Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Benxia Hu, Xin Li, Yongxia Huo, Yafen Yu, Qiuping Zhang, Guijun Chen, Yaping Zhang, Nigel W. Fraser, Dongdong Wu, Jumin Zhou

ABSTRACT

Pathogen invasion triggers a number of cellular responses and alters the host transcriptome. Here we report that the type of changes to cellular transcriptome is related to the type of cellular functions affected by lytic infection of Herpes Simplex Virus type I in Human primary fibroblasts. Specifically, genes involved in stress responses and nuclear transport exhibited mostly changes in alternative polyadenylation (APA), cell cycle genes showed mostly alternative splicing (AS) changes, while genes in neurogenesis, rarely underwent these changes. Transcriptome wide, the infection resulted in 1,032 cases of AS, 161 incidences of APA, 1,827 events of isoform changes, and up regulation of 596 genes and down regulations of 61 genes compared to uninfected cells. Thus, these findings provided important and specific links between cellular responses to HSV-1 infection and the type of alterations to the host transcriptome, highlighting important roles of RNA processing in virus-host interactions. More... »

PAGES

28075

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep28075

    DOI

    http://dx.doi.org/10.1038/srep28075

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042469590

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27354008


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