Cathelicidins in the Tasmanian devil (Sarcophilus harrisii) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-11

AUTHORS

E. Peel, Y. Cheng, J. T. Djordjevic, S. Fox, T. C. Sorrell, K. Belov

ABSTRACT

Tasmanian devil joeys, like other marsupials, are born at a very early stage of development, prior to the development of their adaptive immune system, yet survive in a pathogen-laden pouch and burrow. Antimicrobial peptides, called cathelicidins, which provide innate immune protection during early life, are expressed in the pouch lining, skin and milk of devil dams. These peptides are active against pathogens identified in the pouch microbiome. Of the six characterised cathelicidins, Saha-CATH5 and 6 have broad-spectrum antibacterial activity and are capable of killing problematic human pathogens including methicillin-resistant S. aureus and vancomycin-resistant E. faecalis, while Saha-CATH3 is active against fungi. Saha-CATH5 and 6 were toxic to human A549 cells at 500 μg/mL, which is over seven times the concentration required to kill pathogens. The remaining devil cathelicidins were not active against tested bacterial or fungal strains, but are widely expressed throughout the body, such as in immune tissues, in digestive, respiratory and reproductive tracts, and in the milk and pouch, which indicates that they are likely also important components of the devil immune system. Our results suggest cathelicidins play a role in protecting naive young during pouch life by passive immune transfer in the milk and may modulate pouch microbe populations to reduce potential pathogens. More... »

PAGES

35019

References to SciGraph publications

  • 2001-05. Possible antimicrobial compounds from the pouch of the koala,Phascolarctos cinereus in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
  • 2001-05. Possible antimicrobial compounds from the pouch of the koala, Phascolarctos cinereus in INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
  • 2015-12-21. The Tasmanian devil microbiome—implications for conservation and management in MICROBIOME
  • 2000-01. PR39, a peptide regulator of angiogenesis in NATURE MEDICINE
  • 2010-07-10. The Conserved Marsupial Karyotype: Chromosome Painting and Evolution in MARSUPIAL GENETICS AND GENOMICS
  • 2012-10-14. Cathelicidins: family of antimicrobial peptides. A review in MOLECULAR BIOLOGY REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep35019

    DOI

    http://dx.doi.org/10.1038/srep35019

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036636736

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27725697


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