The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-17

AUTHORS

Ying Xu, Cesare Orlandi, Yan Cao, Shengyan Yang, Chan-Il Choi, Vijayakanth Pagadala, Lutz Birnbaumer, Kirill A. Martemyanov, Noga Vardi

ABSTRACT

Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gαoβ3γ13 and this leads to closure of the TRPM1 channel (melastatin). TRPM1 is thought to be constitutively open, but the mechanism that leads to its closure is unclear. We investigated this question in mouse rod bipolar cells by dialyzing reagents that modify the activity of either Gαo or Gβγ and then observing their effects on the basal holding current. After opening the TRPM1 channels with light, a constitutively active mutant of Gαo closed the channel, but wild-type Gαo did not. After closing the channels by dark adaptation, phosducin or inactive Gαo (both sequester Gβγ) opened the channel while the active mutant of Gαo did not. Co-immunoprecipitation showed that TRPM1 interacts with Gβ3 and with the active and inactive forms of Gαo. Furthermore, bioluminescent energy transfer assays indicated that while Gαo interacts with both the N- and the C- termini of TRPM1, Gβγ interacts only with the N-terminus. Our physiological and biochemical results suggest that both Gαo and Gβγ bind TRPM1 channels and cooperate to close them. More... »

PAGES

20940

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep20940

DOI

http://dx.doi.org/10.1038/srep20940

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016200549

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26883481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dark Adaptation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Darkness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanosine 5'-O-(3-Thiotriphosphate)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterotrimeric GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ion Channel Gating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Light", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myristic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Bipolar Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TRPM Cation Channels", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China", 
          "id": "http://www.grid.ac/institutes/grid.260483.b", 
          "name": [
            "GHM Institute of CNS Regeneration, Jinan University, 510632, Guangzhou, China", 
            "Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Ying", 
        "id": "sg:person.0661123067.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661123067.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orlandi", 
        "givenName": "Cesare", 
        "id": "sg:person.01217757135.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217757135.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Yan", 
        "id": "sg:person.01223646136.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223646136.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GHM Institute of CNS Regeneration, Jinan University, 510632, Guangzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.258164.c", 
          "name": [
            "GHM Institute of CNS Regeneration, Jinan University, 510632, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Shengyan", 
        "id": "sg:person.01127547042.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127547042.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA", 
          "id": "http://www.grid.ac/institutes/grid.280664.e", 
          "name": [
            "National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Chan-Il", 
        "id": "sg:person.01347434623.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347434623.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA", 
          "id": "http://www.grid.ac/institutes/grid.280664.e", 
          "name": [
            "National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pagadala", 
        "givenName": "Vijayakanth", 
        "id": "sg:person.01357116717.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357116717.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA", 
          "id": "http://www.grid.ac/institutes/grid.280664.e", 
          "name": [
            "National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Birnbaumer", 
        "givenName": "Lutz", 
        "id": "sg:person.01331173001.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331173001.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA", 
          "id": "http://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martemyanov", 
        "givenName": "Kirill A.", 
