Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04

AUTHORS

Jennifer J. Ware, Xiangning Chen, Jacqueline Vink, Anu Loukola, Camelia Minica, Rene Pool, Yuri Milaneschi, Massimo Mangino, Cristina Menni, Jingchun Chen, Roseann E. Peterson, Kirsi Auro, Leo-Pekka Lyytikäinen, Juho Wedenoja, Alexander I. Stiby, Gibran Hemani, Gonneke Willemsen, Jouke Jan Hottenga, Tellervo Korhonen, Markku Heliövaara, Markus Perola, Richard J. Rose, Lavinia Paternoster, Nic Timpson, Catherine A. Wassenaar, Andy Z. X. Zhu, George Davey Smith, Olli T. Raitakari, Terho Lehtimäki, Mika Kähönen, Seppo Koskinen, Timothy Spector, Brenda W. J. H. Penninx, Veikko Salomaa, Dorret I. Boomsma, Rachel F. Tyndale, Jaakko Kaprio, Marcus R. Munafò

ABSTRACT

Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking typically employ self-report phenotypes. However, precise biomarker phenotypes may afford greater statistical power and identify novel variants. Here we report the results of a GWAS meta-analysis of levels of cotinine, the primary metabolite of nicotine, in 4,548 daily smokers of European ancestry. We identified a locus close to UGT2B10 at 4q13.2 (minimum p = 5.89 × 10(-10) for rs114612145), which was consequently replicated. This variant is in high linkage disequilibrium with a known functional variant in the UGT2B10 gene which is associated with reduced nicotine and cotinine glucuronidation activity, but intriguingly is not associated with nicotine intake. Additionally, we observed association between multiple variants within the 15q25.1 region and cotinine levels, all located within the CHRNA5-A3-B4 gene cluster or adjacent genes, consistent with previous much larger GWAS using self-report measures of smoking quantity. These results clearly illustrate the increase in power afforded by using precise biomarker measures in GWAS. Perhaps more importantly however, they also highlight that biomarkers do not always mark the phenotype of interest. The use of metabolite data as a proxy for environmental exposures should be carefully considered in the context of individual differences in metabolic pathways. More... »

