A study on the evaluation method and recent clinical efficacy of bevacizumab on the treatment of radiation cerebral necrosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Hongqing Zhuang, Xiangkun Yuan, Yi Zheng, Xubin Li, Joe Y. Chang, Junjie Wang, Xiaoguang Wang, Zhiyong Yuan, Ping Wang

ABSTRACT

In order to investigate the efficacy of bevacizumab on the treatment of radiation cerebral necrosis, patients who were diagnosed with radiation cerebral necrosis by imaging after stereotactic radiotherapy were collected. Bevacizumab was applied at a dose of 5 mg/kg once every three weeks at least three times. The changes in cerebral necrosis symptoms before and after treatment, the cerebral edema volume, the cerebral necrosis volume, and the changes in magnetic resonance imaging (MRI) strengthening phase signals of cerebral necrosis were used as the first observation point. The side effects of bevacizumab were used as the second observation point. Total of 14 radiation cerebral necrosis patients were treated with bevacizumab between June 2011 and February 2013 were collected. There were 12 symptomatic patients, of whom 10 patients (83.3%) had reduced symptoms. The edema index grades of nine patients (64.29%) improved. The cerebral necrosis volumes of 13 patients (92.86%) decreased. The T1 phase signal strengths of the intracranial enhanced MRIs of 12 patients (85.71%) significantly decreased. The clinical side effects of bevacizumab were mild. In conclusion, Preliminary results showed that treatment of radiation cerebral necrosis using bevacizumab was safe and effective. This treatment measure is worthy of further study. More... »

