The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-03

AUTHORS

Tina J. Hieken, Jun Chen, Tanya L. Hoskin, Marina Walther-Antonio, Stephen Johnson, Sheri Ramaker, Jian Xiao, Derek C. Radisky, Keith L. Knutson, Krishna R. Kalari, Janet Z. Yao, Larry M. Baddour, Nicholas Chia, Amy C. Degnim

ABSTRACT

Globally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. The microbiome has been implicated in cancer development and progression at a variety of body sites including stomach, colon, liver, lung and skin. In this study, we assessed breast tissue microbial signatures in intraoperatively obtained samples using 16S rDNA hypervariable tag sequencing. Our results indicate a distinct breast tissue microbiome that is different from the microbiota of breast skin tissue, breast skin swabs and buccal swabs. Furthermore, we identify distinct microbial communities in breast tissues from women with cancer as compared to women with benign breast disease. Malignancy correlated with enrichment in taxa of lower abundance including the genera Fusobacterium, Atopobium, Gluconacetobacter, Hydrogenophaga and Lactobacillus. This work confirms the existence of a distinct breast microbiome and differences between the breast tissue microbiome in benign and malignant disease. These data provide a foundation for future investigation on the role of the breast microbiome in breast carcinogenesis and breast cancer prevention. More... »

PAGES

30751

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep30751

DOI

http://dx.doi.org/10.1038/srep30751

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004326330

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27485780


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34 schema:description Globally breast cancer is the leading cause of cancer death among women. The breast consists of epithelium, stroma and a mucosal immune system that make up a complex microenvironment. Growing awareness of the role of microbes in the microenvironment recently has led to a series of findings important for human health. The microbiome has been implicated in cancer development and progression at a variety of body sites including stomach, colon, liver, lung and skin. In this study, we assessed breast tissue microbial signatures in intraoperatively obtained samples using 16S rDNA hypervariable tag sequencing. Our results indicate a distinct breast tissue microbiome that is different from the microbiota of breast skin tissue, breast skin swabs and buccal swabs. Furthermore, we identify distinct microbial communities in breast tissues from women with cancer as compared to women with benign breast disease. Malignancy correlated with enrichment in taxa of lower abundance including the genera Fusobacterium, Atopobium, Gluconacetobacter, Hydrogenophaga and Lactobacillus. This work confirms the existence of a distinct breast microbiome and differences between the breast tissue microbiome in benign and malignant disease. These data provide a foundation for future investigation on the role of the breast microbiome in breast carcinogenesis and breast cancer prevention.
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41 Benign
42 Fusobacterium
43 Gluconacetobacter
44 Hydrogenophaga
45 Lactobacillus
46 abundance
47 awareness
48 benign breast disease
49 body sites
50 breast
51 breast cancer
52 breast cancer prevention
53 breast carcinogenesis
54 breast disease
55 breast microbiome
56 breast tissue
57 breast tissue microbiome
58 buccal swabs
59 cancer
60 cancer death
61 cancer development
62 cancer prevention
63 carcinogenesis
64 cause
65 colon
66 community
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68 data
69 death
70 development
71 differences
72 disease
73 distinct microbial communities
74 enrichment
75 epithelium
76 existence
77 findings
78 foundation
79 future investigations
80 genus Fusobacterium
81 health
82 human breast tissue
83 human health
84 hypervariable tag sequencing
85 immune system
86 investigation
87 liver
88 low abundance
89 lung
90 malignancy
91 malignant disease
92 microbes
93 microbial communities
94 microbial signatures
95 microbiome
96 microbiota
97 microenvironment
98 mucosal immune system
99 prevention
100 progression
101 results
102 role
103 role of microbes
104 samples
105 sequencing
106 series
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108 signatures
109 sites
110 skin
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