CXCL3 contributes to CD133+ CSCs maintenance and forms a positive feedback regulation loop with CD133 in HCC via Erk1/2 phosphorylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-03

AUTHORS

Lin Zhang, Lixing Zhang, Hong Li, Chao Ge, Fangyu Zhao, Hua Tian, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li

ABSTRACT

Although the chemotactic cytokine CXCL3 is thought to play an important role in tumor initiation and invasion, little is known about its function in hepatocellular carcinoma (HCC). In our previous study, we found that Ikaros inhibited CD133 expression via the MAPK pathway in HCC. Here, we showed that Ikaros may indirectly down-regulate CXCL3 expression in HCC cells, which leads to better outcomes in patients with CD133+ cancer stem cell (CSC) populations. CD133 overexpression induced CXCL3 expression, and silencing of CD133 down-regulated CXCL3 in HCC cells. Knockdown of CXCL3 inhibited CD133+ HCC CSCs’ self-renewal and tumorigenesis. The serum CXCL3 level was higher in HCC patients’ samples than that in healthy individual. HCC patients with higher CXCL3 expression displayed a poor prognosis, and a high level of CXCL3 was significantly associated with vascular invasion and tumor capsule formation. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression, indicating a positive feedback loop between CXCL3 and CD133 gene expression in HCC cells via Erk1/2 activation. Together, our findings indicated that CXCL3 might be a potent therapeutic target for HCC. More... »

PAGES

27426

References to SciGraph publications

  • 2014-05-13. The Inflammation and Liver Cancer in INFLAMMATION AND CANCER
  • 2010-05-27. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms in LEUKEMIA
  • 2010-02-17. Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2007-06-28. Gene therapy with CX3CL1/Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma in GENE THERAPY
  • 2014-01-19. CXCL12 secreted from glioma stem cells regulates their proliferation in JOURNAL OF NEURO-ONCOLOGY
  • 2010-10-28. PAR1- and PAR2-induced innate immune markers are negatively regulated by PI3K/Akt signaling pathway in oral keratinocytes in BMC IMMUNOLOGY
  • 2014-02-09. Stage-specific control of early B cell development by the transcription factor Ikaros in NATURE IMMUNOLOGY
  • 2014-06-02. Receptor-type protein tyrosine phosphatase κ directly dephosphorylates CD133 and regulates downstream AKT activation in ONCOGENE
  • 2014-01-10. Cisplatin targets the stromal cell-derived factor-1-CXC chemokine receptor type 4 axis to suppress metastasis and invasion of ovarian cancer-initiating cells in TUMOR BIOLOGY
  • 2011-11-10. High Expression of CCL20 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma after Curative Resection in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2012-06-30. The role of CXC chemokines and their receptors in the progression and treatment of tumors in JOURNAL OF MOLECULAR HISTOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep27426

