid.239578.2
    638 schema:familyName Chung
    639 schema:givenName Mina K.
    640 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013572701325.94
    641 rdf:type schema:Person
    642 sg:person.015725517277.33 schema:affiliation grid-institutes:grid.6936.a
    643 schema:familyName Meitinger
    644 schema:givenName Thomas
    645 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015725517277.33
    646 rdf:type schema:Person
    647 sg:person.016503223004.14 schema:affiliation grid-institutes:grid.17635.36
    648 schema:familyName Chen
    649 schema:givenName Lin Y.
    650 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016503223004.14
    651 rdf:type schema:Person
    652 sg:person.016674701102.75 schema:affiliation grid-institutes:grid.10419.3d
    653 schema:familyName Jukema
    654 schema:givenName J. Wouter
    655 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016674701102.75
    656 rdf:type schema:Person
    657 sg:person.0611237150.50 schema:affiliation grid-institutes:grid.4567.0
    658 schema:familyName Waldenberger
    659 schema:givenName Melanie
    660 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611237150.50
    661 rdf:type schema:Person
    662 sg:person.0615417510.81 schema:affiliation grid-institutes:grid.189504.1
    663 schema:familyName Xie
    664 schema:givenName Zhijun
    665 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615417510.81
    666 rdf:type schema:Person
    667 sg:person.0657662374.06 schema:affiliation grid-institutes:grid.62560.37
    668 schema:familyName Albert
    669 schema:givenName Christine M.
    670 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657662374.06
    671 rdf:type schema:Person
    672 sg:person.0670056120.12 schema:affiliation grid-institutes:grid.5645.2
    673 schema:familyName Hofman
    674 schema:givenName Albert
    675 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670056120.12
    676 rdf:type schema:Person
    677 sg:person.0705572413.42 schema:affiliation grid-institutes:grid.5603.0
    678 schema:familyName Dörr
    679 schema:givenName Marcus
    680 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705572413.42
    681 rdf:type schema:Person
    682 sg:person.0711543202.46 schema:affiliation grid-institutes:grid.452396.f
    683 schema:familyName Mueller-Nurasyid
    684 schema:givenName Martina
    685 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711543202.46
    686 rdf:type schema:Person
    687 sg:person.0712400456.14 schema:affiliation grid-institutes:grid.5603.0
    688 schema:familyName Völzke
    689 schema:givenName Henry
    690 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712400456.14
    691 rdf:type schema:Person
    692 sg:person.0724723304.99 schema:affiliation grid-institutes:None
    693 schema:familyName Stricker
    694 schema:givenName Bruno H.
    695 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724723304.99
    696 rdf:type schema:Person
    697 sg:person.0727627446.38 schema:affiliation grid-institutes:grid.5645.2
    698 schema:familyName Kors
    699 schema:givenName Jan A.
    700 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727627446.38
    701 rdf:type schema:Person
    702 sg:person.0742714555.32 schema:affiliation grid-institutes:grid.4494.d
    703 schema:familyName van der Harst
    704 schema:givenName Pim
    705 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742714555.32
    706 rdf:type schema:Person
    707 sg:person.0747162463.84 schema:affiliation grid-institutes:grid.10419.3d
    708 schema:familyName Trompet
    709 schema:givenName Stella
    710 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747162463.84
    711 rdf:type schema:Person
    712 sg:person.0760704165.88 schema:affiliation grid-institutes:grid.62560.37
    713 schema:familyName Chasman
    714 schema:givenName Daniel I.
    715 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760704165.88
    716 rdf:type schema:Person
    717 sg:person.0763727005.09 schema:affiliation grid-institutes:grid.280243.f
    718 schema:familyName Psaty
    719 schema:givenName Bruce M.
    720 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763727005.09
    721 rdf:type schema:Person
    722 sg:person.0767751267.74 schema:affiliation grid-institutes:grid.66859.34
    723 schema:familyName Kathiresan
    724 schema:givenName Sekar
    725 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767751267.74
    726 rdf:type schema:Person
    727 sg:person.0770165456.06 schema:affiliation grid-institutes:grid.241167.7
    728 schema:familyName Soliman
    729 schema:givenName Elsayed Z.