PAGES

20092

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/srep20092

DOI

http://dx.doi.org/10.1038/srep20092

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024975364

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26833182


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cotinine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Loci", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucuronosyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smoking", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom", 
            "School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ware", 
        "givenName": "Jennifer J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virginia Commonwealth University", 
          "id": "https://www.grid.ac/institutes/grid.224260.0", 
          "name": [
            "Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiangning", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.12380.38", 
          "name": [
            "Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vink", 
        "givenName": "Jacqueline", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loukola", 
        "givenName": "Anu", 
        "id": "sg:person.01034333505.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034333505.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.12380.38", 
          "name": [
            "Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minica", 
        "givenName": "Camelia", 
        "id": "sg:person.0642616316.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642616316.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.12380.38", 
          "name": [
            "Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pool", 
        "givenName": "Rene", 
        "id": "sg:person.01134036767.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134036767.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, 1081 HL, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milaneschi", 
        "givenName": "Yuri", 
        "id": "sg:person.0633256337.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633256337.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Twin Research and Genetic Epidemiology, King\u2019s College London, London, SE1 7EH, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mangino", 
        "givenName": "Massimo", 
        "id": "sg:person.0711664555.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711664555.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Twin Research and Genetic Epidemiology, King\u2019s College London, London, SE1 7EH, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menni", 
        "givenName": "Cristina", 
        "id": "sg:person.01043744667.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043744667.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virginia Commonwealth University", 
          "id": "https://www.grid.ac/institutes/grid.224260.0", 
          "name": [
            "Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jingchun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virginia Commonwealth University", 
          "id": "https://www.grid.ac/institutes/grid.224260.0", 
          "name": [
            "Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peterson", 
        "givenName": "Roseann E.", 
        "id": "sg:person.01141211611.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141211611.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland", 
            "Institute for Molecular Medicine, University of Helsinki, Helsinki, FI-00014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auro", 
        "givenName": "Kirsi", 
        "id": "sg:person.01102600173.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102600173.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33520, Finland", 
            "Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, FI-33014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lyytik\u00e4inen", 
        "givenName": "Leo-Pekka", 
        "id": "sg:person.01020276562.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020276562.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wedenoja", 
        "givenName": "Juho", 
        "id": "sg:person.0613664645.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613664645.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stiby", 
        "givenName": "Alexander I.", 
        "id": "sg:person.01175335165.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175335165.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom", 
            "School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hemani", 
        "givenName": "Gibran", 
        "id": "sg:person.011234570267.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011234570267.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.12380.38", 
          "name": [
            "Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willemsen", 
        "givenName": "Gonneke", 
        "id": "sg:person.0610017257.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610017257.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.12380.38", 
          "name": [
            "Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hottenga", 
        "givenName": "Jouke Jan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Eastern Finland", 
          "id": "https://www.grid.ac/institutes/grid.9668.1", 
          "name": [
            "Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland", 
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland", 
            "University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, FI-70211, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korhonen", 
        "givenName": "Tellervo", 
        "id": "sg:person.0702763155.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702763155.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heli\u00f6vaara", 
        "givenName": "Markku", 
        "id": "sg:person.015774721017.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015774721017.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tartu", 
          "id": "https://www.grid.ac/institutes/grid.10939.32", 
          "name": [
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland", 
            "Institute for Molecular Medicine, University of Helsinki, Helsinki, FI-00014, Finland", 
            "Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perola", 
        "givenName": "Markus", 
        "id": "sg:person.01104357207.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104357207.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University System", 
          "id": "https://www.grid.ac/institutes/grid.257410.5", 
          "name": [
            "Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, United States"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rose", 
        "givenName": "Richard J.", 
        "id": "sg:person.012760402432.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012760402432.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom", 
            "School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paternoster", 
        "givenName": "Lavinia", 
        "id": "sg:person.01021156177.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021156177.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom", 
            "School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Timpson", 
        "givenName": "Nic", 
        "id": "sg:person.010270473157.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010270473157.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wassenaar", 
        "givenName": "Catherine A.", 
        "id": "sg:person.01066633356.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066633356.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Andy Z. X.", 
        "id": "sg:person.013211217202.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013211217202.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom", 
            "School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "George Davey", 
        "id": "sg:person.010663343457.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010663343457.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Turku", 
          "id": "https://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, FI-20521, Finland", 
            "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FI-20520, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raitakari", 
        "givenName": "Olli T.", 
        "id": "sg:person.01267360065.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267360065.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33520, Finland", 
            "Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, FI-33014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehtim\u00e4ki", 
        "givenName": "Terho", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tampere", 
          "id": "https://www.grid.ac/institutes/grid.5509.9", 
          "name": [
            "Department of Clinical Physiology, Tampere University Hospital, Tampere, FI-33521, Finland", 
            "Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, FI-33014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00e4h\u00f6nen", 
        "givenName": "Mika", 
        "id": "sg:person.01335473265.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335473265.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koskinen", 
        "givenName": "Seppo", 
        "id": "sg:person.01005740523.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005740523.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King's College London", 
