Disrupted brain metabolic connectivity in a 6-OHDA-induced mouse model of Parkinson’s disease examined using persistent homology-based analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09-21

AUTHORS

Hyung-Jun Im, Jarang Hahm, Hyejin Kang, Hongyoon Choi, Hyekyoung Lee, Do Won Hwang, E. Edmund Kim, June-Key Chung, Dong Soo Lee

ABSTRACT

Movement impairments in Parkinson’s disease (PD) are caused by the degeneration of dopaminergic neurons and the consequent disruption of connectivity in the cortico-striatal-thalamic loop. This study evaluated brain metabolic connectivity in a 6-Hydroxydopamine (6-OHDA)-induced mouse model of PD using 18F-fluorodeoxy glucose positron emission tomography (FDG PET). Fourteen PD-model mice and ten control mice were used for the analysis. Voxel-wise t-tests on FDG PET results yielded no significant regional metabolic differences between the PD and control groups. However, the PD group showed lower correlations between the right caudoputamen and the left caudoputamen and right visual cortex. Further network analyses based on the threshold-free persistent homology framework revealed that brain networks were globally disrupted in the PD group, especially between the right auditory cortex and bilateral cortical structures and the left caudoputamen. In conclusion, regional glucose metabolism of PD was preserved, but the metabolic connectivity of the cortico-striatal-thalamic loop was globally impaired in PD. More... »

PAGES

33875

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep33875

DOI

http://dx.doi.org/10.1038/srep33875

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024800927

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27650055


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