Novel PKC-ζ to p47phox interaction is necessary for transformation from blebbishields View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Goodwin G Jinesh, Rikiya Taoka, Qiang Zhang, Siddharth Gorantla, Ashish M Kamat

ABSTRACT

Cancer stem cells are capable of transformation after apoptosis through the blebbishield emergency program. Reactive oxygen species (ROS) play an essential role in transformation. Understanding how ROS are linked to blebbishield-mediated transformation is necessary to develop efficient therapeutics that target the resurrection of cancer stem cells. Here we demonstrate that a novel PKC-ζ to p47(phox) interaction is required for ROS production in cancer cells. The combined use of the S6K inhibitor BI-D1870 with TNF-α inhibited the PKC-ζ to p47(phox) interaction, inhibited ROS production, degraded PKC-ζ, and activated caspases-3 and -8 to block transformation from blebbishields. BI-D1870 also inhibited transformation from cycloheximide-generated blebbishields. Thus ROS and the PKC-ζ to p47(phox) interaction are valid therapeutic targets to block transformation from blebbishields. More... »

PAGES

23965

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep23965

DOI

http://dx.doi.org/10.1038/srep23965

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020016077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27040869


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspase 8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cycloheximide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NADPH Oxidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pteridines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, Unit 1373, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jinesh", 
        "givenName": "Goodwin G", 
        "id": "sg:person.0723312420.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723312420.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, Unit 1373, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taoka", 
        "givenName": "Rikiya", 
        "id": "sg:person.0727663124.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727663124.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, Unit 1373, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Qiang", 
        "id": "sg:person.01317254231.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317254231.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, Unit 1373, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gorantla", 
        "givenName": "Siddharth", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Urology, Unit 1373, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamat", 
        "givenName": "Ashish M", 
        "id": "sg:person.016172066457.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016172066457.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2003.01846.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000283612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000847490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.2729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002895135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-2063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004141521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2005.00660.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958850", 
          "https://doi.org/10.1111/j.1523-1755.2005.00660.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1523-1755.2005.00660.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.13023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005687229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(02)52007-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009558095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2014.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011093700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0023577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017094491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2012.140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018561356", 
          "https://doi.org/10.1038/cdd.2012.140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt1115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019290540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.1211623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023218536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2015.4220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023770448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2015.4220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023770448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-411-1_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027677011", 
          "https://doi.org/10.1007/978-1-60761-411-1_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-411-1_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027677011", 
          "https://doi.org/10.1007/978-1-60761-411-1_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-3225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028949375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2013.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031361234", 
          "https://doi.org/10.1038/cddis.2013.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035817137", 
          "https://doi.org/10.1038/nmeth.2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/onci.20928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040519705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2014.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043175900", 
