Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Alexandre Rouette, Assya Trofimov, David Haberl, Geneviève Boucher, Vincent-Philippe Lavallée, Giovanni D'Angelo, Josée Hébert, Guy Sauvageau, Sébastien Lemieux, Claude Perreault

ABSTRACT

Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas, we report that expression of constitutive proteasome (CP) genes (PSMB5, PSMB6, PSMB7) and immunoproteasome (IP) genes (PSMB8, PSMB9, PSMB10) is increased in most cancer types. In breast cancer, expression of IP genes was determined by the abundance of tumor infiltrating lymphocytes and high expression of IP genes was associated with longer survival. In contrast, IP upregulation in acute myeloid leukemia (AML) was a cell-intrinsic feature that was not associated with longer survival. Expression of IP genes in AML was IFN-independent, correlated with the methylation status of IP genes, and was particularly high in AML with an M5 phenotype and/or MLL rearrangement. Notably, PSMB8 inhibition led to accumulation of polyubiquitinated proteins and cell death in IPhigh but not IPlow AML cells. Co-clustering analysis revealed that genes correlated with IP subunits in non-M5 AMLs were primarily implicated in immune processes. However, in M5 AML, IP genes were primarily co-regulated with genes involved in cell metabolism and proliferation, mitochondrial activity and stress responses. We conclude that M5 AML cells can upregulate IP genes in a cell-intrinsic manner in order to resist cell stress. More... »

PAGES

34019

References to SciGraph publications

  • 2005-12. DNA methylation and gene silencing in cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2005-11. T cells targeted against a single minor histocompatibility antigen can cure solid tumors in NATURE MEDICINE
  • 2014-08. OrthoClust: an orthology-based network framework for clustering data across multiple species in GENOME BIOLOGY
  • 2015-09. The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias in NATURE GENETICS
  • 2002-08. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy in ONCOGENE
  • 2009-07. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis in NATURE MEDICINE
  • 2014-04. Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma in LEUKEMIA
  • 2003-01. Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells in LEUKEMIA
  • 2015-09. Regulation of Immunoproteasome Function in the Lung in SCIENTIFIC REPORTS
  • 2015-03. A comprehensive transcriptional portrait of human cancer cell lines in NATURE BIOTECHNOLOGY
  • 2014-05. Mass-spectrometry-based draft of the human proteome in NATURE
  • 2012-03. Systematic identification of genomic markers of drug sensitivity in cancer cells in NATURE
  • 2014-04. Immunoproteasome in animal models of Duchenne muscular dystrophy in JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
  • 2009-12. ER stress affects processing of MHC class I-associated peptides in BMC IMMUNOLOGY
  • 2015-03. DNMT3A in haematological malignancies in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep34019

