Influence of plasma-activated compounds on melanogenesis and tyrosinase activity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-03-02

AUTHORS

Anser Ali, Zaman Ashraf, Naresh Kumar, Muhammad Rafiq, Farukh Jabeen, Ji Hoon Park, Ki Hong Choi, SeungHyun Lee, Sung-Yum Seo, Eun Ha Choi, Pankaj Attri

ABSTRACT

Many organic chemists around the world synthesize medicinal compounds or extract multiple compounds from plants in order to increase the activity and quality of medicines. In this work, we synthesized new eugenol derivatives (ED) and then treated them with an N2 feeding gas atmospheric pressure plasma jet (APPJ) to increase their utility. We studied the tyrosinase-inhibition activity (activity test) and structural changes (circular dichroism) of tyrosinase with ED and plasma activated eugenol derivatives (PAED) in a cell-free environment. Later, we used docking studies to determine the possible interaction sites of ED and PAED compounds with tyrosinase enzyme. Moreover, we studied the possible effect of ED and PAED on melanin synthesis and its mechanism in melanoma (B16F10) cells. Additionally, we investigated the structural changes that occurred in activated ED after plasma treatment using nuclear magnetic resonance (NMR). Hence, this study provides a new perspective on PAED for the field of plasma medicine. More... »

PAGES

21779

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep21779

DOI

http://dx.doi.org/10.1038/srep21779

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026033769

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26931617


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35 schema:description Many organic chemists around the world synthesize medicinal compounds or extract multiple compounds from plants in order to increase the activity and quality of medicines. In this work, we synthesized new eugenol derivatives (ED) and then treated them with an N2 feeding gas atmospheric pressure plasma jet (APPJ) to increase their utility. We studied the tyrosinase-inhibition activity (activity test) and structural changes (circular dichroism) of tyrosinase with ED and plasma activated eugenol derivatives (PAED) in a cell-free environment. Later, we used docking studies to determine the possible interaction sites of ED and PAED compounds with tyrosinase enzyme. Moreover, we studied the possible effect of ED and PAED on melanin synthesis and its mechanism in melanoma (B16F10) cells. Additionally, we investigated the structural changes that occurred in activated ED after plasma treatment using nuclear magnetic resonance (NMR). Hence, this study provides a new perspective on PAED for the field of plasma medicine.
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42 schema:keywords PAED
43 Quality of Medicines
44 activity
45 atmospheric pressure plasma jet
46 cell-free environment
47 cells
48 changes
49 chemists
50 compounds
51 derivatives
52 docking studies
53 effect
54 environment
55 enzyme
56 eugenol derivatives
57 field
58 influence
59 interaction sites
60 jet
61 magnetic resonance
62 mechanism
63 medicinal compounds
64 medicine
65 melanin synthesis
66 melanogenesis
67 melanoma cells
68 multiple compounds
69 new eugenol derivatives
70 new perspective
71 nuclear magnetic resonance
72 order
73 organic chemists
74 perspective
75 plants
76 plasma
77 plasma jet
78 plasma medicine
79 plasma treatment
80 possible effects
81 possible interaction sites
82 pressure plasma jet
83 quality
84 resonance
85 sites
86 structural changes
87 study
88 synthesis
89 treatment
90 tyrosinase
91 tyrosinase activity
92 tyrosinase enzyme
93 tyrosinase inhibition activity
94 utility
95 work
96 world
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