          "https://doi.org/10.1038/cdd.2014.34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddiscovery.2016.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043585673", 
          "https://doi.org/10.1038/cddiscovery.2016.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddiscovery.2015.69", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043861446", 
          "https://doi.org/10.1038/cddiscovery.2015.69"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471143030.cb0303s04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049823587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.urolonc.2012.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050180662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.4.2921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050374259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m302251200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051217416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2016.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052038879", 
          "https://doi.org/10.1038/cdd.2016.26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20150877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20150877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2012.4905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059231994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2010-1122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064250784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1574888x08666131113123051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069215903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077163454", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078849647", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-07", 
    "datePublishedReg": "2016-07-01", 
    "description": "Cancer stem cells are capable of transformation after apoptosis through the blebbishield emergency program. Reactive oxygen species (ROS) play an essential role in transformation. Understanding how ROS are linked to blebbishield-mediated transformation is necessary to develop efficient therapeutics that target the resurrection of cancer stem cells. Here we demonstrate that a novel PKC-\u03b6 to p47(phox) interaction is required for ROS production in cancer cells. The combined use of the S6K inhibitor BI-D1870 with TNF-\u03b1 inhibited the PKC-\u03b6 to p47(phox) interaction, inhibited ROS production, degraded PKC-\u03b6, and activated caspases-3 and -8 to block transformation from blebbishields. BI-D1870 also inhibited transformation from cycloheximide-generated blebbishields. Thus ROS and the PKC-\u03b6 to p47(phox) interaction are valid therapeutic targets to block transformation from blebbishields. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep23965", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Novel PKC-\u03b6 to p47phox interaction is necessary for transformation from blebbishields", 
    "pagination": "23965", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5f5e82d3bb267300c8416ee6e5f396ded5f7c1671f979a8e034a87df8b509a3c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27040869"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep23965"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020016077"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep23965", 
      "https://app.dimensions.ai/details/publication/pub.1020016077"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/160404/srep23965/full/srep23965.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep23965'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep23965'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep23965'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep23965'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      21 PREDICATES      75 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep23965 schema:about N30ebb3d2effe4d2182a0dcd796033f43
2 N549efd111c9b4d35aaf0b58832abee62
3 N5d1afaae964c4b93a5980ce0f63f0dbf
4 N874ce61deb224c539b22577d362f04ab
5 N94a036eacee54187992504cec5ea9ca5
6 N9b4b092d81724e3d8fdcc190c01bb12d
7 Na4c35ea4a359426d90ad6a48916ffe9f
8 Nae6482b842684624b8891ae1580115c7
9 Nb3afa32d294b4e48a3a9314f54106bc6
10 Nc6fdd9afd6304d868e08ac2933997641
11 Ncedaece124b54d81a51faca834f9c35d
12 Nfd5ec4e568c24c23840cbeb046594825
13 Nfe43d6b0c0ad45a78692670fb8237e3e
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N4c2fcd0a212840bf8a7a8e944f3ed4d9
17 schema:citation sg:pub.10.1007/978-1-60761-411-1_4
18 sg:pub.10.1038/cdd.2012.140
19 sg:pub.10.1038/cdd.2014.34
20 sg:pub.10.1038/cdd.2016.26
21 sg:pub.10.1038/cddis.2013.111
22 sg:pub.10.1038/cddiscovery.2015.69
23 sg:pub.10.1038/cddiscovery.2016.3
24 sg:pub.10.1038/nmeth.2089
25 sg:pub.10.1111/j.1523-1755.2005.00660.x
26 https://app.dimensions.ai/details/publication/pub.1077163454
27 https://app.dimensions.ai/details/publication/pub.1078849647
28 https://doi.org/10.1002/0471143030.cb0303s04
29 https://doi.org/10.1016/j.bbrc.2014.12.010
30 https://doi.org/10.1016/j.urolonc.2012.05.007
31 https://doi.org/10.1016/s0076-6879(02)52007-3
32 https://doi.org/10.1042/bj20150877
33 https://doi.org/10.1046/j.1471-4159.2003.01846.x
34 https://doi.org/10.1074/jbc.m302251200
35 https://doi.org/10.1089/ars.2012.4905
36 https://doi.org/10.1093/nar/gkt1115
37 https://doi.org/10.1111/febs.13023
38 https://doi.org/10.1111/j.1523-1755.2005.00660.x
39 https://doi.org/10.1128/mcb.19.4.2921
40 https://doi.org/10.1158/0008-5472.can-14-3225
41 https://doi.org/10.1158/1078-0432.ccr-13-2063
42 https://doi.org/10.1189/jlb.1211623
43 https://doi.org/10.1210/en.2010-1122
44 https://doi.org/10.1371/journal.pone.0023577
45 https://doi.org/10.1634/stemcells.2007-0885
46 https://doi.org/10.18632/oncotarget.2729
47 https://doi.org/10.2174/1574888x08666131113123051
