Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Takanori Ochi, Yongjia Feng, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, Daniel H Teitelbaum, Nobuhiko Kamada

ABSTRACT

Intestinal resident macrophages (Mϕs) regulate gastrointestinal homeostasis via production of an anti-inflammatory cytokine interleukin (IL)-10. Although a constant replenishment by circulating monocytes is required to maintain the pool of resident Mϕs in the colonic mucosa, the homeostatic regulation of Mϕ in the small intestine (SI) remains unclear. Here, we demonstrate that direct stimulation by dietary amino acids regulates the homeostasis of intestinal Mϕs in the SI. Mice that received total parenteral nutrition (TPN), which deprives the animals of enteral nutrients, displayed a significant decrease of IL-10-producing Mϕs in the SI, whereas the IL-10-producing CD4(+) T cells remained intact. Likewise, enteral nutrient deprivation selectively affected the monocyte-derived F4/80(+) Mϕ population, but not non-monocytic precursor-derived CD103(+) dendritic cells. Notably, in contrast to colonic Mϕs, the replenishment of SI Mϕs and their IL-10 production were not regulated by the gut microbiota. Rather, SI Mϕs were directly regulated by dietary amino acids. Collectively, our study highlights the diet-dependent, microbiota-independent regulation of IL-10-producing resident Mϕs in the SI. More... »

PAGES

27634

References to SciGraph publications

  • 2010-03. The regulation of IL-10 production by immune cells in NATURE REVIEWS IMMUNOLOGY
  • 2014-08-24. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice in NATURE IMMUNOLOGY
  • 2015-12. Intestinal macrophages arising from CCR2+ monocytes control pathogen infection by activating innate lymphoid cells in NATURE COMMUNICATIONS
  • 2013-06-18. Control of pathogens and pathobionts by the gut microbiota in NATURE IMMUNOLOGY
  • 2013-03. Amino acid signalling upstream of mTOR in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-08. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota in NATURE
  • 2011-01. Intestinal macrophages and response to microbial encroachment in MUCOSAL IMMUNOLOGY
  • 2011-05. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells in NATURE IMMUNOLOGY
  • 2010-02. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function in NATURE REVIEWS IMMUNOLOGY
  • 2011-11. Monocyte recruitment during infection and inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2013-07. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome in NATURE
  • 2006-03. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2 in NATURE IMMUNOLOGY
  • 2007-10. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep27634

