Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Xiwen Hu, Jiangchao Li, Qianqian Zhang, Lingyun Zheng, Guang Wang, Xiaohan Zhang, Jingli Zhang, Quliang Gu, Yuxiang Ye, Sun-Wei Guo, Xuesong Yang, Lijing Wang

ABSTRACT

Maternal PI3K p110δ has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110δ (p110δ(D910A/D910A)), we show that fetuses carried by p110δ(D910A/D910A) females were growth retarded and showed increased mortality in utero mainly during placentation. The placentas in p110δ(D910A/D910A) females were anomalously anemic, exhibited thinner spongiotrophoblast layer and looser labyrinth zone, which indicate defective placental vasculogenesis. In addition, p110δ was detected in primary trophoblast giant cells (P-TGC) at early placentation. Maternal PI3K p110δ inactivation affected normal TGCs generation and expansion, impeded the branching of chorioallantoic placenta but enhanced the expression of matrix metalloproteinases (MMP-2, MMP-12). Poor vasculature support for the developing fetoplacental unit resulted in fetal death or gross growth retardation. These data, taken together, provide the first in vivo evidence that p110δ may play an important role in placental vascularization through manipulating trophoblast giant cell. More... »

PAGES

28201

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep28201

DOI

http://dx.doi.org/10.1038/srep28201

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001350455

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27306493


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetal Growth Retardation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Litter Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 12", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placenta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Placentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trophoblasts", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Xiwen", 
        "id": "sg:person.0732036301.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732036301.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jiangchao", 
        "id": "sg:person.01250331460.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250331460.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Qianqian", 
        "id": "sg:person.01023515560.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023515560.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Lingyun", 
        "id": "sg:person.01003361044.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003361044.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jinan University", 
          "id": "https://www.grid.ac/institutes/grid.258164.c", 
          "name": [
            "Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology &Embryology, Medical College, Jinan University, Guangzhou 510632, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Guang", 
        "id": "sg:person.0653077460.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653077460.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiaohan", 
        "id": "sg:person.01114553727.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114553727.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jingli", 
        "id": "sg:person.01162667127.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162667127.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gu", 
        "givenName": "Quliang", 
        "id": "sg:person.01242534447.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242534447.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ye", 
        "givenName": "Yuxiang", 
        "id": "sg:person.0756116626.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756116626.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.8547.e", 
          "name": [
            "Shanghai OB/GYN Hospital, Fudan University, Shanghai 200011, China.", 
            "Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Fudan University, Shanghai, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Sun-Wei", 
        "id": "sg:person.01063263636.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063263636.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jinan University", 
          "id": "https://www.grid.ac/institutes/grid.258164.c", 
          "name": [
            "Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology &Embryology, Medical College, Jinan University, Guangzhou 510632, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Xuesong", 
        "id": "sg:person.01151667660.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151667660.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangdong Pharmaceutical University", 
          "id": "https://www.grid.ac/institutes/grid.411847.f", 
          "name": [
            "Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Lijing", 
        "id": "sg:person.01254172560.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254172560.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1053/plac.2002.0900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001696901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2002.0900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001696901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0074-7696(08)62220-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001789009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-0348-0364-9_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002059243", 
          "https://doi.org/10.1007/978-3-0348-0364-9_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2014.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002135428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.1080340403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002712205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2011.10.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002859912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003087217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep13237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003108987", 
          "https://doi.org/10.1038/srep13237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2007.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003369412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(00)89008-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003395471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci41211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003621279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci41211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003621279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.theriogenology.2012.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004449243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35080570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005186256", 
          "https://doi.org/10.1038/35080570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35080570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005186256", 
          "https://doi.org/10.1038/35080570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.114.304365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006013816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.114.304365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006013816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-11-315705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008320685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.8.6022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009254279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2003.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010083842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.70.1.535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010861050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81769-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011032363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0303-7207(01)00703-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013647043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2004.00223.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013830759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.9.4330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014170867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5332.1669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015740606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci8316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016587347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1997.8685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018795350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2013.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019150381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiol.00001.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019689967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/endo:21:2:123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022126307", 
          "https://doi.org/10.1385/endo:21:2:123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0143-4004(96)90051-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022267524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2004.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022675954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmor.1051980308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022837249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.31.19236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022943903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2009.04.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024734831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10875-014-0012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974178", 