    730 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770165456.06
    731 rdf:type schema:Person
    732 sg:person.0774130006.94 schema:affiliation grid-institutes:grid.241167.7
    733 schema:familyName Ding
    734 schema:givenName Jingzhong
    735 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774130006.94
    736 rdf:type schema:Person
    737 sg:person.0776762265.15 schema:affiliation grid-institutes:grid.5645.2
    738 schema:familyName Heeringa
    739 schema:givenName Jan
    740 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776762265.15
    741 rdf:type schema:Person
    742 sg:pub.10.1007/s00439-005-0034-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011929926
    743 https://doi.org/10.1007/s00439-005-0034-8
    744 rdf:type schema:CreativeWork
    745 sg:pub.10.1038/35048107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010548523
    746 https://doi.org/10.1038/35048107
    747 rdf:type schema:CreativeWork
    748 sg:pub.10.1038/415141a schema:sameAs https://app.dimensions.ai/details/publication/pub.1001484556
    749 https://doi.org/10.1038/415141a
    750 rdf:type schema:CreativeWork
    751 sg:pub.10.1038/456018a schema:sameAs https://app.dimensions.ai/details/publication/pub.1050730348
    752 https://doi.org/10.1038/456018a
    753 rdf:type schema:CreativeWork
    754 sg:pub.10.1038/nature02623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017921358
    755 https://doi.org/10.1038/nature02623
    756 rdf:type schema:CreativeWork
    757 sg:pub.10.1038/nature06007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050786599
    758 https://doi.org/10.1038/nature06007
    759 rdf:type schema:CreativeWork
    760 sg:pub.10.1038/nature08494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005147626
    761 https://doi.org/10.1038/nature08494
    762 rdf:type schema:CreativeWork
    763 sg:pub.10.1038/nature15393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812064
    764 https://doi.org/10.1038/nature15393
    765 rdf:type schema:CreativeWork
    766 sg:pub.10.1038/ng.2261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050255522
    767 https://doi.org/10.1038/ng.2261
    768 rdf:type schema:CreativeWork
    769 sg:pub.10.1038/ng.416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004086691
    770 https://doi.org/10.1038/ng.416
    771 rdf:type schema:CreativeWork
    772 sg:pub.10.1038/ng.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010185673
    773 https://doi.org/10.1038/ng.537
    774 rdf:type schema:CreativeWork
    775 sg:pub.10.1186/1471-2407-6-114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021250631
    776 https://doi.org/10.1186/1471-2407-6-114
    777 rdf:type schema:CreativeWork
    778 grid-institutes:None schema:alternateName Inspectorate of Health Care, Utrecht, the Netherlands
    779 schema:name Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
    780 Inspectorate of Health Care, Utrecht, the Netherlands
    781 rdf:type schema:Organization
    782 grid-institutes:grid.10419.3d schema:alternateName Department of Cardiology, Leiden University Medical Center, the Netherlands
    783 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
    784 schema:name Department of Cardiology, Leiden University Medical Center, the Netherlands
    785 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
    786 rdf:type schema:Organization
    787 grid-institutes:grid.14013.37 schema:alternateName Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    788 schema:name Faculty of Medicine, University of Iceland, Reykjavik, Iceland
    789 Icelandic Heart Association, Kopavogur, Iceland
    790 rdf:type schema:Organization
    791 grid-institutes:grid.17635.36 schema:alternateName Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    792 schema:name Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    793 rdf:type schema:Organization
    794 grid-institutes:grid.189504.1 schema:alternateName Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    795 Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    796 Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA
    797 schema:name Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    798 Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
    799 Department of Medicine, Section of Cardiovascular Medicine and Preventive Medicine, Boston University School of Medicine, Boston, MA, USA
    800 Department of Medicine, Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA
    801 National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA
    802 rdf:type schema:Organization
    803 grid-institutes:grid.189967.8 schema:alternateName Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    804 schema:name Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    805 rdf:type schema:Organization
    806 grid-institutes:grid.21107.35 schema:alternateName McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    807 schema:name McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    808 rdf:type schema:Organization
    809 grid-institutes:grid.239578.2 schema:alternateName Cleveland Clinic, Cleveland, OH, USA
    810 schema:name Cleveland Clinic, Cleveland, OH, USA
    811 rdf:type schema:Organization
    812 grid-institutes:grid.239844.0 schema:alternateName Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA
    813 schema:name Departments of Pediatrics and Medicine, Institute for Translational Genomics and Population Sciences (J.I.R.), LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA
    814 rdf:type schema:Organization
    815 grid-institutes:grid.241116.1 schema:alternateName Mathematical and Statistical Sciences, University of Colorado, Denver, Denver, CO, USA
    816 schema:name Mathematical and Statistical Sciences, University of Colorado, Denver, Denver, CO, USA
    817 National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, USA
    818 rdf:type schema:Organization
    819 grid-institutes:grid.241167.7 schema:alternateName Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
    820 Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
