Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11

AUTHORS

Yong Sook Kim, Hye-yun Jeong, Ah Ra Kim, Woong-Hee Kim, Haaglim Cho, JungIn Um, Youngha Seo, Wan Seok Kang, Suk-Won Jin, Min Chul Kim, Yong-Chul Kim, Da-Woon Jung, Darren R. Williams, Youngkeun Ahn

ABSTRACT

The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this microenvironment is a novel therapeutic approach for MI. We found that the natural compound derivative, BIO ((2'Z,3'E)-6-Bromoindirubin-3'-oxime) modulated the cardiac microenvironment to exert a therapeutic effect on MI. Using a series of co-culture studies, BIO induced proliferation in cardiomyocytes and inhibited proliferation in cardiac fibroblasts. BIO produced multiple anti-fibrotic effects in cardiac fibroblasts. In macrophages, BIO inhibited the expression of pro-inflammatory factors. Significantly, BIO modulated the molecular crosstalk between cardiac fibroblasts and differentiating macrophages to induce polarization to the anti-inflammatory M2 phenotype. In the optically transparent zebrafish-based heart failure model, BIO induced cardiomyocyte proliferation and completely recovered survival rate. BIO is a known glycogen synthase kinase-3β inhibitor, but these effects could not be recapitulated using the classical inhibitor, lithium chloride; indicating novel therapeutic effects of BIO. We identified the mechanism of BIO as differential modulation of p27 protein expression and potent induction of anti-inflammatory interleukin-10. In a rat MI model, BIO reduced fibrosis and improved cardiac performance. Histological analysis revealed modulation of the cardiac microenvironment by BIO, with increased presence of anti-inflammatory M2 macrophages. Our results demonstrate that BIO produces unique effects in the cardiac microenvironment to promote recovery post-MI. More... »

