Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Ha-Rim Seo, Hyo Eun Jeong, Hyung Joon Joo, Seung-Cheol Choi, Chi-Yeon Park, Jong-Ho Kim, Ji-Hyun Choi, Long-Hui Cui, Soon Jun Hong, Seok Chung, Do-Sun Lim

ABSTRACT

The human body contains different endothelial cell types and differences in their angiogenic potential are poorly understood. We compared the functional angiogenic ability of human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells (HUVECs) using a three-dimensional (3D) microfluidic cell culture system. HAECs and HUVECs exhibited similar cellular characteristics in a 2D culture system; however, in the 3D microfluidic angiogenesis system, HAECs exhibited stronger angiogenic potential than HUVECs. Interestingly, the expression level of fibroblast growth factor (FGF)2 and FGF5 under vascular endothelial growth factor (VEGF)-A stimulation was significantly higher in HAECs than in HUVECs. Moreover, small interfering RNA-mediated knockdown of FGF2 and FGF5 more significantly attenuated vascular sprouting induced from HAECs than HUVECs. Our results suggest that HAECs have greater angiogenic potential through FGF2 and FGF5 upregulation and could be a compatible endothelial cell type to achieve robust angiogenesis. More... »

PAGES

28832

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep28832

DOI

http://dx.doi.org/10.1038/srep28832

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030343898

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27357248


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Culture Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblast Growth Factor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblast Growth Factor 5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human Umbilical Vein Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microfluidics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Array Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor A", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seo", 
        "givenName": "Ha-Rim", 
        "id": "sg:person.01146031502.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146031502.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "School of Mechanical Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Hyo Eun", 
        "id": "sg:person.01306106471.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306106471.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joo", 
        "givenName": "Hyung Joon", 
        "id": "sg:person.0601063514.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601063514.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Seung-Cheol", 
        "id": "sg:person.01114000373.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114000373.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Chi-Yeon", 
        "id": "sg:person.01231155067.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231155067.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jong-Ho", 
        "id": "sg:person.01023754545.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023754545.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Ji-Hyun", 
        "id": "sg:person.01277270267.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277270267.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Long-Hui", 
        "id": "sg:person.01175060005.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175060005.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Soon Jun", 
        "id": "sg:person.0644263236.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644263236.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "School of Mechanical Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Seok", 
        "id": "sg:person.0603364343.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603364343.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lim", 
        "givenName": "Do-Sun", 
        "id": "sg:person.01250032611.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250032611.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.09.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000916740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvt096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001366108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.084301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001661470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2012.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003108140", 
          "https://doi.org/10.1038/nprot.2012.051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0596-534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004115692", 
          "https://doi.org/10.1038/nm0596-534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbiosc.2014.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004814431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.08.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005789475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009360999", 
          "https://doi.org/10.1038/nature05571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/386671a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010094120", 
          "https://doi.org/10.1038/386671a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2012.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010578776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0070165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011520972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.0.0070165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011520972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013330715", 
          "https://doi.org/10.1038/74651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013330715", 
          "https://doi.org/10.1038/74651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci35070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018414257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00467.2010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019869391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.16.2040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020745969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90276-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021453631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.200901727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023106361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.200901727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023106361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b807585a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024951719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.004184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025027519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m704917200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026670327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11434-011-4717-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026947694", 
          "https://doi.org/10.1007/s11434-011-4717-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00585.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027597468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.20.8813-8822.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029621896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0017660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029663235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpj.2009.03.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030097085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-08-3057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030833198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-bioeng-071811-150052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033465187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033530938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035817137", 
          "https://doi.org/10.1038/nmeth.2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036852941", 
          "https://doi.org/10.1038/nature04479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036852941", 
          "https://doi.org/10.1038/nature04479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036852941", 
          "https://doi.org/10.1038/nature04479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0603-702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037571015", 
          "https://doi.org/10.1038/nm0603-702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0603-702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037571015", 
          "https://doi.org/10.1038/nm0603-702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci35298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039864681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m601252200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040907147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.6.2260-2268.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043248827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043642630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10456-013-9341-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044084133", 
          "https://doi.org/10.1007/s10456-013-9341-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-008-9147-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045310512", 
          "https://doi.org/10.1007/s00232-008-9147-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00232-008-9147-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045310512", 
          "https://doi.org/10.1007/s00232-008-9147-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.05-1223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045867912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201108062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047822012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-9-98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048913692", 
          "https://doi.org/10.1186/1479-5876-9-98"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/019262339902700113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049803090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/019262339902700113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049803090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050798018", 
          "https://doi.org/10.1038/nature10144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac202170e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055002092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac202170e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055002092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.2006.0333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059313630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2009.0689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5322.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062557236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7809630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12968/jowc.2009.18.12.45609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064825678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/org.4.4.7414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072306862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074956439", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-09", 
    "datePublishedReg": "2016-09-01", 
    "description": "The human body contains different endothelial cell types and differences in their angiogenic potential are poorly understood. We compared the functional angiogenic ability of human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells (HUVECs) using a three-dimensional (3D) microfluidic cell culture system. HAECs and HUVECs exhibited similar cellular characteristics in a 2D culture system; however, in the 3D microfluidic angiogenesis system, HAECs exhibited stronger angiogenic potential than HUVECs. Interestingly, the expression level of fibroblast growth factor (FGF)2 and FGF5 under vascular endothelial growth factor (VEGF)-A stimulation was significantly higher in HAECs than in HUVECs. Moreover, small interfering RNA-mediated knockdown of FGF2 and FGF5 more significantly attenuated vascular sprouting induced from HAECs than HUVECs. Our results suggest that HAECs have greater angiogenic potential through FGF2 and FGF5 upregulation and could be a compatible endothelial cell type to achieve robust angiogenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep28832", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7502439", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system", 
    "pagination": "28832", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "908d374b39dd890c7ad79e64c18db0a6958fff67f2d10e04096db5425b6825f5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27357248"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep28832"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030343898"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep28832", 
      "https://app.dimensions.ai/details/publication/pub.1030343898"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/160630/srep28832/full/srep28832.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep28832'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep28832'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep28832'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep28832'