          "https://doi.org/10.1007/s10875-014-0012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10875-014-0012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974178", 
          "https://doi.org/10.1007/s10875-014-0012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10875-014-0012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974178", 
          "https://doi.org/10.1007/s10875-014-0012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10875-014-0012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974178", 
          "https://doi.org/10.1007/s10875-014-0012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10875-014-0012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974178", 
          "https://doi.org/10.1007/s10875-014-0012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/prg-200059836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026852948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2010.100182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029495169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/6.10.951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032112884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032802342", 
          "https://doi.org/10.1038/nature02991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032802342", 
          "https://doi.org/10.1038/nature02991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci17189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032940593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2002.0887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033284260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2002.0887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033284260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-0436.2005.00044.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033571305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-0436.2005.00044.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033571305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1993.1205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035046846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1073560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036050706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.020099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036909674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0398-271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038634083", 
          "https://doi.org/10.1038/ng0398-271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.873401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041013375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.11.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041669544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9378(70)90123-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042690242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042862164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.10291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043463413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2005.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043968051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.24.8709-8720.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044506537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep13371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045077365", 
          "https://doi.org/10.1038/srep13371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/77076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045863813", 
          "https://doi.org/10.1038/77076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/77076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045863813", 
          "https://doi.org/10.1038/77076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.9.5082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045882118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod63.5.1390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045918892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod63.5.1390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045918892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0143-4004(80)80012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047748670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2013.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048035601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2008-1333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050686000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.1977.tb12676.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050802412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.1977.tb12676.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050802412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2004.03.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051773479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.domaniend.2004.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053285871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.388777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053398621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.853700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060407372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.282.5396.2072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062563523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7809630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7985020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062650868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2013-1082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.16.7.0878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064332408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1387/ijdb.082768dh", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067191034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-09-0548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067717288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-10-0505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067717426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-13-0663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067717835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2527/1995.7361839x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070879182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2527/jas1986.62147x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070901423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/2249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075228742", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076948749", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078151972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1301533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078880914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ansci/62.2.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079806402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082479135", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082508404", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-09", 
    "datePublishedReg": "2016-09-01", 
    "description": "Maternal PI3K p110\u03b4 has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110\u03b4 (p110\u03b4(D910A/D910A)), we show that fetuses carried by p110\u03b4(D910A/D910A) females were growth retarded and showed increased mortality in utero mainly during placentation. The placentas in p110\u03b4(D910A/D910A) females were anomalously anemic, exhibited thinner spongiotrophoblast layer and looser labyrinth zone, which indicate defective placental vasculogenesis. In addition, p110\u03b4 was detected in primary trophoblast giant cells (P-TGC) at early placentation. Maternal PI3K p110\u03b4 inactivation affected normal TGCs generation and expansion, impeded the branching of chorioallantoic placenta but enhanced the expression of matrix metalloproteinases (MMP-2, MMP-12). Poor vasculature support for the developing fetoplacental unit resulted in fetal death or gross growth retardation. These data, taken together, provide the first in vivo evidence that p110\u03b4 may play an important role in placental vascularization through manipulating trophoblast giant cell.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep28201", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7009500", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7194715", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Phosphoinositide 3-Kinase (PI3K) Subunit p110\u03b4 Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse", 
    "pagination": "28201", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "066eeff74d63eaca8272f903a1964071006d9d835b2021f95dafe65b9b000da4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27306493"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep28201"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001350455"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep28201", 
      "https://app.dimensions.ai/details/publication/pub.1001350455"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000549.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/160616/srep28201/full/srep28201.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep28201'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep28201'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep28201'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep28201'


 

This table displays all metadata directly associated to this object as RDF triples.