    DOI

    http://dx.doi.org/10.1038/srep34019

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053654390

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27659694


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Montreal", 
              "id": "https://www.grid.ac/institutes/grid.14848.31", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rouette", 
            "givenName": "Alexandre", 
            "id": "sg:person.0705223522.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705223522.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Montreal", 
              "id": "https://www.grid.ac/institutes/grid.14848.31", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada.", 
                "Department of Computer Science and Operations Research, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Trofimov", 
            "givenName": "Assya", 
            "id": "sg:person.01125316414.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125316414.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Immunology and Cancer", 
              "id": "https://www.grid.ac/institutes/grid.459284.6", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haberl", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Immunology and Cancer", 
              "id": "https://www.grid.ac/institutes/grid.459284.6", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boucher", 
            "givenName": "Genevi\u00e8ve", 
            "id": "sg:person.01356772551.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356772551.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
              "id": "https://www.grid.ac/institutes/grid.414216.4", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada.", 
                "Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.", 
                "Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lavall\u00e9e", 
            "givenName": "Vincent-Philippe", 
            "id": "sg:person.01024206110.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024206110.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
              "id": "https://www.grid.ac/institutes/grid.414216.4", 
              "name": [
                "Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.", 
                "Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "D'Angelo", 
            "givenName": "Giovanni", 
            "id": "sg:person.01206547710.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206547710.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
              "id": "https://www.grid.ac/institutes/grid.414216.4", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada.", 
                "Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.", 
                "Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "H\u00e9bert", 
            "givenName": "Jos\u00e9e", 
            "id": "sg:person.01246405251.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246405251.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
              "id": "https://www.grid.ac/institutes/grid.414216.4", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada.", 
                "Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.", 
                "Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sauvageau", 
            "givenName": "Guy", 
            "id": "sg:person.0660567663.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660567663.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Montreal", 
              "id": "https://www.grid.ac/institutes/grid.14848.31", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Computer Science and Operations Research, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lemieux", 
            "givenName": "S\u00e9bastien", 
            "id": "sg:person.01310657351.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310657351.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H\u00f4pital Maisonneuve-Rosemont", 
              "id": "https://www.grid.ac/institutes/grid.414216.4", 
              "name": [
                "Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.", 
                "Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada.", 
                "Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perreault", 
            "givenName": "Claude", 
            "id": "sg:person.0677260121.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677260121.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/srep10230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000352988", 
              "https://doi.org/10.1038/srep10230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcdb.2012.01.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000712098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pneurobio.2011.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001094061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001969282", 
              "https://doi.org/10.1038/sj.leu.2402708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2402708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001969282", 
              "https://doi.org/10.1038/sj.leu.2402708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008312342", 
              "https://doi.org/10.1038/nature11005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009734077", 
              "https://doi.org/10.1038/nbt.3080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010293997", 
              "https://doi.org/10.1038/ng.3371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01485-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011311382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1406184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011899386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013030095", 
              "https://doi.org/10.1038/nature13319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201110131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013591595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.aad6352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013700027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1400871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013919942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10974-014-9385-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013943566", 
              "https://doi.org/10.1007/s10974-014-9385-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015413259", 
              "https://doi.org/10.1038/sj.onc.1205699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015413259", 
              "https://doi.org/10.1038/sj.onc.1205699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci71602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016034469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018050155", 
              "https://doi.org/10.1038/nm.1978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018050155", 
              "https://doi.org/10.1038/nm.1978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-1316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018100449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.194.1.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018370735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-08-594408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019092248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2012.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019630757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2012.12.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019666451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020670647", 
              "https://doi.org/10.1038/leu.2013.233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020670647", 
              "https://doi.org/10.1038/leu.2013.233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.1113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022000732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.201303543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023095395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1301689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025463655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2014.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026287832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2014-15-8-r100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027477864", 
              "https://doi.org/10.1186/gb-2014-15-8-r100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.02.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028941463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0501711102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029737138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0501711102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029737138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1009778107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030891748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2008.01.086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031436194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00208511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032182002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2172-10-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032406568", 
              "https://doi.org/10.1186/1471-2172-10-10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2007.01.061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032830781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0021800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034510199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncponc0354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034769071", 
              "https://doi.org/10.1038/ncponc0354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncponc0354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034769071", 
              "https://doi.org/10.1038/ncponc0354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034955346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-07-591529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035416728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20131121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038693179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039113899", 
              "https://doi.org/10.1038/nrc3895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044783769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m900566-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044992131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2007.00578.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045256145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1103213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046799788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnmol.2014.00070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048720698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2016.02.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049973998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049990890", 
              "https://doi.org/10.1038/nm1311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049990890", 
              "https://doi.org/10.1038/nm1311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm300434z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055953024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm500716s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055954779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1568009614666140723113139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069191420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.12.6859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074962456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1401177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078954385"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-12", 
        "datePublishedReg": "2016-12-01", 
        "description": "Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas, we report that expression of constitutive proteasome (CP) genes (PSMB5, PSMB6, PSMB7) and immunoproteasome (IP) genes (PSMB8, PSMB9, PSMB10) is increased in most cancer types. In breast cancer, expression of IP genes was determined by the abundance of tumor infiltrating lymphocytes and high expression of IP genes was associated with longer survival. In contrast, IP upregulation in acute myeloid leukemia (AML) was a cell-intrinsic feature that was not associated with longer survival. Expression of IP genes in AML was IFN-independent, correlated with the methylation status of IP genes, and was particularly high in AML with an M5 phenotype and/or MLL rearrangement. Notably, PSMB8 inhibition led to accumulation of polyubiquitinated proteins and cell death in IPhigh but not IPlow AML cells. Co-clustering analysis revealed that genes correlated with IP subunits in non-M5 AMLs were primarily implicated in immune processes. However, in M5 AML, IP genes were primarily co-regulated with genes involved in cell metabolism and proliferation, mitochondrial activity and stress responses. We conclude that M5 AML cells can upregulate IP genes in a cell-intrinsic manner in order to resist cell stress.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/srep34019", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "name": "Expression of immunoproteasome genes is regulated by cell-intrinsic and \u2013extrinsic factors in human cancers", 
        "pagination": "34019", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ff900f7d24ca14d8f9e6ca64833bf36120fa07e07441e10546db892915a3b2f1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27659694"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/srep34019"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053654390"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/srep34019", 
          "https://app.dimensions.ai/details/publication/pub.1053654390"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000551.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/srep/2016/160923/srep34019/full/srep34019.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep34019'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep34019'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep34019'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep34019'