    DOI

    http://dx.doi.org/10.1038/srep27426

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021871344

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27255419


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "AC133 Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Hepatocellular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemokines, CXC", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Down-Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MAP Kinase Signaling System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred BALB C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplastic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Oncology, Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
                "Department of Oncology, Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Lin", 
            "id": "sg:person.0754615444.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754615444.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Lixing", 
            "id": "sg:person.0653462135.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653462135.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Hong", 
            "id": "sg:person.0625153671.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625153671.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ge", 
            "givenName": "Chao", 
            "id": "sg:person.01160767752.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160767752.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Fangyu", 
            "id": "sg:person.01333521256.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333521256.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tian", 
            "givenName": "Hua", 
            "id": "sg:person.01130653150.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130653150.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Qi Dong Liver Cancer Institute, Qi Dong, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Qi Dong Liver Cancer Institute, Qi Dong, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Taoyang", 
            "id": "sg:person.013162461177.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013162461177.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jiang", 
            "givenName": "Guoping", 
            "id": "sg:person.01155020556.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155020556.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.13402.34", 
              "name": [
                "Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xie", 
            "givenName": "Haiyang", 
            "id": "sg:person.0657720126.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657720126.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Institute of Guangxi, Nanning, China", 
              "id": "http://www.grid.ac/institutes/grid.413431.0", 
              "name": [
                "Cancer Institute of Guangxi, Nanning, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cui", 
            "givenName": "Ying", 
            "id": "sg:person.01134435204.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134435204.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yao", 
            "givenName": "Ming", 
            "id": "sg:person.01330252676.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330252676.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China", 
              "id": "http://www.grid.ac/institutes/grid.415869.7", 
              "name": [
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Jinjun", 
            "id": "sg:person.01275216352.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275216352.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s11605-011-1775-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040240451", 
              "https://doi.org/10.1007/s11605-011-1775-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-010-0901-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012674703", 
              "https://doi.org/10.1007/s00384-010-0901-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-014-1364-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001862038", 
              "https://doi.org/10.1007/s11060-014-1364-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10735-012-9435-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023812797", 
              "https://doi.org/10.1007/s10735-012-9435-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-0348-0837-8_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030620833", 
              "https://doi.org/10.1007/978-3-0348-0837-8_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011071072", 
              "https://doi.org/10.1038/ni.2828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2010.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007711866", 
              "https://doi.org/10.1038/leu.2010.99"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-014-1607-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016252105", 
              "https://doi.org/10.1007/s13277-014-1607-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2014.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013469372", 
              "https://doi.org/10.1038/onc.2014.141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3302959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013674814", 
              "https://doi.org/10.1038/sj.gt.3302959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2172-11-53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004786270", 
              "https://doi.org/10.1186/1471-2172-11-53"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-06-03", 
        "datePublishedReg": "2016-06-03", 
        "description": "Although the chemotactic cytokine CXCL3 is thought to play an important role in tumor initiation and invasion, little is known about its function in hepatocellular carcinoma (HCC). In our previous study, we found that Ikaros inhibited CD133 expression via the MAPK pathway in HCC. Here, we showed that Ikaros may indirectly down-regulate CXCL3 expression in HCC cells, which leads to better outcomes in patients with CD133+ cancer stem cell (CSC) populations. CD133 overexpression induced CXCL3 expression, and silencing of CD133 down-regulated CXCL3 in HCC cells. Knockdown of CXCL3 inhibited CD133+ HCC CSCs\u2019 self-renewal and tumorigenesis. The serum CXCL3 level was higher in HCC patients\u2019 samples than that in healthy individual. HCC patients with higher CXCL3 expression displayed a poor prognosis, and a high level of CXCL3 was significantly associated with vascular invasion and tumor capsule formation. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression, indicating a positive feedback loop between CXCL3 and CD133 gene expression in HCC cells via Erk1/2 activation. Together, our findings indicated that CXCL3 might be a potent therapeutic target for HCC.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/srep27426", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7195789", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8342687", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7196824", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "keywords": [
          "hepatocellular carcinoma", 
          "CXCL3 expression", 
          "HCC cells", 
          "HCC patients", 
          "CD133 expression", 
          "tumor capsule formation", 
          "cancer stem cell population", 
          "potent therapeutic target", 
          "CD133 gene expression", 
          "HCC CSCs", 
          "exogenous CXCL3", 
          "poor prognosis", 
          "vascular invasion", 
          "therapeutic target", 
          "better outcomes", 
          "CD133 overexpression", 
          "healthy individuals", 
          "CXCL3", 
          "ETS1 phosphorylation", 
          "CSC maintenance", 
          "CD133", 
          "patients", 
          "tumor initiation", 
          "positive feedback regulation loop", 
          "ERK1/2 phosphorylation", 
          "ERK1/2 activation", 
          "stem cell population", 
          "cell populations", 
          "feedback regulation loop", 
          "MAPK pathway", 
          "positive feedback loop", 
          "capsule formation", 
          "expression", 
          "invasion", 
          "cells", 
          "gene expression", 
          "high levels", 
          "previous studies", 
          "carcinoma", 
          "prognosis", 
          "phosphorylation", 
          "important role", 
          "ERK1/2", 
          "outcomes", 
          "tumorigenesis", 
          "levels", 
          "Ikaros", 
          "knockdown", 
          "activation", 
          "overexpression", 
          "CSC", 
          "initiation", 
          "population", 
          "pathway", 
          "findings", 
          "individuals", 
          "target", 
          "feedback loop", 
          "study", 
          "role", 
          "maintenance", 
          "function", 
          "samples", 
          "regulation loop", 
          "loop", 
          "formation"
        ], 
        "name": "CXCL3 contributes to CD133+ CSCs maintenance and forms a positive feedback regulation loop with CD133 in HCC via Erk1/2 phosphorylation", 
        "pagination": "27426", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021871344"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/srep27426"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27255419"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/srep27426", 
          "https://app.dimensions.ai/details/publication/pub.1021871344"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:41", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_688.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/srep27426"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep27426'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep27426'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep27426'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep27426'