    DOI

    http://dx.doi.org/10.1038/srep27634

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031959406

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27302484


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animal Feed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, CD", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD11b Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemokine CCL2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Homeostasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Integrin alpha Chains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-10", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestinal Mucosa", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestine, Small", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macrophages", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Monocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mucous Membrane", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, CCR2", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.", 
                "Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ochi", 
            "givenName": "Takanori", 
            "id": "sg:person.01311505317.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311505317.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Feng", 
            "givenName": "Yongjia", 
            "id": "sg:person.011111123227.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011111123227.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitamoto", 
            "givenName": "Sho", 
            "id": "sg:person.01054423251.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054423251.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagao-Kitamoto", 
            "givenName": "Hiroko", 
            "id": "sg:person.01042501002.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042501002.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuffa", 
            "givenName": "Peter", 
            "id": "sg:person.01176506725.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176506725.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University", 
              "id": "https://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atarashi", 
            "givenName": "Koji", 
            "id": "sg:person.0727663606.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727663606.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University", 
              "id": "https://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Honda", 
            "givenName": "Kenya", 
            "id": "sg:person.01315560470.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315560470.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teitelbaum", 
            "givenName": "Daniel H", 
            "id": "sg:person.01141402215.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141402215.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamada", 
            "givenName": "Nobuhiko", 
            "id": "sg:person.0601734777.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601734777.82"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1177/0148607113497514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000052699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31818a1522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001637586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31818a1522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001637586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1113/jphysiol.2008.162719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002477339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20101387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003683983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.09.062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003814118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxq449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005099462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.14-269480", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005538543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006276626", 
              "https://doi.org/10.1038/nri2711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006276626", 
              "https://doi.org/10.1038/nri2711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00386.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007158262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2011.09.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007474501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2013.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007714969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpg.0b013e3181819007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008385903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpg.0b013e3181819007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008385903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpg.0b013e3181819007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008385903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0804012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010085149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011872454", 
              "https://doi.org/10.1038/ni.2967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2002.1231527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012638802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jsre.1998.5408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013002978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2009.04026.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013936537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2009.04026.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013936537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1002701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014645635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1200069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015808558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016552598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018109379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1103253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018444996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018717831", 
              "https://doi.org/10.1038/ni.2020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(03)00174-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019070500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020067445", 
              "https://doi.org/10.1038/nature12347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fcimb.2013.00105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020757043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021626925", 
              "https://doi.org/10.1038/ni1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021975364", 
              "https://doi.org/10.1038/nrm3522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021980193", 
              "https://doi.org/10.1038/nature12331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac5560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023436145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2014.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024279204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxg043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026110531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mi.2010.66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027000327", 
              "https://doi.org/10.1038/mi.2010.66"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mi.2010.66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027000327", 
              "https://doi.org/10.1038/mi.2010.66"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0903987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028160635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1221789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029059495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2011.04318.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029686700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030895091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00030.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031308348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci43918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032136570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci43918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032136570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.12.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034013077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci29919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034625764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2014.01.060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035322875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1102662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035985351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037874628", 
              "https://doi.org/10.1038/nri2707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037874628", 
              "https://doi.org/10.1038/nri2707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2014.04.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040288259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clnu.2006.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041277488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chom.2013.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042648394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042722101", 
              "https://doi.org/10.1038/ncomms9010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043661049", 
              "https://doi.org/10.1038/ni.2608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clnu.2009.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044434548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/imr.12192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044807230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045494380", 
              "https://doi.org/10.1038/ni1309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045494380", 
              "https://doi.org/10.1038/ni1309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1200420", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049059332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.201343833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052145789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052610200", 
              "https://doi.org/10.1038/nri3070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2000559", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053197646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/jir.2009.0046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059281101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0884533615609904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063857760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0884533615609904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063857760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.10.6900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077137408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/137.8.1931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077446605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1201746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078728434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079572617", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-09", 
        "datePublishedReg": "2016-09-01", 
        "description": "Intestinal resident macrophages (M\u03d5s) regulate gastrointestinal homeostasis via production of an anti-inflammatory cytokine interleukin (IL)-10. Although a constant replenishment by circulating monocytes is required to maintain the pool of resident M\u03d5s in the colonic mucosa, the homeostatic regulation of M\u03d5 in the small intestine (SI) remains unclear. Here, we demonstrate that direct stimulation by dietary amino acids regulates the homeostasis of intestinal M\u03d5s in the SI. Mice that received total parenteral nutrition (TPN), which deprives the animals of enteral nutrients, displayed a significant decrease of IL-10-producing M\u03d5s in the SI, whereas the IL-10-producing CD4(+) T cells remained intact. Likewise, enteral nutrient deprivation selectively affected the monocyte-derived F4/80(+) M\u03d5 population, but not non-monocytic precursor-derived CD103(+) dendritic cells. Notably, in contrast to colonic M\u03d5s, the replenishment of SI M\u03d5s and their IL-10 production were not regulated by the gut microbiota. Rather, SI M\u03d5s were directly regulated by dietary amino acids. Collectively, our study highlights the diet-dependent, microbiota-independent regulation of IL-10-producing resident M\u03d5s in the SI.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/srep27634", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438986", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2625558", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5862611", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2454339", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "name": "Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine", 
        "pagination": "27634", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "983fae8687552e71f15f6bcba12e12fc1c167ecd54abca9cc9ae96c4729551e2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27302484"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/srep27634"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031959406"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/srep27634", 
          "https://app.dimensions.ai/details/publication/pub.1031959406"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000550.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/srep/2016/160615/srep27634/full/srep27634.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep27634'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep27634'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep27634'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep27634'


     

    This table displays all metadata directly associated to this object as RDF triples.

