Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-30

AUTHORS

Hirotaka Matsuo, Tomoyuki Tsunoda, Keiko Ooyama, Masayuki Sakiyama, Tsuyoshi Sogo, Tappei Takada, Akio Nakashima, Akiyoshi Nakayama, Makoto Kawaguchi, Toshihide Higashino, Kenji Wakai, Hiroshi Ooyama, Ryota Hokari, Hiroshi Suzuki, Kimiyoshi Ichida, Ayano Inui, Shin Fujimori, Nariyoshi Shinomiya

ABSTRACT

To clarify the physiological and pathophysiological roles of intestinal urate excretion via ABCG2 in humans, we genotyped ABCG2 dysfunctional common variants, Q126X (rs72552713) and Q141K (rs2231142), in end-stage renal disease (hemodialysis) and acute gastroenteritis patients, respectively. ABCG2 dysfunction markedly increased serum uric acid (SUA) levels in 106 hemodialysis patients (P = 1.1 × 10−4), which demonstrated the physiological role of ABCG2 for intestinal urate excretion because their urate excretion almost depends on intestinal excretion via ABCG2. Also, ABCG2 dysfunction significantly elevated SUA in 67 acute gastroenteritis patients (P = 6.3 × 10−3) regardless of the degree of dehydration, which demonstrated the pathophysiological role of ABCG2 in acute gastroenteritis. These findings for the first time show ABCG2-mediated intestinal urate excretion in humans, and indicates the physiological and pathophysiological importance of intestinal epithelium as an excretion pathway besides an absorption pathway. Furthermore, increased SUA could be a useful marker not only for dehydration but also epithelial impairment of intestine. More... »

PAGES

31003

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep31003

DOI

http://dx.doi.org/10.1038/srep31003

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004871792

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27571712


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