Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Po-Jen Chen, Yu-Ling Wang, Liang-Mou Kuo, Chwan-Fwu Lin, Chun-Yu Chen, Yung-Fong Tsai, Jiann-Jong Shen, Tsong-Long Hwang

ABSTRACT

Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation. Honokiol, isolated from the Chinese medicinal herb Magnolia officinalis, has various pharmacological activities, including anti-inflammatory effects, yet the nature of honokiol targeting molecules remains to be revealed. Here, we investigated the inhibitory effect of honokiol on neutrophil adhesion and vascular cell adhesion molecule-1 (VCAM-1) expression, which underlie its molecular target, and mechanisms for inactivating nuclear factor κ enhancer binding protein (NF-κB) in mouse cerebral ECs. Honokiol inhibited tumour necrosis factor-α (TNF-α)-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs. The inflammatory transcription factor NF-κB was downregulated by honokiol. Honokiol significantly blocked TNF-α-induced NF-κB p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-κB α (IκBα). From docking model prediction, honokiol directly targeted the ubiquitin-ubiquitin interface of Lys48-linked polychains. Moreover, honokiol prevented the TNF-α-induced Lys48-linked polyubiquitination, including IκBα-polyubiquitin interaction. Honokiol has protective anti-inflammatory effects on TNF-α-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs, at least in part by directly inhibiting ubiquitination-mediated IκBα degradation and then preventing NF-κB nuclear translocation. More... »

PAGES

26554

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep26554

DOI

http://dx.doi.org/10.1038/srep26554

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023573222

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27212040


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biphenyl Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lignans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-KappaB Inhibitor alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutrophils", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Cell Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Po-Jen", 
        "id": "sg:person.01035300277.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035300277.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yu-Ling", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuo", 
        "givenName": "Liang-Mou", 
        "id": "sg:person.01046423661.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046423661.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.418428.3", 
          "name": [
            "Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Chwan-Fwu", 
        "id": "sg:person.0610443422.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610443422.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Chun-Yu", 
        "id": "sg:person.0774020065.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774020065.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsai", 
        "givenName": "Yung-Fong", 
        "id": "sg:person.01073601217.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073601217.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Jiann-Jong", 
        "id": "sg:person.0744402553.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744402553.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.418428.3", 
          "name": [
            "Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan.", 
            "Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.", 
            "Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Tsong-Long", 
        "id": "sg:person.0677042006.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677042006.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.intimp.2013.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003085127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-06-0076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003804404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003970107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003970107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.200717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003970107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000056110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006667711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m309778200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007848589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009453492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-7843.2007.00082.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010415181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/123.4.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010969110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2003.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011190635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2009.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011361036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2012.01098.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011522973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012611716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2004.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013180908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0018490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015296891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11418-011-0623-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016087613", 
          "https://doi.org/10.1007/s11418-011-0623-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2015.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017008958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1314715110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017407127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2012.11.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018641134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.00477.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019099753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2003.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2003.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019613048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2006.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020488515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2013.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021502352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022621132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024333612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(98)01346-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024384699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m302967200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026644442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/mol.64.6.1419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027664872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.acthis.2013.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027955579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2014.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028579342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m504943200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029715667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.22954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030141903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2011.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031176068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-2094-10-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032387183", 