     

    This table displays all metadata directly associated to this object as RDF triples.

    325 TRIPLES      21 PREDICATES      117 URIs      98 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/srep27426 schema:about N0db83f6d842345488db35ab5398613ca
    2 N19e07234d703468cadec04cdde75772c
    3 N1abd27eea48b471196c0d4e473509136
    4 N213942dc023340a48c975ed10a2b96c0
    5 N2a328916bef04f99a6d6643b5efbb560
    6 N68af10732f2142e5b0a8f5c4a1595586
    7 N690c987e12274a3da83d1a350a9cc875
    8 N6df7d618874e40668f30e056ab4bf0bd
    9 N76fd7c24270541b6ba8aa8e2d37c9a97
    10 N88687164038a4bea9c9a8880c0f8099d
    11 Na3ebfc07217e48118f7872a2ba6fdee0
    12 Nabd599764017450b8740e23a3f3a09d5
    13 Nd03c71be3dba49329fcb823db7e9a22a
    14 Nf2ab991ae9f34eb2a424891e8a55b36a
    15 Nf3204b1cae904fe88e2e84662510c6bb
    16 anzsrc-for:11
    17 anzsrc-for:1112
    18 schema:author N71090077b308488c89eb02e20e529d38
    19 schema:citation sg:pub.10.1007/978-3-0348-0837-8_16
    20 sg:pub.10.1007/s00384-010-0901-1
    21 sg:pub.10.1007/s10735-012-9435-x
    22 sg:pub.10.1007/s11060-014-1364-y
    23 sg:pub.10.1007/s11605-011-1775-4
    24 sg:pub.10.1007/s13277-014-1607-8
    25 sg:pub.10.1038/leu.2010.99
    26 sg:pub.10.1038/ni.2828
    27 sg:pub.10.1038/onc.2014.141
    28 sg:pub.10.1038/sj.gt.3302959
    29 sg:pub.10.1186/1471-2172-11-53
    30 schema:datePublished 2016-06-03
    31 schema:datePublishedReg 2016-06-03
    32 schema:description Although the chemotactic cytokine CXCL3 is thought to play an important role in tumor initiation and invasion, little is known about its function in hepatocellular carcinoma (HCC). In our previous study, we found that Ikaros inhibited CD133 expression via the MAPK pathway in HCC. Here, we showed that Ikaros may indirectly down-regulate CXCL3 expression in HCC cells, which leads to better outcomes in patients with CD133+ cancer stem cell (CSC) populations. CD133 overexpression induced CXCL3 expression, and silencing of CD133 down-regulated CXCL3 in HCC cells. Knockdown of CXCL3 inhibited CD133+ HCC CSCs’ self-renewal and tumorigenesis. The serum CXCL3 level was higher in HCC patients’ samples than that in healthy individual. HCC patients with higher CXCL3 expression displayed a poor prognosis, and a high level of CXCL3 was significantly associated with vascular invasion and tumor capsule formation. Exogenous CXCL3 induced Erk1/2 and ETS1 phosphorylation and promoted CD133 expression, indicating a positive feedback loop between CXCL3 and CD133 gene expression in HCC cells via Erk1/2 activation. Together, our findings indicated that CXCL3 might be a potent therapeutic target for HCC.
    33 schema:genre article
    34 schema:isAccessibleForFree true
    35 schema:isPartOf N30a2ca8841f84b91a0e99592e08c8eff
    36 N95438fc7e9294c79ab53555a349bb3a8
    37 sg:journal.1045337
    38 schema:keywords CD133
    39 CD133 expression
    40 CD133 gene expression
    41 CD133 overexpression
    42 CSC
    43 CSC maintenance
    44 CXCL3
    45 CXCL3 expression
    46 ERK1/2
    47 ERK1/2 activation
    48 ERK1/2 phosphorylation
    49 ETS1 phosphorylation
    50 HCC CSCs
    51 HCC cells
    52 HCC patients
    53 Ikaros
    54 MAPK pathway
    55 activation
    56 better outcomes
    57 cancer stem cell population
    58 capsule formation
    59 carcinoma
    60 cell populations
    61 cells
    62 exogenous CXCL3
    63 expression
    64 feedback loop
    65 feedback regulation loop
    66 findings
    67 formation
    68 function
    69 gene expression
    70 healthy individuals
    71 hepatocellular carcinoma
    72 high levels
    73 important role
    74 individuals
    75 initiation
    76 invasion
    77 knockdown
    78 levels
    79 loop
    80 maintenance
    81 outcomes
    82 overexpression
    83 pathway
    84 patients
    85 phosphorylation
    86 poor prognosis
    87 population
    88 positive feedback loop
    89 positive feedback regulation loop
    90 potent therapeutic target
    91 previous studies
    92 prognosis
