Gene expression of muscular and neuronal pathways is cooperatively dysregulated in patients with idiopathic achalasia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-11

AUTHORS

Orazio Palmieri, Tommaso Mazza, Antonio Merla, Caterina Fusilli, Antonello Cuttitta, Giuseppina Martino, Tiziana Latiano, Giuseppe Corritore, Fabrizio Bossa, Orazio Palumbo, Lucia Anna Muscarella, Massimo Carella, Paolo Graziano, Angelo Andriulli, Anna Latiano

ABSTRACT

Idiopathic achalasia is characterized by the absence of peristalsis secondary to loss of neurons in the myenteric plexus that hampers proper relaxation of the lower esophageal sphincter. Achalasia can be considered a multifactorial disorder as it occurs in related individuals and is associated with HLA class II genes, thereby suggesting genetic influence. We used microarray technology and advanced in-silico functional analyses to perform the first genome-wide expression profiling of mRNA in tissue samples from 12 achalasia and 5 control patients. It revealed 1,728 differentially expressed genes, of these, 837 (48.4%) were up-regulated in cases. In particular, genes participating to the smooth muscle contraction biological function were mostly up-regulated. Functional analysis revealed a significant enrichment of neuronal/muscular and neuronal/immunity processes. Upstream regulatory analysis of 180 genes involved in these processes suggested TLR4 and IL18 as critical key-players. Two functional gene networks were significantly over-represented: one involved in organ morphology, skeletal muscle system development and function, and neurological diseases, and the other participating in cell morphology, humoral immune response and cellular movement. These results highlight on pivotal genes that may play critical roles in neuronal/muscular and neuronal/immunity processes, and that may contribute to the onset and development of achalasia. More... »

PAGES

31549

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31549

DOI

http://dx.doi.org/10.1038/srep31549

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037886449

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27511445


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