JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress Disorders, Post-Traumatic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Veterans", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
          "id": "http://www.grid.ac/institutes/grid.254567.7", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bam", 
        "givenName": "Marpe", 
        "id": "sg:person.0677044654.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677044654.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
            "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Xiaoming", 
        "id": "sg:person.01233336052.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233336052.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
          "id": "http://www.grid.ac/institutes/grid.254567.7", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zumbrun", 
        "givenName": "Elizabeth E.", 
        "id": "sg:person.01254532346.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254532346.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
          "id": "http://www.grid.ac/institutes/grid.254567.7", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhong", 
        "givenName": "Yin", 
        "id": "sg:person.01202625653.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202625653.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Present Address: Institute for Tumor Immunology, Ludong University School of Life Sciences, Yantai, Shandong 264025, P.R. China.", 
          "id": "http://www.grid.ac/institutes/grid.443651.1", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
            "Present Address: Institute for Tumor Immunology, Ludong University School of Life Sciences, Yantai, Shandong 264025, P.R. China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Juhua", 
        "id": "sg:person.01235346213.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235346213.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ginsberg", 
        "givenName": "Jay P.", 
        "id": "sg:person.01001372513.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001372513.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leyden", 
        "givenName": "Quinne", 
        "id": "sg:person.01143124273.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143124273.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 29206, Columbia, SC, USA", 
          "id": "http://www.grid.ac/institutes/grid.254567.7", 
          "name": [
            "Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 29206, Columbia, SC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jiajia", 
        "id": "sg:person.0674303713.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674303713.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
          "id": "http://www.grid.ac/institutes/grid.254567.7", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagarkatti", 
        "givenName": "Prakash S.", 
        "id": "sg:person.0734741117.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734741117.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, 29209, Columbia, SC, USA", 
            "William Jennings Bryan Dorn Veterans Medical Center, 6439 Garners Ferry Road, Columbia, 29209-1639, South Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagarkatti", 
        "givenName": "Mitzi", 
        "id": "sg:person.01231106421.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231106421.00"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1385/cbb:38:3:305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048488887", 
          "https://doi.org/10.1385/cbb:38:3:305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043341870", 
          "https://doi.org/10.1038/nature02871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001799892", 
          "https://doi.org/10.1038/nrg1379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-013-1551-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026709722", 
          "https://doi.org/10.1007/s00018-013-1551-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11481-015-9643-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036324869", 
          "https://doi.org/10.1007/s11481-015-9643-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031035095", 
          "https://doi.org/10.1038/nbt.1621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039987283", 
          "https://doi.org/10.1038/nprot.2008.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045130794", 
          "https://doi.org/10.1038/nrg3535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019949980", 
          "https://doi.org/10.1038/ni.2059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000996776", 
          "https://doi.org/10.1038/nri2252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040562725", 
          "https://doi.org/10.1038/nrg3561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-244x-13-40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012478069", 
          "https://doi.org/10.1186/1471-244x-13-40"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2015.9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021847979", 
          "https://doi.org/10.1038/mp.2015.9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-014-0418-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009878722", 
          "https://doi.org/10.1007/s00281-014-0418-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012173499", 
          "https://doi.org/10.1038/sj.onc.1204603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010889060", 
          "https://doi.org/10.1038/nature14192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024414936", 
          "https://doi.org/10.1038/nri3494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2013-14-4-r36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015459845", 
          "https://doi.org/10.1186/gb-2013-14-4-r36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2012.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012205596", 
          "https://doi.org/10.1038/npp.2012.112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01877210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003287409", 
          "https://doi.org/10.1007/bf01877210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027244467", 
          "https://doi.org/10.1038/nri3536"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-08-11", 
    "datePublishedReg": "2016-08-11", 
    "description": "Post-traumatic stress disorder patients experience chronic systemic inflammation. However, the molecular pathways involved and mechanisms regulating the expression of genes involved in inflammatory pathways in PTSD are reported inadequately. Through RNA sequencing and miRNA microarray, we identified 326 genes and 190 miRNAs that were significantly different in their expression levels in the PBMCs of PTSD patients. Expression pairing of the differentially expressed genes and miRNAs indicated an inverse relationship in their expression. Functional analysis of the differentially expressed genes indicated their involvement in the canonical pathways specific to immune system biology. DNA methylation analysis of differentially expressed genes also showed a gradual trend towards differences between control and PTSD patients, again indicating a possible role of this epigenetic mechanism in PTSD inflammation. Overall, combining data from the three techniques provided a holistic view of several pathways in which the differentially expressed genes were impacted through epigenetic mechanisms, in PTSD. Thus, analysis combining data from RNA-Seq, miRNA array and DNA methylation, can provide key evidence about dysregulated pathways and the controlling mechanism in PTSD. Most importantly, the present study provides further evidence that inflammation in PTSD could be epigenetically regulated.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep31209", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2504124", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2552509", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435343", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2465760", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437944", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2401669", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "epigenetic mechanisms", 
      "DNA methylation", 
      "DNA methylation analysis", 
      "expression of genes", 
      "altered miRNA expression", 
      "RNA-seq", 
      "RNA sequencing", 
      "canonical pathways", 
      "systems biology", 
      "functional analysis", 
      "immune system network", 
      "genes", 
      "miRNA expression", 
      "molecular pathways", 
      "methylation analysis", 
      "miRNA microarray", 
      "expression levels", 
      "miRNA array", 
      "pathway", 
      "methylation", 
      "expression", 
      "immune system biology", 
      "possible role", 
      "miRNAs", 
      "mechanism", 
      "miRNA", 
      "biology", 
      "sequencing", 
      "microarray", 
      "further evidence", 
      "inflammatory pathways", 
      "key evidence", 
      "present study", 
      "pairing", 
      "PTSD patients", 
      "evidence", 
      "role", 
      "analysis", 
      "chronic systemic inflammation", 
      "post-traumatic stress disorder patients", 
      "holistic view", 
      "inflammation", 
      "inverse relationship", 
      "systemic inflammation", 
      "disorder patients", 
      "involvement", 
      "patients", 
      "levels", 
      "PTSD", 
      "war veterans", 
      "data", 
      "array", 
      "gradual trend", 
      "control", 
      "PBMC", 
      "relationship", 
      "study", 
      "differences", 
      "outcomes", 
      "veterans", 
      "network", 
      "view", 
      "trends", 
      "technique", 
      "system network"
    ], 
    "name": "Dysregulated immune system networks in war veterans with PTSD is an outcome of altered miRNA expression and DNA methylation", 
    "pagination": "31209", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013128062"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep31209"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27510991"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep31209", 
      "https://app.dimensions.ai/details/publication/pub.1013128062"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_694.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep31209"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

347 TRIPLES      22 PREDICATES      125 URIs      96 LITERALS      20 BLANK NODES