    93 regulation loop
    94 role
    95 samples
    96 stem cell population
    97 study
    98 target
    99 therapeutic target
    100 tumor capsule formation
    101 tumor initiation
    102 tumorigenesis
    103 vascular invasion
    104 schema:name CXCL3 contributes to CD133+ CSCs maintenance and forms a positive feedback regulation loop with CD133 in HCC via Erk1/2 phosphorylation
    105 schema:pagination 27426
    106 schema:productId N3667f8165aac4986aaec66cd2ecaef65
    107 N4937f73913d94ba1958888a735b8b4c0
    108 Nb93927a4970d49179776521c0fe62cd3
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021871344
    110 https://doi.org/10.1038/srep27426
    111 schema:sdDatePublished 2022-10-01T06:41
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher Nf8a1d32f949048ddaac8e50689998a56
    114 schema:url https://doi.org/10.1038/srep27426
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N0db83f6d842345488db35ab5398613ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Carcinogenesis
    120 rdf:type schema:DefinedTerm
    121 N19e07234d703468cadec04cdde75772c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Humans
    123 rdf:type schema:DefinedTerm
    124 N1abd27eea48b471196c0d4e473509136 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Animals
    126 rdf:type schema:DefinedTerm
    127 N213942dc023340a48c975ed10a2b96c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Chemokines, CXC
    129 rdf:type schema:DefinedTerm
    130 N25f564d1c21e4544812b6eee314115f1 rdf:first sg:person.01160767752.14
    131 rdf:rest N35e94bfc07a242bdb3e5597b55e99bb5
    132 N2a328916bef04f99a6d6643b5efbb560 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Neoplastic Stem Cells
    134 rdf:type schema:DefinedTerm
    135 N30a2ca8841f84b91a0e99592e08c8eff schema:issueNumber 1
    136 rdf:type schema:PublicationIssue
    137 N35e94bfc07a242bdb3e5597b55e99bb5 rdf:first sg:person.01333521256.36
    138 rdf:rest Nc6471a69be114f40a07693ea6ca104bf
    139 N3667f8165aac4986aaec66cd2ecaef65 schema:name pubmed_id
    140 schema:value 27255419
    141 rdf:type schema:PropertyValue
    142 N4937f73913d94ba1958888a735b8b4c0 schema:name dimensions_id
    143 schema:value pub.1021871344
    144 rdf:type schema:PropertyValue
    145 N53e6ecdd72e54753bb241b7d68007de9 rdf:first sg:person.01330252676.42
    146 rdf:rest Nee0c2c2189a0467792c29d722d810a9e
    147 N68af10732f2142e5b0a8f5c4a1595586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Male
    149 rdf:type schema:DefinedTerm
    150 N690c987e12274a3da83d1a350a9cc875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Liver Neoplasms
    152 rdf:type schema:DefinedTerm
    153 N6df7d618874e40668f30e056ab4bf0bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Mice, Inbred BALB C
    155 rdf:type schema:DefinedTerm
    156 N71090077b308488c89eb02e20e529d38 rdf:first sg:person.0754615444.11
    157 rdf:rest Nea91445b5f744c4eaa1fce8e0536adaa
    158 N76fd7c24270541b6ba8aa8e2d37c9a97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name AC133 Antigen
    160 rdf:type schema:DefinedTerm
    161 N88687164038a4bea9c9a8880c0f8099d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Phosphorylation
    163 rdf:type schema:DefinedTerm
    164 N95438fc7e9294c79ab53555a349bb3a8 schema:volumeNumber 6
    165 rdf:type schema:PublicationVolume
    166 Na3ebfc07217e48118f7872a2ba6fdee0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name MAP Kinase Signaling System
    168 rdf:type schema:DefinedTerm
    169 Nabd599764017450b8740e23a3f3a09d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Cell Line, Tumor
    171 rdf:type schema:DefinedTerm
    172 Nb0fbeebf043a4c0d864cd7a4168c5305 rdf:first sg:person.01155020556.40
    173 rdf:rest Nb1da247529ff47d1b4955f0fefce3a04
    174 Nb1da247529ff47d1b4955f0fefce3a04 rdf:first sg:person.0657720126.04
    175 rdf:rest Nea6eff6bf06540acb2377fe57ab201e3
    176 Nb93927a4970d49179776521c0fe62cd3 schema:name doi
    177 schema:value 10.1038/srep27426
    178 rdf:type schema:PropertyValue
