Activation of endothelial β-catenin signaling induces heart failure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Akito Nakagawa, Atsuhiko T Naito, Tomokazu Sumida, Seitaro Nomura, Masato Shibamoto, Tomoaki Higo, Katsuki Okada, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Toru Oka, Jong-Kook Lee, Mutsuo Harada, Kazutaka Ueda, Ichiro Shiojima, Florian P Limbourg, Ralf H Adams, Tetsuo Noda, Yasushi Sakata, Hiroshi Akazawa, Issei Komuro

ABSTRACT

Activation of β-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/β-catenin signaling in endothelial cells remain poorly understood. Here, we report that sustained activation of β-catenin signaling in endothelial cells causes cardiac dysfunction through suppressing neuregulin-ErbB pathway in the heart. Conditional gain-of-function mutation of β-catenin, which activates Wnt/β-catenin signaling in Bmx-positive arterial endothelial cells (Bmx/CA mice) led to progressive cardiac dysfunction and 100% mortality at 40 weeks after tamoxifen treatment. Electron microscopic analysis revealed dilatation of T-tubules and degeneration of mitochondria in cardiomyocytes of Bmx/CA mice, which are similar to the changes observed in mice with decreased neuregulin-ErbB signaling. Endothelial expression of Nrg1 and cardiac ErbB signaling were suppressed in Bmx/CA mice. The cardiac dysfunction of Bmx/CA mice was ameliorated by administration of recombinant neuregulin protein. These results collectively suggest that sustained activation of Wnt/β-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling, and that the Wnt/β-catenin/NRG axis in cardiac endothelial cells might become a therapeutic target for heart failure. More... »