482 TRIPLES      21 PREDICATES      130 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep28201 schema:about N104b035d3ab4492aae9f13ed93277e12
2 N2a92d8c776d545008ccb4bad03f4c650
3 N500badbc5400414ba62160f908e969c5
4 N6744a1620bb34a408b37e1670e372279
5 N6d4cfb5cf9da4e1d852ea334f227502e
6 N713fb706cbaf4d5a8eebc1b97656ae64
7 N7574fb9322d7426e92fa17f1de6660c6
8 N9ce4e1df2c04497a9ea94c6e504f996c
9 Naa5a5f99626646a28e00322ac2a05fde
10 Nb6d6455692584e30a8d4d7158e6d82b1
11 Nc2a36fbd63ab450a9e096a117b7844d5
12 Nca3596131291428882fc9d09726e043a
13 Nced4379a77c2477684434c1647ac50b0
14 Nd185df93a94d413b89df37d40e24b99b
15 Ne3265ebbbe214dd69f0a54e9a018ad3b
16 Ne67854b3faf3473cb3a216862e0d7431
17 Nf286a80c88624c428c6a839c76b41388
18 Nf409863328ae4e56bc1507ef946c6669
19 anzsrc-for:11
20 anzsrc-for:1114
21 schema:author Nfffc26ee0f164176a35789bd2cc36343
22 schema:citation sg:pub.10.1007/978-3-0348-0364-9_7
23 sg:pub.10.1007/s10875-014-0012-9
24 sg:pub.10.1038/35080570
25 sg:pub.10.1038/77076
26 sg:pub.10.1038/nature02991
27 sg:pub.10.1038/ng0398-271
28 sg:pub.10.1038/srep13237
29 sg:pub.10.1038/srep13371
30 sg:pub.10.1385/endo:21:2:123
31 https://app.dimensions.ai/details/publication/pub.1075228742
32 https://app.dimensions.ai/details/publication/pub.1076948749
33 https://app.dimensions.ai/details/publication/pub.1078151972
34 https://app.dimensions.ai/details/publication/pub.1082479135
35 https://app.dimensions.ai/details/publication/pub.1082508404
36 https://doi.org/10.1002/dvdy.10291
37 https://doi.org/10.1002/jmor.1051980308
38 https://doi.org/10.1002/mrd.1080340403
39 https://doi.org/10.1006/dbio.1993.1205
40 https://doi.org/10.1006/dbio.1997.8685
41 https://doi.org/10.1016/0002-9378(70)90123-7
42 https://doi.org/10.1016/j.celrep.2015.11.050
43 https://doi.org/10.1016/j.domaniend.2004.06.006
44 https://doi.org/10.1016/j.febslet.2009.04.028
45 https://doi.org/10.1016/j.placenta.2003.10.010
46 https://doi.org/10.1016/j.placenta.2004.04.011
47 https://doi.org/10.1016/j.placenta.2005.01.015
48 https://doi.org/10.1016/j.placenta.2011.10.009
49 https://doi.org/10.1016/j.placenta.2013.04.003
50 https://doi.org/10.1016/j.placenta.2014.04.011
51 https://doi.org/10.1016/j.theriogenology.2012.09.013
52 https://doi.org/10.1016/j.ydbio.2004.03.029
53 https://doi.org/10.1016/j.ydbio.2005.05.010
54 https://doi.org/10.1016/j.ydbio.2007.01.009
55 https://doi.org/10.1016/j.ydbio.2013.07.017
56 https://doi.org/10.1016/s0074-7696(08)62220-2
57 https://doi.org/10.1016/s0092-8674(00)81769-9
58 https://doi.org/10.1016/s0143-4004(80)80012-9
59 https://doi.org/10.1016/s0143-4004(96)90051-x
60 https://doi.org/10.1016/s0168-9525(00)89008-3
61 https://doi.org/10.1016/s0303-7207(01)00703-1
62 https://doi.org/10.1053/plac.2002.0887
63 https://doi.org/10.1053/plac.2002.0900
64 https://doi.org/10.1073/pnas.94.9.4330
65 https://doi.org/10.1073/pnas.95.9.5082
66 https://doi.org/10.1074/jbc.272.31.19236