PAGES

30726

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep30726

DOI

http://dx.doi.org/10.1038/srep30726

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034711115

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27510556


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Microenvironment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Infarction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oximes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411597.f", 
          "name": [
            "Biomedical Research Institute, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yong Sook", 
        "id": "sg:person.01260121360.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260121360.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411597.f", 
          "name": [
            "Research Laboratory of Cardiovascular Regeneration, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Hye-yun", 
        "id": "sg:person.01265744464.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265744464.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Ah Ra", 
        "id": "sg:person.01150550714.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150550714.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Woong-Hee", 
        "id": "sg:person.01047450172.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047450172.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Haaglim", 
        "id": "sg:person.016366065535.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016366065535.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Um", 
        "givenName": "JungIn", 
        "id": "sg:person.07663014335.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07663014335.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seo", 
        "givenName": "Youngha", 
        "id": "sg:person.010460374735.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010460374735.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411597.f", 
          "name": [
            "Research Laboratory of Cardiovascular Regeneration, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Wan Seok", 
        "id": "sg:person.01102502350.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102502350.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Suk-Won", 
        "id": "sg:person.01245045352.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245045352.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411597.f", 
          "name": [
            "Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Min Chul", 
        "id": "sg:person.0625004567.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625004567.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Yong-Chul", 
        "id": "sg:person.01366712164.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366712164.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Da-Woon", 
        "id": "sg:person.01314014045.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314014045.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gwangju Institute of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.61221.36", 
          "name": [
            "School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Darren R.", 
        "id": "sg:person.01104247162.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104247162.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411597.f", 
          "name": [
            "Research Laboratory of Cardiovascular Regeneration, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea", 
            "Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Youngkeun", 
        "id": "sg:person.015526465242.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526465242.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/eurheartj/ehs269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000919078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0053210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001164129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2003.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001271766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvu059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001635272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-7061(98)00235-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004073051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa030207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007297112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2004.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009287213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.2013.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012537019", 
          "https://doi.org/10.1038/emm.2013.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3510095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014870314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3510095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014870314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2003.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016748712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.160614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017957494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.107.160614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017957494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2004.01.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018927486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2005121355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020912903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2005121355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020912903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2006.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021036522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-1536-5-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023929649", 
          "https://doi.org/10.1186/1755-1536-5-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.104.508093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025557371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/187204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025775319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.000331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026653699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2013.12.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027871398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(00)00435-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028070584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2010.147140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028116968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2014.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028616412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.2121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031445813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768095", 
          "https://doi.org/10.1038/nature01611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768095", 
          "https://doi.org/10.1038/nature01611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-77755-7_33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032242922", 
          "https://doi.org/10.1007/978-3-540-77755-7_33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-77755-7_33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032242922", 
          "https://doi.org/10.1007/978-3-540-77755-7_33"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.303613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034860285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.303613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034860285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.008364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035834427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.008364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035834427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.148635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036629352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.109.148635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036629352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0035144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038356898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2004.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039804868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2014.00614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040649017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.223768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042019368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.223768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042019368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044434502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2013.03.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045284548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdrc.20214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047084787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12915-016-0243-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047839721", 
          "https://doi.org/10.1186/s12915-016-0243-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2008.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049455189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.088526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050455229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc3201.092284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051298440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3904/kjim.2010.25.1.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052333486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3904/kjim.2010.25.1.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052333486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-77755-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053154089", 
          "https://doi.org/10.1007/978-3-540-77755-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-77755-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053154089", 
          "https://doi.org/10.1007/978-3-540-77755-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.307778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053171174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.307778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053171174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb3003368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055226243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np500231g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056233134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3510095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1164680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062458925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/onci.25563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072306479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079000828", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082348811", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1998.275.5.e740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083346776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1998.275.5.e740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083346776"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-11", 
    "datePublishedReg": "2016-11-01", 
    "description": "The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this microenvironment is a novel therapeutic approach for MI. We found that the natural compound derivative, BIO ((2'Z,3'E)-6-Bromoindirubin-3'-oxime) modulated the cardiac microenvironment to exert a therapeutic effect on MI. Using a series of co-culture studies, BIO induced proliferation in cardiomyocytes and inhibited proliferation in cardiac fibroblasts. BIO produced multiple anti-fibrotic effects in cardiac fibroblasts. In macrophages, BIO inhibited the expression of pro-inflammatory factors. Significantly, BIO modulated the molecular crosstalk between cardiac fibroblasts and differentiating macrophages to induce polarization to the anti-inflammatory M2 phenotype. In the optically transparent zebrafish-based heart failure model, BIO induced cardiomyocyte proliferation and completely recovered survival rate. BIO is a known glycogen synthase kinase-3\u03b2 inhibitor, but these effects could not be recapitulated using the classical inhibitor, lithium chloride; indicating novel therapeutic effects of BIO. We identified the mechanism of BIO as differential modulation of p27 protein expression and potent induction of anti-inflammatory interleukin-10. In a rat MI model, BIO reduced fibrosis and improved cardiac performance. Histological analysis revealed modulation of the cardiac microenvironment by BIO, with increased presence of anti-inflammatory M2 macrophages. Our results demonstrate that BIO produces unique effects in the cardiac microenvironment to promote recovery post-MI.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep30726", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7499133", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7498844", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment", 
    "pagination": "30726", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a559bbae8c8fd825f6a63ea0c24a550f99e9f0ae5fbcd1caaebf3dfa01242b7c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27510556"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep30726"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034711115"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep30726", 
      "https://app.dimensions.ai/details/publication/pub.1034711115"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/srep30726"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep30726'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep30726'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep30726'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep30726'


 

This table displays all metadata directly associated to this object as RDF triples.

