Genes on a Wire: The Nucleoid-Associated Protein HU Insulates Transcription Units in Escherichia coli View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

Michael Berger, Veneta Gerganova, Petya Berger, Radu Rapiteanu, Viktoras Lisicovas, Ulrich Dobrindt

ABSTRACT

The extent to which chromosomal gene position in prokaryotes affects local gene expression remains an open question. Several studies have shown that chromosomal re-positioning of bacterial transcription units does not alter their expression pattern, except for a general decrease in gene expression levels from chromosomal origin to terminus proximal positions, which is believed to result from gene dosage effects. Surprisingly, the question as to whether this chromosomal context independence is a cis encoded property of a bacterial transcription unit, or if position independence is a property conferred by factors acting in trans, has not been addressed so far. For this purpose, we established a genetic test system assessing the chromosomal positioning effects by means of identical promoter-fluorescent reporter gene fusions inserted equidistantly from OriC into both chromosomal replichores of Escherichia coli K-12. Our investigations of the reporter activities in mutant cells lacking the conserved nucleoid associated protein HU uncovered various drastic chromosomal positional effects on gene transcription. In addition we present evidence that these positional effects are caused by transcriptional activity nearby the insertion site of our reporter modules. We therefore suggest that the nucleoid-associated protein HU is functionally insulating transcription units, most likely by constraining transcription induced DNA supercoiling. More... »

PAGES

31512

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31512

DOI

http://dx.doi.org/10.1038/srep31512

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023687181

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27545593


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