          "https://doi.org/10.1186/1742-2094-10-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199108153250704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032424519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(02)00128-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033196542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(02)00128-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033196542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2005.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033344457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2005.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033344457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s090744490001800x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033941549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2013.00127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034948968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/not222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037447004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2011.01066.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038585825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039392351", 
          "https://doi.org/10.1038/ni1275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039392351", 
          "https://doi.org/10.1038/ni1275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0060749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039464896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.11.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039542068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0710432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040085430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2009.00811.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040820199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2009.00811.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040820199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/brs.0000000000000758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042373525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/brs.0000000000000758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042373525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.22577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042760197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.11-183772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044407280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2008.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046523575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(03)02121-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046869134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(03)02121-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046869134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-0333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047630539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pt.2012.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049910171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2013.01.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051351437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1439-0434.2008.01507.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051496793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biophys-083012-130338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051680172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2008.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052335867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci049714+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055401846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ci049714+", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055401846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2009.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059230983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1100946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062450845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156652412803833508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069186303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0256-4947.83217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072238596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076021108", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1202215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078728897"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-09", 
    "datePublishedReg": "2016-09-01", 
    "description": "Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation. Honokiol, isolated from the Chinese medicinal herb Magnolia officinalis, has various pharmacological activities, including anti-inflammatory effects, yet the nature of honokiol targeting molecules remains to be revealed. Here, we investigated the inhibitory effect of honokiol on neutrophil adhesion and vascular cell adhesion molecule-1 (VCAM-1) expression, which underlie its molecular target, and mechanisms for inactivating nuclear factor \u03ba enhancer binding protein (NF-\u03baB) in mouse cerebral ECs. Honokiol inhibited tumour necrosis factor-\u03b1 (TNF-\u03b1)-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs. The inflammatory transcription factor NF-\u03baB was downregulated by honokiol. Honokiol significantly blocked TNF-\u03b1-induced NF-\u03baB p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-\u03baB \u03b1 (I\u03baB\u03b1). From docking model prediction, honokiol directly targeted the ubiquitin-ubiquitin interface of Lys48-linked polychains. Moreover, honokiol prevented the TNF-\u03b1-induced Lys48-linked polyubiquitination, including I\u03baB\u03b1-polyubiquitin interaction. Honokiol has protective anti-inflammatory effects on TNF-\u03b1-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs, at least in part by directly inhibiting ubiquitination-mediated I\u03baB\u03b1 degradation and then preventing NF-\u03baB nuclear translocation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep26554", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Honokiol suppresses TNF-\u03b1-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of I\u03baB\u03b1", 
    "pagination": "26554", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "704f5e538c2774e41523fa1c3c0b8f5db446da475d690054a60b09fd40fed83e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27212040"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep26554"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023573222"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep26554", 
      "https://app.dimensions.ai/details/publication/pub.1023573222"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/160523/srep26554/full/srep26554.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep26554'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep26554'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep26554'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep26554'


