Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02-15

AUTHORS

Xinwei Li, Deyu Li, Qiongling Li, Yuxia Li, Kuncheng Li, Shuyu Li, Ying Han

ABSTRACT

Memory impairment is a typical characteristic of patients with subcortical vascular mild cognitive impairment (svMCI) or with amnestic mild cognitive impairment (aMCI). The hippocampus, which plays an important role in the consolidation of information from short-term memory to long-term memory, is a heterogeneous structure that consists of several anatomically and functionally distinct subfields. However, whether distinct hippocampal subfields are differentially and selectively affected by svMCI pathology and whether these abnormal changes in hippocampal subfields are different between svMCI and aMCI patients are largely unknown. A total of 26 svMCI patients, 26 aMCI patients and 26 healthy controls matched according to age, gender and years of education were enrolled in this study. We utilized an automated hippocampal subfield segmentation method provided by FreeSurfer to estimate the volume of several hippocampal subfields, including the cornu ammonis (CA) areas, the dentate gyrus (DG), the subiculum and the presubiculum. Compared with controls, the left subiculum and presubiculum and the right CA4/DG displayed significant atrophy in patients with svMCI. Interestingly, we also found significant differences in the volume of the right CA1 between the svMCI and aMCI groups. Taken together, our results reveal region-specific vulnerability of hippocampal subfields to svMCI pathology and identify distinct hippocampal subfield atrophy patterns between svMCI and aMCI patients. More... »

PAGES

20873

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep20873

DOI

http://dx.doi.org/10.1038/srep20873

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050943487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26876151


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