362 TRIPLES      21 PREDICATES      89 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep30726 schema:about N296ff2f12bcf427f8bcf44019289411d
2 N348b326555cf4755b60d58540519c12a
3 N4dee4affb0664e7d833c2274e2f64d3a
4 N6b952590aa3c4b6fa5c17afc81291d27
5 N706c453e3c33464e99d0209f8c65ea06
6 N9c9fb98cd29c4be69ab9d3d750da38ec
7 Nd1959727420f4b6f98cfa459a4e4c83e
8 Neb4627945af14fcbb3b9feaf259eafa4
9 Nfd4c27fc00f745dd9054f4ca385fa017
10 Nfeae43bd56dd4f5392b9c63beb480e9f
11 anzsrc-for:11
12 anzsrc-for:1102
13 schema:author N1b3ce63253ee49a6a7e89379a2da8ed2
14 schema:citation sg:pub.10.1007/978-3-540-77755-7
15 sg:pub.10.1007/978-3-540-77755-7_33
16 sg:pub.10.1038/emm.2013.135
17 sg:pub.10.1038/nature01611
18 sg:pub.10.1186/1755-1536-5-19
19 sg:pub.10.1186/s12915-016-0243-8
20 https://app.dimensions.ai/details/publication/pub.1079000828
21 https://app.dimensions.ai/details/publication/pub.1082348811
22 https://doi.org/10.1002/bdrc.20214
23 https://doi.org/10.1002/stem.2121
24 https://doi.org/10.1016/j.cardiores.2003.11.039
25 https://doi.org/10.1016/j.cardiores.2004.01.027
26 https://doi.org/10.1016/j.cardiores.2004.08.020
27 https://doi.org/10.1016/j.chembiol.2003.11.010
28 https://doi.org/10.1016/j.chembiol.2006.08.004
29 https://doi.org/10.1016/j.chembiol.2014.08.017
30 https://doi.org/10.1016/j.devcel.2008.12.007
31 https://doi.org/10.1016/j.it.2004.09.015
32 https://doi.org/10.1016/j.jss.2013.03.100
33 https://doi.org/10.1016/j.lfs.2013.12.024
34 https://doi.org/10.1016/s0360-3016(00)00435-1
35 https://doi.org/10.1016/s0895-7061(98)00235-0
36 https://doi.org/10.1021/cb3003368
37 https://doi.org/10.1021/np500231g
38 https://doi.org/10.1042/0264-6021:3510095
39 https://doi.org/10.1042/bj3510095
40 https://doi.org/10.1056/nejmoa030207
41 https://doi.org/10.1093/cvr/cvu059
42 https://doi.org/10.1093/eurheartj/ehs269
43 https://doi.org/10.1126/science.1164680
44 https://doi.org/10.1126/science.1178331
45 https://doi.org/10.1136/ard.2010.147140
46 https://doi.org/10.1152/ajpendo.1998.275.5.e740
47 https://doi.org/10.1155/2013/187204
48 https://doi.org/10.1161/circresaha.107.160614
49 https://doi.org/10.1161/circresaha.110.223768
50 https://doi.org/10.1161/circresaha.115.307778
51 https://doi.org/10.1161/circresaha.116.303613
52 https://doi.org/10.1161/circulationaha.104.508093
53 https://doi.org/10.1161/circulationaha.105.000331
54 https://doi.org/10.1161/circulationaha.113.008364
55 https://doi.org/10.1161/hc3201.092284
56 https://doi.org/10.1161/hypertensionaha.109.148635
57 https://doi.org/10.1242/dev.088526
58 https://doi.org/10.1371/journal.pone.0035144
59 https://doi.org/10.1371/journal.pone.0053210
60 https://doi.org/10.1681/asn.2005121355
61 https://doi.org/10.3389/fimmu.2014.00614
62 https://doi.org/10.3904/kjim.2010.25.1.44
63 https://doi.org/10.4161/onci.25563
64 schema:datePublished 2016-11
65 schema:datePublishedReg 2016-11-01
66 schema:description The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this microenvironment is a novel therapeutic approach for MI. We found that the natural compound derivative, BIO ((2'Z,3'E)-6-Bromoindirubin-3'-oxime) modulated the cardiac microenvironment to exert a therapeutic effect on MI. Using a series of co-culture studies, BIO induced proliferation in cardiomyocytes and inhibited proliferation in cardiac fibroblasts. BIO produced multiple anti-fibrotic effects in cardiac fibroblasts. In macrophages, BIO inhibited the expression of pro-inflammatory factors. Significantly, BIO modulated the molecular crosstalk between cardiac fibroblasts and differentiating macrophages to induce polarization to the anti-inflammatory M2 phenotype. In the optically transparent zebrafish-based heart failure model, BIO induced cardiomyocyte proliferation and completely recovered survival rate. BIO is a known glycogen synthase kinase-3β inhibitor, but these effects could not be recapitulated using the classical inhibitor, lithium chloride; indicating novel therapeutic effects of BIO. We identified the mechanism of BIO as differential modulation of p27 protein expression and potent induction of anti-inflammatory interleukin-10. In a rat MI model, BIO reduced fibrosis and improved cardiac performance. Histological analysis revealed modulation of the cardiac microenvironment by BIO, with increased presence of anti-inflammatory M2 macrophages. Our results demonstrate that BIO produces unique effects in the cardiac microenvironment to promote recovery post-MI.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N318166acd9b949c69b8bf6b9a78fb920
71 N35d85ec1e5404cab969e2c9af42a7398
72 sg:journal.1045337
73 schema:name Natural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment
74 schema:pagination 30726
75 schema:productId N2097e2f74cfb4ecdacf5f481284740b2
76 N25924dfdd881434699fa7a11b02e30ac
77 Na21c9b243c074524b74f3bef6b7d1f7b
78 Nbbe8c86c90ad4696a221122fa00e3bf7
79 Neec074b6b3984f4eb8a617e1cf1c5d0b
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034711115
81 https://doi.org/10.1038/srep30726
82 schema:sdDatePublished 2019-04-10T21:44
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nc970e1e7958c48b18aa94b6317720bbf