PAGES

24364

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep24364

DOI

http://dx.doi.org/10.1038/srep24364

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049292154

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27067388


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenesis Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bevacizumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiosurgery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tianjin Medical University Cancer Institute and Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411918.4", 
          "name": [
            "Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, and Tianjin Lung Cancer Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhuang", 
        "givenName": "Hongqing", 
        "id": "sg:person.0760024205.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760024205.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiotherapy, Hebei Province Cangzhou Hospital of integrated traditional and western medicine (Cangzhou No. 2 Hospital), Hebei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Xiangkun", 
        "id": "sg:person.01355566055.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355566055.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daqing Oilfield General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.452354.1", 
          "name": [
            "Daqing Oilfield General Hospital, Heilongjiang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "Yi", 
        "id": "sg:person.01232526121.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232526121.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin Medical University Cancer Institute and Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411918.4", 
          "name": [
            "Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, and Tianjin Lung Cancer Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xubin", 
        "id": "sg:person.01122113300.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122113300.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Joe Y.", 
        "id": "sg:person.014351135104.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014351135104.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University", 
          "id": "https://www.grid.ac/institutes/grid.11135.37", 
          "name": [
            "Department of Radiotherapy, Peking University 3rd Hospital, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Junjie", 
        "id": "sg:person.01300641321.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300641321.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin Medical University Cancer Institute and Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411918.4", 
          "name": [
            "Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, and Tianjin Lung Cancer Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xiaoguang", 
        "id": "sg:person.0660237622.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660237622.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin Medical University Cancer Institute and Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411918.4", 
          "name": [
            "Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, and Tianjin Lung Cancer Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Zhiyong", 
        "id": "sg:person.01012173702.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012173702.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin Medical University Cancer Institute and Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411918.4", 
          "name": [
            "Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, and Tianjin Lung Cancer Center, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Ping", 
        "id": "sg:person.01212576232.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212576232.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11060-011-0610-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000280672", 
          "https://doi.org/10.1007/s11060-011-0610-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.acra.2009.10.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000546355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-014-1488-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004966405", 
          "https://doi.org/10.1007/s11060-014-1488-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2012.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005737358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0029399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007022690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-9-105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008611086", 
          "https://doi.org/10.1186/1748-717x-9-105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12094-013-1129-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012078799", 
          "https://doi.org/10.1007/s12094-013-1129-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocn.2012.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017652772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hoc.2012.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018726572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-8-52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020778642", 
          "https://doi.org/10.1186/1748-717x-8-52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10014-006-0194-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027113641", 
          "https://doi.org/10.1007/s10014-006-0194-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10014-006-0194-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027113641", 
          "https://doi.org/10.1007/s10014-006-0194-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/417913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028154913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/rg.325125002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029401424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-013-1214-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031353911", 
          "https://doi.org/10.1007/s11060-013-1214-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1117/12.2043969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031778590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2013.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038950142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejrad.2008.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039377795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-013-1248-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040364946", 
