Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA View Full Text


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Article Info

DATE

2016-07

AUTHORS

Vanesa Álvarez, Laura Viñas, Alfonso Gallego-Sánchez, Sonia Andrés, María P Sacristán, Avelino Bueno

ABSTRACT

Proliferating-cell nuclear antigen (PCNA) is a DNA sliding clamp with an essential function in DNA replication and a key role in tolerance to DNA damage by ensuring the bypass of lesions. In eukaryotes, DNA damage tolerance is regulated by ubiquitylation of lysine 164 of PCNA through a well-known control mechanism; however, the regulation of PCNA deubiquitylation remains poorly understood. Our work is a systematic and functional study on PCNA deubiquitylating enzymes (DUBs) in Schizosaccharomyces pombe. Our study reveals that the deubiquitylation of PCNA in fission yeast cells is a complex process that requires several ubiquitin proteases dedicated to the deubiquitylation of a specific subnuclear fraction of mono- and di-ubiquitylated PCNA or a particular type of poly-ubiquitylated PCNA and that there is little redundancy among these enzymes. To understand how DUB activity regulates the oscillatory pattern of ubiquitylated PCNA in fission yeast, we assembled multiple DUB mutants and found that a quadruple mutation of ubp2(+), ubp12(+), ubp15(+), and ubp16(+) leads to the stable accumulation of mono-, di-, and poly-ubiquitylated forms of PCNA, increases S-phase duration, and sensitizes cells to DNA damage. Our data suggest that the dynamic ubiquitylation and deubiquitylation of PCNA occurs during S-phase to ensure processive DNA replication. More... »

PAGES

25513

References to SciGraph publications

  • 2012-10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass in NATURE CELL BIOLOGY
  • 2013-08. Readers of PCNA modifications in CHROMOSOMA
  • 1981-12. Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations in MOLECULAR GENETICS AND GENOMICS
  • 2002-09. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO in NATURE
  • 2014-10. Visualization of recombination-mediated damage bypass by template switching in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2015-02. K63 polyubiquitination is a new modulator of the oxidative stress response in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-06. Ubiquitin-dependent DNA damage bypass is separable from genome replication in NATURE
  • 2003-09. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation in NATURE
  • 2008-01. Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA in CELL RESEARCH
  • 2013-12. Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells in NATURE COMMUNICATIONS
  • 2010-03. Maintaining genome stability at the replication fork in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-03-26. Principles of ubiquitin and SUMO modifications in DNA repair in NATURE
  • 2009-02. DNA damage tolerance: when it's OK to make mistakes in NATURE CHEMICAL BIOLOGY
  • 2012-11. DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-04. Regulation of DNA repair throughout the cell cycle in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-05. Regulation of PCNA–protein interactions for genome stability in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-04. Regulation of monoubiquitinated PCNA by DUB autocleavage in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep25513

    DOI

    http://dx.doi.org/10.1038/srep25513

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034315537

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27151298


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