85 schema:url http://www.nature.com/articles/srep30726
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N025d10c22c364eea9046d392c33e8397 rdf:first sg:person.010460374735.00
90 rdf:rest Ncbd28a26d5e84706ad62bec11aa2a801
91 N1b3ce63253ee49a6a7e89379a2da8ed2 rdf:first sg:person.01260121360.25
92 rdf:rest Nb38d1fd2540b4eabb5c489a789fab271
93 N2097e2f74cfb4ecdacf5f481284740b2 schema:name nlm_unique_id
94 schema:value 101563288
95 rdf:type schema:PropertyValue
96 N25924dfdd881434699fa7a11b02e30ac schema:name doi
97 schema:value 10.1038/srep30726
98 rdf:type schema:PropertyValue
99 N296ff2f12bcf427f8bcf44019289411d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Myocytes, Cardiac
101 rdf:type schema:DefinedTerm
102 N318166acd9b949c69b8bf6b9a78fb920 schema:volumeNumber 6
103 rdf:type schema:PublicationVolume
104 N348b326555cf4755b60d58540519c12a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Rats
106 rdf:type schema:DefinedTerm
107 N34ba5b39a504454d9ae9a1d32025f2c4 rdf:first sg:person.01047450172.72
108 rdf:rest Nf45c744cbe5e462c90fe8455a347b9ea
109 N35d85ec1e5404cab969e2c9af42a7398 schema:issueNumber 1
110 rdf:type schema:PublicationIssue
111 N4dee4affb0664e7d833c2274e2f64d3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cellular Microenvironment
113 rdf:type schema:DefinedTerm
114 N5ff3a94494af412c92f4ec9faa9949c6 rdf:first sg:person.01245045352.66
115 rdf:rest Nd893081f399f4364b0439f09c1b18ad8
116 N62e23b242b6948f88271cb2bb6b42532 rdf:first sg:person.01150550714.42
117 rdf:rest N34ba5b39a504454d9ae9a1d32025f2c4
118 N6b952590aa3c4b6fa5c17afc81291d27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Fibroblasts
120 rdf:type schema:DefinedTerm
121 N706c453e3c33464e99d0209f8c65ea06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Animals
123 rdf:type schema:DefinedTerm
124 N7d061c8cc6a54575903cbea95be2a80c rdf:first sg:person.01104247162.62
125 rdf:rest Na496bc52baf94e349027ab2e2e3c6ec7
126 N9c9fb98cd29c4be69ab9d3d750da38ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Myocardial Infarction
128 rdf:type schema:DefinedTerm
129 Na21c9b243c074524b74f3bef6b7d1f7b schema:name readcube_id
130 schema:value a559bbae8c8fd825f6a63ea0c24a550f99e9f0ae5fbcd1caaebf3dfa01242b7c
131 rdf:type schema:PropertyValue
132 Na496bc52baf94e349027ab2e2e3c6ec7 rdf:first sg:person.015526465242.75
133 rdf:rest rdf:nil
134 Nb38d1fd2540b4eabb5c489a789fab271 rdf:first sg:person.01265744464.11
135 rdf:rest N62e23b242b6948f88271cb2bb6b42532
136 Nbbe8c86c90ad4696a221122fa00e3bf7 schema:name dimensions_id
137 schema:value pub.1034711115
138 rdf:type schema:PropertyValue
139 Nc22dd0ce94814770b72fbbb42213cc0e rdf:first sg:person.01366712164.11
140 rdf:rest Ned6fdce1ed3d4747b6907abc8c3d95b6
141 Nc5eadb3d472e4ea1bf865d7dcad48763 rdf:first sg:person.07663014335.54
142 rdf:rest N025d10c22c364eea9046d392c33e8397
143 Nc970e1e7958c48b18aa94b6317720bbf schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Ncbd28a26d5e84706ad62bec11aa2a801 rdf:first sg:person.01102502350.29
146 rdf:rest N5ff3a94494af412c92f4ec9faa9949c6
147 Nd1959727420f4b6f98cfa459a4e4c83e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Macrophages
149 rdf:type schema:DefinedTerm
150 Nd893081f399f4364b0439f09c1b18ad8 rdf:first sg:person.0625004567.02
151 rdf:rest Nc22dd0ce94814770b72fbbb42213cc0e
152 Neb4627945af14fcbb3b9feaf259eafa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Zebrafish
154 rdf:type schema:DefinedTerm
155 Ned6fdce1ed3d4747b6907abc8c3d95b6 rdf:first sg:person.01314014045.38
156 rdf:rest N7d061c8cc6a54575903cbea95be2a80c
157 Neec074b6b3984f4eb8a617e1cf1c5d0b schema:name pubmed_id
158 schema:value 27510556
159 rdf:type schema:PropertyValue
160 Nf45c744cbe5e462c90fe8455a347b9ea rdf:first sg:person.016366065535.00
161 rdf:rest Nc5eadb3d472e4ea1bf865d7dcad48763
162 Nfd4c27fc00f745dd9054f4ca385fa017 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Oximes
164 rdf:type schema:DefinedTerm
165 Nfeae43bd56dd4f5392b9c63beb480e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Cell Proliferation
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
172 schema:name Cardiorespiratory Medicine and Haematology
173 rdf:type schema:DefinedTerm
174 sg:grant.7498844 http://pending.schema.org/fundedItem sg:pub.10.1038/srep30726
175 rdf:type schema:MonetaryGrant
176 sg:grant.7499133 http://pending.schema.org/fundedItem sg:pub.10.1038/srep30726
177 rdf:type schema:MonetaryGrant
178 sg:journal.1045337 schema:issn 2045-2322
179 schema:name Scientific Reports
180 rdf:type schema:Periodical
181 sg:person.010460374735.00 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
182 schema:familyName Seo
183 schema:givenName Youngha
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010460374735.00
185 rdf:type schema:Person
186 sg:person.01047450172.72 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
187 schema:familyName Kim
188 schema:givenName Woong-Hee
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047450172.72
190 rdf:type schema:Person
191 sg:person.01102502350.29 schema:affiliation https://www.grid.ac/institutes/grid.411597.f
192 schema:familyName Kang
193 schema:givenName Wan Seok
