Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Gabriel Pineda, Kathleen M Lennon, Nathaniel P Delos Santos, Florence Lambert-Fliszar, Gennarina L Riso, Elisa Lazzari, Marco A Marra, Sheldon Morris, Asako Sakaue-Sawano, Atsushi Miyawaki, Catriona H M Jamieson

ABSTRACT

While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL) to image live single progenitors on a defined niche coupled with cell cycle gene expression analysis. We have identified key differences in cell cycle regulatory gene expression and transit times between normal and chronic myeloid leukemia progenitors that may inform cancer stem cell eradication strategies. More... »

PAGES

23885

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep23885

DOI

http://dx.doi.org/10.1038/srep23885

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024256694

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27041210


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep23885'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep23885'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep23885'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep23885'


 

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322 https://www.grid.ac/institutes/grid.4708.b schema:alternateName University of Milan
323 schema:name Divisions of Regenerative Medicine and Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0820, USA.
324 Doctoral School of Molecular and Translational Medicine, Department of Health Sciences, University of Milan, Milan, Italy.
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326 https://www.grid.ac/institutes/grid.474690.8 schema:alternateName RIKEN Center for Brain Science
327 schema:name Laboratory for Cell Function and Dynamics, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan.
328 rdf:type schema:Organization
 




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