PAGES

25009

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep25009

DOI

http://dx.doi.org/10.1038/srep25009

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019597074

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27146149


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuregulin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Signaling Pathway", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakagawa", 
        "givenName": "Akito", 
        "id": "sg:person.01341065751.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341065751.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.", 
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.", 
            "Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan.", 
            "Department of Cardiovascular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naito", 
        "givenName": "Atsuhiko T", 
        "id": "sg:person.01305773146.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305773146.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Agency for Medical Research and Development", 
          "id": "https://www.grid.ac/institutes/grid.480536.c", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.", 
            "Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sumida", 
        "givenName": "Tomokazu", 
        "id": "sg:person.01110410751.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110410751.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomura", 
        "givenName": "Seitaro", 
        "id": "sg:person.01156524151.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156524151.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibamoto", 
        "givenName": "Masato", 
        "id": "sg:person.0757071411.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757071411.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higo", 
        "givenName": "Tomoaki", 
        "id": "sg:person.01272752551.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272752551.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Katsuki", 
        "id": "sg:person.01217362357.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217362357.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakai", 
        "givenName": "Taku", 
        "id": "sg:person.0663575051.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663575051.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hashimoto", 
        "givenName": "Akihito", 
        "id": "sg:person.0731710251.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731710251.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuramoto", 
        "givenName": "Yuki", 
        "id": "sg:person.012310305571.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310305571.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oka", 
        "givenName": "Toru", 
        "id": "sg:person.01171206503.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171206503.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan.", 
            "Department of Cardiovascular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jong-Kook", 
        "id": "sg:person.01325702006.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325702006.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harada", 
        "givenName": "Mutsuo", 
        "id": "sg:person.012267264442.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267264442.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Kazutaka", 
        "id": "sg:person.01207056637.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207056637.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Medicine II, Kansai Medical University, Hirakata, Osaka 573-1191, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shiojima", 
        "givenName": "Ichiro", 
        "id": "sg:person.0632605707.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632605707.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Experimentelle Gef\u00e4\u00dfmedizin und Transplantationsforschung/ Koordinator Hypertoniezentrum, Klinik f\u00fcr Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover Carl-Neubergstr. 130625 Hannover, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Limbourg", 
        "givenName": "Florian P", 
        "id": "sg:person.0647470235.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647470235.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of M\u00fcnster", 
          "id": "https://www.grid.ac/institutes/grid.5949.1", 
          "name": [
            "Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of M\u00fcnster, Faculty of Medicine, M\u00fcnster, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "Ralf H", 
        "id": "sg:person.0702247561.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702247561.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cell Biology, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noda", 
        "givenName": "Tetsuo", 
        "id": "sg:person.01265364053.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265364053.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University", 
          "id": "https://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakata", 
        "givenName": "Yasushi", 
        "id": "sg:person.014225726372.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014225726372.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Agency for Medical Research and Development", 
          "id": "https://www.grid.ac/institutes/grid.480536.c", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.", 
            "Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akazawa", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01150350762.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150350762.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Agency for Medical Research and Development", 
          "id": "https://www.grid.ac/institutes/grid.480536.c", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.", 
            "Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komuro", 
        "givenName": "Issei", 
        "id": "sg:person.01012024207.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012024207.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jacc.2011.11.082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000105344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001573-200005000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004261072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.03.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004408654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.093351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005376856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1026061507004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005669928", 
          "https://doi.org/10.1023/a:1026061507004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005670808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013929852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.117.305349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015726171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.117.305349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015726171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378390a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017889408", 
          "https://doi.org/10.1038/378390a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019726015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2005.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020629866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2005.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020629866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2011.487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023094043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64601-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024157812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378386a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025875409", 
          "https://doi.org/10.1038/378386a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122249299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026072782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m600399200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026133627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.09-3567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026290281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.14.4647-4655.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029640369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.223750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030225443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.110.223750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030225443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4827(02)00102-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034409221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-4827(02)00102-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034409221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1686208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036394820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.05.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036979794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.114.300507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038603032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.114.300507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038603032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2012.235382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040822334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041684641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.110.991125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042711216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2010.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044415803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circheartfailure.114.001958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044830753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circheartfailure.114.001958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044830753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)01338-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045852616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0502-459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046930511", 
          "https://doi.org/10.1038/nm0502-459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0502-459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046930511", 
          "https://doi.org/10.1038/nm0502-459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00048.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048452016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-1716.2011.02309.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050926319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378394a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051349142", 
          "https://doi.org/10.1038/378394a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/923805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052004506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.9551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053669618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)01246-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054615105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1369/jhc.4a6341.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065266439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080342049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082310659", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07", 
    "datePublishedReg": "2016-07-01", 
    "description": "Activation of \u03b2-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/\u03b2-catenin signaling in endothelial cells remain poorly understood. Here, we report that sustained activation of \u03b2-catenin signaling in endothelial cells causes cardiac dysfunction through suppressing neuregulin-ErbB pathway in the heart. Conditional gain-of-function mutation of \u03b2-catenin, which activates Wnt/\u03b2-catenin signaling in Bmx-positive arterial endothelial cells (Bmx/CA mice) led to progressive cardiac dysfunction and 100% mortality at 40 weeks after tamoxifen treatment. Electron microscopic analysis revealed dilatation of T-tubules and degeneration of mitochondria in cardiomyocytes of Bmx/CA mice, which are similar to the changes observed in mice with decreased neuregulin-ErbB signaling. Endothelial expression of Nrg1 and cardiac ErbB signaling were suppressed in Bmx/CA mice. The cardiac dysfunction of Bmx/CA mice was ameliorated by administration of recombinant neuregulin protein. These results collectively suggest that sustained activation of Wnt/\u03b2-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling, and that the Wnt/\u03b2-catenin/NRG axis in cardiac endothelial cells might become a therapeutic target for heart failure.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep25009", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5880103", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6138460", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6067898", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Activation of endothelial \u03b2-catenin signaling induces heart failure", 
    "pagination": "25009", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5d5f566d91c848d415c587048fdcf24443c66fd7a8b6c743d10c0657eb615a78"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27146149"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep25009"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019597074"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep25009", 
      "https://app.dimensions.ai/details/publication/pub.1019597074"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/160505/srep25009/full/srep25009.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep25009'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep25009'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep25009'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep25009'


 

This table displays all metadata directly associated to this object as RDF triples.