 

This table displays all metadata directly associated to this object as RDF triples.

371 TRIPLES      21 PREDICATES      96 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep28832 schema:about N0028ca6bd6114b2393327d560fc34c3c
2 N104468bd32c7446d99a01ac8f2bac657
3 N12168eb6793749328def110e7516cab1
4 N126e9bacd90943b996eb449daac80104
5 N12d16ceb987d485b8fa4ed5fcf328e90
6 N1b75e4de06b14c40ad821ee3043df7b2
7 N3756250e2f4d4fa181c86b18a9bdaa7f
8 N46410ab6d207437893fa6312c551c96e
9 N4b1b6e09bd0e447082fcc198ad151231
10 N4fd09bce3b4d435bbebbc96fa0c3aa75
11 N6ffa6310439e494e8a75109a9dbe118d
12 N70ff0ed254544785bd3f1cc6c9d10d0f
13 Nad5f631acca3471c90d83e9428529217
14 Nbd35e0ea3428407fb6e1d7b22602c992
15 Nc473e0a92a2f4ffc8671a25b1f6fa161
16 Nf4b8e5ee2ea94ec18dfe94d00ac1df6c
17 Nfb685618ab984a008e4571eb7e632be7
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N03111b27bff74e8490569e3744be194e
21 schema:citation sg:pub.10.1007/s00232-008-9147-z
22 sg:pub.10.1007/s10456-013-9341-1
23 sg:pub.10.1007/s11434-011-4717-3
24 sg:pub.10.1038/386671a0
25 sg:pub.10.1038/74651
26 sg:pub.10.1038/nature04479
27 sg:pub.10.1038/nature05571
28 sg:pub.10.1038/nature10144
29 sg:pub.10.1038/nm0596-534
30 sg:pub.10.1038/nm0603-702
31 sg:pub.10.1038/nmeth.2089
32 sg:pub.10.1038/nprot.2012.051
33 sg:pub.10.1186/1479-5876-9-98
34 https://app.dimensions.ai/details/publication/pub.1074956439
35 https://doi.org/10.1002/adma.200901727
36 https://doi.org/10.1016/0092-8674(94)90276-3
37 https://doi.org/10.1016/j.biomaterials.2009.09.057
38 https://doi.org/10.1016/j.biomaterials.2012.11.005
39 https://doi.org/10.1016/j.bpj.2009.03.046
40 https://doi.org/10.1016/j.cell.2011.08.039
41 https://doi.org/10.1016/j.jbiosc.2014.02.006
42 https://doi.org/10.1016/j.ydbio.2005.05.023
43 https://doi.org/10.1021/ac202170e
44 https://doi.org/10.1039/b807585a
45 https://doi.org/10.1074/jbc.m601252200
46 https://doi.org/10.1074/jbc.m704917200
47 https://doi.org/10.1083/jcb.201108062
48 https://doi.org/10.1089/ten.2006.0333
49 https://doi.org/10.1089/ten.tea.2009.0689
50 https://doi.org/10.1093/cvr/cvt096
51 https://doi.org/10.1093/hmg/ddr270
52 https://doi.org/10.1101/gad.11.16.2040
53 https://doi.org/10.1126/science.277.5322.55
54 https://doi.org/10.1126/science.7809630
55 https://doi.org/10.1128/mcb.20.6.2260-2268.2000
56 https://doi.org/10.1128/mcb.24.20.8813-8822.2004
57 https://doi.org/10.1146/annurev-bioeng-071811-150052
58 https://doi.org/10.1152/ajpcell.00585.2006
59 https://doi.org/10.1152/ajpheart.00467.2010
60 https://doi.org/10.1167/iovs.05-1223
61 https://doi.org/10.1172/jci35070
62 https://doi.org/10.1172/jci35298
63 https://doi.org/10.1177/019262339902700113
64 https://doi.org/10.1182/blood-2004-08-3057
65 https://doi.org/10.1242/dev.004184
66 https://doi.org/10.1242/jcs.084301
67 https://doi.org/10.12968/jowc.2009.18.12.45609
68 https://doi.org/10.1371/journal.pone.0017660
69 https://doi.org/10.1677/erc.0.0070165
70 https://doi.org/10.4161/org.4.4.7414
71 schema:datePublished 2016-09
72 schema:datePublishedReg 2016-09-01
73 schema:description The human body contains different endothelial cell types and differences in their angiogenic potential are poorly understood. We compared the functional angiogenic ability of human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells (HUVECs) using a three-dimensional (3D) microfluidic cell culture system. HAECs and HUVECs exhibited similar cellular characteristics in a 2D culture system; however, in the 3D microfluidic angiogenesis system, HAECs exhibited stronger angiogenic potential than HUVECs. Interestingly, the expression level of fibroblast growth factor (FGF)2 and FGF5 under vascular endothelial growth factor (VEGF)-A stimulation was significantly higher in HAECs than in HUVECs. Moreover, small interfering RNA-mediated knockdown of FGF2 and FGF5 more significantly attenuated vascular sprouting induced from HAECs than HUVECs. Our results suggest that HAECs have greater angiogenic potential through FGF2 and FGF5 upregulation and could be a compatible endothelial cell type to achieve robust angiogenesis.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N339ebeba16da43679f37a960c712aa2d
78 Nca68293571a84ba09a691bc6f6960fae
79 sg:journal.1045337
80 schema:name Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system
81 schema:pagination 28832
82 schema:productId N4ef7376992b140db814c2df488d91851
83 Nb8700ec687a649fca9906bc003a1de8d
84 Nc26bce80a483457dbecbfb1dc790e26e
85 Nc5829a38dfa04d3595087f201b5ff299
86 Ne1a1128656194f7b94b8249e1c9b7b45
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343898
88 https://doi.org/10.1038/srep28832
89 schema:sdDatePublished 2019-04-10T16:49
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Nca1d4192d723445c85abcbc0e7cfdb13
92 schema:url http://www.nature.com/srep/2016/160630/srep28832/full/srep28832.html
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0028ca6bd6114b2393327d560fc34c3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Endothelial Cells