          "id": "https://www.grid.ac/institutes/grid.13097.3c", 
          "name": [
            "Department of Twin Research and Genetic Epidemiology, King\u2019s College London, London, SE1 7EH, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spector", 
        "givenName": "Timothy", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, 1081 HL, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Penninx", 
        "givenName": "Brenda W. J. H.", 
        "id": "sg:person.011235144537.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011235144537.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salomaa", 
        "givenName": "Veikko", 
        "id": "sg:person.01106502627.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106502627.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.12380.38", 
          "name": [
            "Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boomsma", 
        "givenName": "Dorret I.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada", 
            "Department of Psychiatry, Campbell Family Mental Health Research Institute of the Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tyndale", 
        "givenName": "Rachel F.", 
        "id": "sg:person.01027276476.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027276476.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland", 
            "National Institute for Health and Welfare, Helsinki, FI-00271, Finland", 
            "Institute for Molecular Medicine, University of Helsinki, Helsinki, FI-00014, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaprio", 
        "givenName": "Jaakko", 
        "id": "sg:person.015767231737.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015767231737.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bristol", 
          "id": "https://www.grid.ac/institutes/grid.5337.2", 
          "name": [
            "MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom", 
            "School of Experimental Psychology and UK Centre for Tobacco and Alcohol Studies, University of Bristol, Bristol, BS8 1TU, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Munaf\u00f2", 
        "givenName": "Marcus R.", 
        "id": "sg:person.012323752451.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012323752451.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature06846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000224730", 
          "https://doi.org/10.1038/nature06846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-09-0959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007505207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2010.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009497006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddp322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011022101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgs306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013165032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1360-0443.2012.04077.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014900412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015286406", 
          "https://doi.org/10.1038/ng.571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015286406", 
          "https://doi.org/10.1038/ng.571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-05-0723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017105847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022092141", 
          "https://doi.org/10.1038/ng.572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022092141", 
          "https://doi.org/10.1038/ng.572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-11-288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023780871", 
          "https://doi.org/10.1186/1471-2105-11-288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-11-288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023780871", 
          "https://doi.org/10.1186/1471-2105-11-288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drugalcdep.2006.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025121603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0070938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030298628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-14-1381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031064263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/pmed.1995.1031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032022117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-12-1234-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037163206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881112458731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045702289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881112458731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045702289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048010930", 
          "https://doi.org/10.1038/ng.573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048010930", 
          "https://doi.org/10.1038/ng.573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-4582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048528519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1001053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050535929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.57.1.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051366472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-09-1303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052540332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djs191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052860397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-14-0815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053200105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060340229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2105/ajph.83.9.1335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068874783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078759268", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-04", 
    "datePublishedReg": "2016-04-01", 
    "description": "Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking typically employ self-report phenotypes. However, precise biomarker phenotypes may afford greater statistical power and identify novel variants. Here we report the results of a GWAS meta-analysis of levels of cotinine, the primary metabolite of nicotine, in 4,548 daily smokers of European ancestry. We identified a locus close to UGT2B10 at 4q13.2 (minimum p\u2009=\u20095.89\u2009\u00d7\u200910(-10) for rs114612145), which was consequently replicated. This variant is in high linkage disequilibrium with a known functional variant in the UGT2B10 gene which is associated with reduced nicotine and cotinine glucuronidation activity, but intriguingly is not associated with nicotine intake. Additionally, we observed association between multiple variants within the 15q25.1 region and cotinine levels, all located within the CHRNA5-A3-B4 gene cluster or adjacent genes, consistent with previous much larger GWAS using self-report measures of smoking quantity. These results clearly illustrate the increase in power afforded by using precise biomarker measures in GWAS. Perhaps more importantly however, they also highlight that biomarkers do not always mark the phenotype of interest. The use of metabolite data as a proxy for environmental exposures should be carefully considered in the context of individual differences in metabolic pathways. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/srep20092", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2689487", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2487131", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3560505", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2443632", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2685382", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3791356", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3560531", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3560132", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2786197", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4682805", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3773756", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2633413", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3783527", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3786024", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3499662", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2485901", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4576591", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2622805", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2", 
    "pagination": "20092", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "76fb1b693e5104f7c0bfc538cb0c51e8eadf6285cd1389d5ae6e3a4812ba7a65"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26833182"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/srep20092"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024975364"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/srep20092", 
      "https://app.dimensions.ai/details/publication/pub.1024975364"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/srep20092"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/srep20092'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/srep20092'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/srep20092'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/srep20092'