 

This table displays all metadata directly associated to this object as RDF triples.

384 TRIPLES      21 PREDICATES      109 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep26554 schema:about N0450249248424d1b944f960a0e27e7f5
2 N0dacdf29f9bb4c0e9189fa3f0773adb4
3 N151dcbd2ed3b4f649f094430a1b8662e
4 N18bdb904dfd342e88b878026834bd5f9
5 N260cb8019f634a80ab14e59b1f4841fc
6 N29985ee11d374a0388d09d6a29aa0354
7 N387fde1df7d044f396b5a5156fc8f4f7
8 N3c7d2386eca94e55a4d2aa198323b660
9 N45557af232404c16a231973cf953dd9b
10 N45c34c7ea0cf4501bfe204be4b5db5b2
11 N7951f063211c4a76971868627d6340a5
12 N7cae55a1a72f49f09358699dfa171eb6
13 N8108a9c23b844e39865c537eb2b3c979
14 Nb2fd9065c1334ccc86e7ee45f5a89ebc
15 Nb32ffe06140f49319c23543086e94f9d
16 Nf2733768436947168e091f7dd6585eaa
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author N9f422924a04a494ab358529796e34445
20 schema:citation sg:pub.10.1007/s11418-011-0623-x
21 sg:pub.10.1038/ni1275
22 sg:pub.10.1186/1742-2094-10-15
23 https://app.dimensions.ai/details/publication/pub.1076021108
24 https://doi.org/10.1002/jcc.20084
25 https://doi.org/10.1002/jcp.22954
26 https://doi.org/10.1002/jor.22577
27 https://doi.org/10.1016/j.acthis.2013.11.005
28 https://doi.org/10.1016/j.autrev.2003.09.006
29 https://doi.org/10.1016/j.bbamcr.2013.03.011
30 https://doi.org/10.1016/j.bcp.2005.08.011
31 https://doi.org/10.1016/j.biopha.2015.01.007
32 https://doi.org/10.1016/j.brainres.2003.08.026
33 https://doi.org/10.1016/j.cell.2008.01.020
34 https://doi.org/10.1016/j.expneurol.2014.04.006
35 https://doi.org/10.1016/j.freeradbiomed.2008.11.014
36 https://doi.org/10.1016/j.freeradbiomed.2011.03.026
37 https://doi.org/10.1016/j.ijpharm.2013.01.049
38 https://doi.org/10.1016/j.immuni.2008.12.020
39 https://doi.org/10.1016/j.intimp.2013.11.010
40 https://doi.org/10.1016/j.it.2006.09.003
41 https://doi.org/10.1016/j.molcel.2009.10.002
42 https://doi.org/10.1016/j.molcel.2009.11.029
43 https://doi.org/10.1016/j.nbd.2009.07.030
44 https://doi.org/10.1016/j.neulet.2012.11.052
45 https://doi.org/10.1016/j.pt.2012.05.008
46 https://doi.org/10.1016/j.tcb.2012.04.001
47 https://doi.org/10.1016/j.tibs.2004.11.001
48 https://doi.org/10.1016/s0014-2999(03)02121-6
49 https://doi.org/10.1016/s0301-0082(02)00128-4
50 https://doi.org/10.1016/s0962-8924(98)01346-4
51 https://doi.org/10.1021/ci049714+
52 https://doi.org/10.1056/nejm199108153250704
53 https://doi.org/10.1073/pnas.1314715110
54 https://doi.org/10.1074/jbc.m302967200
55 https://doi.org/10.1074/jbc.m309778200
56 https://doi.org/10.1074/jbc.m504943200
57 https://doi.org/10.1089/ars.2009.2440
58 https://doi.org/10.1093/brain/123.4.687
59 https://doi.org/10.1093/nar/gkr366
60 https://doi.org/10.1093/neuonc/not222
61 https://doi.org/10.1096/fj.11-183772
62 https://doi.org/10.1097/brs.0000000000000758
63 https://doi.org/10.1107/s090744490001800x
64 https://doi.org/10.1111/j.1439-0434.2008.01507.x
65 https://doi.org/10.1111/j.1582-4934.2009.00811.x
66 https://doi.org/10.1111/j.1600-065x.2011.01066.x
67 https://doi.org/10.1111/j.1600-065x.2012.01098.x
68 https://doi.org/10.1111/j.1742-7843.2007.00082.x
69 https://doi.org/10.1124/mol.64.6.1419
70 https://doi.org/10.1126/science.1100946
71 https://doi.org/10.1146/annurev-biophys-083012-130338
72 https://doi.org/10.1152/ajplung.00477.2005
73 https://doi.org/10.1158/1078-0432.ccr-10-0333
74 https://doi.org/10.1158/1541-7786.mcr-06-0076
75 https://doi.org/10.1159/000056110
76 https://doi.org/10.1161/circresaha.109.200717
77 https://doi.org/10.1189/jlb.0710432
78 https://doi.org/10.1371/journal.pone.0018490
79 https://doi.org/10.1371/journal.pone.0060749
80 https://doi.org/10.2174/156652412803833508
81 https://doi.org/10.3389/fphar.2013.00127
82 https://doi.org/10.4049/jimmunol.1202215
83 https://doi.org/10.4103/0256-4947.83217
84 schema:datePublished 2016-09
85 schema:datePublishedReg 2016-09-01
86 schema:description Adhesion molecules expressed on cerebral endothelial cells (ECs) mediate leukocyte recruitment and play a significant role in cerebral inflammation. Increased levels of adhesion molecules on the EC surface induce leukocyte infiltration into inflammatory areas and are thus hallmarkers of inflammation. Honokiol, isolated from the Chinese medicinal herb Magnolia officinalis, has various pharmacological activities, including anti-inflammatory effects, yet the nature of honokiol targeting molecules remains to be revealed. Here, we investigated the inhibitory effect of honokiol on neutrophil adhesion and vascular cell adhesion molecule-1 (VCAM-1) expression, which underlie its molecular target, and mechanisms for inactivating nuclear factor κ enhancer binding protein (NF-κB) in mouse cerebral ECs. Honokiol inhibited tumour necrosis factor-α (TNF-α)-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs. The inflammatory transcription factor NF-κB was downregulated by honokiol. Honokiol significantly blocked TNF-α-induced NF-κB p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-κB α (IκBα). From docking model prediction, honokiol directly targeted the ubiquitin-ubiquitin interface of Lys48-linked polychains. Moreover, honokiol prevented the TNF-α-induced Lys48-linked polyubiquitination, including IκBα-polyubiquitin interaction. Honokiol has protective anti-inflammatory effects on TNF-α-induced neutrophil adhesion and VCAM-1 gene expression in cerebral ECs, at least in part by directly inhibiting ubiquitination-mediated IκBα degradation and then preventing NF-κB nuclear translocation.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree true