98 rdf:type schema:DefinedTerm
99 N03111b27bff74e8490569e3744be194e rdf:first sg:person.01146031502.11
100 rdf:rest N722315152a5b42639ab4e81ab6fd1796
101 N104468bd32c7446d99a01ac8f2bac657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Fibroblast Growth Factor 5
103 rdf:type schema:DefinedTerm
104 N12168eb6793749328def110e7516cab1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Microfluidics
106 rdf:type schema:DefinedTerm
107 N126e9bacd90943b996eb449daac80104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Vascular Endothelial Growth Factor A
109 rdf:type schema:DefinedTerm
110 N12d16ceb987d485b8fa4ed5fcf328e90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Up-Regulation
112 rdf:type schema:DefinedTerm
113 N1b75e4de06b14c40ad821ee3043df7b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name RNA, Small Interfering
115 rdf:type schema:DefinedTerm
116 N1f802bc9bd5d4fe2966b8c2af200566e rdf:first sg:person.01114000373.93
117 rdf:rest Nb8cb0a466a084254a9f888193962d69b
118 N2ef4a1e8a6724c55ae850dd007ff8025 rdf:first sg:person.01175060005.54
119 rdf:rest N992f11e88802497a8fc46f1e3bb553b7
120 N31c137b94c26455bb2d48234edf7e54b rdf:first sg:person.01250032611.23
121 rdf:rest rdf:nil
122 N339ebeba16da43679f37a960c712aa2d schema:volumeNumber 6
123 rdf:type schema:PublicationVolume
124 N3756250e2f4d4fa181c86b18a9bdaa7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N46410ab6d207437893fa6312c551c96e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Collagen Type I
129 rdf:type schema:DefinedTerm
130 N4b1b6e09bd0e447082fcc198ad151231 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Fibroblast Growth Factor 2
132 rdf:type schema:DefinedTerm
133 N4ef7376992b140db814c2df488d91851 schema:name doi
134 schema:value 10.1038/srep28832
135 rdf:type schema:PropertyValue
136 N4fd09bce3b4d435bbebbc96fa0c3aa75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cytokines
138 rdf:type schema:DefinedTerm
139 N5fb75117e71449f992a7c3d3896a9561 rdf:first sg:person.01023754545.64
140 rdf:rest Na7e702b4292d4285aab1c56beec9b775
141 N6ffa6310439e494e8a75109a9dbe118d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neovascularization, Physiologic
143 rdf:type schema:DefinedTerm
144 N70ff0ed254544785bd3f1cc6c9d10d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Protein Array Analysis
146 rdf:type schema:DefinedTerm
147 N722315152a5b42639ab4e81ab6fd1796 rdf:first sg:person.01306106471.83
148 rdf:rest Ncd4fa766c58f4abaa2520ddfe7dbf69a
149 N8586b9a8d9d344ad876c0cee316b5058 rdf:first sg:person.0603364343.13
150 rdf:rest N31c137b94c26455bb2d48234edf7e54b
151 N992f11e88802497a8fc46f1e3bb553b7 rdf:first sg:person.0644263236.90
152 rdf:rest N8586b9a8d9d344ad876c0cee316b5058
153 Na7e702b4292d4285aab1c56beec9b775 rdf:first sg:person.01277270267.04
154 rdf:rest N2ef4a1e8a6724c55ae850dd007ff8025
155 Nad5f631acca3471c90d83e9428529217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cell Culture Techniques
157 rdf:type schema:DefinedTerm
158 Nb8700ec687a649fca9906bc003a1de8d schema:name pubmed_id
159 schema:value 27357248
160 rdf:type schema:PropertyValue
161 Nb8cb0a466a084254a9f888193962d69b rdf:first sg:person.01231155067.03
162 rdf:rest N5fb75117e71449f992a7c3d3896a9561
163 Nbd35e0ea3428407fb6e1d7b22602c992 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Aorta
165 rdf:type schema:DefinedTerm
166 Nc26bce80a483457dbecbfb1dc790e26e schema:name dimensions_id
167 schema:value pub.1030343898
168 rdf:type schema:PropertyValue
169 Nc473e0a92a2f4ffc8671a25b1f6fa161 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Cells, Cultured
171 rdf:type schema:DefinedTerm
172 Nc5829a38dfa04d3595087f201b5ff299 schema:name readcube_id
173 schema:value 908d374b39dd890c7ad79e64c18db0a6958fff67f2d10e04096db5425b6825f5
174 rdf:type schema:PropertyValue
175 Nca1d4192d723445c85abcbc0e7cfdb13 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nca68293571a84ba09a691bc6f6960fae schema:issueNumber 1
178 rdf:type schema:PublicationIssue
179 Ncd4fa766c58f4abaa2520ddfe7dbf69a rdf:first sg:person.0601063514.31
180 rdf:rest N1f802bc9bd5d4fe2966b8c2af200566e
181 Ne1a1128656194f7b94b8249e1c9b7b45 schema:name nlm_unique_id
182 schema:value 101563288
183 rdf:type schema:PropertyValue
184 Nf4b8e5ee2ea94ec18dfe94d00ac1df6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Human Umbilical Vein Endothelial Cells
186 rdf:type schema:DefinedTerm
187 Nfb685618ab984a008e4571eb7e632be7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name RNA Interference
189 rdf:type schema:DefinedTerm
190 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biological Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
194 schema:name Biochemistry and Cell Biology
195 rdf:type schema:DefinedTerm
196 sg:grant.7502439 http://pending.schema.org/fundedItem sg:pub.10.1038/srep28832
197 rdf:type schema:MonetaryGrant
198 sg:journal.1045337 schema:issn 2045-2322
199 schema:name Scientific Reports
