Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-19

AUTHORS

Anurodh Shankar Agrawal, Tianlei Ying, Xinrong Tao, Tania Garron, Abdullah Algaissi, Yanping Wang, Lili Wang, Bi-Hung Peng, Shibo Jiang, Dimiter S. Dimitrov, Chien-Te K. Tseng

ABSTRACT

Middle East Respiratory Syndrome coronavirus (MERS-CoV) has repeatedly caused outbreaks in the Arabian Peninsula. To date, no approved medical countermeasures (MCM) are available to combat MERS-CoV infections. Several neutralizing human monoclonal antibodies (mAbs), including m336, a germline-like human mAb, have been chosen as promising MCM for MERS-CoV. However, their clinical development has been hindered by the lack of a robust animal model that recapitulate the morbidity and mortality of human infections. We assessed the prophylactic and therapeutic efficacy of m336 by using well-characterized transgenic mice shown to be highly sensitive to MERS-CoV infection and disease. We found that mice treated with m336 prior to or post lethal MERS-CoV challenging were fully protected, compared to control mice which sufferered from profound weight loss and uniform death within days after infection. Taken together, these results support further development of m336 and other human monoclonal antibodies as potential therapeutics for MERS-CoV infection. More... »

PAGES

31629

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31629

DOI

http://dx.doi.org/10.1038/srep31629

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014649875

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27538452


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