 

This table displays all metadata directly associated to this object as RDF triples.

526 TRIPLES      21 PREDICATES      65 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/srep20092 schema:about N112cdb6bcae74cbdb257d93cc7671e83
2 N210844a72dbf45a28f624dcae21b0cdc
3 N4457fdda2e1a49939c4ddae3c0af26bc
4 N79573c46310c47ad9eff6f8f758b1742
5 N866a1a0e30e449a893a69c240ee0c0d3
6 N878bc5b55fe541e4a7ec4707e5276f23
7 N9d2f0b7fb3804af49f3d2301b3895e79
8 Nbc694f6551ed4aa2a34c7f54d770a06c
9 Nf2fc3510ebea4cf59d616c1b9a7f481b
10 Nf68e9361f431484a9334732f02174b21
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N008ff3e5fecb400abd53af23086284b7
14 schema:citation sg:pub.10.1038/nature06846
15 sg:pub.10.1038/ng.571
16 sg:pub.10.1038/ng.572
17 sg:pub.10.1038/ng.573
18 sg:pub.10.1186/1471-2105-11-288
19 https://app.dimensions.ai/details/publication/pub.1078759268
20 https://doi.org/10.1006/pmed.1995.1031
21 https://doi.org/10.1016/j.ajhg.2010.11.011
22 https://doi.org/10.1016/j.drugalcdep.2006.06.017
23 https://doi.org/10.1093/carcin/bgs306
24 https://doi.org/10.1093/hmg/ddp322
25 https://doi.org/10.1093/jnci/djs191
26 https://doi.org/10.1097/fpc.0000000000000011
27 https://doi.org/10.1111/j.1360-0443.2012.04077.x
28 https://doi.org/10.1124/pr.57.1.3
29 https://doi.org/10.1158/0008-5472.can-09-4582
30 https://doi.org/10.1158/1055-9965.epi-05-0723
31 https://doi.org/10.1158/1055-9965.epi-09-0959
32 https://doi.org/10.1158/1055-9965.epi-09-1303
33 https://doi.org/10.1158/1055-9965.epi-12-1234-t
34 https://doi.org/10.1158/1055-9965.epi-14-0815
35 https://doi.org/10.1158/1055-9965.epi-14-1381
36 https://doi.org/10.1177/0269881112458731
37 https://doi.org/10.1371/journal.pgen.1001053
38 https://doi.org/10.1371/journal.pone.0070938
39 https://doi.org/10.2105/ajph.83.9.1335
40 schema:datePublished 2016-04
41 schema:datePublishedReg 2016-04-01
42 schema:description Genome-wide association studies (GWAS) of complex behavioural phenotypes such as cigarette smoking typically employ self-report phenotypes. However, precise biomarker phenotypes may afford greater statistical power and identify novel variants. Here we report the results of a GWAS meta-analysis of levels of cotinine, the primary metabolite of nicotine, in 4,548 daily smokers of European ancestry. We identified a locus close to UGT2B10 at 4q13.2 (minimum p = 5.89 × 10(-10) for rs114612145), which was consequently replicated. This variant is in high linkage disequilibrium with a known functional variant in the UGT2B10 gene which is associated with reduced nicotine and cotinine glucuronidation activity, but intriguingly is not associated with nicotine intake. Additionally, we observed association between multiple variants within the 15q25.1 region and cotinine levels, all located within the CHRNA5-A3-B4 gene cluster or adjacent genes, consistent with previous much larger GWAS using self-report measures of smoking quantity. These results clearly illustrate the increase in power afforded by using precise biomarker measures in GWAS. Perhaps more importantly however, they also highlight that biomarkers do not always mark the phenotype of interest. The use of metabolite data as a proxy for environmental exposures should be carefully considered in the context of individual differences in metabolic pathways.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N998cd38e07744d3c8f2328fac8040759
47 Nc7b75806d24843e4af7dd6cbec45ec45
48 sg:journal.1045337
49 schema:name Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2
50 schema:pagination 20092
51 schema:productId N5a38186848514742b30aeb8705ffca92
52 N5d672c49dfaf404d904c5d9d776490cf
53 N8d500b5a6df14fbb89f28a112aeecbcd
54 Nc52b1494ec7148958d5f744b35dddc05
55 Nf3b2b5e31fd0482bb1c29169a53e9ff2
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024975364
57 https://doi.org/10.1038/srep20092
58 schema:sdDatePublished 2019-04-10T14:16
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Ne8fd3fb406a24756b5caa1c21f9a1c0c
61 schema:url http://www.nature.com/articles/srep20092
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N008ff3e5fecb400abd53af23086284b7 rdf:first Nac6a3838f1c84f51bc09d76b50f604f7
66 rdf:rest N390bfc2f7b024d67bbf36e82e94a4f08
67 N06d58a1bae504ff8b0ca4b8d3e4ddb84 rdf:first N95ed1ff4abc14381ad54b681ce95cd09
68 rdf:rest Ne59e02c86e0740539a68c64ab4458108
69 N098807e39fee436fb5b37941cfa79c09 rdf:first sg:person.01175335165.31
70 rdf:rest Ne72b3ac2ff2d496ba85471d6cca86e4c
71 N0a8af26e30ee4379897f974fad9510aa rdf:first sg:person.01102600173.33
72 rdf:rest Nbfb9b56bc01b4df59d2392cc950e125f
73 N112cdb6bcae74cbdb257d93cc7671e83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Smoking
75 rdf:type schema:DefinedTerm
76 N121bd6c1fa7246fcaf468ad7e504959b schema:affiliation https://www.grid.ac/institutes/grid.5509.9
77 schema:familyName Lehtimäki
78 schema:givenName Terho
79 rdf:type schema:Person
80 N13ffd68685ff438db5776bbfd806e331 rdf:first sg:person.01106502627.67
81 rdf:rest N06d58a1bae504ff8b0ca4b8d3e4ddb84
82 N1a82e9087a694ccfbfad7a1b03d6a129 rdf:first sg:person.01066633356.75
83 rdf:rest Nfae5e50c327d41348e358ab7edf32c09
84 N1df45f243b534d6984c089121fb54c46 rdf:first sg:person.01021156177.43
85 rdf:rest N2fdb3d5f32794883b22576e64664b238
86 N210844a72dbf45a28f624dcae21b0cdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Linkage Disequilibrium
88 rdf:type schema:DefinedTerm
89 N25338ca1f61448c4acc7c23cd24b2774 schema:affiliation https://www.grid.ac/institutes/grid.224260.0
90 schema:familyName Chen
91 schema:givenName Xiangning
92 rdf:type schema:Person
93 N25c7b577613349c9a49923c782ab6d24 rdf:first sg:person.012760402432.02
94 rdf:rest N1df45f243b534d6984c089121fb54c46
95 N2fdb3d5f32794883b22576e64664b238 rdf:first sg:person.010270473157.40
96 rdf:rest N1a82e9087a694ccfbfad7a1b03d6a129
97 N390bfc2f7b024d67bbf36e82e94a4f08 rdf:first N25338ca1f61448c4acc7c23cd24b2774