398 TRIPLES      21 PREDICATES      79 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep25009 schema:about N55999708dae84217807c988e105fe465
2 N61d7decf3b3047658ef9145e236bb26f
3 N8d6ffd41071d4d10bb96fc120a6a5abd
4 N9fd3a103dc0a4b21818e0ae210b9515c
5 Nb0915fa1dad541d6953d6a3c702a9f57
6 Nca1b4ce557ea4d53b5aace3b31694b06
7 Ndaf17efbc84745bda92b42614b039732
8 Ndc609b7cbe0d4e75af5643229e5781d1
9 Nf68fe2bc006a44438ae8b99c5338c7f2
10 Nf8df2e5fe0764a8da41bccf542ebe1e5
11 anzsrc-for:11
12 anzsrc-for:1102
13 schema:author N84b2de0e03454774bfcc59a5b1fbbbde
14 schema:citation sg:pub.10.1023/a:1026061507004
15 sg:pub.10.1038/378386a0
16 sg:pub.10.1038/378390a0
17 sg:pub.10.1038/378394a0
18 sg:pub.10.1038/nature03319
19 sg:pub.10.1038/nm0502-459
20 https://app.dimensions.ai/details/publication/pub.1080342049
21 https://app.dimensions.ai/details/publication/pub.1082310659
22 https://doi.org/10.1016/j.cell.2004.12.021
23 https://doi.org/10.1016/j.cell.2006.10.018
24 https://doi.org/10.1016/j.cell.2012.05.012
25 https://doi.org/10.1016/j.celrep.2015.03.007
26 https://doi.org/10.1016/j.devcel.2010.05.006
27 https://doi.org/10.1016/j.jacc.2006.05.057
28 https://doi.org/10.1016/j.jacc.2011.11.082
29 https://doi.org/10.1016/j.yexcr.2005.08.017
30 https://doi.org/10.1016/s0002-9440(10)64601-9
31 https://doi.org/10.1016/s0014-4827(02)00102-7
32 https://doi.org/10.1016/s0014-5793(00)01338-7
33 https://doi.org/10.1016/s0092-8674(04)01246-2
34 https://doi.org/10.1038/emboj.2011.487
35 https://doi.org/10.1073/pnas.122249299
36 https://doi.org/10.1074/jbc.m600399200
37 https://doi.org/10.1097/00001573-200005000-00013
38 https://doi.org/10.1101/gad.1686208
39 https://doi.org/10.1111/j.1748-1716.2011.02309.x
40 https://doi.org/10.1113/jphysiol.2012.235382
41 https://doi.org/10.1128/mcb.21.14.4647-4655.2001
42 https://doi.org/10.1152/ajpheart.00048.2005
43 https://doi.org/10.1155/2014/923805
44 https://doi.org/10.1161/circheartfailure.114.001958
45 https://doi.org/10.1161/circresaha.110.223750
46 https://doi.org/10.1161/circresaha.114.300507
47 https://doi.org/10.1161/circresaha.117.305349
48 https://doi.org/10.1161/circulationaha.110.991125
49 https://doi.org/10.1167/iovs.09-3567
50 https://doi.org/10.1172/jci39942
51 https://doi.org/10.1200/jco.2005.04.9551
52 https://doi.org/10.1242/dev.093351
53 https://doi.org/10.1369/jhc.4a6341.2005
54 schema:datePublished 2016-07
55 schema:datePublishedReg 2016-07-01
56 schema:description Activation of β-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/β-catenin signaling in endothelial cells remain poorly understood. Here, we report that sustained activation of β-catenin signaling in endothelial cells causes cardiac dysfunction through suppressing neuregulin-ErbB pathway in the heart. Conditional gain-of-function mutation of β-catenin, which activates Wnt/β-catenin signaling in Bmx-positive arterial endothelial cells (Bmx/CA mice) led to progressive cardiac dysfunction and 100% mortality at 40 weeks after tamoxifen treatment. Electron microscopic analysis revealed dilatation of T-tubules and degeneration of mitochondria in cardiomyocytes of Bmx/CA mice, which are similar to the changes observed in mice with decreased neuregulin-ErbB signaling. Endothelial expression of Nrg1 and cardiac ErbB signaling were suppressed in Bmx/CA mice. The cardiac dysfunction of Bmx/CA mice was ameliorated by administration of recombinant neuregulin protein. These results collectively suggest that sustained activation of Wnt/β-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB signaling, and that the Wnt/β-catenin/NRG axis in cardiac endothelial cells might become a therapeutic target for heart failure.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf Naeedc4affa3c4607a91a6acf17a978e5
61 Nf31139fb702f4c039d1e234c6fd44c29
62 sg:journal.1045337
63 schema:name Activation of endothelial β-catenin signaling induces heart failure
64 schema:pagination 25009
65 schema:productId N0352782a43664903ae035c7c6827bd31
66 N15eccbc581644093836e1a6f29b4cad0
67 N4c50e9ba05c3435c9da8ea8673e88795
68 N888ce19c5efe4d4f8de0cdaf319f75fe
69 Na7a22e6be1654681a814a0e5b634b69d
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019597074
71 https://doi.org/10.1038/srep25009
72 schema:sdDatePublished 2019-04-10T20:06
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N76a31f04035d421e8cfe3d0676e49de2
75 schema:url http://www.nature.com/srep/2016/160505/srep25009/full/srep25009.html
