Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-27

AUTHORS

Yanhui Liu, Jagannath Padmanabhan, Bettina Cheung, Jingbei Liu, Zheng Chen, B. Ellen Scanley, Donna Wesolowski, Mariyah Pressley, Christine C. Broadbridge, Sidney Altman, Udo D. Schwarz, Themis R. Kyriakides, Jan Schroers

ABSTRACT

Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategies to optimize compositions out of a vast phase space, making alloy development time consuming and labor intensive. Here, we challenge the conventional paradigm by proposing a combinatorial strategy that enables parallel screening of a multitude of alloys. Utilizing a typical metallic glass forming alloy system Zr-Cu-Al-Ag as an example, we demonstrate how glass formation and antibacterial activity, two unrelated properties, can be simultaneously characterized and the optimal composition can be efficiently identified. We found that in the Zr-Cu-Al-Ag alloy system fully glassy phase can be obtained in a wide compositional range by co-sputtering and antibacterial activity is strongly dependent on alloy compositions. Our results indicate that antibacterial activity is sensitive to Cu and Ag while essentially remains unchanged within a wide range of Zr and Al. The proposed strategy not only facilitates development of high-performing alloys, but also provides a tool to unveil the composition dependence of properties in a highly parallel fashion, which helps the development of new materials by design. More... »

PAGES

26950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep26950

DOI

http://dx.doi.org/10.1038/srep26950

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022920064

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27230692


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Materials Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alloys", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aluminum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combinatorial Chemistry Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Copper", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glass", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Atomic Force", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Silver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zirconium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yanhui", 
        "id": "sg:person.013014771543.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013014771543.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Padmanabhan", 
        "givenName": "Jagannath", 
        "id": "sg:person.01206360636.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206360636.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheung", 
        "givenName": "Bettina", 
        "id": "sg:person.01324500623.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324500623.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jingbei", 
        "id": "sg:person.01262432721.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262432721.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Zheng", 
        "id": "sg:person.0575562303.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575562303.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physics, Southern Connecticut State University, 06515, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.263848.3", 
          "name": [
            "Department of Physics, Southern Connecticut State University, 06515, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scanley", 
        "givenName": "B. Ellen", 
        "id": "sg:person.01006137213.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006137213.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular, Cellular and Developmental Biology, Yale University, 06520, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular, Cellular and Developmental Biology, Yale University, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wesolowski", 
        "givenName": "Donna", 
        "id": "sg:person.01064424625.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064424625.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pressley", 
        "givenName": "Mariyah", 
        "id": "sg:person.0760124103.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760124103.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physics, Southern Connecticut State University, 06515, New Haven, Connecticut, USA", 
          "id": "http://www.grid.ac/institutes/grid.263848.3", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Physics, Southern Connecticut State University, 06515, New Haven, Connecticut, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broadbridge", 
        "givenName": "Christine C.", 
        "id": "sg:person.01026237303.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026237303.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular, Cellular and Developmental Biology, Yale University, 06520, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Molecular, Cellular and Developmental Biology, Yale University, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altman", 
        "givenName": "Sidney", 
        "id": "sg:person.01200653225.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200653225.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemical and Environmental Engineering, Yale University, 06520, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA", 
            "Department of Chemical and Environmental Engineering, Yale University, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwarz", 
        "givenName": "Udo D.", 
        "id": "sg:person.01043170137.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043170137.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yale University, 06520, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA", 
            "Department of Pathology, Yale University, 06520, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyriakides", 
        "givenName": "Themis R.", 
        "id": "sg:person.010477474237.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010477474237.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA", 
          "id": "http://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA", 