        "id": "sg:person.01050454533.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050454533.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Neuroscience, University of Pennsylvania, 19104, Philadelphia, PA, USA", 
          "id": "http://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "Department of Neuroscience, University of Pennsylvania, 19104, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vardi", 
        "givenName": "Noga", 
        "id": "sg:person.01173651471.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173651471.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrm2299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027419051", 
          "https://doi.org/10.1038/nrm2299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/380255a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044826362", 
          "https://doi.org/10.1038/380255a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/16703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047713783", 
          "https://doi.org/10.1038/16703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/351063a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005201648", 
          "https://doi.org/10.1038/351063a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-007-0265-3_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052959814", 
          "https://doi.org/10.1007/978-94-007-0265-3_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/346269a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014706399", 
          "https://doi.org/10.1038/346269a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325321a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042146376", 
          "https://doi.org/10.1038/325321a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-02-17", 
    "datePublishedReg": "2016-02-17", 
    "description": "Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein G\u03b1o\u03b23\u03b313 and this leads to closure of the TRPM1 channel (melastatin). TRPM1 is thought to be constitutively open, but the mechanism that leads to its closure is unclear. We investigated this question in mouse rod bipolar cells by dialyzing reagents that modify the activity of either G\u03b1o or G\u03b2\u03b3 and then observing their effects on the basal holding current. After opening the TRPM1 channels with light, a constitutively active mutant of G\u03b1o closed the channel, but wild-type G\u03b1o did not. After closing the channels by dark adaptation, phosducin or inactive G\u03b1o (both sequester G\u03b2\u03b3) opened the channel while the active mutant of G\u03b1o did not. Co-immunoprecipitation showed that TRPM1 interacts with G\u03b23 and with the active and inactive forms of G\u03b1o. Furthermore, bioluminescent energy transfer assays indicated that while G\u03b1o interacts with both the N- and the C- termini of TRPM1, G\u03b2\u03b3 interacts only with the N-terminus. Our physiological and biochemical results suggest that both G\u03b1o and G\u03b2\u03b3 bind TRPM1 channels and cooperate to close them.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/srep20940", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2507570", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8340617", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2506303", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439118", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2406093", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2717715", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "TRPM1 channels", 
      "active mutant", 
      "metabotropic glutamate receptor mGluR6", 
      "G protein Go", 
      "mouse rod bipolar cells", 
      "energy transfer assay", 
      "\u03b2\u03b3 subunits", 
      "C-terminus", 
      "N-terminus", 
      "bipolar cells", 
      "G\u03b1o", 
      "inactive form", 
      "transfer assay", 
      "mutants", 
      "G\u03b2\u03b3", 
      "TRPM1", 
      "mammalian retina", 
      "rod bipolar cells", 
      "biochemical results", 
      "cells", 
      "G\u03b23", 
      "subunits", 
      "dark adaptation", 
      "photoreceptors", 
      "cascade", 
      "mGluR6", 
      "assays", 
      "adaptation", 
      "glutamate", 
      "retina", 
      "mechanism", 
      "closure", 
      "basal", 
      "activity", 
      "channels", 
      "GO", 
      "light", 
      "form", 
      "reagents", 
      "effect", 
      "transmission", 
      "results", 
      "questions"
    ], 
    "name": "The TRPM1 channel in ON-bipolar cells is gated by both the \u03b1 and the \u03b2\u03b3 subunits of the G-protein Go", 