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N005fc3bdd5fe4460b95eac76d1f32b05 rdf:first sg:person.01272752551.11
80 rdf:rest N5c841ddbcf904bfca2e0ddbc7c69acf0
81 N0352782a43664903ae035c7c6827bd31 schema:name pubmed_id
82 schema:value 27146149
83 rdf:type schema:PropertyValue
84 N03f1729ea30944a4beceb896cdd6385e rdf:first sg:person.0702247561.03
85 rdf:rest Nde00fa7f759545df92cfc1bc09ecb641
86 N0c0413e1e70d49da9ffd892d1b465734 schema:name Department of Cell Biology, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan.
87 rdf:type schema:Organization
88 N0e96264e7f124eef94d8849e23b66f36 rdf:first sg:person.01156524151.60
89 rdf:rest Nebf710db4c5f4d49a9554d531106fe8d
90 N11ff1625d4194f70aa806ac2eba541eb rdf:first sg:person.0731710251.65
91 rdf:rest Nf72bebca85ff4756a5c26b0926b2fd4d
92 N15eccbc581644093836e1a6f29b4cad0 schema:name doi
93 schema:value 10.1038/srep25009
94 rdf:type schema:PropertyValue
95 N3eda0fe689de4146b109772d5fcd7275 rdf:first sg:person.012267264442.26
96 rdf:rest Na05251207dd24c9fa501878e0d5ebc16
97 N4258f37db1824e54afa5041cc159c43b rdf:first sg:person.0663575051.75
98 rdf:rest N11ff1625d4194f70aa806ac2eba541eb
99 N4c50e9ba05c3435c9da8ea8673e88795 schema:name readcube_id
100 schema:value 5d5f566d91c848d415c587048fdcf24443c66fd7a8b6c743d10c0657eb615a78
101 rdf:type schema:PropertyValue
102 N55999708dae84217807c988e105fe465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Survival Analysis
104 rdf:type schema:DefinedTerm
105 N5b4dba7d2cf64c798cf1a1ed1bae8b35 schema:name Experimentelle Gefäßmedizin und Transplantationsforschung/ Koordinator Hypertoniezentrum, Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover Carl-Neubergstr. 130625 Hannover, Germany.
106 rdf:type schema:Organization
107 N5c841ddbcf904bfca2e0ddbc7c69acf0 rdf:first sg:person.01217362357.46
108 rdf:rest N4258f37db1824e54afa5041cc159c43b
109 N61d7decf3b3047658ef9145e236bb26f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Wnt Signaling Pathway
111 rdf:type schema:DefinedTerm
112 N76a31f04035d421e8cfe3d0676e49de2 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N84abbe223d6d4b44b6d6276a78681385 rdf:first sg:person.01012024207.33
115 rdf:rest rdf:nil
116 N84b2de0e03454774bfcc59a5b1fbbbde rdf:first sg:person.01341065751.44
117 rdf:rest Nb87955b1ace6422eb823557f8c2d544a
118 N888ce19c5efe4d4f8de0cdaf319f75fe schema:name nlm_unique_id
119 schema:value 101563288
120 rdf:type schema:PropertyValue
121 N8d6ffd41071d4d10bb96fc120a6a5abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mice
123 rdf:type schema:DefinedTerm
124 N9336bf7fe7e8430c9fb60175d18e11f4 rdf:first sg:person.01171206503.05
125 rdf:rest Nec8f494a591c40c7842a9ebe3663935f
126 N9daf2f3daa8e467784089c000b4c2344 rdf:first sg:person.01110410751.13
127 rdf:rest N0e96264e7f124eef94d8849e23b66f36
128 N9fd3a103dc0a4b21818e0ae210b9515c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Disease Models, Animal
130 rdf:type schema:DefinedTerm
131 Na05251207dd24c9fa501878e0d5ebc16 rdf:first sg:person.01207056637.25
132 rdf:rest Nae0482d02396465787f3d30799c9f1bd
133 Na7a22e6be1654681a814a0e5b634b69d schema:name dimensions_id
134 schema:value pub.1019597074
135 rdf:type schema:PropertyValue
136 Nae0482d02396465787f3d30799c9f1bd rdf:first sg:person.0632605707.34
137 rdf:rest Nff09bae774d74bd5b6922d84ec738de9
138 Naeedc4affa3c4607a91a6acf17a978e5 schema:issueNumber 1
139 rdf:type schema:PublicationIssue
140 Nb0915fa1dad541d6953d6a3c702a9f57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Endothelial Cells
142 rdf:type schema:DefinedTerm
143 Nb87955b1ace6422eb823557f8c2d544a rdf:first sg:person.01305773146.13
144 rdf:rest N9daf2f3daa8e467784089c000b4c2344
145 Nc1591e5c29154a918e16de7bfa68b543 rdf:first sg:person.01150350762.93
146 rdf:rest N84abbe223d6d4b44b6d6276a78681385
147 Nca1b4ce557ea4d53b5aace3b31694b06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Heart Failure
149 rdf:type schema:DefinedTerm
150 Ndaf17efbc84745bda92b42614b039732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Neuregulin-1
152 rdf:type schema:DefinedTerm
153 Ndc609b7cbe0d4e75af5643229e5781d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Animals
155 rdf:type schema:DefinedTerm
156 Nde00fa7f759545df92cfc1bc09ecb641 rdf:first sg:person.01265364053.49
157 rdf:rest Ne75f3f7b3dca4ca2a95de1a7550d7635
158 Ne75f3f7b3dca4ca2a95de1a7550d7635 rdf:first sg:person.014225726372.06
