miRNA profiles in livers with different mass deficits after partial hepatectomy and miR-106b~25 cluster accelerating hepatocyte proliferation in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-10

AUTHORS

Xiao Xu, Zhikun Liu, Jianguo Wang, Qi Ling, Haiyang Xie, Haijun Guo, Xuyong Wei, Lin Zhou, Shusen Zheng

ABSTRACT

Partial hepatectomy (PH) promotes the reentry of quiescent hepatocytes into cell cycle for regrowth. miRNA profiles in livers with different mass deficits after PH have not been investigated and miRNAs implicated in liver regeneration remain unclear. We generated miRNA profiles from normal and remnant livers at 6, 12, 24 and 36 hours after 1/3 or 2/3PH using microarrays. Compared with normal livers, the proportion of altered miRNAs decreased with time after 1/3PH, but increased after 2/3PH. Most of altered miRNAs between 1/3 and 2/3PH exhibited similar up- or down-regulation, but lower expression magnitude for 1/3PH. Among differentially expressed miRNAs between 2/3PH with robust DNA replication and 1/3PH with a minimal replicative response, we identified miR-101a, miR-92a, miR-25, miR-93 and miR-106b as key regulators of cell cycle. In 2/3PH model, overexpression of miR-106b~25 cluster tended to accelerate liver regeneration, while inhibition of miR-106b~25 cluster markedly repressed regenerative response and delayed recovery of liver function. Mechanistically, RB1 and KAT2B with cell cycle arrest activity were identified as novel targets of miR-106b/93 and miR-25, respectively. Overall, we featured miRNA profiles and dynamics after 1/3 and 2/3PH and identified miR-106b~25 cluster as being involved in timely cell cycle entry of hepatocytes after PH. More... »

PAGES

31267

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31267

DOI

http://dx.doi.org/10.1038/srep31267

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033604837

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27507706


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