Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Yu Shrike Zhang, Jae-Byum Chang, Mario Moisés Alvarez, Grissel Trujillo-de Santiago, Julio Aleman, Byambaa Batzaya, Vaishali Krishnadoss, Aishwarya Aravamudhan Ramanujam, Mehdi Kazemzadeh-Narbat, Fei Chen, Paul W Tillberg, Mehmet Remzi Dokmeci, Edward S Boyden, Ali Khademhosseini

ABSTRACT

To date, much effort has been expended on making high-performance microscopes through better instrumentation. Recently, it was discovered that physical magnification of specimens was possible, through a technique called expansion microscopy (ExM), raising the question of whether physical magnification, coupled to inexpensive optics, could together match the performance of high-end optical equipment, at a tiny fraction of the price. Here we show that such "hybrid microscopy" methods--combining physical and optical magnifications--can indeed achieve high performance at low cost. By physically magnifying objects, then imaging them on cheap miniature fluorescence microscopes ("mini-microscopes"), it is possible to image at a resolution comparable to that previously attainable only with benchtop microscopes that present costs orders of magnitude higher. We believe that this unprecedented hybrid technology that combines expansion microscopy, based on physical magnification, and mini-microscopy, relying on conventional optics--a process we refer to as Expansion Mini-Microscopy (ExMM)--is a highly promising alternative method for performing cost-effective, high-resolution imaging of biological samples. With further advancement of the technology, we believe that ExMM will find widespread applications for high-resolution imaging particularly in research and healthcare scenarios in undeveloped countries or remote places. More... »

PAGES

22691

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep22691

DOI

http://dx.doi.org/10.1038/srep22691

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031087305

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26975883


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