159 rdf:rest Nc1591e5c29154a918e16de7bfa68b543
160 Nebf710db4c5f4d49a9554d531106fe8d rdf:first sg:person.0757071411.00
161 rdf:rest N005fc3bdd5fe4460b95eac76d1f32b05
162 Nec8f494a591c40c7842a9ebe3663935f rdf:first sg:person.01325702006.12
163 rdf:rest N3eda0fe689de4146b109772d5fcd7275
164 Nf31139fb702f4c039d1e234c6fd44c29 schema:volumeNumber 6
165 rdf:type schema:PublicationVolume
166 Nf68fe2bc006a44438ae8b99c5338c7f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Receptor, Epidermal Growth Factor
168 rdf:type schema:DefinedTerm
169 Nf72bebca85ff4756a5c26b0926b2fd4d rdf:first sg:person.012310305571.98
170 rdf:rest N9336bf7fe7e8430c9fb60175d18e11f4
171 Nf8df2e5fe0764a8da41bccf542ebe1e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name beta Catenin
173 rdf:type schema:DefinedTerm
174 Nff09bae774d74bd5b6922d84ec738de9 rdf:first sg:person.0647470235.39
175 rdf:rest N03f1729ea30944a4beceb896cdd6385e
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
180 schema:name Cardiorespiratory Medicine and Haematology
181 rdf:type schema:DefinedTerm
182 sg:grant.5880103 http://pending.schema.org/fundedItem sg:pub.10.1038/srep25009
183 rdf:type schema:MonetaryGrant
184 sg:grant.6067898 http://pending.schema.org/fundedItem sg:pub.10.1038/srep25009
185 rdf:type schema:MonetaryGrant
186 sg:grant.6138460 http://pending.schema.org/fundedItem sg:pub.10.1038/srep25009
187 rdf:type schema:MonetaryGrant
188 sg:journal.1045337 schema:issn 2045-2322
189 schema:name Scientific Reports
190 rdf:type schema:Periodical
191 sg:person.01012024207.33 schema:affiliation https://www.grid.ac/institutes/grid.480536.c
192 schema:familyName Komuro
193 schema:givenName Issei
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012024207.33
195 rdf:type schema:Person
196 sg:person.01110410751.13 schema:affiliation https://www.grid.ac/institutes/grid.480536.c
197 schema:familyName Sumida
198 schema:givenName Tomokazu
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110410751.13
200 rdf:type schema:Person
201 sg:person.01150350762.93 schema:affiliation https://www.grid.ac/institutes/grid.480536.c
202 schema:familyName Akazawa
203 schema:givenName Hiroshi
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150350762.93
205 rdf:type schema:Person
206 sg:person.01156524151.60 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
207 schema:familyName Nomura
208 schema:givenName Seitaro
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156524151.60
210 rdf:type schema:Person
211 sg:person.01171206503.05 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
212 schema:familyName Oka
213 schema:givenName Toru
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171206503.05
215 rdf:type schema:Person
216 sg:person.01207056637.25 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
217 schema:familyName Ueda
218 schema:givenName Kazutaka
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207056637.25
220 rdf:type schema:Person
221 sg:person.01217362357.46 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
222 schema:familyName Okada
223 schema:givenName Katsuki
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217362357.46
225 rdf:type schema:Person
226 sg:person.012267264442.26 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
227 schema:familyName Harada
228 schema:givenName Mutsuo
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267264442.26
230 rdf:type schema:Person
231 sg:person.012310305571.98 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
232 schema:familyName Kuramoto
233 schema:givenName Yuki
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310305571.98
235 rdf:type schema:Person
236 sg:person.01265364053.49 schema:affiliation N0c0413e1e70d49da9ffd892d1b465734
237 schema:familyName Noda
238 schema:givenName Tetsuo
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265364053.49
240 rdf:type schema:Person
241 sg:person.01272752551.11 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
242 schema:familyName Higo
243 schema:givenName Tomoaki
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272752551.11
245 rdf:type schema:Person
246 sg:person.01305773146.13 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
247 schema:familyName Naito
248 schema:givenName Atsuhiko T
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305773146.13
250 rdf:type schema:Person
251 sg:person.01325702006.12 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
