Elongator Protein 3 (Elp3) stabilizes Snail1 and regulates neural crest migration in Xenopus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Xiangcai Yang, Jiejing Li, Wanli Zeng, Chaocui Li, Bingyu Mao

ABSTRACT

Elongator protein 3 (Elp3) is the enzymatic unit of the elongator protein complex, a histone acetyltransferase complex involved in transcriptional elongation. It has long been shown to play an important role in cell migration; however, the underlying mechanism is unknown. Here, we showed that Elp3 is expressed in pre-migratory and migrating neural crest cells in Xenopus embryos, and knockdown of Elp3 inhibited neural crest cell migration. Interestingly, Elp3 binds Snail1 through its zinc-finger domain and inhibits its ubiquitination by β-Trcp without interfering with the Snail1/Trcp interaction. We showed evidence that Elp3-mediated stabilization of Snail1 was likely involved in the activation of N-cadherin in neural crest cells to regulate their migratory ability. Our findings provide a new mechanism for the function of Elp3 in cell migration through stabilizing Snail1, a master regulator of cell motility. More... »

PAGES

26238

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep26238

DOI

http://dx.doi.org/10.1038/srep26238

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007187083

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27189455


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