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102502350.29
195 rdf:type schema:Person
196 sg:person.01104247162.62 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
197 schema:familyName Williams
198 schema:givenName Darren R.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104247162.62
200 rdf:type schema:Person
201 sg:person.01150550714.42 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
202 schema:familyName Kim
203 schema:givenName Ah Ra
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150550714.42
205 rdf:type schema:Person
206 sg:person.01245045352.66 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
207 schema:familyName Jin
208 schema:givenName Suk-Won
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245045352.66
210 rdf:type schema:Person
211 sg:person.01260121360.25 schema:affiliation https://www.grid.ac/institutes/grid.411597.f
212 schema:familyName Kim
213 schema:givenName Yong Sook
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260121360.25
215 rdf:type schema:Person
216 sg:person.01265744464.11 schema:affiliation https://www.grid.ac/institutes/grid.411597.f
217 schema:familyName Jeong
218 schema:givenName Hye-yun
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265744464.11
220 rdf:type schema:Person
221 sg:person.01314014045.38 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
222 schema:familyName Jung
223 schema:givenName Da-Woon
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314014045.38
225 rdf:type schema:Person
226 sg:person.01366712164.11 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
227 schema:familyName Kim
228 schema:givenName Yong-Chul
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366712164.11
230 rdf:type schema:Person
231 sg:person.015526465242.75 schema:affiliation https://www.grid.ac/institutes/grid.411597.f
232 schema:familyName Ahn
233 schema:givenName Youngkeun
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526465242.75
235 rdf:type schema:Person
236 sg:person.016366065535.00 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
237 schema:familyName Cho
238 schema:givenName Haaglim
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016366065535.00
240 rdf:type schema:Person
241 sg:person.0625004567.02 schema:affiliation https://www.grid.ac/institutes/grid.411597.f
242 schema:familyName Kim
243 schema:givenName Min Chul
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625004567.02
245 rdf:type schema:Person
246 sg:person.07663014335.54 schema:affiliation https://www.grid.ac/institutes/grid.61221.36
247 schema:familyName Um
248 schema:givenName JungIn
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07663014335.54
250 rdf:type schema:Person
251 sg:pub.10.1007/978-3-540-77755-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053154089
252 https://doi.org/10.1007/978-3-540-77755-7
253 rdf:type schema:CreativeWork
254 sg:pub.10.1007/978-3-540-77755-7_33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032242922
255 https://doi.org/10.1007/978-3-540-77755-7_33
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/emm.2013.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012537019
258 https://doi.org/10.1038/emm.2013.135
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nature01611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031768095
261 https://doi.org/10.1038/nature01611
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/1755-1536-5-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023929649
264 https://doi.org/10.1186/1755-1536-5-19
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/s12915-016-0243-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047839721
267 https://doi.org/10.1186/s12915-016-0243-8
268 rdf:type schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1079000828 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1082348811 schema:CreativeWork
271 https://doi.org/10.1002/bdrc.20214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047084787
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/stem.2121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031445813
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.cardiores.2003.11.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016748712
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.cardiores.2004.01.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018927486
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.cardiores.2004.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039804868
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.chembiol.2003.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001271766
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.chembiol.2006.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021036522
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.chembiol.2014.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028616412
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.devcel.2008.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049455189
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.it.2004.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009287213