98 rdf:rest Ne25240b462f744d1af02c8e209af499c
99 N3b086cd310f74ebba8445d9f3bda078a rdf:first N121bd6c1fa7246fcaf468ad7e504959b
100 rdf:rest Nd8a9b8bf04314c3f84b0b74b7c40a766
101 N3f075621b76f45f6b6b7907bc75507f8 rdf:first sg:person.010663343457.34
102 rdf:rest N6baa73d6061e4003ac1f8a15c7406761
103 N4457fdda2e1a49939c4ddae3c0af26bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Genome-Wide Association Study
105 rdf:type schema:DefinedTerm
106 N49f0d383a54e47ac861633e5e4108812 rdf:first sg:person.0610017257.08
107 rdf:rest N8faf4021b5324c21a43cb94a483e123f
108 N4dfcc36319984933a9439b33624203a2 rdf:first sg:person.01134036767.86
109 rdf:rest N93a799bf5f53446a9efa065a1f445636
110 N5a38186848514742b30aeb8705ffca92 schema:name doi
111 schema:value 10.1038/srep20092
112 rdf:type schema:PropertyValue
113 N5d672c49dfaf404d904c5d9d776490cf schema:name pubmed_id
114 schema:value 26833182
115 rdf:type schema:PropertyValue
116 N5deae62f905c419ca8555c87a83c2eb5 rdf:first sg:person.0642616316.73
117 rdf:rest N4dfcc36319984933a9439b33624203a2
118 N5e2b3e13981d4020b352c0708a3788fc schema:affiliation https://www.grid.ac/institutes/grid.12380.38
119 schema:familyName Hottenga
120 schema:givenName Jouke Jan
121 rdf:type schema:Person
122 N6baa73d6061e4003ac1f8a15c7406761 rdf:first sg:person.01267360065.55
123 rdf:rest N3b086cd310f74ebba8445d9f3bda078a
124 N6da20fa9854e4173b03810faadca2d03 rdf:first sg:person.011235144537.09
125 rdf:rest N13ffd68685ff438db5776bbfd806e331
126 N74437af3f9444b9d8b006c1f46bb206b rdf:first sg:person.012323752451.84
127 rdf:rest rdf:nil
128 N79573c46310c47ad9eff6f8f758b1742 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Chromosomes, Human, Pair 4
130 rdf:type schema:DefinedTerm
131 N7e32736203d2463a9ea65b75875c135b rdf:first sg:person.01141211611.54
132 rdf:rest N0a8af26e30ee4379897f974fad9510aa
133 N810cbcce2d9a45ffa06b28b9503009f8 rdf:first sg:person.01043744667.67
134 rdf:rest Na6f5baca43564bdcbaa281db8ca4e295
135 N860a00f8bf504c8eb6360d9df69c5f90 rdf:first sg:person.0711664555.48
136 rdf:rest N810cbcce2d9a45ffa06b28b9503009f8
137 N866a1a0e30e449a893a69c240ee0c0d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cotinine
139 rdf:type schema:DefinedTerm
140 N878bc5b55fe541e4a7ec4707e5276f23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Humans
142 rdf:type schema:DefinedTerm
143 N8d500b5a6df14fbb89f28a112aeecbcd schema:name nlm_unique_id
144 schema:value 101563288
145 rdf:type schema:PropertyValue
146 N8e578e1bdeb94ddfbf29f4c3ea8fb7f3 rdf:first sg:person.01005740523.46
147 rdf:rest Nf7f1cad9a7944a3984d97ae1fd17f342
148 N8faf4021b5324c21a43cb94a483e123f rdf:first N5e2b3e13981d4020b352c0708a3788fc
149 rdf:rest Naabe43642de04abda354eb0e13d07676
150 N93a799bf5f53446a9efa065a1f445636 rdf:first sg:person.0633256337.62
151 rdf:rest N860a00f8bf504c8eb6360d9df69c5f90
152 N953c1c250007461cb79cddee66c0cbdd schema:affiliation https://www.grid.ac/institutes/grid.12380.38
153 schema:familyName Vink
154 schema:givenName Jacqueline
155 rdf:type schema:Person
156 N95ed1ff4abc14381ad54b681ce95cd09 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
157 schema:familyName Boomsma
158 schema:givenName Dorret I.
159 rdf:type schema:Person
160 N998cd38e07744d3c8f2328fac8040759 schema:issueNumber 1
161 rdf:type schema:PublicationIssue
162 N9d2f0b7fb3804af49f3d2301b3895e79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Female
164 rdf:type schema:DefinedTerm
165 Na6f5baca43564bdcbaa281db8ca4e295 rdf:first Nfc08f030ee8f46ef82b7d7a8d0c97dcc
166 rdf:rest N7e32736203d2463a9ea65b75875c135b
167 Naabe43642de04abda354eb0e13d07676 rdf:first sg:person.0702763155.55
168 rdf:rest Nfdda3146513e45f19c1b8eef20bbfce5
169 Nac4a80b8d5904e6cbda1686138350028 rdf:first sg:person.015767231737.16
170 rdf:rest N74437af3f9444b9d8b006c1f46bb206b
171 Nac6a3838f1c84f51bc09d76b50f604f7 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
172 schema:familyName Ware
173 schema:givenName Jennifer J.
174 rdf:type schema:Person
175 Nb473d0c91d834c0bb4f9a206f22c8312 rdf:first sg:person.01034333505.72
176 rdf:rest N5deae62f905c419ca8555c87a83c2eb5
177 Nb6d83faa5d1b477483b79c6afd89cc07 rdf:first sg:person.01104357207.40
178 rdf:rest N25c7b577613349c9a49923c782ab6d24
179 Nbc694f6551ed4aa2a34c7f54d770a06c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Male
181 rdf:type schema:DefinedTerm
182 Nbfb9b56bc01b4df59d2392cc950e125f rdf:first sg:person.01020276562.45
183 rdf:rest Nfe2fefea8f004877bcfa8b3f3a3f64f9
184 Nc52b1494ec7148958d5f744b35dddc05 schema:name readcube_id
185 schema:value 76fb1b693e5104f7c0bfc538cb0c51e8eadf6285cd1389d5ae6e3a4812ba7a65
186 rdf:type schema:PropertyValue
187 Nc7b75806d24843e4af7dd6cbec45ec45 schema:volumeNumber 6
188 rdf:type schema:PublicationVolume
189 Nd8a9b8bf04314c3f84b0b74b7c40a766 rdf:first sg:person.01335473265.62
190 rdf:rest N8e578e1bdeb94ddfbf29f4c3ea8fb7f3
191 Ne25240b462f744d1af02c8e209af499c rdf:first N953c1c250007461cb79cddee66c0cbdd
192 rdf:rest Nb473d0c91d834c0bb4f9a206f22c8312
193 Ne59e02c86e0740539a68c64ab4458108 rdf:first sg:person.01027276476.49
194 rdf:rest Nac4a80b8d5904e6cbda1686138350028
195 Ne72b3ac2ff2d496ba85471d6cca86e4c rdf:first sg:person.011234570267.86
196 rdf:rest N49f0d383a54e47ac861633e5e4108812
197 Ne8fd3fb406a24756b5caa1c21f9a1c0c schema:name Springer Nature - SN SciGraph project
198 rdf:type schema:Organization
199 Nf2fc3510ebea4cf59d616c1b9a7f481b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Genetic Loci
201 rdf:type schema:DefinedTerm
202 Nf3b2b5e31fd0482bb1c29169a53e9ff2 schema:name dimensions_id
203 schema:value pub.1024975364
204 rdf:type schema:PropertyValue
205 Nf68e9361f431484a9334732f02174b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Glucuronosyltransferase
207 rdf:type schema:DefinedTerm
208 Nf7f1cad9a7944a3984d97ae1fd17f342 rdf:first Nfb0e1cb6fcf145a2b928f850a5b27204
209 rdf:rest N6da20fa9854e4173b03810faadca2d03