90 schema:isPartOf N2870e34c6fb642a3a985b0e576c13c87
91 N79d6a46f69794dbdabae18c4edff5a8c
92 sg:journal.1045337
93 schema:name Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα
94 schema:pagination 26554
95 schema:productId N1e6b531ade8b49a79d2d58f843c721c2
96 N223a1a7d084047e7924a1eba4330fe1f
97 N2984dad9154544b3b69b76a4f779f7ed
98 N40b8cb5ea372433ead67baba21380904
99 Nfd11a86dcdb4492aad97bf844a6315fb
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023573222
101 https://doi.org/10.1038/srep26554
102 schema:sdDatePublished 2019-04-10T14:16
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nc4de670f7dd14bd5be1c343da7681f43
105 schema:url http://www.nature.com/srep/2016/160523/srep26554/full/srep26554.html
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N0450249248424d1b944f960a0e27e7f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Mice
111 rdf:type schema:DefinedTerm
112 N0dacdf29f9bb4c0e9189fa3f0773adb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name NF-KappaB Inhibitor alpha
114 rdf:type schema:DefinedTerm
115 N151dcbd2ed3b4f649f094430a1b8662e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Animals
117 rdf:type schema:DefinedTerm
118 N18bdb904dfd342e88b878026834bd5f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Adhesion
120 rdf:type schema:DefinedTerm
121 N1e6b531ade8b49a79d2d58f843c721c2 schema:name dimensions_id
122 schema:value pub.1023573222
123 rdf:type schema:PropertyValue
124 N223a1a7d084047e7924a1eba4330fe1f schema:name nlm_unique_id
125 schema:value 101563288
126 rdf:type schema:PropertyValue
127 N260cb8019f634a80ab14e59b1f4841fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Lignans
129 rdf:type schema:DefinedTerm
130 N2870e34c6fb642a3a985b0e576c13c87 schema:issueNumber 1
131 rdf:type schema:PublicationIssue
132 N2984dad9154544b3b69b76a4f779f7ed schema:name doi
133 schema:value 10.1038/srep26554
134 rdf:type schema:PropertyValue
135 N29985ee11d374a0388d09d6a29aa0354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Neutrophils
137 rdf:type schema:DefinedTerm
138 N325422bdd4e34a08a3339f14873163e1 rdf:first sg:person.01073601217.23
139 rdf:rest Nc71b80b7fe80496eb532203940e889e4
140 N387fde1df7d044f396b5a5156fc8f4f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Proteolysis
142 rdf:type schema:DefinedTerm
143 N3c7d2386eca94e55a4d2aa198323b660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression Regulation
145 rdf:type schema:DefinedTerm
146 N40b8cb5ea372433ead67baba21380904 schema:name readcube_id
147 schema:value 704f5e538c2774e41523fa1c3c0b8f5db446da475d690054a60b09fd40fed83e
148 rdf:type schema:PropertyValue
149 N45557af232404c16a231973cf953dd9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cells, Cultured
151 rdf:type schema:DefinedTerm
152 N45c34c7ea0cf4501bfe204be4b5db5b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Ubiquitination
154 rdf:type schema:DefinedTerm
155 N500069180c2c41e480aaa37f57f0c26a schema:affiliation https://www.grid.ac/institutes/grid.145695.a
156 schema:familyName Wang
157 schema:givenName Yu-Ling
158 rdf:type schema:Person
159 N7951f063211c4a76971868627d6340a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Biphenyl Compounds
161 rdf:type schema:DefinedTerm
162 N79d6a46f69794dbdabae18c4edff5a8c schema:volumeNumber 6
163 rdf:type schema:PublicationVolume
164 N7cae55a1a72f49f09358699dfa171eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 N8108a9c23b844e39865c537eb2b3c979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Vascular Cell Adhesion Molecule-1
169 rdf:type schema:DefinedTerm
170 N8a56e92d92164e5cba0e44baa25236be rdf:first sg:person.0774020065.33
171 rdf:rest N325422bdd4e34a08a3339f14873163e1
172 N9f422924a04a494ab358529796e34445 rdf:first sg:person.01035300277.92
173 rdf:rest Nf8bd8a8d161142b5b08067ad5340396e
174 Na7640ce4ae1d458ba244d8e1c1d2b933 rdf:first sg:person.0610443422.61
175 rdf:rest N8a56e92d92164e5cba0e44baa25236be
176 Nb2fd9065c1334ccc86e7ee45f5a89ebc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Endothelial Cells
178 rdf:type schema:DefinedTerm
179 Nb32ffe06140f49319c23543086e94f9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Brain
181 rdf:type schema:DefinedTerm
182 Nc1867c6c231a48e18201b0c402ef78f6 rdf:first sg:person.01046423661.19
183 rdf:rest Na7640ce4ae1d458ba244d8e1c1d2b933
184 Nc4de670f7dd14bd5be1c343da7681f43 schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 Nc71b80b7fe80496eb532203940e889e4 rdf:first sg:person.0744402553.80
187 rdf:rest Nfeecadc6258a4ccc8e5e764925318c88
188 Nf2733768436947168e091f7dd6585eaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Tumor Necrosis Factor-alpha
190 rdf:type schema:DefinedTerm
191 Nf8bd8a8d161142b5b08067ad5340396e rdf:first N500069180c2c41e480aaa37f57f0c26a
192 rdf:rest Nc1867c6c231a48e18201b0c402ef78f6
193 Nfd11a86dcdb4492aad97bf844a6315fb schema:name pubmed_id
194 schema:value 27212040
195 rdf:type schema:PropertyValue
196 Nfeecadc6258a4ccc8e5e764925318c88 rdf:first sg:person.0677042006.14
197 rdf:rest rdf:nil
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
202 schema:name Immunology
203 rdf:type schema:DefinedTerm
204 sg:journal.1045337 schema:issn 2045-2322
205 schema:name Scientific Reports
206 rdf:type schema:Periodical
207 sg:person.01035300277.92 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
