Ontology type: schema:ScholarlyArticle Open Access: True
2016-09
AUTHORSBenxia Hu, Xin Li, Yongxia Huo, Yafen Yu, Qiuping Zhang, Guijun Chen, Yaping Zhang, Nigel W. Fraser, Dongdong Wu, Jumin Zhou
ABSTRACTPathogen invasion triggers a number of cellular responses and alters the host transcriptome. Here we report that the type of changes to cellular transcriptome is related to the type of cellular functions affected by lytic infection of Herpes Simplex Virus type I in Human primary fibroblasts. Specifically, genes involved in stress responses and nuclear transport exhibited mostly changes in alternative polyadenylation (APA), cell cycle genes showed mostly alternative splicing (AS) changes, while genes in neurogenesis, rarely underwent these changes. Transcriptome wide, the infection resulted in 1,032 cases of AS, 161 incidences of APA, 1,827 events of isoform changes, and up regulation of 596 genes and down regulations of 61 genes compared to uninfected cells. Thus, these findings provided important and specific links between cellular responses to HSV-1 infection and the type of alterations to the host transcriptome, highlighting important roles of RNA processing in virus-host interactions. More... »
PAGES28075
http://scigraph.springernature.com/pub.10.1038/srep28075
DOIhttp://dx.doi.org/10.1038/srep28075
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/27354008
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep28075'
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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep28075'
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This table displays all metadata directly associated to this object as RDF triples.
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