Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Cuiling Qi, Bin Li, Yang Yang, Yongxia Yang, Jialin Li, Qin Zhou, Yinxin Wen, Cuiling Zeng, Lingyun Zheng, Qianqian Zhang, Jiangchao Li, Xiaodong He, Jia Zhou, Chunkui Shao, Lijing Wang

ABSTRACT

Drug repurposing of non-cancer drugs represents an attractive approach to develop new cancer therapy. Using the TRAMP transgenic mouse model, glipizide, a widely used drug for type 2 diabetes mellitus, has been identified to suppress prostate cancer (PC) growth and metastasis. Angiogenesis is intimately associated with various human cancer developments. Intriguingly, glipizide significantly reduces microvessel density in PC tumor tissues, while not inhibiting prostate cancer cell proliferation from the MTT assay and flow cytometry investigation. Moreover, glipizide inhibits the tubular structure formation of human umbilical vein endothelial cells by regulating the HMGIY/Angiopoietin-1 signaling pathway. Taken together, these results demonstrate that glipizide has the potential to be repurposed as an effective therapeutic for the treatment of PC by targeting tumor-induced angiogenesis. More... »

PAGES

27819

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep27819

DOI

http://dx.doi.org/10.1038/srep27819

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002922471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27292155


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