Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-27

AUTHORS

Jun Chen, Nicholas Chia, Krishna R. Kalari, Janet Z. Yao, Martina Novotna, M. Mateo Paz Soldan, David H. Luckey, Eric V. Marietta, Patricio R. Jeraldo, Xianfeng Chen, Brian G. Weinshenker, Moses Rodriguez, Orhun H. Kantarci, Heidi Nelson, Joseph A. Murray, Ashutosh K. Mangalam

ABSTRACT

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3–V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS. More... »

PAGES

28484

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep28484

DOI

http://dx.doi.org/10.1038/srep28484

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022902680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27346372


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24 schema:description Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3–V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
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31 Blautia
32 Further studies
33 Haemophilus
34 MS patients
35 Mycoplana
36 Parabacteroides
37 Prevotella genus
38 Psuedomonas
39 RNA genes
40 V3-V5 region
41 abundance
42 abundance of Parabacteroides
43 age
44 analysis
45 community profiles
46 control
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48 disease
49 distinct gut microbiota
50 distinct microbial community profiles
51 dysbiosis
52 environmental factors
53 etiology
54 etiopathogenesis
55 etiopathogenesis of MS
56 exact nature
57 factors
58 fecal microbiome analysis
59 fecal microbiota
60 gastrointestinal microbiota
61 gender-matched healthy controls
62 genes
63 genus
64 group
65 gut microbial populations
66 gut microbiota
67 healthy controls
68 hypervariable tag sequencing
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70 immune-mediated diseases
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73 microbial community profiles
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75 microbial populations
76 microbiome analysis
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78 multiple sclerosis
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80 nature
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