    "pagination": "20940", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016200549"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep20940"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26883481"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep20940", 
      "https://app.dimensions.ai/details/publication/pub.1016200549"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_687.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/srep20940"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep20940'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep20940'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep20940'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep20940'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      92 URIs      77 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep20940 schema:about N0479e6dcd3c844a2b63d6fdb738e1b04
2 N286e168b3427411184bea27c24838071
3 N369e8e33bd49492bb05f13665a25b83c
4 N40b7d8f6f3f84aa8862f36ac61a209bc
5 N5663a260f2b34eea82bf147ccd9af6fd
6 N59d8ba91b9064e9a85cb4f30ab6da1e0
7 N61efdeba688c4a9c8d552334faf43455
8 N6e0fde3e99c74edfa9658b16ef7a2081
9 N7f54088212f3415993c6881ec9a897fe
10 N86ec4bbf5998443eabb909b604a1d732
11 N908a58acb7634027b634ac18088e0fce
12 N9d760525f84a4f4b89ee7ca6c5b9c2eb
13 Nc45bd2843cb046cd86e2d47240348189
14 Nd531f266f5fb4868afbc0f96c2015acc
15 Ndf8d50a40a5f48f1810fb6d963f18150
16 Ne0c655df3ec543fa83a8d4c0048a22ef
17 Nff99829b9d9643229ad49a2dc1919928
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N363c2c7351a64147912f045e6032bf66
21 schema:citation sg:pub.10.1007/978-94-007-0265-3_7
22 sg:pub.10.1038/16703
23 sg:pub.10.1038/325321a0
24 sg:pub.10.1038/346269a0
25 sg:pub.10.1038/351063a0
26 sg:pub.10.1038/380255a0
27 sg:pub.10.1038/nrm2299
28 schema:datePublished 2016-02-17
29 schema:datePublishedReg 2016-02-17
30 schema:description Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gαoβ3γ13 and this leads to closure of the TRPM1 channel (melastatin). TRPM1 is thought to be constitutively open, but the mechanism that leads to its closure is unclear. We investigated this question in mouse rod bipolar cells by dialyzing reagents that modify the activity of either Gαo or Gβγ and then observing their effects on the basal holding current. After opening the TRPM1 channels with light, a constitutively active mutant of Gαo closed the channel, but wild-type Gαo did not. After closing the channels by dark adaptation, phosducin or inactive Gαo (both sequester Gβγ) opened the channel while the active mutant of Gαo did not. Co-immunoprecipitation showed that TRPM1 interacts with Gβ3 and with the active and inactive forms of Gαo. Furthermore, bioluminescent energy transfer assays indicated that while Gαo interacts with both the N- and the C- termini of TRPM1, Gβγ interacts only with the N-terminus. Our physiological and biochemical results suggest that both Gαo and Gβγ bind TRPM1 channels and cooperate to close them.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N4f1f8fb5620b4c29969a47a477ca82e6
34 Nc4a5da52dc254d86aaebe3caf0a88aa7
35 sg:journal.1045337
36 schema:keywords C-terminus
37 G protein Go
38 GO
39 Gαo
40 Gβ3
41 Gβγ
42 N-terminus
43 TRPM1
44 TRPM1 channels
45 active mutant
46 activity
47 adaptation
48 assays
49 basal
50 biochemical results
51 bipolar cells
52 cascade
53 cells
54 channels
55 closure
56 dark adaptation
57 effect
58 energy transfer assay
59 form
60 glutamate
61 inactive form
62 light
63 mGluR6
64 mammalian retina
65 mechanism
66 metabotropic glutamate receptor mGluR6
67 mouse rod bipolar cells
68 mutants
69 photoreceptors
70 questions
71 reagents
72 results
73 retina
74 rod bipolar cells
75 subunits
76 transfer assay
77 transmission
78 βγ subunits
79 schema:name The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go
80 schema:pagination 20940
81 schema:productId N26fa273393314f2b8cf0d0ee046ea75f
82 N5b9e2280644c4998829de80d9580f5ce
83 N629f9af02372409daeb9365f087ab47f
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016200549
85 https://doi.org/10.1038/srep20940
86 schema:sdDatePublished 2022-10-01T06:41
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N4f7e9e2a2a1744f69fb6be04acba7160
89 schema:url https://doi.org/10.1038/srep20940
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N0479e6dcd3c844a2b63d6fdb738e1b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Retinal Bipolar Cells
95 rdf:type schema:DefinedTerm
96 N1527d49233a94d60845eb29d45f1d438 rdf:first sg:person.01223646136.08
97 rdf:rest N82d3aa71c5d04863b04ef63b0f44aa35
98 N26fa273393314f2b8cf0d0ee046ea75f schema:name doi