210 Nfae5e50c327d41348e358ab7edf32c09 rdf:first sg:person.013211217202.30
211 rdf:rest N3f075621b76f45f6b6b7907bc75507f8
212 Nfb0e1cb6fcf145a2b928f850a5b27204 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
213 schema:familyName Spector
214 schema:givenName Timothy
215 rdf:type schema:Person
216 Nfc08f030ee8f46ef82b7d7a8d0c97dcc schema:affiliation https://www.grid.ac/institutes/grid.224260.0
217 schema:familyName Chen
218 schema:givenName Jingchun
219 rdf:type schema:Person
220 Nfdda3146513e45f19c1b8eef20bbfce5 rdf:first sg:person.015774721017.48
221 rdf:rest Nb6d83faa5d1b477483b79c6afd89cc07
222 Nfe2fefea8f004877bcfa8b3f3a3f64f9 rdf:first sg:person.0613664645.53
223 rdf:rest N098807e39fee436fb5b37941cfa79c09
224 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
225 schema:name Biological Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
228 schema:name Genetics
229 rdf:type schema:DefinedTerm
230 sg:grant.2443632 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
231 rdf:type schema:MonetaryGrant
232 sg:grant.2485901 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
233 rdf:type schema:MonetaryGrant
234 sg:grant.2487131 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
235 rdf:type schema:MonetaryGrant
236 sg:grant.2622805 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
237 rdf:type schema:MonetaryGrant
238 sg:grant.2633413 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
239 rdf:type schema:MonetaryGrant
240 sg:grant.2685382 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
241 rdf:type schema:MonetaryGrant
242 sg:grant.2689487 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
243 rdf:type schema:MonetaryGrant
244 sg:grant.2786197 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
245 rdf:type schema:MonetaryGrant
246 sg:grant.3499662 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
247 rdf:type schema:MonetaryGrant
248 sg:grant.3560132 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
249 rdf:type schema:MonetaryGrant
250 sg:grant.3560505 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
251 rdf:type schema:MonetaryGrant
252 sg:grant.3560531 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
253 rdf:type schema:MonetaryGrant
254 sg:grant.3773756 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
255 rdf:type schema:MonetaryGrant
256 sg:grant.3783527 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
257 rdf:type schema:MonetaryGrant
258 sg:grant.3786024 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
259 rdf:type schema:MonetaryGrant
260 sg:grant.3791356 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
261 rdf:type schema:MonetaryGrant
262 sg:grant.4576591 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
263 rdf:type schema:MonetaryGrant
264 sg:grant.4682805 http://pending.schema.org/fundedItem sg:pub.10.1038/srep20092
265 rdf:type schema:MonetaryGrant
266 sg:journal.1045337 schema:issn 2045-2322
267 schema:name Scientific Reports
268 rdf:type schema:Periodical
269 sg:person.01005740523.46 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
270 schema:familyName Koskinen
271 schema:givenName Seppo
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005740523.46
273 rdf:type schema:Person
274 sg:person.01020276562.45 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
275 schema:familyName Lyytikäinen
276 schema:givenName Leo-Pekka
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020276562.45
278 rdf:type schema:Person
279 sg:person.01021156177.43 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
280 schema:familyName Paternoster
281 schema:givenName Lavinia
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021156177.43
283 rdf:type schema:Person
284 sg:person.010270473157.40 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
285 schema:familyName Timpson
286 schema:givenName Nic
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010270473157.40
288 rdf:type schema:Person
289 sg:person.01027276476.49 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
290 schema:familyName Tyndale
291 schema:givenName Rachel F.
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027276476.49
293 rdf:type schema:Person
294 sg:person.01034333505.72 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
295 schema:familyName Loukola
296 schema:givenName Anu
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034333505.72
298 rdf:type schema:Person
299 sg:person.01043744667.67 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
300 schema:familyName Menni
301 schema:givenName Cristina
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043744667.67
303 rdf:type schema:Person
304 sg:person.010663343457.34 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
305 schema:familyName Smith
306 schema:givenName George Davey
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010663343457.34
308 rdf:type schema:Person
309 sg:person.01066633356.75 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
310 schema:familyName Wassenaar
311 schema:givenName Catherine A.
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066633356.75
313 rdf:type schema:Person
314 sg:person.01102600173.33 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
315 schema:familyName Auro
316 schema:givenName Kirsi
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102600173.33
318 rdf:type schema:Person
319 sg:person.01104357207.40 schema:affiliation https://www.grid.ac/institutes/grid.10939.32
320 schema:familyName Perola
321 schema:givenName Markus
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104357207.40
323 rdf:type schema:Person
324 sg:person.01106502627.67 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
325 schema:familyName Salomaa
326 schema:givenName Veikko
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106502627.67
328 rdf:type schema:Person
329 sg:person.011234570267.86 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