     

    This table displays all metadata directly associated to this object as RDF triples.

    315 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/srep34019 schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N72a7e6ef9e384c359beef8a5b0981105
    4 schema:citation sg:pub.10.1007/s10974-014-9385-x
    5 sg:pub.10.1038/leu.2013.233
    6 sg:pub.10.1038/nature11005
    7 sg:pub.10.1038/nature13319
    8 sg:pub.10.1038/nbt.3080
    9 sg:pub.10.1038/ncponc0354
    10 sg:pub.10.1038/ng.3371
    11 sg:pub.10.1038/nm.1978
    12 sg:pub.10.1038/nm1311
    13 sg:pub.10.1038/nrc3895
    14 sg:pub.10.1038/sj.leu.2402708
    15 sg:pub.10.1038/sj.onc.1205699
    16 sg:pub.10.1038/srep10230
    17 sg:pub.10.1186/1471-2172-10-10
    18 sg:pub.10.1186/gb-2014-15-8-r100
    19 https://doi.org/10.1002/emmm.201303543
    20 https://doi.org/10.1002/stem.1113
    21 https://doi.org/10.1016/j.cell.2009.02.024
    22 https://doi.org/10.1016/j.coi.2012.11.004
    23 https://doi.org/10.1016/j.febslet.2007.01.061
    24 https://doi.org/10.1016/j.immuni.2016.02.025
    25 https://doi.org/10.1016/j.jmb.2008.01.086
    26 https://doi.org/10.1016/j.molonc.2014.07.011
    27 https://doi.org/10.1016/j.pneurobio.2011.10.001
    28 https://doi.org/10.1016/j.semcdb.2012.01.019
    29 https://doi.org/10.1016/j.stem.2012.12.013
    30 https://doi.org/10.1021/jm300434z
    31 https://doi.org/10.1021/jm500716s
    32 https://doi.org/10.1056/nejmoa1301689
    33 https://doi.org/10.1056/nejmra1406184
    34 https://doi.org/10.1073/pnas.0501711102
    35 https://doi.org/10.1073/pnas.1009778107
    36 https://doi.org/10.1074/mcp.m900566-mcp200
    37 https://doi.org/10.1083/jcb.201110131
    38 https://doi.org/10.1084/jem.194.1.1
    39 https://doi.org/10.1084/jem.20131121
    40 https://doi.org/10.1111/j.1600-065x.2007.00578.x
    41 https://doi.org/10.1126/scitranslmed.aad6352
    42 https://doi.org/10.1128/mcb.01485-08
    43 https://doi.org/10.1158/0008-5472.can-11-1316
    44 https://doi.org/10.1158/1078-0432.ccr-12-1424
    45 https://doi.org/10.1158/1078-0432.ccr-13-1877
    46 https://doi.org/10.1172/jci71602
    47 https://doi.org/10.1182/blood-2014-07-591529
    48 https://doi.org/10.1182/blood-2014-08-594408
    49 https://doi.org/10.1183/09031936.00208511
    50 https://doi.org/10.1371/journal.pone.0021800
    51 https://doi.org/10.2174/1568009614666140723113139
    52 https://doi.org/10.3389/fnmol.2014.00070
    53 https://doi.org/10.4049/jimmunol.1103213
    54 https://doi.org/10.4049/jimmunol.1400871
    55 https://doi.org/10.4049/jimmunol.1401177
    56 https://doi.org/10.4049/jimmunol.167.12.6859
    57 schema:datePublished 2016-12
    58 schema:datePublishedReg 2016-12-01
    59 schema:description Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas, we report that expression of constitutive proteasome (CP) genes (PSMB5, PSMB6, PSMB7) and immunoproteasome (IP) genes (PSMB8, PSMB9, PSMB10) is increased in most cancer types. In breast cancer, expression of IP genes was determined by the abundance of tumor infiltrating lymphocytes and high expression of IP genes was associated with longer survival. In contrast, IP upregulation in acute myeloid leukemia (AML) was a cell-intrinsic feature that was not associated with longer survival. Expression of IP genes in AML was IFN-independent, correlated with the methylation status of IP genes, and was particularly high in AML with an M5 phenotype and/or MLL rearrangement. Notably, PSMB8 inhibition led to accumulation of polyubiquitinated proteins and cell death in IP<sup>high</sup> but not IP<sup>low</sup> AML cells. Co-clustering analysis revealed that genes correlated with IP subunits in non-M5 AMLs were primarily implicated in immune processes. However, in M5 AML, IP genes were primarily co-regulated with genes involved in cell metabolism and proliferation, mitochondrial activity and stress responses. We conclude that M5 AML cells can upregulate IP genes in a cell-intrinsic manner in order to resist cell stress.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree true
    63 schema:isPartOf N5b29e6d7785c4e9f927f2fbeb863fd78
    64 Nde9c2c07a5424da29d6ce0f00becc820
    65 sg:journal.1045337
    66 schema:name Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers
    67 schema:pagination 34019
    68 schema:productId N0abbec2b52224ca2a1406766557da1e1
    69 N4cbfb0dfc47f41818fe0c76f820e7c4d
    70 Nad29b13714f5468e9087f11be5439f12
    71 Nb58d80e536584b118da15dd3af94514a
    72 Nef464f2e8ec64b5bb89b01d6bd40ade6
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053654390
    74 https://doi.org/10.1038/srep34019
    75 schema:sdDatePublished 2019-04-10T22:39
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher Nad644659deb344b5a411d9115a7b049d
