Functional organization of the HIV lipid envelope View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Nerea Huarte, Pablo Carravilla, Antonio Cruz, Maier Lorizate, Jon A Nieto-Garai, Hans-Georg Kräusslich, Jesús Pérez-Gil, Jose Requejo-Isidro, José L Nieva

ABSTRACT

The chemical composition of the human immunodeficiency virus type 1 (HIV-1) membrane is critical for fusion and entry into target cells, suggesting that preservation of a functional lipid bilayer organization may be required for efficient infection. HIV-1 acquires its envelope from the host cell plasma membrane at sites enriched in raft-type lipids. Furthermore, infectious particles display aminophospholipids on their surface, indicative of dissipation of the inter-leaflet lipid asymmetry metabolically generated at cellular membranes. By combining two-photon excited Laurdan fluorescence imaging and atomic force microscopy, we have obtained unprecedented insights into the phase state of membranes reconstituted from viral lipids (i.e., extracted from infectious HIV-1 particles), established the role played by the different specimens in the mixtures, and characterized the effects of membrane-active virucidal agents on membrane organization. In determining the molecular basis underlying lipid packing and lateral heterogeneity of the HIV-1 membrane, our results may help develop compounds with antiviral activity acting by perturbing the functional organization of the lipid envelope. More... »

PAGES

34190

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep34190

DOI

http://dx.doi.org/10.1038/srep34190

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033132974

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27678107


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