48 https://doi.org/10.3892/or.2015.4220
49 https://doi.org/10.4161/onci.20928
50 schema:datePublished 2016-07
51 schema:datePublishedReg 2016-07-01
52 schema:description Cancer stem cells are capable of transformation after apoptosis through the blebbishield emergency program. Reactive oxygen species (ROS) play an essential role in transformation. Understanding how ROS are linked to blebbishield-mediated transformation is necessary to develop efficient therapeutics that target the resurrection of cancer stem cells. Here we demonstrate that a novel PKC-ζ to p47(phox) interaction is required for ROS production in cancer cells. The combined use of the S6K inhibitor BI-D1870 with TNF-α inhibited the PKC-ζ to p47(phox) interaction, inhibited ROS production, degraded PKC-ζ, and activated caspases-3 and -8 to block transformation from blebbishields. BI-D1870 also inhibited transformation from cycloheximide-generated blebbishields. Thus ROS and the PKC-ζ to p47(phox) interaction are valid therapeutic targets to block transformation from blebbishields.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N98cbd47dc9204dedb16bd0431ee70146
57 Nba19a623139d453881770181756b1a76
58 sg:journal.1045337
59 schema:name Novel PKC-ζ to p47phox interaction is necessary for transformation from blebbishields
60 schema:pagination 23965
61 schema:productId N0804c3a5d36146f4951c20704ae1f078
62 N68aba6b2e7b64d43a7c8980f2ff6556a
63 N74f85683eac642baa1d25e14e5c45ff5
64 N88e80d01f7df4909b786bcfb77c617a0
65 Nd860686b3d8a4be19717cbed307b9c8c
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020016077
67 https://doi.org/10.1038/srep23965
68 schema:sdDatePublished 2019-04-10T15:08
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Nf9d8f1cdc4ff43baa89742fcfb20ddc3
71 schema:url http://www.nature.com/srep/2016/160404/srep23965/full/srep23965.html
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0804c3a5d36146f4951c20704ae1f078 schema:name nlm_unique_id
76 schema:value 101563288
77 rdf:type schema:PropertyValue
78 N0fbda41434284d308f62c592a2fe30ef schema:affiliation https://www.grid.ac/institutes/grid.240145.6
79 schema:familyName Gorantla
80 schema:givenName Siddharth
81 rdf:type schema:Person
82 N20ce0b9d4ac04f738ffb8c541fc487fa rdf:first sg:person.01317254231.03
83 rdf:rest N8c19b3bf09cb462a9ecab43a653baa14
84 N30ebb3d2effe4d2182a0dcd796033f43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Tumor Necrosis Factor-alpha
86 rdf:type schema:DefinedTerm
87 N4c2fcd0a212840bf8a7a8e944f3ed4d9 rdf:first sg:person.0723312420.75
88 rdf:rest Ne300271ef1804cfdab4de706144462e7
89 N549efd111c9b4d35aaf0b58832abee62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Protein Kinase C
91 rdf:type schema:DefinedTerm
92 N5d1afaae964c4b93a5980ce0f63f0dbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Neoplastic Stem Cells
94 rdf:type schema:DefinedTerm
95 N68aba6b2e7b64d43a7c8980f2ff6556a schema:name dimensions_id
96 schema:value pub.1020016077
97 rdf:type schema:PropertyValue
98 N74f85683eac642baa1d25e14e5c45ff5 schema:name doi
99 schema:value 10.1038/srep23965
100 rdf:type schema:PropertyValue
101 N874ce61deb224c539b22577d362f04ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cell Transformation, Neoplastic
103 rdf:type schema:DefinedTerm
104 N88e80d01f7df4909b786bcfb77c617a0 schema:name pubmed_id
105 schema:value 27040869
106 rdf:type schema:PropertyValue
107 N8c19b3bf09cb462a9ecab43a653baa14 rdf:first N0fbda41434284d308f62c592a2fe30ef
108 rdf:rest Na63029d67f964a75b45093cb30869d1c
109 N94a036eacee54187992504cec5ea9ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Protein Binding
111 rdf:type schema:DefinedTerm
112 N98cbd47dc9204dedb16bd0431ee70146 schema:issueNumber 1
113 rdf:type schema:PublicationIssue
114 N9b4b092d81724e3d8fdcc190c01bb12d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cycloheximide
116 rdf:type schema:DefinedTerm
117 Na4c35ea4a359426d90ad6a48916ffe9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Pteridines
119 rdf:type schema:DefinedTerm
120 Na63029d67f964a75b45093cb30869d1c rdf:first sg:person.016172066457.96
121 rdf:rest rdf:nil
122 Nae6482b842684624b8891ae1580115c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name NADPH Oxidases
124 rdf:type schema:DefinedTerm
125 Nb3afa32d294b4e48a3a9314f54106bc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cell Line, Tumor
127 rdf:type schema:DefinedTerm
128 Nba19a623139d453881770181756b1a76 schema:volumeNumber 6
129 rdf:type schema:PublicationVolume
130 Nc6fdd9afd6304d868e08ac2933997641 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 Ncedaece124b54d81a51faca834f9c35d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Reactive Oxygen Species
135 rdf:type schema:DefinedTerm
136 Nd860686b3d8a4be19717cbed307b9c8c schema:name readcube_id
137 schema:value 5f5e82d3bb267300c8416ee6e5f396ded5f7c1671f979a8e034a87df8b509a3c
138 rdf:type schema:PropertyValue
139 Ne300271ef1804cfdab4de706144462e7 rdf:first sg:person.0727663124.74
140 rdf:rest N20ce0b9d4ac04f738ffb8c541fc487fa
141 Nf9d8f1cdc4ff43baa89742fcfb20ddc3 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 Nfd5ec4e568c24c23840cbeb046594825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Caspase 3
145 rdf:type schema:DefinedTerm
146 Nfe43d6b0c0ad45a78692670fb8237e3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Caspase 8
148 rdf:type schema:DefinedTerm
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
153 schema:name Oncology and Carcinogenesis
154 rdf:type schema:DefinedTerm
155 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/srep23965
156 rdf:type schema:MonetaryGrant
157 sg:journal.1045337 schema:issn 2045-2322
158 schema:name Scientific Reports
159 rdf:type schema:Periodical
