Reversible cardiac hypertrophy induced by PEG-coated gold nanoparticles in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04

AUTHORS

Chengzhi Yang, Aiju Tian, Zijian Li

ABSTRACT

Gold nanoparticles (GNPs) are attracting more and more attention for their great potential value in biomedical application. Currently, no study has been reported on the chronic cardiac toxicity of GNPs after repeated administration. Here we carried out a comprehensive evaluation of the chronic cardiac toxicity of GNPs to the heart. Polyethylene glycol (PEG) -coated GNPs at three different sizes (10, 30 and 50 nm) or PBS was administrated to mice via tail vein for 14 consecutive days. Then the mice were euthanized at 2 weeks, 4 weeks or 12 weeks after the first injection. The accumulation of GNPs in the mouse heart and their effects on cardiac function, structure, fibrosis and inflammation were analysized. GNPs with smaller size showed higher accumulation and faster elimination. None of the three sizes of GNPs affected cardiac systolic function. The LVIDd (left ventricular end-diastolicinner-dimension), LVMass (left ventricular mass) and HW/BW (heart weight/body weight) were significantly increased in the mice receiving 10 nm PEG-GNPs for 2 weeks, but not for 4 weeks or 12 weeks. These results indicated that the accumulation of small size GNPs can induce reversible cardiac hypertrophy. Our results provide the basis for the further biomedical applications of GNPs in cardiac diseases. More... »

