Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Riccardo Giampieri, Lisa Salvatore, Michela Del Prete, Tiziana Prochilo, Marco D'Anzeo, Cristian Loretelli, Fotios Loupakis, Giuseppe Aprile, Elena Maccaroni, Kalliopi Andrikou, Maristella Bianconi, Alessandro Bittoni, Luca Faloppi, Laura Demurtas, Rodolfo Montironi, Marina Scarpelli, Alfredo Falcone, Alberto Zaniboni, Mario Scartozzi, Stefano Cascinu

ABSTRACT

Regorafenib monotherapy is a potential option for metastatic colorectal cancer patients. However, the lack of predictive factors and the severe toxicities related to treatment have made its use in clinical practice challenging. Polymorphisms of VEGF and its receptor (VEGFR) genes might regulate angiogenesis and thus potentially influence outcome during anti-angiogenesis treatment such as regorafenib. Aim of our study was to evaluate the role of VEGF and VEGFR genotyping in determining clinical outcome for colorectal cancer patients receiving regorafenib. We retrospectively collected clinical data and samples (tumour or blood) of 138 metastatic colorectal cancer patients treated with regorafenib. We analysed the correlation of different VEGF-A, VEGF-C and VEGFR-1,2,3 single nucleotide polymorphisms (SNPs) with patients' progression-free survival (PFS) and overall survival (OS). Results from angiogenesis genotyping showed that only VEGF-A rs2010963 maintained an independent correlation with PFS and OS. Among clinical factors only ECOG PS was independently correlated with OS, whereas no correlation with PFS was evident. Grouping together those results allowed further patients stratification into 3 prognostic groups: favourable, intermediate and unfavourable. VEGF-A rs2010963 genotyping may represent an important tool for a more accurate selection of optimal candidates for regorafenib therapy. More... »

PAGES

25195

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep25195

DOI

http://dx.doi.org/10.1038/srep25195

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037296765

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27117754


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