    418 TRIPLES      21 PREDICATES      112 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/srep27634 schema:about N10ce920763254a37bf419cf8758798e7
    2 N1270e51853aa4fac8a3270ea70179b9e
    3 N18edf3839ec644df9479c1c4d4ff0203
    4 N26dfc89f42ba4df2b7816c8144881631
    5 N2f91b1544af14b269ba8ca86d22fe7c2
    6 N3d1936081f8742a59c4f5cdabfca8dc4
    7 N4cf2b3baf38e425d9277186c1e756a0f
    8 N526f4a9434ba4c76824621123f136fa2
    9 N5713ced89fb845ecae77fde53e5d9ab0
    10 N614f05f99eae468ca8442bd0abd79041
    11 N730508832ea441578a9eef6564640ec3
    12 N75984c3bb37e4c90b6516b22b48ab824
    13 N7c20ff5b49174f118b5d85ef91dd2ed2
    14 N82f3c7bd606241038723cba08bea6ada
    15 N90a80de98cc3402798c931f11617547a
    16 Na338fab7fcb74f4d9f5939b7be5d0238
    17 Nb8960db5cdd74583ac6fedf66e688e2d
    18 Nc5acf65644ad4ad983dc35eb46c73afa
    19 Nd033d70450dc4c208320ccf1671d3fc1
    20 Ndf2d5b671feb45f69c28d127d8396d16
    21 Nffd9e1d8e4ff4269b6c9a6de994fcd7f
    22 anzsrc-for:11
    23 anzsrc-for:1107
    24 schema:author Nf32cd5282f9c44d0918eb59189417a38
    25 schema:citation sg:pub.10.1038/mi.2010.66
    26 sg:pub.10.1038/nature12331
    27 sg:pub.10.1038/nature12347
    28 sg:pub.10.1038/ncomms9010
    29 sg:pub.10.1038/ni.2020
    30 sg:pub.10.1038/ni.2608
    31 sg:pub.10.1038/ni.2967
    32 sg:pub.10.1038/ni1309
    33 sg:pub.10.1038/ni1511
    34 sg:pub.10.1038/nri2707
    35 sg:pub.10.1038/nri2711
    36 sg:pub.10.1038/nri3070
    37 sg:pub.10.1038/nrm3522
    38 https://app.dimensions.ai/details/publication/pub.1079572617
    39 https://doi.org/10.1002/eji.201343833
    40 https://doi.org/10.1006/jsre.1998.5408
    41 https://doi.org/10.1016/j.ccr.2012.02.007
    42 https://doi.org/10.1016/j.chom.2013.05.013
    43 https://doi.org/10.1016/j.clnu.2006.01.005
    44 https://doi.org/10.1016/j.clnu.2009.04.002
    45 https://doi.org/10.1016/j.immuni.2008.05.019
    46 https://doi.org/10.1016/j.immuni.2011.12.011
    47 https://doi.org/10.1016/j.immuni.2013.12.007
    48 https://doi.org/10.1016/j.immuni.2014.04.007
    49 https://doi.org/10.1016/j.it.2014.04.003
    50 https://doi.org/10.1016/j.molimm.2011.09.023
    51 https://doi.org/10.1016/s1074-7613(03)00174-2
    52 https://doi.org/10.1053/gast.2002.1231527
    53 https://doi.org/10.1053/j.gastro.2008.09.062
    54 https://doi.org/10.1053/j.gastro.2014.01.060
    55 https://doi.org/10.1056/nejmoa1102662
    56 https://doi.org/10.1084/jem.20101387
    57 https://doi.org/10.1089/jir.2009.0046
    58 https://doi.org/10.1093/intimm/dxg043
    59 https://doi.org/10.1093/intimm/dxq449
    60 https://doi.org/10.1093/jn/137.8.1931
    61 https://doi.org/10.1096/fj.14-269480
    62 https://doi.org/10.1097/mpg.0b013e3181819007
    63 https://doi.org/10.1097/sla.0b013e31818a1522
    64 https://doi.org/10.1111/imr.12192
    65 https://doi.org/10.1111/j.1365-2249.2011.04318.x
    66 https://doi.org/10.1111/j.1749-6632.2009.04026.x
    67 https://doi.org/10.1113/jphysiol.2008.162719
    68 https://doi.org/10.1126/science.1198469
    69 https://doi.org/10.1126/science.1221789
    70 https://doi.org/10.1126/science.aac5560
    71 https://doi.org/10.1126/scisignal.2000559
    72 https://doi.org/10.1152/ajpgi.00030.2010
    73 https://doi.org/10.1152/ajpgi.00386.2007
    74 https://doi.org/10.1172/jci29919
    75 https://doi.org/10.1172/jci43918
    76 https://doi.org/10.1177/0148607113497514
    77 https://doi.org/10.1177/0884533615609904
    78 https://doi.org/10.3389/fcimb.2013.00105
    79 https://doi.org/10.4049/jimmunol.0804012
    80 https://doi.org/10.4049/jimmunol.0903987
    81 https://doi.org/10.4049/jimmunol.1002701
    82 https://doi.org/10.4049/jimmunol.1103253
    83 https://doi.org/10.4049/jimmunol.1200069
    84 https://doi.org/10.4049/jimmunol.1200420
    85 https://doi.org/10.4049/jimmunol.1201746
    86 https://doi.org/10.4049/jimmunol.175.10.6900
    87 schema:datePublished 2016-09
    88 schema:datePublishedReg 2016-09-01
    89 schema:description Intestinal resident macrophages (Mϕs) regulate gastrointestinal homeostasis via production of an anti-inflammatory cytokine interleukin (IL)-10. Although a constant replenishment by circulating monocytes is required to maintain the pool of resident Mϕs in the colonic mucosa, the homeostatic regulation of Mϕ in the small intestine (SI) remains unclear. Here, we demonstrate that direct stimulation by dietary amino acids regulates the homeostasis of intestinal Mϕs in the SI. Mice that received total parenteral nutrition (TPN), which deprives the animals of enteral nutrients, displayed a significant decrease of IL-10-producing Mϕs in the SI, whereas the IL-10-producing CD4(+) T cells remained intact. Likewise, enteral nutrient deprivation selectively affected the monocyte-derived F4/80(+) Mϕ population, but not non-monocytic precursor-derived CD103(+) dendritic cells. Notably, in contrast to colonic Mϕs, the replenishment of SI Mϕs and their IL-10 production were not regulated by the gut microbiota. Rather, SI Mϕs were directly regulated by dietary amino acids. Collectively, our study highlights the diet-dependent, microbiota-independent regulation of IL-10-producing resident Mϕs in the SI.