160 sg:person.01317254231.03 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
161 schema:familyName Zhang
162 schema:givenName Qiang
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317254231.03
164 rdf:type schema:Person
165 sg:person.016172066457.96 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
166 schema:familyName Kamat
167 schema:givenName Ashish M
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016172066457.96
169 rdf:type schema:Person
170 sg:person.0723312420.75 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
171 schema:familyName Jinesh
172 schema:givenName Goodwin G
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723312420.75
174 rdf:type schema:Person
175 sg:person.0727663124.74 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
176 schema:familyName Taoka
177 schema:givenName Rikiya
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727663124.74
179 rdf:type schema:Person
180 sg:pub.10.1007/978-1-60761-411-1_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027677011
181 https://doi.org/10.1007/978-1-60761-411-1_4
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/cdd.2012.140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018561356
184 https://doi.org/10.1038/cdd.2012.140
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/cdd.2014.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043175900
187 https://doi.org/10.1038/cdd.2014.34
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/cdd.2016.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052038879
190 https://doi.org/10.1038/cdd.2016.26
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/cddis.2013.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031361234
193 https://doi.org/10.1038/cddis.2013.111
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/cddiscovery.2015.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043861446
196 https://doi.org/10.1038/cddiscovery.2015.69
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/cddiscovery.2016.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043585673
199 https://doi.org/10.1038/cddiscovery.2016.3
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
202 https://doi.org/10.1038/nmeth.2089
203 rdf:type schema:CreativeWork
204 sg:pub.10.1111/j.1523-1755.2005.00660.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004958850
205 https://doi.org/10.1111/j.1523-1755.2005.00660.x
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1077163454 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1078849647 schema:CreativeWork
209 https://doi.org/10.1002/0471143030.cb0303s04 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049823587
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.bbrc.2014.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011093700
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.urolonc.2012.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050180662
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0076-6879(02)52007-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009558095
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1042/bj20150877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717168
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1046/j.1471-4159.2003.01846.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000283612
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1074/jbc.m302251200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051217416
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1089/ars.2012.4905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231994
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1093/nar/gkt1115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019290540
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1111/febs.13023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005687229
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.1523-1755.2005.00660.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004958850
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1128/mcb.19.4.2921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050374259
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1158/0008-5472.can-14-3225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028949375
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1158/1078-0432.ccr-13-2063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004141521
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1189/jlb.1211623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023218536
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1210/en.2010-1122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064250784
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1371/journal.pone.0023577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017094491
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1634/stemcells.2007-0885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000847490
244 rdf:type schema:CreativeWork
245 https://doi.org/10.18632/oncotarget.2729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002895135
246 rdf:type schema:CreativeWork
247 https://doi.org/10.2174/1574888x08666131113123051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069215903
248 rdf:type schema:CreativeWork
249 https://doi.org/10.3892/or.2015.4220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023770448
250 rdf:type schema:CreativeWork
251 https://doi.org/10.4161/onci.20928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040519705
252 rdf:type schema:CreativeWork
253 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
254 schema:name Department of Urology, Unit 1373, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA.
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...