330 schema:familyName Hemani
331 schema:givenName Gibran
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011234570267.86
333 rdf:type schema:Person
334 sg:person.011235144537.09 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
335 schema:familyName Penninx
336 schema:givenName Brenda W. J. H.
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011235144537.09
338 rdf:type schema:Person
339 sg:person.01134036767.86 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
340 schema:familyName Pool
341 schema:givenName Rene
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134036767.86
343 rdf:type schema:Person
344 sg:person.01141211611.54 schema:affiliation https://www.grid.ac/institutes/grid.224260.0
345 schema:familyName Peterson
346 schema:givenName Roseann E.
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141211611.54
348 rdf:type schema:Person
349 sg:person.01175335165.31 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
350 schema:familyName Stiby
351 schema:givenName Alexander I.
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175335165.31
353 rdf:type schema:Person
354 sg:person.012323752451.84 schema:affiliation https://www.grid.ac/institutes/grid.5337.2
355 schema:familyName Munafò
356 schema:givenName Marcus R.
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012323752451.84
358 rdf:type schema:Person
359 sg:person.01267360065.55 schema:affiliation https://www.grid.ac/institutes/grid.1374.1
360 schema:familyName Raitakari
361 schema:givenName Olli T.
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267360065.55
363 rdf:type schema:Person
364 sg:person.012760402432.02 schema:affiliation https://www.grid.ac/institutes/grid.257410.5
365 schema:familyName Rose
366 schema:givenName Richard J.
367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012760402432.02
368 rdf:type schema:Person
369 sg:person.013211217202.30 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
370 schema:familyName Zhu
371 schema:givenName Andy Z. X.
372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013211217202.30
373 rdf:type schema:Person
374 sg:person.01335473265.62 schema:affiliation https://www.grid.ac/institutes/grid.5509.9
375 schema:familyName Kähönen
376 schema:givenName Mika
377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335473265.62
378 rdf:type schema:Person
379 sg:person.015767231737.16 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
380 schema:familyName Kaprio
381 schema:givenName Jaakko
382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015767231737.16
383 rdf:type schema:Person
384 sg:person.015774721017.48 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
385 schema:familyName Heliövaara
386 schema:givenName Markku
387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015774721017.48
388 rdf:type schema:Person
389 sg:person.0610017257.08 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
390 schema:familyName Willemsen
391 schema:givenName Gonneke
392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610017257.08
393 rdf:type schema:Person
394 sg:person.0613664645.53 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
395 schema:familyName Wedenoja
396 schema:givenName Juho
397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613664645.53
398 rdf:type schema:Person
399 sg:person.0633256337.62 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
400 schema:familyName Milaneschi
401 schema:givenName Yuri
402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633256337.62
403 rdf:type schema:Person
404 sg:person.0642616316.73 schema:affiliation https://www.grid.ac/institutes/grid.12380.38
405 schema:familyName Minica
406 schema:givenName Camelia
407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642616316.73
408 rdf:type schema:Person
409 sg:person.0702763155.55 schema:affiliation https://www.grid.ac/institutes/grid.9668.1
410 schema:familyName Korhonen
411 schema:givenName Tellervo
412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702763155.55
413 rdf:type schema:Person
414 sg:person.0711664555.48 schema:affiliation https://www.grid.ac/institutes/grid.13097.3c
415 schema:familyName Mangino
416 schema:givenName Massimo
417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711664555.48
418 rdf:type schema:Person
419 sg:pub.10.1038/nature06846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000224730
420 https://doi.org/10.1038/nature06846
421 rdf:type schema:CreativeWork
422 sg:pub.10.1038/ng.571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015286406
423 https://doi.org/10.1038/ng.571
424 rdf:type schema:CreativeWork
425 sg:pub.10.1038/ng.572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022092141
426 https://doi.org/10.1038/ng.572
427 rdf:type schema:CreativeWork
428 sg:pub.10.1038/ng.573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048010930
429 https://doi.org/10.1038/ng.573
430 rdf:type schema:CreativeWork
431 sg:pub.10.1186/1471-2105-11-288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023780871
432 https://doi.org/10.1186/1471-2105-11-288
433 rdf:type schema:CreativeWork
434 https://app.dimensions.ai/details/publication/pub.1078759268 schema:CreativeWork
435 https://doi.org/10.1006/pmed.1995.1031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032022117
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1016/j.ajhg.2010.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009497006
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1016/j.drugalcdep.2006.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025121603
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1093/carcin/bgs306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013165032
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1093/hmg/ddp322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011022101
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1093/jnci/djs191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052860397