    90 schema:genre research_article
    91 schema:inLanguage en
    92 schema:isAccessibleForFree true
    93 schema:isPartOf Nae2dfd32ba2c4341a7ed5b9ddf00fbf6
    94 Nd214d4c5cc724e37bbcfe22f283d05bf
    95 sg:journal.1045337
    96 schema:name Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine
    97 schema:pagination 27634
    98 schema:productId N2245d955305c4499b84819a45d540cc9
    99 N228eddf4e5a6497ab2d78be437fd7450
    100 Nba790f70b1e74d1394e5b52403528f41
    101 Nd944c5e1837242e59544edf04a2f697c
    102 Neaff9f47158147708cc4e9492328a199
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031959406
    104 https://doi.org/10.1038/srep27634
    105 schema:sdDatePublished 2019-04-10T15:58
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher Nf3a6fb341c7440449a4afa4020ff5d8a
    108 schema:url http://www.nature.com/srep/2016/160615/srep27634/full/srep27634.html
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N10ce920763254a37bf419cf8758798e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name CD4-Positive T-Lymphocytes
    114 rdf:type schema:DefinedTerm
    115 N1270e51853aa4fac8a3270ea70179b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Receptors, CCR2
    117 rdf:type schema:DefinedTerm
    118 N18edf3839ec644df9479c1c4d4ff0203 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Macrophages
    120 rdf:type schema:DefinedTerm
    121 N2245d955305c4499b84819a45d540cc9 schema:name doi
    122 schema:value 10.1038/srep27634
    123 rdf:type schema:PropertyValue
    124 N228eddf4e5a6497ab2d78be437fd7450 schema:name readcube_id
    125 schema:value 983fae8687552e71f15f6bcba12e12fc1c167ecd54abca9cc9ae96c4729551e2
    126 rdf:type schema:PropertyValue
    127 N26dfc89f42ba4df2b7816c8144881631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Homeostasis
    129 rdf:type schema:DefinedTerm
    130 N2f91b1544af14b269ba8ca86d22fe7c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Integrin alpha Chains
    132 rdf:type schema:DefinedTerm
    133 N3c1953bef3974882a36967f8721773eb rdf:first sg:person.01141402215.01
    134 rdf:rest Ne9c7883ff02b42dfbf36cc50d261a6cb
    135 N3d1936081f8742a59c4f5cdabfca8dc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Gastrointestinal Microbiome
    137 rdf:type schema:DefinedTerm
    138 N4cf2b3baf38e425d9277186c1e756a0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Mucous Membrane
    140 rdf:type schema:DefinedTerm
    141 N526f4a9434ba4c76824621123f136fa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Chemokine CCL2
    143 rdf:type schema:DefinedTerm
    144 N5713ced89fb845ecae77fde53e5d9ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Intestine, Small
    146 rdf:type schema:DefinedTerm
    147 N614f05f99eae468ca8442bd0abd79041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name CD11b Antigen
    149 rdf:type schema:DefinedTerm
    150 N730508832ea441578a9eef6564640ec3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Interleukin-10
    152 rdf:type schema:DefinedTerm
    153 N75860faca6f145979f7512f61d35b47a rdf:first sg:person.01042501002.30
    154 rdf:rest Nc4dfeb3791604a6ba1196ea46e711459
    155 N75984c3bb37e4c90b6516b22b48ab824 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Mice, Inbred C57BL
    157 rdf:type schema:DefinedTerm
    158 N794e2f2ffd7c406582f47ded6595ed91 rdf:first sg:person.0727663606.09
    159 rdf:rest Nb48bebbfb80e42988639f38e7d83a864
    160 N7c20ff5b49174f118b5d85ef91dd2ed2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Cytokines
    162 rdf:type schema:DefinedTerm
    163 N82f3c7bd606241038723cba08bea6ada schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Animal Feed
    165 rdf:type schema:DefinedTerm
    166 N90a80de98cc3402798c931f11617547a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Male
    168 rdf:type schema:DefinedTerm
    169 Na338fab7fcb74f4d9f5939b7be5d0238 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Intestinal Mucosa
    171 rdf:type schema:DefinedTerm
    172 Nae2dfd32ba2c4341a7ed5b9ddf00fbf6 schema:issueNumber 1
    173 rdf:type schema:PublicationIssue
    174 Nb48bebbfb80e42988639f38e7d83a864 rdf:first sg:person.01315560470.25
    175 rdf:rest N3c1953bef3974882a36967f8721773eb