200 rdf:type schema:Periodical
201 sg:person.01023754545.64 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
202 schema:familyName Kim
203 schema:givenName Jong-Ho
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023754545.64
205 rdf:type schema:Person
206 sg:person.01114000373.93 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
207 schema:familyName Choi
208 schema:givenName Seung-Cheol
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114000373.93
210 rdf:type schema:Person
211 sg:person.01146031502.11 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
212 schema:familyName Seo
213 schema:givenName Ha-Rim
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146031502.11
215 rdf:type schema:Person
216 sg:person.01175060005.54 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
217 schema:familyName Cui
218 schema:givenName Long-Hui
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175060005.54
220 rdf:type schema:Person
221 sg:person.01231155067.03 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
222 schema:familyName Park
223 schema:givenName Chi-Yeon
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231155067.03
225 rdf:type schema:Person
226 sg:person.01250032611.23 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
227 schema:familyName Lim
228 schema:givenName Do-Sun
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250032611.23
230 rdf:type schema:Person
231 sg:person.01277270267.04 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
232 schema:familyName Choi
233 schema:givenName Ji-Hyun
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277270267.04
235 rdf:type schema:Person
236 sg:person.01306106471.83 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
237 schema:familyName Jeong
238 schema:givenName Hyo Eun
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306106471.83
240 rdf:type schema:Person
241 sg:person.0601063514.31 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
242 schema:familyName Joo
243 schema:givenName Hyung Joon
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601063514.31
245 rdf:type schema:Person
246 sg:person.0603364343.13 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
247 schema:familyName Chung
248 schema:givenName Seok
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603364343.13
250 rdf:type schema:Person
251 sg:person.0644263236.90 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
252 schema:familyName Hong
253 schema:givenName Soon Jun
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644263236.90
255 rdf:type schema:Person
256 sg:pub.10.1007/s00232-008-9147-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1045310512
257 https://doi.org/10.1007/s00232-008-9147-z
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s10456-013-9341-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044084133
260 https://doi.org/10.1007/s10456-013-9341-1
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s11434-011-4717-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026947694
263 https://doi.org/10.1007/s11434-011-4717-3
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/386671a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010094120
266 https://doi.org/10.1038/386671a0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/74651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013330715
269 https://doi.org/10.1038/74651
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nature04479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036852941
272 https://doi.org/10.1038/nature04479
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nature05571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009360999
275 https://doi.org/10.1038/nature05571
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nature10144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050798018
278 https://doi.org/10.1038/nature10144
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nm0596-534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004115692
281 https://doi.org/10.1038/nm0596-534
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nm0603-702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037571015
284 https://doi.org/10.1038/nm0603-702
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
287 https://doi.org/10.1038/nmeth.2089
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nprot.2012.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003108140
290 https://doi.org/10.1038/nprot.2012.051
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/1479-5876-9-98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048913692
293 https://doi.org/10.1186/1479-5876-9-98
294 rdf:type schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1074956439 schema:CreativeWork
296 https://doi.org/10.1002/adma.200901727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023106361
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/0092-8674(94)90276-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021453631