    179 Nc6471a69be114f40a07693ea6ca104bf rdf:first sg:person.01130653150.15
    180 rdf:rest Nc89f658d636e4b84ad3e24bf894ba4b3
    181 Nc89f658d636e4b84ad3e24bf894ba4b3 rdf:first sg:person.013162461177.58
    182 rdf:rest Nb0fbeebf043a4c0d864cd7a4168c5305
    183 Nd03c71be3dba49329fcb823db7e9a22a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Carcinoma, Hepatocellular
    185 rdf:type schema:DefinedTerm
    186 Nd1468c6a6f8d45f6b2bb1c7d83954d77 rdf:first sg:person.0625153671.44
    187 rdf:rest N25f564d1c21e4544812b6eee314115f1
    188 Nea6eff6bf06540acb2377fe57ab201e3 rdf:first sg:person.01134435204.50
    189 rdf:rest N53e6ecdd72e54753bb241b7d68007de9
    190 Nea91445b5f744c4eaa1fce8e0536adaa rdf:first sg:person.0653462135.03
    191 rdf:rest Nd1468c6a6f8d45f6b2bb1c7d83954d77
    192 Nee0c2c2189a0467792c29d722d810a9e rdf:first sg:person.01275216352.01
    193 rdf:rest rdf:nil
    194 Nf2ab991ae9f34eb2a424891e8a55b36a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Mice
    196 rdf:type schema:DefinedTerm
    197 Nf3204b1cae904fe88e2e84662510c6bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Down-Regulation
    199 rdf:type schema:DefinedTerm
    200 Nf8a1d32f949048ddaac8e50689998a56 schema:name Springer Nature - SN SciGraph project
    201 rdf:type schema:Organization
    202 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Medical and Health Sciences
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Oncology and Carcinogenesis
    207 rdf:type schema:DefinedTerm
    208 sg:grant.7195789 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27426
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.7196824 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27426
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.8342687 http://pending.schema.org/fundedItem sg:pub.10.1038/srep27426
    213 rdf:type schema:MonetaryGrant
    214 sg:journal.1045337 schema:issn 2045-2322
    215 schema:name Scientific Reports
    216 schema:publisher Springer Nature
    217 rdf:type schema:Periodical
    218 sg:person.01130653150.15 schema:affiliation grid-institutes:grid.415869.7
    219 schema:familyName Tian
    220 schema:givenName Hua
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130653150.15
    222 rdf:type schema:Person
    223 sg:person.01134435204.50 schema:affiliation grid-institutes:grid.413431.0
    224 schema:familyName Cui
    225 schema:givenName Ying
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134435204.50
    227 rdf:type schema:Person
    228 sg:person.01155020556.40 schema:affiliation grid-institutes:grid.13402.34
    229 schema:familyName Jiang
    230 schema:givenName Guoping
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155020556.40
    232 rdf:type schema:Person
    233 sg:person.01160767752.14 schema:affiliation grid-institutes:grid.415869.7
    234 schema:familyName Ge
    235 schema:givenName Chao
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160767752.14
    237 rdf:type schema:Person
    238 sg:person.01275216352.01 schema:affiliation grid-institutes:grid.415869.7
    239 schema:familyName Li
    240 schema:givenName Jinjun
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275216352.01
    242 rdf:type schema:Person
    243 sg:person.013162461177.58 schema:affiliation grid-institutes:None
    244 schema:familyName Chen
    245 schema:givenName Taoyang
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013162461177.58
    247 rdf:type schema:Person
    248 sg:person.01330252676.42 schema:affiliation grid-institutes:grid.415869.7
    249 schema:familyName Yao
    250 schema:givenName Ming
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330252676.42
    252 rdf:type schema:Person
    253 sg:person.01333521256.36 schema:affiliation grid-institutes:grid.415869.7
    254 schema:familyName Zhao
    255 schema:givenName Fangyu
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333521256.36
    257 rdf:type schema:Person
    258 sg:person.0625153671.44 schema:affiliation grid-institutes:grid.415869.7