67 https://doi.org/10.1074/jbc.275.8.6022
68 https://doi.org/10.1074/jbc.m112.388777
69 https://doi.org/10.1081/prg-200059836
70 https://doi.org/10.1093/ansci/62.2.47
71 https://doi.org/10.1093/emboj/cdg057
72 https://doi.org/10.1093/molehr/6.10.951
73 https://doi.org/10.1095/biolreprod63.5.1390
74 https://doi.org/10.1101/gad.853700
75 https://doi.org/10.1101/gad.873401
76 https://doi.org/10.1111/j.1432-0436.2005.00044.x
77 https://doi.org/10.1111/j.1471-0528.1977.tb12676.x
78 https://doi.org/10.1111/j.1471-0528.2004.00223.x
79 https://doi.org/10.1126/science.1073560
80 https://doi.org/10.1126/science.277.5332.1669
81 https://doi.org/10.1126/science.282.5396.2072
82 https://doi.org/10.1126/science.7809630
83 https://doi.org/10.1126/science.7985020
84 https://doi.org/10.1128/mcb.22.24.8709-8720.2002
85 https://doi.org/10.1146/annurev.biochem.70.1.535
86 https://doi.org/10.1152/physiol.00001.2005
87 https://doi.org/10.1161/atvbaha.114.304365
88 https://doi.org/10.1172/jci17189
89 https://doi.org/10.1172/jci41211
90 https://doi.org/10.1172/jci8316
91 https://doi.org/10.1182/blood-2010-11-315705
92 https://doi.org/10.1210/en.2008-1333
93 https://doi.org/10.1210/me.2013-1082
94 https://doi.org/10.1210/mend.16.7.0878
95 https://doi.org/10.1242/dev.020099
96 https://doi.org/10.1387/ijdb.082768dh
97 https://doi.org/10.1530/rep-09-0548
98 https://doi.org/10.1530/rep-10-0505
99 https://doi.org/10.1530/rep-13-0663
100 https://doi.org/10.2353/ajpath.2010.100182
101 https://doi.org/10.2527/1995.7361839x
102 https://doi.org/10.2527/jas1986.62147x
103 https://doi.org/10.2741/2249
104 https://doi.org/10.4049/jimmunol.1301533
105 schema:datePublished 2016-09
106 schema:datePublishedReg 2016-09-01
107 schema:description Maternal PI3K p110δ has been implicated in smaller litter sizes in mice, but its underlying mechanism remains unclear. The placenta is an indispensable chimeric organ that supports mammalian embryonic development. Using a mouse model of genetic inactivation of PI3K p110δ (p110δ(D910A/D910A)), we show that fetuses carried by p110δ(D910A/D910A) females were growth retarded and showed increased mortality in utero mainly during placentation. The placentas in p110δ(D910A/D910A) females were anomalously anemic, exhibited thinner spongiotrophoblast layer and looser labyrinth zone, which indicate defective placental vasculogenesis. In addition, p110δ was detected in primary trophoblast giant cells (P-TGC) at early placentation. Maternal PI3K p110δ inactivation affected normal TGCs generation and expansion, impeded the branching of chorioallantoic placenta but enhanced the expression of matrix metalloproteinases (MMP-2, MMP-12). Poor vasculature support for the developing fetoplacental unit resulted in fetal death or gross growth retardation. These data, taken together, provide the first in vivo evidence that p110δ may play an important role in placental vascularization through manipulating trophoblast giant cell.
