Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03-15

AUTHORS

Tayyaba Afsar, Janeen H. Trembley, Christine E. Salomon, Suhail Razak, Muhammad Rashid Khan, Khalil Ahmed

ABSTRACT

Acacia hydaspica R. Parker is known for its medicinal uses in multiple ailments. In this study, we performed bioassay-guided fractionation of cytotoxic compounds from A. hydaspica and investigated their effects on growth and signaling activity in prostate and breast cancer cell lines. Four active polyphenolic compounds were identified as 7-O-galloyl catechin (GC), catechin (C), methyl gallate (MG), and catechin-3-O-gallate (CG). The four compounds inhibited prostate cancer PC-3 cell growth in a dose-dependent manner, whereas CG and MG inhibited breast cancer MDA-MB-231 cell growth. All tested compounds inhibited cell survival and colony growth in both cell lines, and there was evidence of chromatin condensation, cell shrinkage and apoptotic bodies. Further, acridine orange, ethidium bromide, propidium iodide and DAPI staining demonstrated that cell death occurred partly via apoptosis in both PC-3 and MDA-MB-231 cells. In PC-3 cells treatment repressed the expression of anti-apoptotic molecules Bcl-2, Bcl-xL and survivin, coupled with down-regulation of signaling pathways AKT, NFκB, ERK1/2 and JAK/STAT. In MDA-MB-231 cells, treatment induced reduction of CK2α, Bcl-xL, survivin and xIAP protein expression along with suppression of NFκB, JAK/STAT and PI3K pathways. Our findings suggest that certain polyphenolic compounds derived from A. hydaspica may be promising chemopreventive/therapeutic candidates against cancer. More... »

PAGES

23077

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep23077

DOI

http://dx.doi.org/10.1038/srep23077

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040070396

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26975752


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120 polyphenolic compounds
121 propidium iodide
122 prostate
123 protein expression
124 reduction
125 shrinkage
126 signal transduction pathways
127 staining
128 study
129 suppression
130 suppression of NFκB
131 survival
132 survivin
133 therapeutic candidate
134 transduction pathways
135 treatment
136 uses
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