A possible link between loading, inflammation and healing: Immune cell populations during tendon healing in the rat View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Parmis Blomgran, Robert Blomgran, Jan Ernerudh, Per Aspenberg

ABSTRACT

Loading influences tendon healing, and so does inflammation. We hypothesized that the two are connected. 48 rats underwent Achilles tendon transection. Half of the rats received Botox injections into calf muscles to reduce mechanical loading. Cells from the regenerating tissue were analyzed by flow cytometry. In the loaded group, the regenerating tissue contained 83% leukocytes (CD45(+)) day 1, and 23% day 10. The M1/M2 macrophage ratio (CCR7/CD206) peaked at day 3, while T helper (CD3(+)CD4(+)) and Treg cells (CD25(+) Foxp3(+)) increased over time. With Botox, markers associated with down-regulation of inflammation were more common day 5 (CD163, CD206, CD25, Foxp3), and M1 or M2 macrophages and Treg cells were virtually absent day 10, while still present with full loading. The primary variable, CCR7/CD206 ratio day 5, was higher with full loading (p = 0.001) and the Treg cell fraction was lower (p < 0.001). Free cage activity loading is known to increase size and strength of the tendon in this model compared to Botox. Loading now appeared to delay the switch to an M2 type of inflammation with more Treg cells. It seems a prolonged M1 phase due to loading might make the tendon regenerate bigger. More... »

PAGES

29824

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep29824

DOI

http://dx.doi.org/10.1038/srep29824

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040809813

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27405922


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