108 schema:genre research_article
109 schema:inLanguage en
110 schema:isAccessibleForFree true
111 schema:isPartOf N3b38b022beea432a9c1b1eaf37a18afa
112 Nf0e33f2ff3a64dd480526344af187b3b
113 sg:journal.1045337
114 schema:name Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse
115 schema:pagination 28201
116 schema:productId N314867d73724439785299f14e47754ef
117 N362b01ddd539441a88719cf0ef39779f
118 N3ff272060c974959b140611b217d885c
119 N501110a125d24fa1ba8f77e35c2218bf
120 N6e17b42af63045e794993c150679f471
121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001350455
122 https://doi.org/10.1038/srep28201
123 schema:sdDatePublished 2019-04-10T14:16
124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
125 schema:sdPublisher Nb383532bd40443be8274ff18f9e1a917
126 schema:url http://www.nature.com/srep/2016/160616/srep28201/full/srep28201.html
127 sgo:license sg:explorer/license/
128 sgo:sdDataset articles
129 rdf:type schema:ScholarlyArticle
130 N0de25c57a8214a33912415e09a39bb95 rdf:first sg:person.01250331460.95
131 rdf:rest N32f684cf1d6b4aa3a42bd124b8f9cb56
132 N104b035d3ab4492aae9f13ed93277e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Phosphatidylinositol 3-Kinases
134 rdf:type schema:DefinedTerm
135 N22d75cd742224958b2946a20ec7fe0dc rdf:first sg:person.01063263636.49
136 rdf:rest N9341644bed1d46e28062a29573d71ec5
137 N2a92d8c776d545008ccb4bad03f4c650 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Matrix Metalloproteinase 12
139 rdf:type schema:DefinedTerm
140 N314867d73724439785299f14e47754ef schema:name dimensions_id
141 schema:value pub.1001350455
142 rdf:type schema:PropertyValue
143 N32f684cf1d6b4aa3a42bd124b8f9cb56 rdf:first sg:person.01023515560.04
144 rdf:rest Ne7ac233696384d139832409b44512fc6
145 N362b01ddd539441a88719cf0ef39779f schema:name doi
146 schema:value 10.1038/srep28201
147 rdf:type schema:PropertyValue
148 N3b38b022beea432a9c1b1eaf37a18afa schema:volumeNumber 6
149 rdf:type schema:PublicationVolume
150 N3ff272060c974959b140611b217d885c schema:name pubmed_id
151 schema:value 27306493
152 rdf:type schema:PropertyValue
153 N500badbc5400414ba62160f908e969c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cell Differentiation
155 rdf:type schema:DefinedTerm
156 N501110a125d24fa1ba8f77e35c2218bf schema:name readcube_id
157 schema:value 066eeff74d63eaca8272f903a1964071006d9d835b2021f95dafe65b9b000da4
158 rdf:type schema:PropertyValue
159 N536eca0d24ab4aa8af6aec6bf9374ce5 rdf:first sg:person.0653077460.08
160 rdf:rest N72a7f8dd388e4c62852dadbec2072c32
161 N60323ef5fa8e4e16ae163f1ad6c6ef0e rdf:first sg:person.0756116626.51
162 rdf:rest N22d75cd742224958b2946a20ec7fe0dc
163 N6744a1620bb34a408b37e1670e372279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Placenta
165 rdf:type schema:DefinedTerm
166 N68d2728201804902863862ad31fabe02 rdf:first sg:person.01242534447.44
167 rdf:rest N60323ef5fa8e4e16ae163f1ad6c6ef0e
168 N6d4cfb5cf9da4e1d852ea334f227502e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Disease Models, Animal
170 rdf:type schema:DefinedTerm
171 N6e17b42af63045e794993c150679f471 schema:name nlm_unique_id
172 schema:value 101563288
173 rdf:type schema:PropertyValue
174 N713fb706cbaf4d5a8eebc1b97656ae64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Placentation
176 rdf:type schema:DefinedTerm
177 N72a7f8dd388e4c62852dadbec2072c32 rdf:first sg:person.01114553727.43
178 rdf:rest Nc8ed11932aa247f0b0d3c26bff882722
179 N7574fb9322d7426e92fa17f1de6660c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Animals
181 rdf:type schema:DefinedTerm
182 N9341644bed1d46e28062a29573d71ec5 rdf:first sg:person.01151667660.79
183 rdf:rest N9d685f804fad4da8bc4ac1aaf09298aa
184 N9ce4e1df2c04497a9ea94c6e504f996c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Neovascularization, Physiologic
186 rdf:type schema:DefinedTerm
187 N9d685f804fad4da8bc4ac1aaf09298aa rdf:first sg:person.01254172560.34
188 rdf:rest rdf:nil
189 Naa5a5f99626646a28e00322ac2a05fde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Trophoblasts
191 rdf:type schema:DefinedTerm
192 Nb383532bd40443be8274ff18f9e1a917 schema:name Springer Nature - SN SciGraph project
193 rdf:type schema:Organization
194 Nb6d6455692584e30a8d4d7158e6d82b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Fetal Growth Retardation
196 rdf:type schema:DefinedTerm
197 Nc2a36fbd63ab450a9e096a117b7844d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Male
199 rdf:type schema:DefinedTerm
200 Nc8ed11932aa247f0b0d3c26bff882722 rdf:first sg:person.01162667127.79
201 rdf:rest N68d2728201804902863862ad31fabe02
202 Nca3596131291428882fc9d09726e043a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Mice
204 rdf:type schema:DefinedTerm
205 Nced4379a77c2477684434c1647ac50b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Matrix Metalloproteinase 2
207 rdf:type schema:DefinedTerm
208 Nd185df93a94d413b89df37d40e24b99b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Mice, Inbred C57BL
210 rdf:type schema:DefinedTerm
211 Ne3265ebbbe214dd69f0a54e9a018ad3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Female
213 rdf:type schema:DefinedTerm
214 Ne67854b3faf3473cb3a216862e0d7431 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Pregnancy
216 rdf:type schema:DefinedTerm
217 Ne7ac233696384d139832409b44512fc6 rdf:first sg:person.01003361044.88
218 rdf:rest N536eca0d24ab4aa8af6aec6bf9374ce5