    176 Nb8960db5cdd74583ac6fedf66e688e2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Amino Acids
    178 rdf:type schema:DefinedTerm
    179 Nba790f70b1e74d1394e5b52403528f41 schema:name nlm_unique_id
    180 schema:value 101563288
    181 rdf:type schema:PropertyValue
    182 Nc4dfeb3791604a6ba1196ea46e711459 rdf:first sg:person.01176506725.00
    183 rdf:rest N794e2f2ffd7c406582f47ded6595ed91
    184 Nc5acf65644ad4ad983dc35eb46c73afa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Monocytes
    186 rdf:type schema:DefinedTerm
    187 Nd033d70450dc4c208320ccf1671d3fc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Antigens, CD
    189 rdf:type schema:DefinedTerm
    190 Nd214d4c5cc724e37bbcfe22f283d05bf schema:volumeNumber 6
    191 rdf:type schema:PublicationVolume
    192 Nd944c5e1837242e59544edf04a2f697c schema:name pubmed_id
    193 schema:value 27302484
    194 rdf:type schema:PropertyValue
    195 Ndb18c30d29b7431b8b66936080485c0e rdf:first sg:person.011111123227.14
    196 rdf:rest Nf4a65a6c9a8442f2bf937ba8424f0a40
    197 Ndf2d5b671feb45f69c28d127d8396d16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Animals
    199 rdf:type schema:DefinedTerm
    200 Ne9c7883ff02b42dfbf36cc50d261a6cb rdf:first sg:person.0601734777.82
    201 rdf:rest rdf:nil
    202 Neaff9f47158147708cc4e9492328a199 schema:name dimensions_id
    203 schema:value pub.1031959406
    204 rdf:type schema:PropertyValue
    205 Nf32cd5282f9c44d0918eb59189417a38 rdf:first sg:person.01311505317.17
    206 rdf:rest Ndb18c30d29b7431b8b66936080485c0e
    207 Nf3a6fb341c7440449a4afa4020ff5d8a schema:name Springer Nature - SN SciGraph project
    208 rdf:type schema:Organization
    209 Nf4a65a6c9a8442f2bf937ba8424f0a40 rdf:first sg:person.01054423251.70
    210 rdf:rest N75860faca6f145979f7512f61d35b47a
    211 Nffd9e1d8e4ff4269b6c9a6de994fcd7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Mice
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Medical and Health Sciences
    216 rdf:type schema:DefinedTerm
    217 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Immunology
    219 rdf:type schema:DefinedTerm
    220 sg:grant.2438986 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27634
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.2454339 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27634
    223 rdf:type schema:MonetaryGrant
    224 sg:grant.2625558 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27634
    225 rdf:type schema:MonetaryGrant
    226 sg:grant.5862611 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27634
    227 rdf:type schema:MonetaryGrant
    228 sg:journal.1045337 schema:issn 2045-2322
    229 schema:name Scientific Reports
    230 rdf:type schema:Periodical
    231 sg:person.01042501002.30 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    232 schema:familyName Nagao-Kitamoto
    233 schema:givenName Hiroko
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042501002.30
    235 rdf:type schema:Person
    236 sg:person.01054423251.70 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    237 schema:familyName Kitamoto
    238 schema:givenName Sho
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054423251.70
    240 rdf:type schema:Person
    241 sg:person.011111123227.14 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    242 schema:familyName Feng
    243 schema:givenName Yongjia
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011111123227.14
    245 rdf:type schema:Person
    246 sg:person.01141402215.01 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    247 schema:familyName Teitelbaum
    248 schema:givenName Daniel H
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141402215.01
    250 rdf:type schema:Person
    251 sg:person.01176506725.00 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    252 schema:familyName Kuffa
    253 schema:givenName Peter
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176506725.00
    255 rdf:type schema:Person
    256 sg:person.01311505317.17 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    257 schema:familyName Ochi
    258 schema:givenName Takanori
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311505317.17
    260 rdf:type schema:Person
    261 sg:person.01315560470.25 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
    262 schema:familyName Honda
    263 schema:givenName Kenya
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315560470.25
    265 rdf:type schema:Person
    266 sg:person.0601734777.82 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    267 schema:familyName Kamada
    268 schema:givenName Nobuhiko
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601734777.82