208 schema:familyName Chen
209 schema:givenName Po-Jen
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035300277.92
211 rdf:type schema:Person
212 sg:person.01046423661.19 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
213 schema:familyName Kuo
214 schema:givenName Liang-Mou
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046423661.19
216 rdf:type schema:Person
217 sg:person.01073601217.23 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
218 schema:familyName Tsai
219 schema:givenName Yung-Fong
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073601217.23
221 rdf:type schema:Person
222 sg:person.0610443422.61 schema:affiliation https://www.grid.ac/institutes/grid.418428.3
223 schema:familyName Lin
224 schema:givenName Chwan-Fwu
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610443422.61
226 rdf:type schema:Person
227 sg:person.0677042006.14 schema:affiliation https://www.grid.ac/institutes/grid.418428.3
228 schema:familyName Hwang
229 schema:givenName Tsong-Long
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677042006.14
231 rdf:type schema:Person
232 sg:person.0744402553.80 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
233 schema:familyName Shen
234 schema:givenName Jiann-Jong
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744402553.80
236 rdf:type schema:Person
237 sg:person.0774020065.33 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
238 schema:familyName Chen
239 schema:givenName Chun-Yu
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774020065.33
241 rdf:type schema:Person
242 sg:pub.10.1007/s11418-011-0623-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016087613
243 https://doi.org/10.1007/s11418-011-0623-x
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ni1275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039392351
246 https://doi.org/10.1038/ni1275
247 rdf:type schema:CreativeWork
248 sg:pub.10.1186/1742-2094-10-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032387183
249 https://doi.org/10.1186/1742-2094-10-15
250 rdf:type schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1076021108 schema:CreativeWork
252 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/jcp.22954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030141903
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/jor.22577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042760197
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.acthis.2013.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027955579
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.autrev.2003.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011190635
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.bbamcr.2013.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021502352
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.bcp.2005.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033344457
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.biopha.2015.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017008958
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.brainres.2003.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019613048
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.cell.2008.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009453492
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.expneurol.2014.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028579342
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.freeradbiomed.2008.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046523575
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.freeradbiomed.2011.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031176068
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.ijpharm.2013.01.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051351437
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.immuni.2008.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052335867
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.intimp.2013.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003085127
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.it.2006.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020488515
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.molcel.2009.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012611716
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.molcel.2009.11.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039542068
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.nbd.2009.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011361036
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.neulet.2012.11.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018641134
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.pt.2012.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049910171
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.tcb.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022621132
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.tibs.2004.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013180908
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/s0014-2999(03)02121-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046869134
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s0301-0082(02)00128-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033196542