219 Nf0e33f2ff3a64dd480526344af187b3b schema:issueNumber 1
220 rdf:type schema:PublicationIssue
221 Nf286a80c88624c428c6a839c76b41388 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Mice, Transgenic
223 rdf:type schema:DefinedTerm
224 Nf409863328ae4e56bc1507ef946c6669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
225 schema:name Litter Size
226 rdf:type schema:DefinedTerm
227 Nfffc26ee0f164176a35789bd2cc36343 rdf:first sg:person.0732036301.72
228 rdf:rest N0de25c57a8214a33912415e09a39bb95
229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
230 schema:name Medical and Health Sciences
231 rdf:type schema:DefinedTerm
232 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
233 schema:name Paediatrics and Reproductive Medicine
234 rdf:type schema:DefinedTerm
235 sg:grant.7009500 http://pending.schema.org/fundedItem sg:pub.10.1038/srep28201
236 rdf:type schema:MonetaryGrant
237 sg:grant.7194715 http://pending.schema.org/fundedItem sg:pub.10.1038/srep28201
238 rdf:type schema:MonetaryGrant
239 sg:journal.1045337 schema:issn 2045-2322
240 schema:name Scientific Reports
241 rdf:type schema:Periodical
242 sg:person.01003361044.88 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
243 schema:familyName Zheng
244 schema:givenName Lingyun
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003361044.88
246 rdf:type schema:Person
247 sg:person.01023515560.04 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
248 schema:familyName Zhang
249 schema:givenName Qianqian
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023515560.04
251 rdf:type schema:Person
252 sg:person.01063263636.49 schema:affiliation https://www.grid.ac/institutes/grid.8547.e
253 schema:familyName Guo
254 schema:givenName Sun-Wei
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063263636.49
256 rdf:type schema:Person
257 sg:person.01114553727.43 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
258 schema:familyName Zhang
259 schema:givenName Xiaohan
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114553727.43
261 rdf:type schema:Person
262 sg:person.01151667660.79 schema:affiliation https://www.grid.ac/institutes/grid.258164.c
263 schema:familyName Yang
264 schema:givenName Xuesong
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151667660.79
266 rdf:type schema:Person
267 sg:person.01162667127.79 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
268 schema:familyName Zhang
269 schema:givenName Jingli
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162667127.79
271 rdf:type schema:Person
272 sg:person.01242534447.44 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
273 schema:familyName Gu
274 schema:givenName Quliang
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242534447.44
276 rdf:type schema:Person
277 sg:person.01250331460.95 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
278 schema:familyName Li
279 schema:givenName Jiangchao
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250331460.95
281 rdf:type schema:Person
282 sg:person.01254172560.34 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
283 schema:familyName Wang
284 schema:givenName Lijing
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254172560.34
286 rdf:type schema:Person
287 sg:person.0653077460.08 schema:affiliation https://www.grid.ac/institutes/grid.258164.c
288 schema:familyName Wang
289 schema:givenName Guang
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653077460.08
291 rdf:type schema:Person
292 sg:person.0732036301.72 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
293 schema:familyName Hu
294 schema:givenName Xiwen
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732036301.72
296 rdf:type schema:Person
297 sg:person.0756116626.51 schema:affiliation https://www.grid.ac/institutes/grid.411847.f
298 schema:familyName Ye
299 schema:givenName Yuxiang
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756116626.51
301 rdf:type schema:Person
302 sg:pub.10.1007/978-3-0348-0364-9_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002059243
303 https://doi.org/10.1007/978-3-0348-0364-9_7
304 rdf:type schema:CreativeWork
305 sg:pub.10.1007/s10875-014-0012-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025974178
306 https://doi.org/10.1007/s10875-014-0012-9
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/35080570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005186256
309 https://doi.org/10.1038/35080570
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/77076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045863813
312 https://doi.org/10.1038/77076
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/nature02991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032802342
315 https://doi.org/10.1038/nature02991
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/ng0398-271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038634083
318 https://doi.org/10.1038/ng0398-271
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/srep13237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003108987
321 https://doi.org/10.1038/srep13237
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/srep13371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045077365
324 https://doi.org/10.1038/srep13371
325 rdf:type schema:CreativeWork
326 sg:pub.10.1385/endo:21:2:123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022126307