99 schema:value 10.1038/srep20940
100 rdf:type schema:PropertyValue
101 N286e168b3427411184bea27c24838071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N332d8fe70c4d425482ceee7d393881c0 rdf:first sg:person.01331173001.25
105 rdf:rest N86c411ac70d44b3f8db661424ac3df45
106 N363c2c7351a64147912f045e6032bf66 rdf:first sg:person.0661123067.90
107 rdf:rest N9596966a7f624f4cbf6ef972e03c2649
108 N369e8e33bd49492bb05f13665a25b83c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Guanosine 5'-O-(3-Thiotriphosphate)
110 rdf:type schema:DefinedTerm
111 N40b7d8f6f3f84aa8862f36ac61a209bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Mutation
113 rdf:type schema:DefinedTerm
114 N4f1f8fb5620b4c29969a47a477ca82e6 schema:volumeNumber 6
115 rdf:type schema:PublicationVolume
116 N4f7e9e2a2a1744f69fb6be04acba7160 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N5663a260f2b34eea82bf147ccd9af6fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Darkness
120 rdf:type schema:DefinedTerm
121 N59d8ba91b9064e9a85cb4f30ab6da1e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name TRPM Cation Channels
123 rdf:type schema:DefinedTerm
124 N5b9e2280644c4998829de80d9580f5ce schema:name dimensions_id
125 schema:value pub.1016200549
126 rdf:type schema:PropertyValue
127 N61efdeba688c4a9c8d552334faf43455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Light
129 rdf:type schema:DefinedTerm
130 N629f9af02372409daeb9365f087ab47f schema:name pubmed_id
131 schema:value 26883481
132 rdf:type schema:PropertyValue
133 N6e0fde3e99c74edfa9658b16ef7a2081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Rats
135 rdf:type schema:DefinedTerm
136 N7f54088212f3415993c6881ec9a897fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Protein Binding
138 rdf:type schema:DefinedTerm
139 N82d3aa71c5d04863b04ef63b0f44aa35 rdf:first sg:person.01127547042.86
140 rdf:rest Nfc9a3f41f4424c5c9c086c20885043d4
141 N86c411ac70d44b3f8db661424ac3df45 rdf:first sg:person.01050454533.21
142 rdf:rest Nc3c79775185a45b594af8b32ff65f9ee
143 N86ec4bbf5998443eabb909b604a1d732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Dark Adaptation
145 rdf:type schema:DefinedTerm
146 N908a58acb7634027b634ac18088e0fce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 N9596966a7f624f4cbf6ef972e03c2649 rdf:first sg:person.01217757135.05
150 rdf:rest N1527d49233a94d60845eb29d45f1d438
151 N9d760525f84a4f4b89ee7ca6c5b9c2eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Heterotrimeric GTP-Binding Proteins
153 rdf:type schema:DefinedTerm
154 Nc3c79775185a45b594af8b32ff65f9ee rdf:first sg:person.01173651471.34
155 rdf:rest rdf:nil
156 Nc45bd2843cb046cd86e2d47240348189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mice
158 rdf:type schema:DefinedTerm
159 Nc4a5da52dc254d86aaebe3caf0a88aa7 schema:issueNumber 1
160 rdf:type schema:PublicationIssue
161 Nd531f266f5fb4868afbc0f96c2015acc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Ion Channel Gating
163 rdf:type schema:DefinedTerm
164 Ndf8d50a40a5f48f1810fb6d963f18150 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Line
166 rdf:type schema:DefinedTerm
167 Ne0c655df3ec543fa83a8d4c0048a22ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Models, Animal
169 rdf:type schema:DefinedTerm
170 Ne747442e7aa24c5f845f46ad7138e9cd rdf:first sg:person.01357116717.32
171 rdf:rest N332d8fe70c4d425482ceee7d393881c0
172 Nfc9a3f41f4424c5c9c086c20885043d4 rdf:first sg:person.01347434623.24
173 rdf:rest Ne747442e7aa24c5f845f46ad7138e9cd
174 Nff99829b9d9643229ad49a2dc1919928 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Myristic Acid
176 rdf:type schema:DefinedTerm
177 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
178 schema:name Biological Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
181 schema:name Biochemistry and Cell Biology
182 rdf:type schema:DefinedTerm
183 sg:grant.2406093 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20940
184 rdf:type schema:MonetaryGrant
185 sg:grant.2439118 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20940
186 rdf:type schema:MonetaryGrant
187 sg:grant.2506303 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20940
188 rdf:type schema:MonetaryGrant
189 sg:grant.2507570 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20940
190 rdf:type schema:MonetaryGrant
191 sg:grant.2717715 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20940
192 rdf:type schema:MonetaryGrant
193 sg:grant.8340617 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20940
194 rdf:type schema:MonetaryGrant
195 sg:journal.1045337 schema:issn 2045-2322
196 schema:name Scientific Reports