            "Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schroers", 
        "givenName": "Jan", 
        "id": "sg:person.01145527322.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145527322.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1557/s0883769400053252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067964161", 
          "https://doi.org/10.1557/s0883769400053252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms4238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009249502", 
          "https://doi.org/10.1038/ncomms4238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro3028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050020783", 
          "https://doi.org/10.1038/nrmicro3028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13404-015-0167-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003356527", 
          "https://doi.org/10.1007/s13404-015-0167-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1557/jmr.2006.0020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050874480", 
          "https://doi.org/10.1557/jmr.2006.0020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11837-005-0093-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022270993", 
          "https://doi.org/10.1007/s11837-005-0093-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat3939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026325779", 
          "https://doi.org/10.1038/nmat3939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11434-012-4997-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007575420", 
          "https://doi.org/10.1007/s11434-012-4997-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-010-2980-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049347985", 
          "https://doi.org/10.1007/s00253-010-2980-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms8043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039285401", 
          "https://doi.org/10.1038/ncomms8043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00253-013-5012-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025259582", 
          "https://doi.org/10.1007/s00253-013-5012-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018290838", 
          "https://doi.org/10.1038/nature07718"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-05-27", 
    "datePublishedReg": "2016-05-27", 
    "description": "Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategies to optimize compositions out of a vast phase space, making alloy development time consuming and labor intensive. Here, we challenge the conventional paradigm by proposing a combinatorial strategy that enables parallel screening of a multitude of alloys. Utilizing a typical metallic glass forming alloy system Zr-Cu-Al-Ag as an example, we demonstrate how glass formation and antibacterial activity, two unrelated properties, can be simultaneously characterized and the optimal composition can be efficiently identified. We found that in the Zr-Cu-Al-Ag alloy system fully glassy phase can be obtained in a wide compositional range by co-sputtering and antibacterial activity is strongly dependent on alloy compositions. Our results indicate that antibacterial activity is sensitive to Cu and Ag while essentially remains unchanged within a wide range of Zr and Al. The proposed strategy not only facilitates development of high-performing alloys, but also provides a tool to unveil the composition dependence of properties in a highly parallel fashion, which helps the development of new materials by design.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep26950", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2685979", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3127424", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "Zr\u2013Cu", 
      "metallic glasses", 
      "thin film metallic glasses", 
      "typical metallic glasses", 
      "multiple constituent elements", 
      "metallic alloys", 
      "vast phase space", 
      "alloy composition", 
      "alloy system", 
      "glassy phase", 
      "alloy", 
      "new materials", 
      "Al-Ag", 
      "optimal composition", 
      "technological applications", 
      "glass formation", 
      "combinatorial development", 
      "error approach", 
      "wide compositional range", 
      "glass", 
      "constituent elements", 
      "properties", 
      "composition dependence", 
      "phase space", 
      "compositional range", 
      "wide range", 
      "time consuming", 
      "Zr", 
      "range", 
      "materials", 
      "composition", 
      "design", 
      "antibacterial activity", 
      "applications", 
      "Cu", 
      "unrelated strategies", 
      "Ag", 
      "phase", 
      "consuming", 
      "unrelated properties", 
      "system", 
      "al", 
      "dependence", 
      "order", 
      "integration", 
      "elements", 
      "strategies", 
      "development", 
      "formation", 
      "results", 
      "example", 
      "conventional paradigm", 
      "approach", 
      "tool", 
      "parallel screening", 
      "space", 
      "parallel fashion", 
      "multitude", 
      "activity", 
      "fashion", 
      "combinatorial strategies", 
      "paradigm", 
      "development paradigm", 
      "plurality", 
      "screening", 
      "labor", 
      "trials", 
      "sequential trials"
    ], 
    "name": "Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses", 
    "pagination": "26950", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022920064"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep26950"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27230692"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep26950", 
      "https://app.dimensions.ai/details/publication/pub.1022920064"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_719.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep26950"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep26950'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep26950'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep26950'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep26950'