327 https://doi.org/10.1385/endo:21:2:123
328 rdf:type schema:CreativeWork
329 https://app.dimensions.ai/details/publication/pub.1075228742 schema:CreativeWork
330 https://app.dimensions.ai/details/publication/pub.1076948749 schema:CreativeWork
331 https://app.dimensions.ai/details/publication/pub.1078151972 schema:CreativeWork
332 https://app.dimensions.ai/details/publication/pub.1082479135 schema:CreativeWork
333 https://app.dimensions.ai/details/publication/pub.1082508404 schema:CreativeWork
334 https://doi.org/10.1002/dvdy.10291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043463413
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1002/jmor.1051980308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022837249
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1002/mrd.1080340403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002712205
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1006/dbio.1993.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035046846
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1006/dbio.1997.8685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018795350
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/0002-9378(70)90123-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042690242
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/j.celrep.2015.11.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041669544
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/j.domaniend.2004.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053285871
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/j.febslet.2009.04.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024734831
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/j.placenta.2003.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010083842
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1016/j.placenta.2004.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022675954
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1016/j.placenta.2005.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043968051
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1016/j.placenta.2011.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002859912
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1016/j.placenta.2013.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019150381
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1016/j.placenta.2014.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002135428
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/j.theriogenology.2012.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004449243
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/j.ydbio.2004.03.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051773479
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/j.ydbio.2005.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003087217
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/j.ydbio.2007.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003369412
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/j.ydbio.2013.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048035601
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1016/s0074-7696(08)62220-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001789009
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1016/s0092-8674(00)81769-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011032363
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1016/s0143-4004(80)80012-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047748670
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1016/s0143-4004(96)90051-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022267524
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1016/s0168-9525(00)89008-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003395471
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1016/s0303-7207(01)00703-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013647043
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1053/plac.2002.0887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033284260
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1053/plac.2002.0900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001696901
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1073/pnas.94.9.4330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014170867
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1073/pnas.95.9.5082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045882118
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1074/jbc.272.31.19236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022943903
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1074/jbc.275.8.6022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009254279
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1074/jbc.m112.388777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053398621
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1081/prg-200059836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026852948
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1093/ansci/62.2.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079806402
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1093/emboj/cdg057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042862164