    821 Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
    822 Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
    823 schema:name Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
    824 Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
    825 Department of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
    826 Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
    827 rdf:type schema:Organization
    828 grid-institutes:grid.280243.f schema:alternateName Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA
    829 schema:name Departments of Medicine, Cardiovascular Health Research Unit, Epidemiology and Health Services, University of Washington, Seattle, WA, USA
    830 Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA
    831 rdf:type schema:Organization
    832 grid-institutes:grid.34477.33 schema:alternateName Department of Biostatistics, University of Washington, Seattle, WA, USA
    833 Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    834 schema:name Department of Biostatistics, University of Washington, Seattle, WA, USA
    835 Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    836 Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA
    837 rdf:type schema:Organization
    838 grid-institutes:grid.38142.3c schema:alternateName Harvard Medical School, Boston, MA, USA
    839 schema:name Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA
    840 Harvard Medical School, Boston, MA, USA
    841 rdf:type schema:Organization
    842 grid-institutes:grid.419475.a schema:alternateName National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    843 schema:name National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    844 rdf:type schema:Organization
    845 grid-institutes:grid.4494.d schema:alternateName Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    846 schema:name Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    847 rdf:type schema:Organization
    848 grid-institutes:grid.452396.f schema:alternateName DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
    849 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
    850 schema:name DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
    851 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
    852 Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany
    853 Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany
    854 Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    855 rdf:type schema:Organization
    856 grid-institutes:grid.4567.0 schema:alternateName Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    857 schema:name DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
    858 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
    859 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany
    860 rdf:type schema:Organization
    861 grid-institutes:grid.5252.0 schema:alternateName Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany
    862 schema:name Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany
    863 rdf:type schema:Organization
    864 grid-institutes:grid.5603.0 schema:alternateName Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
    865 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
    866 schema:name DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
    867 Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
    868 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
    869 rdf:type schema:Organization
    870 grid-institutes:grid.5645.2 schema:alternateName Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
    871 Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
    872 Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, the Netherlands
    873 schema:name Department of Epidemiology & Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
    874 Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
    875 Department of Medical Informatics, Erasmus MC - University Medical Center Rotterdam, the Netherlands
    876 rdf:type schema:Organization
    877 grid-institutes:grid.62560.37 schema:alternateName Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA
    878 schema:name Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA
    879 rdf:type schema:Organization
    880 grid-institutes:grid.66859.34 schema:alternateName Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
    881 schema:name Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    882 Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    883 Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    884 Harvard Medical School, Boston, MA, USA
    885 Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
    886 rdf:type schema:Organization
    887 grid-institutes:grid.6936.a schema:alternateName Institute of Human Genetics, Technische Universität München, Munich, Germany
    888 schema:name DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
    889 Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
    890 Institute of Human Genetics, Technische Universität München, Munich, Germany
    891 rdf:type schema:Organization
    892 grid-institutes:grid.7700.0 schema:alternateName Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    893 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany
    894 schema:name Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    895 Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    896 Synlab Academy, Synlab Services, GmbH P5,7, 68161 Mannheim, Germany
    897 Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany
    898 rdf:type schema:Organization
    899 grid-institutes:grid.8756.c schema:alternateName Institute of Health and Wellbeing, College of Veterinary, Medical and Life Sciences, University of Glasgow, United Kingdom
    900 Robertson Center for Biostatistics, University of Glasgow, United Kingdom
    901 schema:name Institute of Health and Wellbeing, College of Veterinary, Medical and Life Sciences, University of Glasgow, United Kingdom
    902 Robertson Center for Biostatistics, University of Glasgow, United Kingdom
    903 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...