252 schema:familyName Lee
253 schema:givenName Jong-Kook
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325702006.12
255 rdf:type schema:Person
256 sg:person.01341065751.44 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
257 schema:familyName Nakagawa
258 schema:givenName Akito
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341065751.44
260 rdf:type schema:Person
261 sg:person.014225726372.06 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
262 schema:familyName Sakata
263 schema:givenName Yasushi
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014225726372.06
265 rdf:type schema:Person
266 sg:person.0632605707.34 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
267 schema:familyName Shiojima
268 schema:givenName Ichiro
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632605707.34
270 rdf:type schema:Person
271 sg:person.0647470235.39 schema:affiliation N5b4dba7d2cf64c798cf1a1ed1bae8b35
272 schema:familyName Limbourg
273 schema:givenName Florian P
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647470235.39
275 rdf:type schema:Person
276 sg:person.0663575051.75 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
277 schema:familyName Sakai
278 schema:givenName Taku
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663575051.75
280 rdf:type schema:Person
281 sg:person.0702247561.03 schema:affiliation https://www.grid.ac/institutes/grid.5949.1
282 schema:familyName Adams
283 schema:givenName Ralf H
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702247561.03
285 rdf:type schema:Person
286 sg:person.0731710251.65 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
287 schema:familyName Hashimoto
288 schema:givenName Akihito
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731710251.65
290 rdf:type schema:Person
291 sg:person.0757071411.00 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
292 schema:familyName Shibamoto
293 schema:givenName Masato
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757071411.00
295 rdf:type schema:Person
296 sg:pub.10.1023/a:1026061507004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005669928
297 https://doi.org/10.1023/a:1026061507004
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/378386a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025875409
300 https://doi.org/10.1038/378386a0
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/378390a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017889408
303 https://doi.org/10.1038/378390a0
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/378394a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051349142
306 https://doi.org/10.1038/378394a0
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/nature03319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766632
309 https://doi.org/10.1038/nature03319
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/nm0502-459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046930511
312 https://doi.org/10.1038/nm0502-459
313 rdf:type schema:CreativeWork
314 https://app.dimensions.ai/details/publication/pub.1080342049 schema:CreativeWork
315 https://app.dimensions.ai/details/publication/pub.1082310659 schema:CreativeWork
316 https://doi.org/10.1016/j.cell.2004.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019726015
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.cell.2006.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041684641
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.cell.2012.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005670808
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.celrep.2015.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004408654
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.devcel.2010.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044415803
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/j.jacc.2006.05.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036979794
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/j.jacc.2011.11.082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000105344
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.yexcr.2005.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020629866
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/s0002-9440(10)64601-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024157812
