A polyalanine peptide derived from polar fish with anti-infectious activities View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08

AUTHORS

Marlon H Cardoso, Suzana M Ribeiro, Diego O Nolasco, César de la Fuente-Núñez, Mário R Felício, Sónia Gonçalves, Carolina O Matos, Luciano M Liao, Nuno C Santos, Robert E W Hancock, Octávio L Franco, Ludovico Migliolo

ABSTRACT

Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising alternative to counter bacterial infections includes the antimicrobial peptides (AMPs), which have emerged as model molecules for rational design strategies. Here we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleuronectes americanus. Pa-MAP 1.9 was active against Gram-negative planktonic bacteria and biofilms, without being cytotoxic to mammalian cells. By using AFM, leakage assays, CD spectroscopy and in silico tools, we found that Pa-MAP 1.9 may be acting both on intracellular targets and on the bacterial surface, also being more efficient at interacting with anionic LUVs mimicking Gram-negative bacterial surface, where this peptide adopts α-helical conformations, than cholesterol-enriched LUVs mimicking mammalian cells. Thus, as bacteria present varied physiological features that favor antibiotic-resistance, Pa-MAP 1.9 could be a promising candidate in the development of tools against infections caused by pathogenic bacteria. More... »

PAGES

21385

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep21385

DOI

http://dx.doi.org/10.1038/srep21385

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024374203

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26916401


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