Diagnosis of adults Xp11.2 translocation renal cell carcinoma by immunohistochemistry and FISH assays: clinicopathological data from ethnic Chinese population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-16

AUTHORS

Yuanyuan Qu, Chengyuan Gu, Hongkai Wang, Kun Chang, Xiaoqun Yang, Xiaoyan Zhou, Bo Dai, Yao Zhu, Guohai Shi, Hailiang Zhang, Dingwei Ye

ABSTRACT

This study aimed to assess the utility of transcription factor E3 (TFE3) break-apart fluorescence in situ hybridization (FISH) assay in diagnosis of Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and to compare the clinicopathological features between adult Xp11.2 RCC and non-Xp11.2 RCC. 76 pathologically suspected Xp11.2 RCCs were recruited from our institution. Both TFE3 immunohistochemistry (IHC) and TFE3 FISH assay were performed for the entire cohort. The progression-free survival (PFS) and overall survival (OS) curves were estimated using the Kaplan-Meier method. FISH analysis confirmed 30 Xp11.2 RCCs, including 28 cases with positive TFE3 immunostaining and 2 cases with negative immunostaining. The false-positive and false-negative rates were 6.7% (2/30) and 4.3% (2/46), respectively, for TFE3 IHC compared with FISH assay. Xp11.2 RCC was significantly associated with higher pathological stage and Fuhrman nuclear grade compared with non-Xp11.2 RCC (P < 0.05). The median PFS and OS for TFE3 FISH-positive group were 13.0 months (95% CI, 8.4-17.6 months) and 50.0 months (95% CI, 27.6-72.4 months), respectively, while the median PFS and OS had not been reached for TFE3 FISH-negative group. In conclusion, TFE3 break-apart FISH assay is a highly useful and standard diagnostic method for Xp11.2 RCC. Adult Xp11.2 RCC is clinically aggressive and often presents at advanced stage with poor prognosis. More... »

PAGES

21677

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep21677

DOI

http://dx.doi.org/10.1038/srep21677

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044755243

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26880493


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29 schema:description This study aimed to assess the utility of transcription factor E3 (TFE3) break-apart fluorescence in situ hybridization (FISH) assay in diagnosis of Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and to compare the clinicopathological features between adult Xp11.2 RCC and non-Xp11.2 RCC. 76 pathologically suspected Xp11.2 RCCs were recruited from our institution. Both TFE3 immunohistochemistry (IHC) and TFE3 FISH assay were performed for the entire cohort. The progression-free survival (PFS) and overall survival (OS) curves were estimated using the Kaplan-Meier method. FISH analysis confirmed 30 Xp11.2 RCCs, including 28 cases with positive TFE3 immunostaining and 2 cases with negative immunostaining. The false-positive and false-negative rates were 6.7% (2/30) and 4.3% (2/46), respectively, for TFE3 IHC compared with FISH assay. Xp11.2 RCC was significantly associated with higher pathological stage and Fuhrman nuclear grade compared with non-Xp11.2 RCC (P < 0.05). The median PFS and OS for TFE3 FISH-positive group were 13.0 months (95% CI, 8.4-17.6 months) and 50.0 months (95% CI, 27.6-72.4 months), respectively, while the median PFS and OS had not been reached for TFE3 FISH-negative group. In conclusion, TFE3 break-apart FISH assay is a highly useful and standard diagnostic method for Xp11.2 RCC. Adult Xp11.2 RCC is clinically aggressive and often presents at advanced stage with poor prognosis.
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37 E3 (TFE3) break-apart fluorescence
38 FISH analysis
39 FISH assay
40 FISH-negative group
41 FISH-positive group
42 Fuhrman nuclear grade
43 Kaplan-Meier method
44 OS
45 RCC
46 TFE3
47 TFE3 FISH
48 TFE3 FISH-negative group
49 TFE3 FISH-positive group
50 TFE3 break-apart FISH assay
51 TFE3 immunohistochemistry
52 Xp11.2 RCC
53 Xp11.2 translocation renal cell carcinoma
54 adult Xp11.2 RCC
55 adult Xp11.2 translocation renal cell carcinoma
56 advanced stage
57 analysis
58 assays
59 break-apart FISH assay
60 break-apart fluorescence
61 carcinoma
62 cases
63 cell carcinoma
64 clinicopathological data
65 clinicopathological features
66 cohort
67 conclusion
68 curves
69 data
70 diagnosis
71 diagnostic methods
72 entire cohort
73 ethnic Chinese population
74 factor E3 (TFE3) break-apart fluorescence
75 false negative rate
76 features
77 fish
78 fluorescence
79 grade
80 group
81 higher pathological stage
82 hybridization
83 immunohistochemistry
84 immunostaining
85 institutions
86 median progression-free survival
87 method
88 months
89 negative immunostaining
90 non-Xp11.2 RCC
91 nuclear grade
92 overall survival curves
93 pathological stage
94 poor prognosis
95 population
96 positive TFE3
97 prognosis
98 progression-free survival
99 rate
100 renal cell carcinoma
101 situ hybridization
102 stage
103 standard diagnostic method
104 study
105 survival
106 survival curves
107 transcription factor E3 (TFE3) break-apart fluorescence
108 translocation renal cell carcinoma
109 utility
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