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/s0962-8924(98)01346-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024384699
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1021/ci049714+ schema:sameAs https://app.dimensions.ai/details/publication/pub.1055401846
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1056/nejm199108153250704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032424519
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1073/pnas.1314715110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017407127
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1074/jbc.m302967200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026644442
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1074/jbc.m309778200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007848589
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1074/jbc.m504943200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029715667
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1089/ars.2009.2440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059230983
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1093/brain/123.4.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010969110
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1093/nar/gkr366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024333612
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1093/neuonc/not222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037447004
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1096/fj.11-183772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044407280
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1097/brs.0000000000000758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042373525
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1107/s090744490001800x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033941549
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1111/j.1439-0434.2008.01507.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051496793
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1111/j.1582-4934.2009.00811.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040820199
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1111/j.1600-065x.2011.01066.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038585825
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1111/j.1600-065x.2012.01098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011522973
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1111/j.1742-7843.2007.00082.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010415181
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1124/mol.64.6.1419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027664872
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1126/science.1100946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062450845
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1146/annurev-biophys-083012-130338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051680172
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1152/ajplung.00477.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019099753
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1158/1078-0432.ccr-10-0333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047630539
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1158/1541-7786.mcr-06-0076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003804404
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1159/000056110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006667711
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1161/circresaha.109.200717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003970107
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1189/jlb.0710432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040085430
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1371/journal.pone.0018490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015296891
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pone.0060749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039464896
363 rdf:type schema:CreativeWork
364 https://doi.org/10.2174/156652412803833508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069186303
365 rdf:type schema:CreativeWork
366 https://doi.org/10.3389/fphar.2013.00127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034948968
367 rdf:type schema:CreativeWork
368 https://doi.org/10.4049/jimmunol.1202215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078728897
369 rdf:type schema:CreativeWork
370 https://doi.org/10.4103/0256-4947.83217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072238596
371 rdf:type schema:CreativeWork
372 https://www.grid.ac/institutes/grid.145695.a schema:alternateName Chang Gung University
373 schema:name Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan.
374 Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
375 Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
376 Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
377 Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.418428.3 schema:alternateName Chang Gung University of Science and Technology
380 schema:name Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan.
381 Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
382 Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
383 Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.
384 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...