    78 schema:url http://www.nature.com/srep/2016/160923/srep34019/full/srep34019.html
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N06e40fcf0c8f4d4da04ec43a6d0b0df0 rdf:first Nc63cd3dd55b04ad5b4fcb0022a377306
    83 rdf:rest N7996b247bed84ece92730612a1331dff
    84 N0abbec2b52224ca2a1406766557da1e1 schema:name doi
    85 schema:value 10.1038/srep34019
    86 rdf:type schema:PropertyValue
    87 N114c7a00b28a48d98d7f5b8e96d1dfaf rdf:first sg:person.01206547710.96
    88 rdf:rest N48bded5f450a49b698e2914ff6a35efd
    89 N30187dfaa4c34e30a10b914fecea0be8 rdf:first sg:person.01125316414.06
    90 rdf:rest N06e40fcf0c8f4d4da04ec43a6d0b0df0
    91 N48bded5f450a49b698e2914ff6a35efd rdf:first sg:person.01246405251.37
    92 rdf:rest N7d06e09b23fe4d069b3a042f226398c5
    93 N4cbfb0dfc47f41818fe0c76f820e7c4d schema:name pubmed_id
    94 schema:value 27659694
    95 rdf:type schema:PropertyValue
    96 N59de5928d03647f0a43bb0a783d36128 rdf:first sg:person.01310657351.35
    97 rdf:rest Nc4bbdf2fa03849ca8dd93fce70e71b8c
    98 N5b29e6d7785c4e9f927f2fbeb863fd78 schema:volumeNumber 6
    99 rdf:type schema:PublicationVolume
    100 N72a7e6ef9e384c359beef8a5b0981105 rdf:first sg:person.0705223522.90
    101 rdf:rest N30187dfaa4c34e30a10b914fecea0be8
    102 N76514ed2f83a4e1b88486175ba3528cd rdf:first sg:person.01024206110.16
    103 rdf:rest N114c7a00b28a48d98d7f5b8e96d1dfaf
    104 N7996b247bed84ece92730612a1331dff rdf:first sg:person.01356772551.65
    105 rdf:rest N76514ed2f83a4e1b88486175ba3528cd
    106 N7d06e09b23fe4d069b3a042f226398c5 rdf:first sg:person.0660567663.03
    107 rdf:rest N59de5928d03647f0a43bb0a783d36128
    108 Nad29b13714f5468e9087f11be5439f12 schema:name readcube_id
    109 schema:value ff900f7d24ca14d8f9e6ca64833bf36120fa07e07441e10546db892915a3b2f1
    110 rdf:type schema:PropertyValue
    111 Nad644659deb344b5a411d9115a7b049d schema:name Springer Nature - SN SciGraph project
    112 rdf:type schema:Organization
    113 Nb58d80e536584b118da15dd3af94514a schema:name dimensions_id
    114 schema:value pub.1053654390
    115 rdf:type schema:PropertyValue
    116 Nc4bbdf2fa03849ca8dd93fce70e71b8c rdf:first sg:person.0677260121.18
    117 rdf:rest rdf:nil
    118 Nc63cd3dd55b04ad5b4fcb0022a377306 schema:affiliation https://www.grid.ac/institutes/grid.459284.6
    119 schema:familyName Haberl
    120 schema:givenName David
    121 rdf:type schema:Person
    122 Nde9c2c07a5424da29d6ce0f00becc820 schema:issueNumber 1
    123 rdf:type schema:PublicationIssue
    124 Nef464f2e8ec64b5bb89b01d6bd40ade6 schema:name nlm_unique_id
    125 schema:value 101563288
    126 rdf:type schema:PropertyValue
    127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    128 schema:name Medical and Health Sciences
    129 rdf:type schema:DefinedTerm
    130 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    131 schema:name Oncology and Carcinogenesis
    132 rdf:type schema:DefinedTerm
    133 sg:journal.1045337 schema:issn 2045-2322
    134 schema:name Scientific Reports
    135 rdf:type schema:Periodical
    136 sg:person.01024206110.16 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
    137 schema:familyName Lavallée
    138 schema:givenName Vincent-Philippe
    139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024206110.16
    140 rdf:type schema:Person
    141 sg:person.01125316414.06 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
    142 schema:familyName Trofimov
    143 schema:givenName Assya
    144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125316414.06
    145 rdf:type schema:Person
    146 sg:person.01206547710.96 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
    147 schema:familyName D'Angelo
    148 schema:givenName Giovanni
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206547710.96
    150 rdf:type schema:Person
    151 sg:person.01246405251.37 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
    152 schema:familyName Hébert
    153 schema:givenName Josée
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246405251.37
    155 rdf:type schema:Person
    156 sg:person.01310657351.35 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
    157 schema:familyName Lemieux
    158 schema:givenName Sébastien
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310657351.35
    160 rdf:type schema:Person
    161 sg:person.01356772551.65 schema:affiliation https://www.grid.ac/institutes/grid.459284.6
    162 schema:familyName Boucher
    163 schema:givenName Geneviève
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356772551.65
    165 rdf:type schema:Person
    166 sg:person.0660567663.03 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
    167 schema:familyName Sauvageau