    270 rdf:type schema:Person
    271 sg:person.0727663606.09 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
    272 schema:familyName Atarashi
    273 schema:givenName Koji
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727663606.09
    275 rdf:type schema:Person
    276 sg:pub.10.1038/mi.2010.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027000327
    277 https://doi.org/10.1038/mi.2010.66
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nature12331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021980193
    280 https://doi.org/10.1038/nature12331
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nature12347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020067445
    283 https://doi.org/10.1038/nature12347
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/ncomms9010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042722101
    286 https://doi.org/10.1038/ncomms9010
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/ni.2020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018717831
    289 https://doi.org/10.1038/ni.2020
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/ni.2608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043661049
    292 https://doi.org/10.1038/ni.2608
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/ni.2967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011872454
    295 https://doi.org/10.1038/ni.2967
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/ni1309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045494380
    298 https://doi.org/10.1038/ni1309
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/ni1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021626925
    301 https://doi.org/10.1038/ni1511
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nri2707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037874628
    304 https://doi.org/10.1038/nri2707
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nri2711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006276626
    307 https://doi.org/10.1038/nri2711
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/nri3070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052610200
    310 https://doi.org/10.1038/nri3070
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/nrm3522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021975364
    313 https://doi.org/10.1038/nrm3522
    314 rdf:type schema:CreativeWork
    315 https://app.dimensions.ai/details/publication/pub.1079572617 schema:CreativeWork
    316 https://doi.org/10.1002/eji.201343833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052145789
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1006/jsre.1998.5408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013002978
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.ccr.2012.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030895091
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/j.chom.2013.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042648394
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.clnu.2006.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041277488
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/j.clnu.2009.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044434548
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/j.immuni.2008.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016552598
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/j.immuni.2011.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034013077
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/j.immuni.2013.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007714969
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.immuni.2014.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040288259
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/j.it.2014.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024279204
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/j.molimm.2011.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007474501
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/s1074-7613(03)00174-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019070500
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1053/gast.2002.1231527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012638802
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1053/j.gastro.2008.09.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003814118
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1053/j.gastro.2014.01.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035322875
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1056/nejmoa1102662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035985351