          "https://doi.org/10.1007/s11060-013-1248-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2176/nmc.ra.2014-0188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044425726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-6-128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044483759", 
          "https://doi.org/10.1186/1748-717x-6-128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms150711832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045288042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-013-1233-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047466390", 
          "https://doi.org/10.1007/s11060-013-1233-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-010-2184-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051578368", 
          "https://doi.org/10.1007/s00066-010-2184-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suponc.2011.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054750663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.con.0000413662.35174.a8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064343998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.con.0000413662.35174.a8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064343998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.con.0000413662.35174.a8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064343998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr/59853976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064569702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr3597.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068196678"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07", 
    "datePublishedReg": "2016-07-01", 
    "description": "In order to investigate the efficacy of bevacizumab on the treatment of radiation cerebral necrosis, patients who were diagnosed with radiation cerebral necrosis by imaging after stereotactic radiotherapy were collected. Bevacizumab was applied at a dose of 5\u2009mg/kg once every three weeks at least three times. The changes in cerebral necrosis symptoms before and after treatment, the cerebral edema volume, the cerebral necrosis volume, and the changes in magnetic resonance imaging (MRI) strengthening phase signals of cerebral necrosis were used as the first observation point. The side effects of bevacizumab were used as the second observation point. Total of 14 radiation cerebral necrosis patients were treated with bevacizumab between June 2011 and February 2013 were collected. There were 12 symptomatic patients, of whom 10 patients (83.3%) had reduced symptoms. The edema index grades of nine patients (64.29%) improved. The cerebral necrosis volumes of 13 patients (92.86%) decreased. The T1 phase signal strengths of the intracranial enhanced MRIs of 12 patients (85.71%) significantly decreased. The clinical side effects of bevacizumab were mild. In conclusion, Preliminary results showed that treatment of radiation cerebral necrosis using bevacizumab was safe and effective. This treatment measure is worthy of further study. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep24364", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7006045", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "A study on the evaluation method and recent clinical efficacy of bevacizumab on the treatment of radiation cerebral necrosis", 
    "pagination": "24364", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ead1a2d603c9cbe3493fa13fd8807e0c284726ce2cbd1085e07e40cc1faeb3e1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27067388"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep24364"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049292154"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep24364", 
      "https://app.dimensions.ai/details/publication/pub.1049292154"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000551.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/srep24364"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep24364'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep24364'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep24364'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep24364'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      68 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep24364 schema:about N02565fb6ce0c41888be30ea808388201
2 N05e6e0b9ced647e9a7f1bd35f12ae739
3 N18f06683ebec49b0bc01a78edf5bab51
4 N379c4b4315eb423cafc16e218347c69a
5 N51189794656440208dbb188979d885c6
6 N5cbdc722def946ac8ea1dac0b2ffe800
7 N65545bf0427442c887488e233308cfca
8 N67d4f7335a0e40f2b86f69dbb1183fb5
9 N8d8b81216af94590920e663bd0f40db4
10 N987fcaaeeea84e179c00d693467eda2c
11 N9f3a15de181e4ce68dca0c0029e0ace1
12 Nd0740b79d88144f2a004e2868a3b2017
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author Nd2e717ad384b45dca2b8620564800531
16 schema:citation sg:pub.10.1007/s00066-010-2184-4
17 sg:pub.10.1007/s10014-006-0194-9
18 sg:pub.10.1007/s11060-011-0610-9
19 sg:pub.10.1007/s11060-013-1214-3
20 sg:pub.10.1007/s11060-013-1233-0
21 sg:pub.10.1007/s11060-013-1248-6
22 sg:pub.10.1007/s11060-014-1488-0
23 sg:pub.10.1007/s12094-013-1129-7
24 sg:pub.10.1186/1748-717x-6-128
25 sg:pub.10.1186/1748-717x-8-52
26 sg:pub.10.1186/1748-717x-9-105
27 https://doi.org/10.1016/j.acra.2009.10.024
28 https://doi.org/10.1016/j.ejrad.2008.08.009
29 https://doi.org/10.1016/j.expneurol.2012.03.011
30 https://doi.org/10.1016/j.hoc.2012.04.007
31 https://doi.org/10.1016/j.ijrobp.2013.05.015
32 https://doi.org/10.1016/j.jocn.2012.09.011
33 https://doi.org/10.1016/j.suponc.2011.11.002
34 https://doi.org/10.1117/12.2043969
35 https://doi.org/10.1148/rg.325125002
36 https://doi.org/10.1155/2014/417913
37 https://doi.org/10.1212/01.con.0000413662.35174.a8
38 https://doi.org/10.1259/bjr/59853976
39 https://doi.org/10.1371/journal.pone.0029399
40 https://doi.org/10.1667/rr3597.1
41 https://doi.org/10.2176/nmc.ra.2014-0188
42 https://doi.org/10.3390/ijms150711832
43 schema:datePublished 2016-07
44 schema:datePublishedReg 2016-07-01