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1093/molehr/6.10.951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032112884
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1095/biolreprod63.5.1390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045918892
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1101/gad.853700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407372
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1101/gad.873401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041013375
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1111/j.1432-0436.2005.00044.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033571305
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1111/j.1471-0528.1977.tb12676.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050802412
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1111/j.1471-0528.2004.00223.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013830759
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1126/science.1073560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036050706
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1126/science.277.5332.1669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015740606
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1126/science.282.5396.2072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563523
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1126/science.7809630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649803
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1126/science.7985020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650868
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1128/mcb.22.24.8709-8720.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044506537
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1146/annurev.biochem.70.1.535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010861050
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1152/physiol.00001.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019689967
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1161/atvbaha.114.304365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006013816
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1172/jci17189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032940593
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1172/jci41211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003621279
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1172/jci8316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016587347
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1182/blood-2010-11-315705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008320685
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1210/en.2008-1333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050686000
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1210/me.2013-1082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328960
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1210/mend.16.7.0878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332408
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1242/dev.020099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036909674
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1387/ijdb.082768dh schema:sameAs https://app.dimensions.ai/details/publication/pub.1067191034
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1530/rep-09-0548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717288
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1530/rep-10-0505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717426
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1530/rep-13-0663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717835
461 rdf:type schema:CreativeWork
462 https://doi.org/10.2353/ajpath.2010.100182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029495169
463 rdf:type schema:CreativeWork
464 https://doi.org/10.2527/1995.7361839x schema:sameAs https://app.dimensions.ai/details/publication/pub.1070879182
465 rdf:type schema:CreativeWork
466 https://doi.org/10.2527/jas1986.62147x schema:sameAs https://app.dimensions.ai/details/publication/pub.1070901423
467 rdf:type schema:CreativeWork
468 https://doi.org/10.2741/2249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914568
469 rdf:type schema:CreativeWork
470 https://doi.org/10.4049/jimmunol.1301533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078880914
471 rdf:type schema:CreativeWork
472 https://www.grid.ac/institutes/grid.258164.c schema:alternateName Jinan University
473 schema:name Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology &Embryology, Medical College, Jinan University, Guangzhou 510632, China.
474 rdf:type schema:Organization
475 https://www.grid.ac/institutes/grid.411847.f schema:alternateName Guangdong Pharmaceutical University
476 schema:name School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China.
477 Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, China.
478 rdf:type schema:Organization
479 https://www.grid.ac/institutes/grid.8547.e schema:alternateName Fudan University
480 schema:name Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Fudan University, Shanghai, China.
481 Shanghai OB/GYN Hospital, Fudan University, Shanghai 200011, China.
482 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...