 

This table displays all metadata directly associated to this object as RDF triples.

322 TRIPLES      21 PREDICATES      116 URIs      96 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep26950 schema:about N0ad61b0d3bec4907b9b7b10f8e68fa1c
2 N2d540ea4361146499655a277e1420c23
3 N42c7723c9e04432e84206c3f629d4f6c
4 N6b1fcbfa6c52487fbbe3c73a6eb558eb
5 N6ff7ec3696614d41853466226e2426d7
6 N73cc1573b86b41e589badaa976cc1035
7 N7e49afd8bbea4d7ba9af83ba54f3ec41
8 N9aee3f2a93ad4fbdbbcd7ce545b5af94
9 Na5a6f9570e494ba78dc853452f9c8d8f
10 Nb76f4fdc610f4c319610777725000fa5
11 Nd9b669b1195649a288e8dce6e829947b
12 anzsrc-for:09
13 anzsrc-for:0912
14 schema:author N54b689c7d9f54176b257fb13c1f0bedb
15 schema:citation sg:pub.10.1007/s00253-010-2980-x
16 sg:pub.10.1007/s00253-013-5012-9
17 sg:pub.10.1007/s11434-012-4997-2
18 sg:pub.10.1007/s11837-005-0093-2
19 sg:pub.10.1007/s13404-015-0167-z
20 sg:pub.10.1038/nature07718
21 sg:pub.10.1038/ncomms4238
22 sg:pub.10.1038/ncomms8043
23 sg:pub.10.1038/nmat3939
24 sg:pub.10.1038/nrmicro3028
25 sg:pub.10.1557/jmr.2006.0020
26 sg:pub.10.1557/s0883769400053252
27 schema:datePublished 2016-05-27
28 schema:datePublishedReg 2016-05-27
29 schema:description Metallic alloys are normally composed of multiple constituent elements in order to achieve integration of a plurality of properties required in technological applications. However, conventional alloy development paradigm, by sequential trial-and-error approach, requires completely unrelated strategies to optimize compositions out of a vast phase space, making alloy development time consuming and labor intensive. Here, we challenge the conventional paradigm by proposing a combinatorial strategy that enables parallel screening of a multitude of alloys. Utilizing a typical metallic glass forming alloy system Zr-Cu-Al-Ag as an example, we demonstrate how glass formation and antibacterial activity, two unrelated properties, can be simultaneously characterized and the optimal composition can be efficiently identified. We found that in the Zr-Cu-Al-Ag alloy system fully glassy phase can be obtained in a wide compositional range by co-sputtering and antibacterial activity is strongly dependent on alloy compositions. Our results indicate that antibacterial activity is sensitive to Cu and Ag while essentially remains unchanged within a wide range of Zr and Al. The proposed strategy not only facilitates development of high-performing alloys, but also provides a tool to unveil the composition dependence of properties in a highly parallel fashion, which helps the development of new materials by design.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf N0e5fe722115b44c9850151cf04a695ad
33 N89db77bbd1b8448d8876725621f74a8b
34 sg:journal.1045337
35 schema:keywords Ag
36 Al-Ag
37 Cu
38 Zr
39 Zr–Cu
40 activity
41 al
42 alloy
43 alloy composition
44 alloy system
45 antibacterial activity
46 applications
47 approach
48 combinatorial development
49 combinatorial strategies
50 composition
51 composition dependence
52 compositional range
53 constituent elements
54 consuming
55 conventional paradigm
56 dependence
57 design
58 development
59 development paradigm
60 elements
61 error approach
62 example
63 fashion
64 formation
65 glass
66 glass formation
67 glassy phase
68 integration
69 labor
70 materials
71 metallic alloys
72 metallic glasses
73 multiple constituent elements
74 multitude
75 new materials
76 optimal composition
77 order
78 paradigm
79 parallel fashion
80 parallel screening
81 phase
82 phase space
83 plurality
84 properties
85 range
86 results
87 screening
88 sequential trials
89 space
90 strategies
91 system
92 technological applications
93 thin film metallic glasses
94 time consuming
95 tool
96 trials
97 typical metallic glasses
98 unrelated properties
99 unrelated strategies
100 vast phase space
101 wide compositional range
102 wide range
103 schema:name Combinatorial development of antibacterial Zr-Cu-Al-Ag thin film metallic glasses
104 schema:pagination 26950
105 schema:productId N2f2e6418702a44bc94d84d194d8332c8
106 Nb8c1240b59e046daa274790939089f5f
107 Ne714348dcaab4f95a848f39a3ccafc6f
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022920064
109 https://doi.org/10.1038/srep26950
110 schema:sdDatePublished 2022-10-01T06:42
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N1f2fd2d26b7e438faa6c1061a4d833c0
113 schema:url https://doi.org/10.1038/srep26950
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N0ad61b0d3bec4907b9b7b10f8e68fa1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Copper
119 rdf:type schema:DefinedTerm
120 N0e5fe722115b44c9850151cf04a695ad schema:volumeNumber 6
121 rdf:type schema:PublicationVolume
122 N1f2fd2d26b7e438faa6c1061a4d833c0 schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N274a7bb1f2724b778c1a9f651734fcb2 rdf:first sg:person.01026237303.34
125 rdf:rest N794fea2d9c3549dfb7a4a6a9c0e1fb23
126 N2d540ea4361146499655a277e1420c23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Microscopy, Atomic Force
128 rdf:type schema:DefinedTerm
129 N2f2e6418702a44bc94d84d194d8332c8 schema:name doi