45 schema:description In order to investigate the efficacy of bevacizumab on the treatment of radiation cerebral necrosis, patients who were diagnosed with radiation cerebral necrosis by imaging after stereotactic radiotherapy were collected. Bevacizumab was applied at a dose of 5 mg/kg once every three weeks at least three times. The changes in cerebral necrosis symptoms before and after treatment, the cerebral edema volume, the cerebral necrosis volume, and the changes in magnetic resonance imaging (MRI) strengthening phase signals of cerebral necrosis were used as the first observation point. The side effects of bevacizumab were used as the second observation point. Total of 14 radiation cerebral necrosis patients were treated with bevacizumab between June 2011 and February 2013 were collected. There were 12 symptomatic patients, of whom 10 patients (83.3%) had reduced symptoms. The edema index grades of nine patients (64.29%) improved. The cerebral necrosis volumes of 13 patients (92.86%) decreased. The T1 phase signal strengths of the intracranial enhanced MRIs of 12 patients (85.71%) significantly decreased. The clinical side effects of bevacizumab were mild. In conclusion, Preliminary results showed that treatment of radiation cerebral necrosis using bevacizumab was safe and effective. This treatment measure is worthy of further study.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N05549203b3a240d8921641abe1192190
50 Nddac8afe5e77469c8575022b3855bf76
51 sg:journal.1045337
52 schema:name A study on the evaluation method and recent clinical efficacy of bevacizumab on the treatment of radiation cerebral necrosis
53 schema:pagination 24364
54 schema:productId N12dd7b2306ee4f16a48ec21ee0e2e526
55 N1c104113db1e4ce996b29b68d22ac661
56 N27c105b8a72b49e0afe74567cefbb65e
57 N5a52c2db7a654d7494bd7c0acaf756a7
58 N93cdc93ad30e402981087f6fa10b781b
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049292154
60 https://doi.org/10.1038/srep24364
61 schema:sdDatePublished 2019-04-10T22:39
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nbaae08a365f3475095035bbe41abce40
64 schema:url http://www.nature.com/articles/srep24364
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N014817f0fb074846b57ff6cf9888f70a schema:name Department of Radiotherapy, Hebei Province Cangzhou Hospital of integrated traditional and western medicine (Cangzhou No. 2 Hospital), Hebei, China
69 rdf:type schema:Organization
70 N02565fb6ce0c41888be30ea808388201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Necrosis
72 rdf:type schema:DefinedTerm
73 N05549203b3a240d8921641abe1192190 schema:issueNumber 1
74 rdf:type schema:PublicationIssue
75 N05e6e0b9ced647e9a7f1bd35f12ae739 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Brain
77 rdf:type schema:DefinedTerm
78 N0bc503b3da7f4f44a5f33be5a2691faf rdf:first sg:person.0660237622.70
79 rdf:rest N6e7dcda6f2754df9b553f60ab6385cc6
80 N1128dea056a944c59c3b70086603ed57 rdf:first sg:person.01122113300.17
81 rdf:rest N9a7acb04a5984c2c861c182b7c27b011
82 N12dd7b2306ee4f16a48ec21ee0e2e526 schema:name dimensions_id
83 schema:value pub.1049292154
84 rdf:type schema:PropertyValue
85 N18f06683ebec49b0bc01a78edf5bab51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Bevacizumab
87 rdf:type schema:DefinedTerm
88 N1a8cbdcf3b6d4461bef35e9a23c353be rdf:first sg:person.01212576232.51
89 rdf:rest rdf:nil
90 N1c104113db1e4ce996b29b68d22ac661 schema:name nlm_unique_id
91 schema:value 101563288
92 rdf:type schema:PropertyValue
93 N1e15a356900742c1a120931092767b27 rdf:first sg:person.01300641321.19
94 rdf:rest N0bc503b3da7f4f44a5f33be5a2691faf
95 N27c105b8a72b49e0afe74567cefbb65e schema:name readcube_id
96 schema:value ead1a2d603c9cbe3493fa13fd8807e0c284726ce2cbd1085e07e40cc1faeb3e1
97 rdf:type schema:PropertyValue
98 N30ea6cfb99c548bda702a75a05cdf6a6 rdf:first sg:person.01355566055.62
99 rdf:rest Naf123f6e14fc4f1faac16f6502fe9e62
100 N379c4b4315eb423cafc16e218347c69a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Aged
102 rdf:type schema:DefinedTerm
103 N51189794656440208dbb188979d885c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Treatment Outcome
105 rdf:type schema:DefinedTerm
106 N5a52c2db7a654d7494bd7c0acaf756a7 schema:name pubmed_id
107 schema:value 27067388
108 rdf:type schema:PropertyValue
109 N5cbdc722def946ac8ea1dac0b2ffe800 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Angiogenesis Inhibitors
111 rdf:type schema:DefinedTerm
112 N65545bf0427442c887488e233308cfca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Brain Neoplasms
114 rdf:type schema:DefinedTerm
115 N67d4f7335a0e40f2b86f69dbb1183fb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Humans
117 rdf:type schema:DefinedTerm
118 N6e7dcda6f2754df9b553f60ab6385cc6 rdf:first sg:person.01012173702.78
119 rdf:rest N1a8cbdcf3b6d4461bef35e9a23c353be
120 N8d8b81216af94590920e663bd0f40db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Adult
122 rdf:type schema:DefinedTerm
123 N93cdc93ad30e402981087f6fa10b781b schema:name doi
124 schema:value 10.1038/srep24364
125 rdf:type schema:PropertyValue
126 N987fcaaeeea84e179c00d693467eda2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N9a7acb04a5984c2c861c182b7c27b011 rdf:first sg:person.014351135104.56
130 rdf:rest N1e15a356900742c1a120931092767b27
131 N9f3a15de181e4ce68dca0c0029e0ace1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Radiosurgery
133 rdf:type schema:DefinedTerm
134 Naf123f6e14fc4f1faac16f6502fe9e62 rdf:first sg:person.01232526121.92
135 rdf:rest N1128dea056a944c59c3b70086603ed57
136 Nbaae08a365f3475095035bbe41abce40 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Nd0740b79d88144f2a004e2868a3b2017 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Magnetic Resonance Imaging
140 rdf:type schema:DefinedTerm
141 Nd2e717ad384b45dca2b8620564800531 rdf:first sg:person.0760024205.35
142 rdf:rest N30ea6cfb99c548bda702a75a05cdf6a6
143 Nddac8afe5e77469c8575022b3855bf76 schema:volumeNumber 6
144 rdf:type schema:PublicationVolume
145 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
146 schema:name Medical and Health Sciences
147 rdf:type schema:DefinedTerm
148 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
149 schema:name Clinical Sciences
150 rdf:type schema:DefinedTerm
151 sg:grant.7006045 http://pending.schema.org/fundedItem sg:pub.10.1038/srep24364
152 rdf:type schema:MonetaryGrant
153 sg:journal.1045337 schema:issn 2045-2322
154 schema:name Scientific Reports
155 rdf:type schema:Periodical
156 sg:person.01012173702.78 schema:affiliation https://www.grid.ac/institutes/grid.411918.4
157 schema:familyName Yuan
158 schema:givenName Zhiyong
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012173702.78
160 rdf:type schema:Person
161 sg:person.01122113300.17 schema:affiliation https://www.grid.ac/institutes/grid.411918.4
162 schema:familyName Li
163 schema:givenName Xubin
