RNAi down-regulation of cinnamate-4-hydroxylase increases artemisinin biosynthesis in Artemisia annua View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-25

AUTHORS

Ritesh Kumar, Divya Vashisth, Amita Misra, Qussen Akhtar, Syed Uzma Jalil, Karuna Shanker, Madan Mohan Gupta, Prashant Kumar Rout, Anil Kumar Gupta, Ajit Kumar Shasany

ABSTRACT

Cinnamate-4-hydroxylase (C4H) converts trans-cinnamic acid (CA) to p-coumaric acid (COA) in the phenylpropanoid/lignin biosynthesis pathway. Earlier we reported increased expression of AaCYP71AV1 (an important gene of artemisinin biosynthesis pathway) caused by CA treatment in Artemisia annua. Hence, AaC4H gene was identified, cloned, characterized and silenced in A. annua with the assumption that the elevated internal CA due to knock down may increase the artemisinin yield. Accumulation of trans-cinnamic acid in the plant due to AaC4H knockdown was accompanied with the reduction of p-coumaric acid, total phenolics, anthocyanin, cinnamate-4-hydroxylase (C4H) and phenylalanine ammonia lyase (PAL) activities but increase in salicylic acid (SA) and artemisinin. Interestingly, feeding trans-cinnamic acid to the RNAi line increased the level of artemisinin along with benzoic (BA) and SA with no effect on the downstream metabolites p-coumaric acid, coniferylaldehyde and sinapaldehyde, whereas p-coumaric acid feeding increased the content of downstream coniferylaldehyde and sinapaldehyde with no effect on BA, SA, trans-cinnamic acid or artemisinin. SA is reported earlier to be inducing the artemisinin yield. This report demonstrates the link between the phenylpropanoid/lignin pathway with artemisinin pathway through SA, triggered by accumulation of trans-cinnamic acid because of the blockage at C4H. More... »

PAGES

26458

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep26458

DOI

http://dx.doi.org/10.1038/srep26458

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007244150

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27220407


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74 levels of artemisinin
75 lignin biosynthesis pathway
76 lignin pathway
77 lines
78 link
79 lyase activity
80 pathway
81 phenolics
82 phenylalanine ammonia-lyase activity
83 phenylpropanoid/lignin biosynthesis pathway
84 phenylpropanoid/lignin pathway
85 plants
86 reduction
87 regulation
88 report
89 salicylic acid
90 sinapaldehyde
91 total phenolics
92 trans-cinnamic acid
93 treatment
94 yield
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