    168 schema:givenName Guy
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660567663.03
    170 rdf:type schema:Person
    171 sg:person.0677260121.18 schema:affiliation https://www.grid.ac/institutes/grid.414216.4
    172 schema:familyName Perreault
    173 schema:givenName Claude
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677260121.18
    175 rdf:type schema:Person
    176 sg:person.0705223522.90 schema:affiliation https://www.grid.ac/institutes/grid.14848.31
    177 schema:familyName Rouette
    178 schema:givenName Alexandre
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705223522.90
    180 rdf:type schema:Person
    181 sg:pub.10.1007/s10974-014-9385-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013943566
    182 https://doi.org/10.1007/s10974-014-9385-x
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1038/leu.2013.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020670647
    185 https://doi.org/10.1038/leu.2013.233
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1038/nature11005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008312342
    188 https://doi.org/10.1038/nature11005
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nature13319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013030095
    191 https://doi.org/10.1038/nature13319
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nbt.3080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009734077
    194 https://doi.org/10.1038/nbt.3080
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/ncponc0354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034769071
    197 https://doi.org/10.1038/ncponc0354
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/ng.3371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010293997
    200 https://doi.org/10.1038/ng.3371
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nm.1978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018050155
    203 https://doi.org/10.1038/nm.1978
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nm1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049990890
    206 https://doi.org/10.1038/nm1311
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nrc3895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039113899
    209 https://doi.org/10.1038/nrc3895
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/sj.leu.2402708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001969282
    212 https://doi.org/10.1038/sj.leu.2402708
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/sj.onc.1205699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015413259
    215 https://doi.org/10.1038/sj.onc.1205699
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/srep10230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000352988
    218 https://doi.org/10.1038/srep10230
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1186/1471-2172-10-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032406568
    221 https://doi.org/10.1186/1471-2172-10-10
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1186/gb-2014-15-8-r100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027477864
    224 https://doi.org/10.1186/gb-2014-15-8-r100
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/emmm.201303543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023095395
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/stem.1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022000732
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/j.cell.2009.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028941463
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/j.coi.2012.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019630757
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/j.febslet.2007.01.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032830781
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.immuni.2016.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049973998
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.jmb.2008.01.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031436194
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.molonc.2014.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026287832
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.pneurobio.2011.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001094061
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.semcdb.2012.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000712098
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.stem.2012.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019666451
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1021/jm300434z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953024
