The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

Robert Carreras-Torres, Philip C Haycock, Caroline L Relton, Richard M Martin, George Davey Smith, Peter Kraft, Chi Gao, Shelley Tworoger, Loïc Le Marchand, Lynne R Wilkens, Sungshim L Park, Christopher Haiman, John K Field, Michael Davies, Michael Marcus, Geoffrey Liu, Neil E Caporaso, David C Christiani, Yongyue Wei, Chu Chen, Jennifer A Doherty, Gianluca Severi, Gary E Goodman, Rayjean J Hung, Christopher I Amos, James McKay, Mattias Johansson, Paul Brennan

ABSTRACT

Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse causality. We used the two-sample Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiology by constructing a genetic instrument for BMI, based on results from the GIANT consortium, which was evaluated in relation to lung cancer risk using GWAS results on 16,572 lung cancer cases and 21,480 controls. Results were stratified by histological subtype, smoking status and sex. An increase of one standard deviation (SD) in BMI (4.65 Kg/m(2)) raised the risk for lung cancer overall (OR = 1.13; P = 0.10). This was driven by associations with squamous cell (SQ) carcinoma (OR = 1.45; P = 1.2 × 10(-3)) and small cell (SC) carcinoma (OR = 1.81; P = 0.01). An inverse trend was seen for adenocarcinoma (AD) (OR = 0.82; P = 0.06). In stratified analyses, a 1 SD increase in BMI was inversely associated with overall lung cancer in never smokers (OR = 0.50; P = 0.02). These results indicate that higher BMI may increase the risk of certain types of lung cancer, in particular SQ and SC carcinoma. More... »

PAGES

31121

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31121

DOI

http://dx.doi.org/10.1038/srep31121

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011769902

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27487993


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