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122113300.17
165 rdf:type schema:Person
166 sg:person.01212576232.51 schema:affiliation https://www.grid.ac/institutes/grid.411918.4
167 schema:familyName Wang
168 schema:givenName Ping
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212576232.51
170 rdf:type schema:Person
171 sg:person.01232526121.92 schema:affiliation https://www.grid.ac/institutes/grid.452354.1
172 schema:familyName Zheng
173 schema:givenName Yi
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232526121.92
175 rdf:type schema:Person
176 sg:person.01300641321.19 schema:affiliation https://www.grid.ac/institutes/grid.11135.37
177 schema:familyName Wang
178 schema:givenName Junjie
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300641321.19
180 rdf:type schema:Person
181 sg:person.01355566055.62 schema:affiliation N014817f0fb074846b57ff6cf9888f70a
182 schema:familyName Yuan
183 schema:givenName Xiangkun
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355566055.62
185 rdf:type schema:Person
186 sg:person.014351135104.56 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
187 schema:familyName Chang
188 schema:givenName Joe Y.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014351135104.56
190 rdf:type schema:Person
191 sg:person.0660237622.70 schema:affiliation https://www.grid.ac/institutes/grid.411918.4
192 schema:familyName Wang
193 schema:givenName Xiaoguang
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660237622.70
195 rdf:type schema:Person
196 sg:person.0760024205.35 schema:affiliation https://www.grid.ac/institutes/grid.411918.4
197 schema:familyName Zhuang
198 schema:givenName Hongqing
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760024205.35
200 rdf:type schema:Person
201 sg:pub.10.1007/s00066-010-2184-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051578368
202 https://doi.org/10.1007/s00066-010-2184-4
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s10014-006-0194-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027113641
205 https://doi.org/10.1007/s10014-006-0194-9
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/s11060-011-0610-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000280672
208 https://doi.org/10.1007/s11060-011-0610-9
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s11060-013-1214-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031353911
211 https://doi.org/10.1007/s11060-013-1214-3
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s11060-013-1233-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047466390
214 https://doi.org/10.1007/s11060-013-1233-0
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s11060-013-1248-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040364946
217 https://doi.org/10.1007/s11060-013-1248-6
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s11060-014-1488-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004966405
220 https://doi.org/10.1007/s11060-014-1488-0
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s12094-013-1129-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012078799
223 https://doi.org/10.1007/s12094-013-1129-7
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/1748-717x-6-128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044483759
226 https://doi.org/10.1186/1748-717x-6-128
227 rdf:type schema:CreativeWork
228 sg:pub.10.1186/1748-717x-8-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020778642
229 https://doi.org/10.1186/1748-717x-8-52
230 rdf:type schema:CreativeWork
231 sg:pub.10.1186/1748-717x-9-105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008611086
232 https://doi.org/10.1186/1748-717x-9-105
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.acra.2009.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000546355
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.ejrad.2008.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039377795
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.expneurol.2012.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005737358
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.hoc.2012.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018726572
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.ijrobp.2013.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038950142
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.jocn.2012.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017652772
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.suponc.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054750663
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1117/12.2043969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031778590
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1148/rg.325125002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029401424
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1155/2014/417913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028154913
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1212/01.con.0000413662.35174.a8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064343998
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1259/bjr/59853976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064569702
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1371/journal.pone.0029399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007022690
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1667/rr3597.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196678
261 rdf:type schema:CreativeWork
262 https://doi.org/10.2176/nmc.ra.2014-0188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044425726
263 rdf:type schema:CreativeWork
264 https://doi.org/10.3390/ijms150711832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045288042
265 rdf:type schema:CreativeWork
266 https://www.grid.ac/institutes/grid.11135.37 schema:alternateName Peking University
267 schema:name Department of Radiotherapy, Peking University 3rd Hospital, Beijing, China
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
270 schema:name Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.411918.4 schema:alternateName Tianjin Medical University Cancer Institute and Hospital
273 schema:name Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, and Tianjin Lung Cancer Center, Tianjin, China
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.452354.1 schema:alternateName Daqing Oilfield General Hospital
276 schema:name Daqing Oilfield General Hospital, Heilongjiang, China
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...