Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Petri Wiklund, Xiaobo Zhang, Satu Pekkala, Reija Autio, Lingjia Kong, Yifan Yang, Sirkka Keinänen-Kiukaanniemi, Markku Alen, Sulin Cheng

ABSTRACT

Insulin resistance is associated adiposity, but the mechanisms are not fully understood. In this study, we aimed to identify early metabolic alterations associated with insulin resistance in normoglycemic women with varying degree of adiposity. One-hundred and ten young and middle-aged women were divided into low and high IR groups based on their median HOMA-IR (0.9 ± 0.4 vs. 2.8 ± 1.2). Body composition was assessed using DXA, skeletal muscle and liver fat by proton magnetic resonance spectroscopy, serum metabolites by nuclear magnetic resonance spectroscopy and adipose tissue and skeletal muscle gene expression by microarrays. High HOMA-IR subjects had higher serum branched-chain amino acid concentrations (BCAA) (p < 0.05 for both). Gene expression analysis of subcutaneous adipose tissue revealed significant down-regulation of genes related to BCAA catabolism and mitochondrial energy metabolism and up-regulation of several inflammation-related pathways in high HOMA-IR subjects (p < 0.05 for all), but no differentially expressed genes in skeletal muscle were found. In conclusion, in normoglycemic women insulin resistance was associated with increased serum BCAA concentrations, down-regulation of mitochondrial energy metabolism and increased expression of inflammation-related genes in the adipose tissue. More... »

PAGES

24540

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/srep24540

    DOI

    http://dx.doi.org/10.1038/srep24540

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045575590

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27080554


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