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01050454533.21 schema:affiliation grid-institutes:grid.214007.0
200 schema:familyName Martemyanov
201 schema:givenName Kirill A.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050454533.21
203 rdf:type schema:Person
204 sg:person.01127547042.86 schema:affiliation grid-institutes:grid.258164.c
205 schema:familyName Yang
206 schema:givenName Shengyan
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127547042.86
208 rdf:type schema:Person
209 sg:person.01173651471.34 schema:affiliation grid-institutes:grid.25879.31
210 schema:familyName Vardi
211 schema:givenName Noga
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173651471.34
213 rdf:type schema:Person
214 sg:person.01217757135.05 schema:affiliation grid-institutes:grid.214007.0
215 schema:familyName Orlandi
216 schema:givenName Cesare
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217757135.05
218 rdf:type schema:Person
219 sg:person.01223646136.08 schema:affiliation grid-institutes:grid.214007.0
220 schema:familyName Cao
221 schema:givenName Yan
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223646136.08
223 rdf:type schema:Person
224 sg:person.01331173001.25 schema:affiliation grid-institutes:grid.280664.e
225 schema:familyName Birnbaumer
226 schema:givenName Lutz
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331173001.25
228 rdf:type schema:Person
229 sg:person.01347434623.24 schema:affiliation grid-institutes:grid.280664.e
230 schema:familyName Choi
231 schema:givenName Chan-Il
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347434623.24
233 rdf:type schema:Person
234 sg:person.01357116717.32 schema:affiliation grid-institutes:grid.280664.e
235 schema:familyName Pagadala
236 schema:givenName Vijayakanth
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357116717.32
238 rdf:type schema:Person
239 sg:person.0661123067.90 schema:affiliation grid-institutes:grid.260483.b
240 schema:familyName Xu
241 schema:givenName Ying
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661123067.90
243 rdf:type schema:Person
244 sg:pub.10.1007/978-94-007-0265-3_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052959814
245 https://doi.org/10.1007/978-94-007-0265-3_7
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/16703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047713783
248 https://doi.org/10.1038/16703
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/325321a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042146376
251 https://doi.org/10.1038/325321a0
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/346269a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014706399
254 https://doi.org/10.1038/346269a0
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/351063a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005201648
257 https://doi.org/10.1038/351063a0
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/380255a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044826362
260 https://doi.org/10.1038/380255a0
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nrm2299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027419051
263 https://doi.org/10.1038/nrm2299
264 rdf:type schema:CreativeWork
265 grid-institutes:grid.214007.0 schema:alternateName Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA
266 schema:name Department of Neuroscience, The Scripps Research Institute, 33458, Jupiter, FL, USA
267 rdf:type schema:Organization
268 grid-institutes:grid.258164.c schema:alternateName GHM Institute of CNS Regeneration, Jinan University, 510632, Guangzhou, China
269 schema:name GHM Institute of CNS Regeneration, Jinan University, 510632, Guangzhou, China
270 rdf:type schema:Organization
271 grid-institutes:grid.25879.31 schema:alternateName Department of Neuroscience, University of Pennsylvania, 19104, Philadelphia, PA, USA
272 schema:name Department of Neuroscience, University of Pennsylvania, 19104, Philadelphia, PA, USA
273 rdf:type schema:Organization
274 grid-institutes:grid.260483.b schema:alternateName Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China
275 schema:name Co-Innovation Center of Neuroregeneration, Nantong University, Jiangsu, China
276 GHM Institute of CNS Regeneration, Jinan University, 510632, Guangzhou, China
277 rdf:type schema:Organization
278 grid-institutes:grid.280664.e schema:alternateName National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA
279 schema:name National Institute of Environmental Health. Sciences., Research Triangle Park, 27709, NC, USA
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...