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.jss.2013.03.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045284548
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.lfs.2013.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027871398
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0360-3016(00)00435-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028070584
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s0895-7061(98)00235-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004073051
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1021/cb3003368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055226243
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1021/np500231g schema:sameAs https://app.dimensions.ai/details/publication/pub.1056233134
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1042/0264-6021:3510095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715019
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1042/bj3510095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014870314
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1056/nejmoa030207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007297112
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/cvr/cvu059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001635272
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/eurheartj/ehs269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000919078
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1126/science.1164680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458925
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1126/science.1178331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044434502
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1136/ard.2010.147140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028116968
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1152/ajpendo.1998.275.5.e740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083346776
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1155/2013/187204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025775319
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1161/circresaha.107.160614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017957494
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1161/circresaha.110.223768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042019368
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1161/circresaha.115.307778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053171174
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1161/circresaha.116.303613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034860285
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1161/circulationaha.104.508093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025557371
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1161/circulationaha.105.000331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026653699
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1161/circulationaha.113.008364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035834427
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1161/hc3201.092284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051298440
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1161/hypertensionaha.109.148635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036629352
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1242/dev.088526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050455229
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1371/journal.pone.0035144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038356898
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1371/journal.pone.0053210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001164129
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1681/asn.2005121355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020912903
348 rdf:type schema:CreativeWork
349 https://doi.org/10.3389/fimmu.2014.00614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040649017
350 rdf:type schema:CreativeWork
351 https://doi.org/10.3904/kjim.2010.25.1.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052333486
352 rdf:type schema:CreativeWork
353 https://doi.org/10.4161/onci.25563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306479
354 rdf:type schema:CreativeWork
355 https://www.grid.ac/institutes/grid.411597.f schema:alternateName Chonnam National University Hospital
356 schema:name Biomedical Research Institute, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea
357 Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea
358 Research Laboratory of Cardiovascular Regeneration, Chonnam National University Hospital, Gwangju, 61469, Republic of Korea
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.61221.36 schema:alternateName Gwangju Institute of Science and Technology
361 schema:name School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-Dong, Buk-Gu, Gwangju 61005, Republic of Korea
362 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...