Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-09

AUTHORS

Jingshu Xu, Paul Begley, Stephanie J. Church, Stefano Patassini, Selina McHarg, Nina Kureishy, Katherine A. Hollywood, Henry J. Waldvogel, Hong Liu, Shaoping Zhang, Wanchang Lin, Karl Herholz, Clinton Turner, Beth J. Synek, Maurice A. Curtis, Jack Rivers-Auty, Catherine B. Lawrence, Katherine A. B. Kellett, Nigel M. Hooper, Emma R. L. C. Vardy, Donghai Wu, Richard D. Unwin, Richard L. M. Faull, Andrew W. Dowsey, Garth J. S. Cooper

ABSTRACT

Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer’s disease (AD). Here we sought to further elucidate the processes that cause neurodegeneration in AD by measuring levels of metabolites and metals in brain regions that undergo different degrees of damage. We employed mass spectrometry (MS) to measure metabolites and metals in seven post-mortem brain regions of nine AD patients and nine controls, and plasma-glucose and plasma-copper levels in an ante-mortem case-control study. Glucose, sorbitol and fructose were markedly elevated in all AD brain regions, whereas copper was correspondingly deficient throughout (all P < 0.0001). In the ante-mortem case-control study, by contrast, plasma-glucose and plasma-copper levels did not differ between patients and controls. There were pervasive defects in regulation of glucose and copper in AD brain but no evidence for corresponding systemic abnormalities in plasma. Elevation of brain glucose and deficient brain copper potentially contribute to the pathogenesis of neurodegeneration in AD. More... »

PAGES

27524

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  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    6

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep27524

    DOI

    http://dx.doi.org/10.1038/srep27524

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002779022

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27276998


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