PAGES

20203

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep20203

DOI

http://dx.doi.org/10.1038/srep20203

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025238829

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26830764


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiomegaly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coated Materials, Biocompatible", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gold", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation Mediators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metal Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Particle Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyethylene Glycols", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Chengzhi", 
        "id": "sg:person.01145321162.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145321162.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Aiju", 
        "id": "sg:person.0652372062.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652372062.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zijian", 
        "id": "sg:person.07460443154.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07460443154.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0733-8651(05)70154-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000963903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-bioeng-071811-150124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000993927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfb.2014.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001574876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201000134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003002062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c0cs00018c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004400899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004692245", 
          "https://doi.org/10.1038/nrd2591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004692245", 
          "https://doi.org/10.1038/nrd2591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0091350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006185220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cmdc.201100311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006733346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-511x-10-133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007709820", 
          "https://doi.org/10.1186/1476-511x-10-133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.1994.1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009769917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrcardio.2014.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010191575", 
          "https://doi.org/10.1038/nrcardio.2014.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfb.2008.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011173146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1359-6446(05)03575-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012403694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep00847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013258574", 
          "https://doi.org/10.1038/srep00847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013891227", 
          "https://doi.org/10.1038/nbt872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013891227", 
          "https://doi.org/10.1038/nbt872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2008.12.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015930777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.1896.sp000596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017624566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2012.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019079001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2013.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019415929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b514191e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019624713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00393-003-0458-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020187442", 
          "https://doi.org/10.1007/s00393-003-0458-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1289/ehp.7339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021597152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aca.2011.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024461069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2012.11.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025716422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2007.12.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028529625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2010.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032735525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vph.2012.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034148158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyu046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040765597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/21691401.2014.971807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041221409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2014.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041973457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cis.2013.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042206323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-511x-10-205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048247825", 
          "https://doi.org/10.1186/1476-511x-10-205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfb.2015.08.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048358681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.02.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049569435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-4-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052832373", 
          "https://doi.org/10.1186/1743-8977-4-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja809236a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055860238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja809236a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055860238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja900591t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055860638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja900591t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055860638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp057170o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056064326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp057170o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056064326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl202559p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056218833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl202559p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056218833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl900031y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056221800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nl900031y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056221800"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04", 
    "datePublishedReg": "2016-04-01", 
    "description": "Gold nanoparticles (GNPs) are attracting more and more attention for their great potential value in biomedical application. Currently, no study has been reported on the chronic cardiac toxicity of GNPs after repeated administration. Here we carried out a comprehensive evaluation of the chronic cardiac toxicity of GNPs to the heart. Polyethylene glycol (PEG) -coated GNPs at three different sizes (10, 30 and 50\u2009nm) or PBS was administrated to mice via tail vein for 14 consecutive days. Then the mice were euthanized at 2 weeks, 4 weeks or 12 weeks after the first injection. The accumulation of GNPs in the mouse heart and their effects on cardiac function, structure, fibrosis and inflammation were analysized. GNPs with smaller size showed higher accumulation and faster elimination. None of the three sizes of GNPs affected cardiac systolic function. The LVIDd (left ventricular end-diastolicinner-dimension), LVMass (left ventricular mass) and HW/BW (heart weight/body weight) were significantly increased in the mice receiving 10\u2009nm PEG-GNPs for 2 weeks, but not for 4 weeks or 12 weeks. These results indicated that the accumulation of small size GNPs can induce reversible cardiac hypertrophy. Our results provide the basis for the further biomedical applications of GNPs in cardiac diseases. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep20203", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7180985", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Reversible cardiac hypertrophy induced by PEG-coated gold nanoparticles in mice", 