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1097/fpc.0000000000000011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340229
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1111/j.1360-0443.2012.04077.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014900412
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1124/pr.57.1.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051366472
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1158/0008-5472.can-09-4582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048528519
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1158/1055-9965.epi-05-0723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017105847
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1158/1055-9965.epi-09-0959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007505207
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1158/1055-9965.epi-09-1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052540332
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1158/1055-9965.epi-12-1234-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1037163206
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1158/1055-9965.epi-14-0815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053200105
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1158/1055-9965.epi-14-1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031064263
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1177/0269881112458731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045702289
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1371/journal.pgen.1001053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050535929
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1371/journal.pone.0070938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030298628
472 rdf:type schema:CreativeWork
473 https://doi.org/10.2105/ajph.83.9.1335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068874783
474 rdf:type schema:CreativeWork
475 https://www.grid.ac/institutes/grid.10939.32 schema:alternateName University of Tartu
476 schema:name Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia
477 Institute for Molecular Medicine, University of Helsinki, Helsinki, FI-00014, Finland
478 National Institute for Health and Welfare, Helsinki, FI-00271, Finland
479 rdf:type schema:Organization
480 https://www.grid.ac/institutes/grid.12380.38 schema:alternateName VU University Amsterdam
481 schema:name Department of Biological Psychology, VU University, Amsterdam, 1081 BT, Netherlands
482 rdf:type schema:Organization
483 https://www.grid.ac/institutes/grid.13097.3c schema:alternateName King's College London
484 schema:name Department of Twin Research and Genetic Epidemiology, King’s College London, London, SE1 7EH, United Kingdom
485 rdf:type schema:Organization
486 https://www.grid.ac/institutes/grid.1374.1 schema:alternateName University of Turku
487 schema:name Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, FI-20521, Finland
488 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FI-20520, Finland
489 rdf:type schema:Organization
490 https://www.grid.ac/institutes/grid.14758.3f schema:alternateName National Institute for Health and Welfare
491 schema:name National Institute for Health and Welfare, Helsinki, FI-00271, Finland
492 rdf:type schema:Organization
493 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
494 schema:name Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, 1081 HL, Netherlands
495 rdf:type schema:Organization
496 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
497 schema:name Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5S 1A8, Canada
498 Department of Psychiatry, Campbell Family Mental Health Research Institute of the Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
499 rdf:type schema:Organization
500 https://www.grid.ac/institutes/grid.224260.0 schema:alternateName Virginia Commonwealth University
501 schema:name Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
502 rdf:type schema:Organization
503 https://www.grid.ac/institutes/grid.257410.5 schema:alternateName Indiana University System
504 schema:name Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, United States
505 rdf:type schema:Organization
506 https://www.grid.ac/institutes/grid.5337.2 schema:alternateName University of Bristol
507 schema:name MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS8 2BN, United Kingdom
508 School of Experimental Psychology and UK Centre for Tobacco and Alcohol Studies, University of Bristol, Bristol, BS8 1TU, United Kingdom
509 School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom
510 rdf:type schema:Organization
511 https://www.grid.ac/institutes/grid.5509.9 schema:alternateName University of Tampere
512 schema:name Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33520, Finland
513 Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, FI-33014, Finland
514 Department of Clinical Physiology, Tampere University Hospital, Tampere, FI-33521, Finland
515 Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, FI-33014, Finland
516 rdf:type schema:Organization
517 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
518 schema:name Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland
519 Institute for Molecular Medicine, University of Helsinki, Helsinki, FI-00014, Finland
520 National Institute for Health and Welfare, Helsinki, FI-00271, Finland
521 rdf:type schema:Organization
522 https://www.grid.ac/institutes/grid.9668.1 schema:alternateName University of Eastern Finland
523 schema:name Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland
524 National Institute for Health and Welfare, Helsinki, FI-00271, Finland
525 University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, FI-70211, Finland
526 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...