130 schema:value 10.1038/srep26950
131 rdf:type schema:PropertyValue
132 N42c7723c9e04432e84206c3f629d4f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Anti-Bacterial Agents
134 rdf:type schema:DefinedTerm
135 N54b689c7d9f54176b257fb13c1f0bedb rdf:first sg:person.013014771543.17
136 rdf:rest N7e688ccd9806436999854e955d5f8363
137 N5c63c6f917a24de7ac3c5bd6677b489d rdf:first sg:person.010477474237.59
138 rdf:rest N5ee25a1c1ad34b8fb0e7e8da0d36b2c1
139 N5ee25a1c1ad34b8fb0e7e8da0d36b2c1 rdf:first sg:person.01145527322.19
140 rdf:rest rdf:nil
141 N5f85eba91e694a78b13ba30f1ea35d98 rdf:first sg:person.01064424625.43
142 rdf:rest N6089000fdcf344a2b2fc6da13476a90e
143 N6089000fdcf344a2b2fc6da13476a90e rdf:first sg:person.0760124103.20
144 rdf:rest N274a7bb1f2724b778c1a9f651734fcb2
145 N6b1fcbfa6c52487fbbe3c73a6eb558eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Combinatorial Chemistry Techniques
147 rdf:type schema:DefinedTerm
148 N6ff7ec3696614d41853466226e2426d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Silver
150 rdf:type schema:DefinedTerm
151 N73cc1573b86b41e589badaa976cc1035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Zirconium
153 rdf:type schema:DefinedTerm
154 N794fea2d9c3549dfb7a4a6a9c0e1fb23 rdf:first sg:person.01200653225.01
155 rdf:rest N7ced21996cec4ced96d1ffa5338b78cb
156 N7ced21996cec4ced96d1ffa5338b78cb rdf:first sg:person.01043170137.23
157 rdf:rest N5c63c6f917a24de7ac3c5bd6677b489d
158 N7e49afd8bbea4d7ba9af83ba54f3ec41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Escherichia coli
160 rdf:type schema:DefinedTerm
161 N7e688ccd9806436999854e955d5f8363 rdf:first sg:person.01206360636.53
162 rdf:rest Ncf7fa0bbdaae4771b1541b394bef5c34
163 N843bffcfd759476fbc9fbf5f8b482cd0 rdf:first sg:person.01006137213.29
164 rdf:rest N5f85eba91e694a78b13ba30f1ea35d98
165 N89db77bbd1b8448d8876725621f74a8b schema:issueNumber 1
166 rdf:type schema:PublicationIssue
167 N9aee3f2a93ad4fbdbbcd7ce545b5af94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Alloys
169 rdf:type schema:DefinedTerm
170 Na56eaed3d084413e99d67020935a789f rdf:first sg:person.0575562303.61
171 rdf:rest N843bffcfd759476fbc9fbf5f8b482cd0
172 Na5a6f9570e494ba78dc853452f9c8d8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Aluminum
174 rdf:type schema:DefinedTerm
175 Nb76f4fdc610f4c319610777725000fa5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Glass
177 rdf:type schema:DefinedTerm
178 Nb8c1240b59e046daa274790939089f5f schema:name dimensions_id
179 schema:value pub.1022920064
180 rdf:type schema:PropertyValue
181 Ncf7fa0bbdaae4771b1541b394bef5c34 rdf:first sg:person.01324500623.01
182 rdf:rest Nfe0aeaabbc6d49cab4f414557f2135af
183 Nd9b669b1195649a288e8dce6e829947b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Structure-Activity Relationship
185 rdf:type schema:DefinedTerm
186 Ne714348dcaab4f95a848f39a3ccafc6f schema:name pubmed_id
187 schema:value 27230692
188 rdf:type schema:PropertyValue
189 Nfe0aeaabbc6d49cab4f414557f2135af rdf:first sg:person.01262432721.25
190 rdf:rest Na56eaed3d084413e99d67020935a789f
191 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
192 schema:name Engineering
193 rdf:type schema:DefinedTerm
194 anzsrc-for:0912 schema:inDefinedTermSet anzsrc-for:
195 schema:name Materials Engineering
196 rdf:type schema:DefinedTerm
197 sg:grant.2685979 http://pending.schema.org/fundedItem sg:pub.10.1038/srep26950
198 rdf:type schema:MonetaryGrant
199 sg:grant.3127424 http://pending.schema.org/fundedItem sg:pub.10.1038/srep26950
200 rdf:type schema:MonetaryGrant
201 sg:journal.1045337 schema:issn 2045-2322
202 schema:name Scientific Reports
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.01006137213.29 schema:affiliation grid-institutes:grid.263848.3
206 schema:familyName Scanley
207 schema:givenName B. Ellen
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006137213.29
209 rdf:type schema:Person
210 sg:person.01026237303.34 schema:affiliation grid-institutes:grid.263848.3
211 schema:familyName Broadbridge
212 schema:givenName Christine C.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026237303.34
214 rdf:type schema:Person
215 sg:person.01043170137.23 schema:affiliation grid-institutes:grid.47100.32
216 schema:familyName Schwarz
217 schema:givenName Udo D.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043170137.23
219 rdf:type schema:Person
220 sg:person.010477474237.59 schema:affiliation grid-institutes:grid.47100.32
221 schema:familyName Kyriakides
222 schema:givenName Themis R.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010477474237.59
224 rdf:type schema:Person
225 sg:person.01064424625.43 schema:affiliation grid-institutes:grid.47100.32
226 schema:familyName Wesolowski
227 schema:givenName Donna
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064424625.43
229 rdf:type schema:Person
230 sg:person.01145527322.19 schema:affiliation grid-institutes:grid.47100.32
231 schema:familyName Schroers
232 schema:givenName Jan
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145527322.19
234 rdf:type schema:Person
235 sg:person.01200653225.01 schema:affiliation grid-institutes:grid.47100.32