    "pagination": "20203", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "783ce8dbd341d001edc2e452b13763f16ba5c475a84ced57a17df55210b57d11"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26830764"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep20203"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025238829"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep20203", 
      "https://app.dimensions.ai/details/publication/pub.1025238829"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/srep/2016/160201/srep20203/full/srep20203.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep20203'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep20203'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep20203'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep20203'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep20203 schema:about N09348843540e4c4eb9e0ae811115384f
2 N11dc369256b040a1aa01790cde6425a8
3 N31545a6b462746baa717beb72f6b08bd
4 N3a2e019cfc894ddbaf3a012e890b3c4f
5 N420c858c96a646cd9f948354567125ee
6 N4e063f4305c041c6a846f310d3d627cc
7 N609a7080fe704c0daa77ec1a2a552622
8 N6174193166f54254b6ae5ce181b36e2c
9 N8e0e87f84aa54dcb839f4db4db2dc471
10 N9a81165d7e12458096a61b5132a38e49
11 Nb2d800a3613944ce9deaaac14b774495
12 Nbed72af7bbbd40cd848fd0673ef98e42
13 Nc574d438bec44b26b596cb67f1c2fb22
14 Nc6de108e9d944199aae484802e149544
15 Nc9995cf282184072b717d9eb5b72ce9a
16 Nc9ab00431f914ea093e2eca6740b1ac3
17 Ne3f1a1482fdc47c2a63dd67f1d2495b0
18 anzsrc-for:11
19 anzsrc-for:1102
20 schema:author Nd3a90aa23fb4426fa563c64161d6a5b0
21 schema:citation sg:pub.10.1007/s00393-003-0458-2
22 sg:pub.10.1038/nbt872
23 sg:pub.10.1038/nrcardio.2014.28
24 sg:pub.10.1038/nrd2591
25 sg:pub.10.1038/srep00847
26 sg:pub.10.1186/1476-511x-10-133
27 sg:pub.10.1186/1476-511x-10-205
28 sg:pub.10.1186/1743-8977-4-10
29 https://doi.org/10.1002/cmdc.201100311
30 https://doi.org/10.1002/smll.201000134
31 https://doi.org/10.1006/jmcc.1994.1036
32 https://doi.org/10.1016/j.aca.2011.12.008
33 https://doi.org/10.1016/j.bbrc.2010.02.046
34 https://doi.org/10.1016/j.biomaterials.2007.12.037
35 https://doi.org/10.1016/j.cis.2013.06.003
36 https://doi.org/10.1016/j.colsurfb.2008.07.004
37 https://doi.org/10.1016/j.colsurfb.2014.01.006
38 https://doi.org/10.1016/j.colsurfb.2015.08.032
39 https://doi.org/10.1016/j.jconrel.2014.04.027
40 https://doi.org/10.1016/j.nano.2012.01.008
41 https://doi.org/10.1016/j.taap.2008.12.023
42 https://doi.org/10.1016/j.taap.2010.02.013
43 https://doi.org/10.1016/j.toxlet.2012.11.022
44 https://doi.org/10.1016/j.toxlet.2013.07.018
45 https://doi.org/10.1016/j.vph.2012.07.003
46 https://doi.org/10.1016/s0733-8651(05)70154-5
47 https://doi.org/10.1016/s1359-6446(05)03575-0
48 https://doi.org/10.1021/ja809236a
49 https://doi.org/10.1021/ja900591t
50 https://doi.org/10.1021/jp057170o
51 https://doi.org/10.1021/nl202559p
52 https://doi.org/10.1021/nl900031y
53 https://doi.org/10.1039/b514191e
54 https://doi.org/10.1039/c0cs00018c
55 https://doi.org/10.1093/jjco/hyu046
56 https://doi.org/10.1113/jphysiol.1896.sp000596
57 https://doi.org/10.1146/annurev-bioeng-071811-150124
58 https://doi.org/10.1289/ehp.7339
59 https://doi.org/10.1371/journal.pone.0091350
60 https://doi.org/10.3109/21691401.2014.971807
61 schema:datePublished 2016-04
62 schema:datePublishedReg 2016-04-01
63 schema:description Gold nanoparticles (GNPs) are attracting more and more attention for their great potential value in biomedical application. Currently, no study has been reported on the chronic cardiac toxicity of GNPs after repeated administration. Here we carried out a comprehensive evaluation of the chronic cardiac toxicity of GNPs to the heart. Polyethylene glycol (PEG) -coated GNPs at three different sizes (10, 30 and 50 nm) or PBS was administrated to mice via tail vein for 14 consecutive days. Then the mice were euthanized at 2 weeks, 4 weeks or 12 weeks after the first injection. The accumulation of GNPs in the mouse heart and their effects on cardiac function, structure, fibrosis and inflammation were analysized. GNPs with smaller size showed higher accumulation and faster elimination. None of the three sizes of GNPs affected cardiac systolic function. The LVIDd (left ventricular end-diastolicinner-dimension), LVMass (left ventricular mass) and HW/BW (heart weight/body weight) were significantly increased in the mice receiving 10 nm PEG-GNPs for 2 weeks, but not for 4 weeks or 12 weeks. These results indicated that the accumulation of small size GNPs can induce reversible cardiac hypertrophy. Our results provide the basis for the further biomedical applications of GNPs in cardiac diseases.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N9df48b00406b4b3f9e25b7209739ac66
68 Nd9890f1dc4a74adcbf5fcfc9f1dd30ce
69 sg:journal.1045337
70 schema:name Reversible cardiac hypertrophy induced by PEG-coated gold nanoparticles in mice
71 schema:pagination 20203
72 schema:productId N3ef75273d61d47f9b86d95da07d58e12
73 N41094b4411084009befaacf700f5b090
74 N7cc9cad84a814283a8fb2d65faac5cf4
75 N7e8e47a61d7a4df9a0cdd0348d474401
76 Na65bb0cf35ae4371bdfe5caf5fb04e24
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025238829
78 https://doi.org/10.1038/srep20203
79 schema:sdDatePublished 2019-04-11T02:19
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N769777744abf4bc2b8eb83280df7055a
82 schema:url http://www.nature.com/srep/2016/160201/srep20203/full/srep20203.html
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N09348843540e4c4eb9e0ae811115384f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Mice
88 rdf:type schema:DefinedTerm
89 N0b19a2656cfd4ab2a2c63fd1a942a81a rdf:first sg:person.07460443154.78
90 rdf:rest rdf:nil
91 N11dc369256b040a1aa01790cde6425a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Inflammation Mediators
93 rdf:type schema:DefinedTerm
94 N2cc430b71a704884b9effe5fb090238d schema:name Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China.
95 rdf:type schema:Organization
96 N31545a6b462746baa717beb72f6b08bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Myocardium
98 rdf:type schema:DefinedTerm
99 N3a2e019cfc894ddbaf3a012e890b3c4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cytokines
101 rdf:type schema:DefinedTerm
102 N3ef75273d61d47f9b86d95da07d58e12 schema:name pubmed_id
103 schema:value 26830764
104 rdf:type schema:PropertyValue
105 N41094b4411084009befaacf700f5b090 schema:name dimensions_id
106 schema:value pub.1025238829
107 rdf:type schema:PropertyValue
108 N420c858c96a646cd9f948354567125ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Animals
110 rdf:type schema:DefinedTerm
111 N4e063f4305c041c6a846f310d3d627cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Models, Biological
113 rdf:type schema:DefinedTerm
114 N5bb244c5d09d4a6da9263ef2bfd40372 schema:name Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China.
115 rdf:type schema:Organization
116 N609a7080fe704c0daa77ec1a2a552622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Metal Nanoparticles
118 rdf:type schema:DefinedTerm
119 N6174193166f54254b6ae5ce181b36e2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Gold
121 rdf:type schema:DefinedTerm
122 N769777744abf4bc2b8eb83280df7055a schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 N7b2c9b8c0fd240a99aac6813832a74b7 rdf:first sg:person.0652372062.19
125 rdf:rest N0b19a2656cfd4ab2a2c63fd1a942a81a
126 N7cc9cad84a814283a8fb2d65faac5cf4 schema:name readcube_id
127 schema:value 783ce8dbd341d001edc2e452b13763f16ba5c475a84ced57a17df55210b57d11
128 rdf:type schema:PropertyValue
129 N7e8e47a61d7a4df9a0cdd0348d474401 schema:name nlm_unique_id
130 schema:value 101563288
131 rdf:type schema:PropertyValue
132 N8e0e87f84aa54dcb839f4db4db2dc471 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Inflammation
134 rdf:type schema:DefinedTerm
135 N9a81165d7e12458096a61b5132a38e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cardiomegaly
