Systems pathway engineering of Corynebacterium crenatum for improved L-arginine production View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Zaiwei Man, Meijuan Xu, Zhiming Rao, Jing Guo, Taowei Yang, Xian Zhang, Zhenghong Xu

ABSTRACT

L-arginine is an important amino acid in food and pharmaceutical industries. Until now, the main production method of L-arginine in China is the highly polluting keratin acid hydrolysis. The industrial level L-arginine production by microbial fermentation has become an important task. In previous work, we obtained a new L-arginine producing Corynebacterium crenatum (subspecies of Corynebacterium glutamicum) through screening and mutation breeding. In this work, we performed systems pathway engineering of C. crenatum for improved L-arginine production, involving amplification of L-arginine biosynthetic pathway flux by removal of feedback inhibition and overexpression of arginine operon; optimization of NADPH supply by modulation of metabolic flux distribution between glycolysis and pentose phosphate pathway; increasing glucose consumption by strengthening the preexisting glucose transporter and exploitation of new glucose uptake system; channeling excess carbon flux from glycolysis into tricarboxylic acid cycle to alleviate the glucose overflow metabolism; redistribution of carbon flux at α-ketoglutarate metabolic node to channel more flux into L-arginine biosynthetic pathway; minimization of carbon and cofactor loss by attenuation of byproducts formation. The final strain could produce 87.3 g L(-1) L-arginine with yield up to 0.431 g L-arginine g(-1) glucose in fed-batch fermentation. More... »

PAGES

28629

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep28629

DOI

http://dx.doi.org/10.1038/srep28629

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021578568

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27338253


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