Epidermal growth factor gene is a newly identified candidate gene for gout View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-10

AUTHORS

Lin Han, Chunwei Cao, Zhaotong Jia, Shiguo Liu, Zhen Liu, Ruosai Xin, Can Wang, Xinde Li, Wei Ren, Xuefeng Wang, Changgui Li

ABSTRACT

Chromosome 4q25 has been identified as a genomic region associated with gout. However, the associations of gout with the genes in this region have not yet been confirmed. Here, we performed two-stage analysis to determine whether variations in candidate genes in the 4q25 region are associated with gout in a male Chinese Han population. We first evaluated 96 tag single nucleotide polymorphisms (SNPs) in eight inflammatory/immune pathway- or glucose/lipid metabolism-related genes in the 4q25 region in 480 male gout patients and 480 controls. The SNP rs12504538, located in the elongation of very-long-chain-fatty-acid-like family member 6 gene (Elovl6), was found to be associated with gout susceptibility (Padjusted = 0.00595). In the second stage of analysis, we performed fine mapping analysis of 93 tag SNPs in Elovl6 and in the epidermal growth factor gene (EGF) and its flanking regions in 1017 male patients gout and 1897 healthy male controls. We observed a significant association between the T allele of EGF rs2298999 and gout (odds ratio = 0.77, 95% confidence interval = 0.67–0.88, Padjusted = 6.42 × 10−3). These results provide the first evidence for an association between the EGF rs2298999 C/T polymorphism and gout. Our findings should be validated in additional populations. More... »

PAGES

31082

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31082

DOI

http://dx.doi.org/10.1038/srep31082

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010833936

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27506295


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37 schema:description Chromosome 4q25 has been identified as a genomic region associated with gout. However, the associations of gout with the genes in this region have not yet been confirmed. Here, we performed two-stage analysis to determine whether variations in candidate genes in the 4q25 region are associated with gout in a male Chinese Han population. We first evaluated 96 tag single nucleotide polymorphisms (SNPs) in eight inflammatory/immune pathway- or glucose/lipid metabolism-related genes in the 4q25 region in 480 male gout patients and 480 controls. The SNP rs12504538, located in the elongation of very-long-chain-fatty-acid-like family member 6 gene (Elovl6), was found to be associated with gout susceptibility (Padjusted = 0.00595). In the second stage of analysis, we performed fine mapping analysis of 93 tag SNPs in Elovl6 and in the epidermal growth factor gene (EGF) and its flanking regions in 1017 male patients gout and 1897 healthy male controls. We observed a significant association between the T allele of EGF rs2298999 and gout (odds ratio = 0.77, 95% confidence interval = 0.67–0.88, Padjusted = 6.42 × 10−3). These results provide the first evidence for an association between the EGF rs2298999 C/T polymorphism and gout. Our findings should be validated in additional populations.
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45 Han population
46 T allele
47 T polymorphism
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53 candidate genes
54 chromosome 4q25
55 control
56 elongation
57 epidermal growth factor gene
58 evidence
59 factor genes
60 findings
61 fine-mapping analysis
62 first evidence
63 flanking regions
64 genes
65 genomic regions
66 gout
67 gout patients
68 gout susceptibility
69 growth factor gene
70 healthy male controls
71 immune pathways
72 lipid metabolism-related genes
73 male Chinese Han population
74 male controls
75 male gout patients
76 mapping analysis
77 member 6 gene
78 metabolism-related genes
79 nucleotide polymorphisms
80 pathway
81 patients
82 polymorphism
83 population
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85 results
86 second stage
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