A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04-27

AUTHORS

Raphaële Castagné, Cyrille Delpierre, Michelle Kelly-Irving, Gianluca Campanella, Florence Guida, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Soterios Kyrtopoulos, Fatemeh Saberi Hosnijeh, Thierry Lang, Roel Vermeulen, Paolo Vineis, Silvia Stringhini, Marc Chadeau-Hyam

ABSTRACT

Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002), and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course. More... »

PAGES

25170

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep25170

DOI

http://dx.doi.org/10.1038/srep25170

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050605593

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27117519


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21 schema:description Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002), and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father's occupation and the highest household occupation, revealing a significant difference between "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.
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29 European Prospective Investigation
30 Italian component
31 Nutrition Cohort
32 Prospective Investigation
33 SEP experiences
34 SEP indicators
35 adult inflammatory burden
36 adulthood
37 adulthood SEP
38 analysis
39 array
40 association
41 biological embedding
42 blood-derived inflammation profiles
43 burden
44 cancer
45 childhood
46 cohort
47 combination
48 components
49 consequences
50 course
51 differences
52 different points
53 early life
54 effect
55 embedding
56 experience
57 father's occupation
58 fathers
59 health
60 highest household occupation
61 household occupation
62 increase
63 indicators
64 inflammation markers
65 inflammation profile
66 inflammatory burden
67 inflammatory markers
68 inflammatory score
69 interaction
70 investigation
71 levels
72 life
73 life course
74 low SEP
75 low socioeconomic position
76 manual occupations
77 markers
78 mobility
79 modest increase
80 multiplex array
81 occupation
82 participants
83 plasma levels
84 point
85 poor health
86 position
87 potential biological embedding
88 profile
89 scores
90 significant differences
91 social mobility
92 socioeconomic position
93 strong effect
94 upward social mobility
95 young adulthood
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