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/s0014-4827(02)00102-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034409221
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/s0014-5793(00)01338-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045852616
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/s0092-8674(04)01246-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054615105
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1038/emboj.2011.487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023094043
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1073/pnas.122249299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026072782
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1074/jbc.m600399200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026133627
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/00001573-200005000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004261072
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gad.1686208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036394820
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.1748-1716.2011.02309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050926319
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1113/jphysiol.2012.235382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040822334
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1128/mcb.21.14.4647-4655.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029640369
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1152/ajpheart.00048.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048452016
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1155/2014/923805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052004506
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1161/circheartfailure.114.001958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044830753
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1161/circresaha.110.223750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030225443
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1161/circresaha.114.300507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038603032
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1161/circresaha.117.305349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015726171
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1161/circulationaha.110.991125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042711216
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1167/iovs.09-3567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026290281
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1172/jci39942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013929852
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1200/jco.2005.04.9551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053669618
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1242/dev.093351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005376856
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1369/jhc.4a6341.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065266439
379 rdf:type schema:CreativeWork
380 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
381 schema:name Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
382 Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
383 Department of Cardiovascular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
384 Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan.
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
387 schema:name Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
388 rdf:type schema:Organization
389 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
390 schema:name Department of Medicine II, Kansai Medical University, Hirakata, Osaka 573-1191, Japan.
391 rdf:type schema:Organization
392 https://www.grid.ac/institutes/grid.480536.c schema:alternateName Japan Agency for Medical Research and Development
393 schema:name Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
394 Japan Agency for Medical Research and Development, AMED-CREST, Chiyoda-ku, Tokyo 100-0004, Japan.
395 rdf:type schema:Organization
396 https://www.grid.ac/institutes/grid.5949.1 schema:alternateName University of Münster
397 schema:name Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, University of Münster, Faculty of Medicine, Münster, Germany.
398 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...