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1084/jem.20101387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003683983
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1089/jir.2009.0046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059281101
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1093/intimm/dxg043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026110531
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1093/intimm/dxq449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005099462
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1093/jn/137.8.1931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077446605
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1096/fj.14-269480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005538543
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1097/mpg.0b013e3181819007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008385903
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1097/sla.0b013e31818a1522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001637586
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1111/imr.12192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044807230
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1365-2249.2011.04318.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029686700
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1111/j.1749-6632.2009.04026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013936537
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1113/jphysiol.2008.162719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002477339
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1126/science.1198469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018109379
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1126/science.1221789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029059495
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1126/science.aac5560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023436145
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1126/scisignal.2000559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053197646
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1152/ajpgi.00030.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031308348
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1152/ajpgi.00386.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007158262
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1172/jci29919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034625764
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1172/jci43918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032136570
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1177/0148607113497514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000052699
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1177/0884533615609904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063857760
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.3389/fcimb.2013.00105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020757043
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.4049/jimmunol.0804012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010085149
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.4049/jimmunol.0903987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028160635
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.4049/jimmunol.1002701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014645635
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.4049/jimmunol.1103253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018444996
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.4049/jimmunol.1200069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015808558
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.4049/jimmunol.1200420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049059332
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.4049/jimmunol.1201746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078728434
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.4049/jimmunol.175.10.6900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077137408
    411 rdf:type schema:CreativeWork
    412 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
    413 schema:name Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
    414 Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
    415 rdf:type schema:Organization
    416 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
    417 schema:name Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
    418 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...