A practical online tool to estimate antiretroviral coverage for HIV infected and susceptible populations needed to reduce local HIV epidemics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Antoine Chaillon, Martin Hoenigl, Sanjay R Mehta, Nadir Weibel, Susan J Little, Davey M Smith

ABSTRACT

It remains unclear what proportions of HIV-infected and uninfected people should receive effective antiretroviral therapy (ART) to control local HIV epidemics. We developed a flexible model to evaluate the impact of treatment as prevention (TasP) and pre-exposure prophylaxis (PrEP) on HIV incidence in local communities. We evaluated this tool for determining what TasP and PrEP targets are needed to substantially reduce the HIV epidemic in San Diego, which is predominately comprised of men who have sex with men. By increasing the proportion of HIV-infected individuals on ART from 30% to 50%, 686 new infections would be prevented over five years in San Diego. By providing PrEP to 30% of MSM to the age group that account for 90% of local HIV incident cases (21-52 years), we could prevent 433 infections over five years. When combining these initiatives, a PrEP coverage rate of 40% and TasP coverage rate of 34% would be expected to decrease the number of new infections by over half in one year. This online tool is designed to help local public health planners and policy makers to estimate program outcomes and costs that may lead to better control of their local HIV epidemics. More... »

PAGES

28707

References to SciGraph publications

  • 2015-07-07. How to beat HIV in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep28707

    DOI

    http://dx.doi.org/10.1038/srep28707

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048205379

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27337983


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    RDF/XML is a standard XML format for linked data.

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    304 schema:name Department of Computer Science and Engineering, University of California San Diego, California, United States.
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    308 schema:name Division of Infectious Diseases, University of California, San Diego, La Jolla, California, United States of America.
    309 Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America.
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