137 rdf:type schema:DefinedTerm
138 N9df48b00406b4b3f9e25b7209739ac66 schema:volumeNumber 6
139 rdf:type schema:PublicationVolume
140 Na65bb0cf35ae4371bdfe5caf5fb04e24 schema:name doi
141 schema:value 10.1038/srep20203
142 rdf:type schema:PropertyValue
143 Nb2d800a3613944ce9deaaac14b774495 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Fibrosis
145 rdf:type schema:DefinedTerm
146 Nbed72af7bbbd40cd848fd0673ef98e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Biomarkers
148 rdf:type schema:DefinedTerm
149 Nc574d438bec44b26b596cb67f1c2fb22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Disease Models, Animal
151 rdf:type schema:DefinedTerm
152 Nc6de108e9d944199aae484802e149544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Particle Size
154 rdf:type schema:DefinedTerm
155 Nc9995cf282184072b717d9eb5b72ce9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Coated Materials, Biocompatible
157 rdf:type schema:DefinedTerm
158 Nc9ab00431f914ea093e2eca6740b1ac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Polyethylene Glycols
160 rdf:type schema:DefinedTerm
161 Nd3a90aa23fb4426fa563c64161d6a5b0 rdf:first sg:person.01145321162.70
162 rdf:rest N7b2c9b8c0fd240a99aac6813832a74b7
163 Nd9890f1dc4a74adcbf5fcfc9f1dd30ce schema:issueNumber 1
164 rdf:type schema:PublicationIssue
165 Ne3f1a1482fdc47c2a63dd67f1d2495b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Heart Function Tests
167 rdf:type schema:DefinedTerm
168 Nf72cf18262374ea59a6632f7fa2114b9 schema:name Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education and Beijing Key Laboratory of Cardiovasicular Receptors Research Beijing 100191, China.
169 rdf:type schema:Organization
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
174 schema:name Cardiorespiratory Medicine and Haematology
175 rdf:type schema:DefinedTerm
176 sg:grant.7180985 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20203
177 rdf:type schema:MonetaryGrant
178 sg:journal.1045337 schema:issn 2045-2322
179 schema:name Scientific Reports
180 rdf:type schema:Periodical
181 sg:person.01145321162.70 schema:affiliation Nf72cf18262374ea59a6632f7fa2114b9
182 schema:familyName Yang
183 schema:givenName Chengzhi
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145321162.70
185 rdf:type schema:Person
186 sg:person.0652372062.19 schema:affiliation N5bb244c5d09d4a6da9263ef2bfd40372
187 schema:familyName Tian
188 schema:givenName Aiju
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652372062.19
190 rdf:type schema:Person
191 sg:person.07460443154.78 schema:affiliation N2cc430b71a704884b9effe5fb090238d
192 schema:familyName Li
193 schema:givenName Zijian
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07460443154.78
195 rdf:type schema:Person
196 sg:pub.10.1007/s00393-003-0458-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020187442
197 https://doi.org/10.1007/s00393-003-0458-2
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nbt872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013891227
200 https://doi.org/10.1038/nbt872
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/nrcardio.2014.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010191575
203 https://doi.org/10.1038/nrcardio.2014.28
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/nrd2591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004692245
206 https://doi.org/10.1038/nrd2591
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/srep00847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013258574
209 https://doi.org/10.1038/srep00847
210 rdf:type schema:CreativeWork
211 sg:pub.10.1186/1476-511x-10-133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007709820
212 https://doi.org/10.1186/1476-511x-10-133
213 rdf:type schema:CreativeWork
214 sg:pub.10.1186/1476-511x-10-205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048247825
215 https://doi.org/10.1186/1476-511x-10-205
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/1743-8977-4-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052832373
218 https://doi.org/10.1186/1743-8977-4-10
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/cmdc.201100311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006733346
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/smll.201000134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003002062
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1006/jmcc.1994.1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009769917
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.aca.2011.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024461069
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.bbrc.2010.02.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049569435
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.biomaterials.2007.12.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028529625
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.cis.2013.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042206323
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.colsurfb.2008.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011173146
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.colsurfb.2014.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001574876
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.colsurfb.2015.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048358681
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.jconrel.2014.04.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041973457
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.nano.2012.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019079001
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.taap.2008.12.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015930777
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.taap.2010.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032735525
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.toxlet.2012.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025716422
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.toxlet.2013.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019415929
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.vph.2012.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034148158
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s0733-8651(05)70154-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000963903
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s1359-6446(05)03575-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012403694
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1021/ja809236a schema:sameAs https://app.dimensions.ai/details/publication/pub.1055860238
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1021/ja900591t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055860638
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1021/jp057170o schema:sameAs https://app.dimensions.ai/details/publication/pub.1056064326
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1021/nl202559p schema:sameAs https://app.dimensions.ai/details/publication/pub.1056218833
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1021/nl900031y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056221800
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1039/b514191e schema:sameAs https://app.dimensions.ai/details/publication/pub.1019624713
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1039/c0cs00018c schema:sameAs https://app.dimensions.ai/details/publication/pub.1004400899
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/jjco/hyu046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040765597
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1113/jphysiol.1896.sp000596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017624566
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1146/annurev-bioeng-071811-150124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000993927
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1289/ehp.7339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021597152
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1371/journal.pone.0091350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006185220
281 rdf:type schema:CreativeWork
282 https://doi.org/10.3109/21691401.2014.971807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041221409
283 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...