    259 schema:familyName Li
    260 schema:givenName Hong
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625153671.44
    262 rdf:type schema:Person
    263 sg:person.0653462135.03 schema:affiliation grid-institutes:grid.415869.7
    264 schema:familyName Zhang
    265 schema:givenName Lixing
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653462135.03
    267 rdf:type schema:Person
    268 sg:person.0657720126.04 schema:affiliation grid-institutes:grid.13402.34
    269 schema:familyName Xie
    270 schema:givenName Haiyang
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657720126.04
    272 rdf:type schema:Person
    273 sg:person.0754615444.11 schema:affiliation grid-institutes:None
    274 schema:familyName Zhang
    275 schema:givenName Lin
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754615444.11
    277 rdf:type schema:Person
    278 sg:pub.10.1007/978-3-0348-0837-8_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030620833
    279 https://doi.org/10.1007/978-3-0348-0837-8_16
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s00384-010-0901-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012674703
    282 https://doi.org/10.1007/s00384-010-0901-1
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s10735-012-9435-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023812797
    285 https://doi.org/10.1007/s10735-012-9435-x
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s11060-014-1364-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001862038
    288 https://doi.org/10.1007/s11060-014-1364-y
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s11605-011-1775-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040240451
    291 https://doi.org/10.1007/s11605-011-1775-4
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s13277-014-1607-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016252105
    294 https://doi.org/10.1007/s13277-014-1607-8
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/leu.2010.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007711866
    297 https://doi.org/10.1038/leu.2010.99
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/ni.2828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011071072
    300 https://doi.org/10.1038/ni.2828
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/onc.2014.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013469372
    303 https://doi.org/10.1038/onc.2014.141
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/sj.gt.3302959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013674814
    306 https://doi.org/10.1038/sj.gt.3302959
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1186/1471-2172-11-53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004786270
    309 https://doi.org/10.1186/1471-2172-11-53
    310 rdf:type schema:CreativeWork
    311 grid-institutes:None schema:alternateName Department of Oncology, Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China
    312 Qi Dong Liver Cancer Institute, Qi Dong, China
    313 schema:name Department of Oncology, Cancer Research Institute, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China
    314 Qi Dong Liver Cancer Institute, Qi Dong, China
    315 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    316 rdf:type schema:Organization
    317 grid-institutes:grid.13402.34 schema:alternateName Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    318 schema:name Department of General Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    319 rdf:type schema:Organization
    320 grid-institutes:grid.413431.0 schema:alternateName Cancer Institute of Guangxi, Nanning, China
    321 schema:name Cancer Institute of Guangxi, Nanning, China
    322 rdf:type schema:Organization
    323 grid-institutes:grid.415869.7 schema:alternateName State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    324 schema:name State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    325 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...