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.biomaterials.2009.09.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000916740
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.biomaterials.2012.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010578776
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.bpj.2009.03.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030097085
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cell.2011.08.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005789475
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.jbiosc.2014.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004814431
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.ydbio.2005.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043642630
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1021/ac202170e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055002092
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1039/b807585a schema:sameAs https://app.dimensions.ai/details/publication/pub.1024951719
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1074/jbc.m601252200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040907147
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1074/jbc.m704917200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026670327
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1083/jcb.201108062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047822012
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1089/ten.2006.0333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059313630
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1089/ten.tea.2009.0689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315493
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1093/cvr/cvt096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001366108
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1093/hmg/ddr270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033530938
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1101/gad.11.16.2040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020745969
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1126/science.277.5322.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557236
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1126/science.7809630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649803
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1128/mcb.20.6.2260-2268.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043248827
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1128/mcb.24.20.8813-8822.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029621896
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1146/annurev-bioeng-071811-150052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033465187
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1152/ajpcell.00585.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027597468
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1152/ajpheart.00467.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019869391
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1167/iovs.05-1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045867912
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1172/jci35070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018414257
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1172/jci35298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039864681
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1177/019262339902700113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049803090
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1182/blood-2004-08-3057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030833198
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1242/dev.004184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025027519
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1242/jcs.084301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001661470
359 rdf:type schema:CreativeWork
360 https://doi.org/10.12968/jowc.2009.18.12.45609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064825678
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pone.0017660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029663235
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1677/erc.0.0070165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011520972
365 rdf:type schema:CreativeWork
366 https://doi.org/10.4161/org.4.4.7414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306862
367 rdf:type schema:CreativeWork
368 https://www.grid.ac/institutes/grid.222754.4 schema:alternateName Korea University
369 schema:name Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
370 School of Mechanical Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
371 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...