236 schema:familyName Altman
237 schema:givenName Sidney
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200653225.01
239 rdf:type schema:Person
240 sg:person.01206360636.53 schema:affiliation grid-institutes:grid.47100.32
241 schema:familyName Padmanabhan
242 schema:givenName Jagannath
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206360636.53
244 rdf:type schema:Person
245 sg:person.01262432721.25 schema:affiliation grid-institutes:grid.47100.32
246 schema:familyName Liu
247 schema:givenName Jingbei
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262432721.25
249 rdf:type schema:Person
250 sg:person.013014771543.17 schema:affiliation grid-institutes:grid.47100.32
251 schema:familyName Liu
252 schema:givenName Yanhui
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013014771543.17
254 rdf:type schema:Person
255 sg:person.01324500623.01 schema:affiliation grid-institutes:grid.47100.32
256 schema:familyName Cheung
257 schema:givenName Bettina
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324500623.01
259 rdf:type schema:Person
260 sg:person.0575562303.61 schema:affiliation grid-institutes:grid.47100.32
261 schema:familyName Chen
262 schema:givenName Zheng
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575562303.61
264 rdf:type schema:Person
265 sg:person.0760124103.20 schema:affiliation grid-institutes:grid.47100.32
266 schema:familyName Pressley
267 schema:givenName Mariyah
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760124103.20
269 rdf:type schema:Person
270 sg:pub.10.1007/s00253-010-2980-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049347985
271 https://doi.org/10.1007/s00253-010-2980-x
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s00253-013-5012-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025259582
274 https://doi.org/10.1007/s00253-013-5012-9
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s11434-012-4997-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007575420
277 https://doi.org/10.1007/s11434-012-4997-2
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s11837-005-0093-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022270993
280 https://doi.org/10.1007/s11837-005-0093-2
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/s13404-015-0167-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1003356527
283 https://doi.org/10.1007/s13404-015-0167-z
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature07718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018290838
286 https://doi.org/10.1038/nature07718
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/ncomms4238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009249502
289 https://doi.org/10.1038/ncomms4238
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/ncomms8043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039285401
292 https://doi.org/10.1038/ncomms8043
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nmat3939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026325779
295 https://doi.org/10.1038/nmat3939
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nrmicro3028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050020783
298 https://doi.org/10.1038/nrmicro3028
299 rdf:type schema:CreativeWork
300 sg:pub.10.1557/jmr.2006.0020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050874480
301 https://doi.org/10.1557/jmr.2006.0020
302 rdf:type schema:CreativeWork
303 sg:pub.10.1557/s0883769400053252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067964161
304 https://doi.org/10.1557/s0883769400053252
305 rdf:type schema:CreativeWork
306 grid-institutes:grid.263848.3 schema:alternateName Department of Physics, Southern Connecticut State University, 06515, New Haven, Connecticut, USA
307 schema:name Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA
308 Department of Physics, Southern Connecticut State University, 06515, New Haven, Connecticut, USA
309 rdf:type schema:Organization
310 grid-institutes:grid.47100.32 schema:alternateName Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA
311 Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA
312 Department of Chemical and Environmental Engineering, Yale University, 06520, New Haven, CT, USA
313 Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA
314 Department of Molecular, Cellular and Developmental Biology, Yale University, 06520, New Haven, CT, USA
315 Department of Pathology, Yale University, 06520, New Haven, CT, USA
316 schema:name Center for Research on Interface Structures and Phenomena, Yale University, 06511, New Haven, CT, USA
317 Department of Biomedical Engineering, Yale University, 06511, New Haven, CT, USA
318 Department of Chemical and Environmental Engineering, Yale University, 06520, New Haven, CT, USA
319 Department of Mechanical Engineering and Materials Science, Yale University, 06511, New Haven, CT, USA
320 Department of Molecular, Cellular and Developmental Biology, Yale University, 06520, New Haven, CT, USA
321 Department of Pathology, Yale University, 06520, New Haven, CT, USA
322 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...