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1021/jm500716s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055954779
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1056/nejmoa1301689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025463655
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1056/nejmra1406184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011899386
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1073/pnas.0501711102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029737138
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1073/pnas.1009778107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030891748
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1074/mcp.m900566-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044992131
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1083/jcb.201110131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013591595
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1084/jem.194.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018370735
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1084/jem.20131121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038693179
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1111/j.1600-065x.2007.00578.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045256145
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1126/scitranslmed.aad6352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013700027
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1128/mcb.01485-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011311382
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1158/0008-5472.can-11-1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018100449
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1158/1078-0432.ccr-12-1424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034955346
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1158/1078-0432.ccr-13-1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044783769
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1172/jci71602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016034469
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1182/blood-2014-07-591529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035416728
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1182/blood-2014-08-594408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019092248
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1183/09031936.00208511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032182002
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1371/journal.pone.0021800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034510199
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.2174/1568009614666140723113139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069191420
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.3389/fnmol.2014.00070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048720698
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.4049/jimmunol.1103213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046799788
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.4049/jimmunol.1400871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013919942
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.4049/jimmunol.1401177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078954385
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.4049/jimmunol.167.12.6859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074962456
    301 rdf:type schema:CreativeWork
    302 https://www.grid.ac/institutes/grid.14848.31 schema:alternateName University of Montreal
    303 schema:name Department of Computer Science and Operations Research, Université de Montréal, Montreal, Quebec, Canada.
    304 Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
    305 Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.
    306 rdf:type schema:Organization
    307 https://www.grid.ac/institutes/grid.414216.4 schema:alternateName Hôpital Maisonneuve-Rosemont
    308 schema:name Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
    309 Division of Hematology-Oncology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
    310 Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.
    311 Quebec Leukemia Cell Bank, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
    312 rdf:type schema:Organization
    313 https://www.grid.ac/institutes/grid.459284.6 schema:alternateName Institute for Research in Immunology and Cancer
    314 schema:name Institute for Research in Immunology and Cancer, Montreal, Quebec, Canada.
    315 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...